Comparison of protection against H5N1 influenza virus in mouse offspring provided by maternal vaccination with HA DNA and inactivated vaccine.
Identifieur interne : 001581 ( Ncbi/Curation ); précédent : 001580; suivant : 001582Comparison of protection against H5N1 influenza virus in mouse offspring provided by maternal vaccination with HA DNA and inactivated vaccine.
Auteurs : Fenghua Zhang [République populaire de Chine] ; Fang Fang ; Haiyan Chang ; Bo Peng ; Jian Wu ; Jianjun Chen ; Hanzhong Wang ; Ze ChenSource :
- Archives of virology [ 1432-8798 ] ; 2013.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (sang), Facteurs de l'âge, Femelle, Immunité acquise d'origine maternelle (immunologie), Infections à Orthomyxoviridae (), Infections à Orthomyxoviridae (immunologie), Relation dose-réponse (immunologie), Souris, Souris de lignée BALB C, Sous-type H5N1 du virus de la grippe A (immunologie), Vaccins antigrippaux (administration et posologie), Vaccins antigrippaux (immunologie), Vaccins antigrippaux (usage thérapeutique), Vaccins inactivés (immunologie), Vaccins inactivés (usage thérapeutique).
- MESH :
- administration et posologie : Vaccins antigrippaux.
- immunologie : Immunité acquise d'origine maternelle, Infections à Orthomyxoviridae, Sous-type H5N1 du virus de la grippe A, Vaccins antigrippaux, Vaccins inactivés.
- sang : Anticorps antiviraux.
- usage thérapeutique : Vaccins antigrippaux, Vaccins inactivés.
- Animaux, Facteurs de l'âge, Femelle, Infections à Orthomyxoviridae, Relation dose-réponse (immunologie), Souris, Souris de lignée BALB C.
English descriptors
- KwdEn :
- Age Factors, Animals, Antibodies, Viral (blood), Dose-Response Relationship, Immunologic, Female, Immunity, Maternally-Acquired (immunology), Influenza A Virus, H5N1 Subtype (immunology), Influenza Vaccines (administration & dosage), Influenza Vaccines (immunology), Influenza Vaccines (therapeutic use), Mice, Mice, Inbred BALB C, Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (prevention & control), Vaccines, Inactivated (immunology), Vaccines, Inactivated (therapeutic use).
- MESH :
- chemical , administration & dosage : Influenza Vaccines.
- chemical , blood : Antibodies, Viral.
- immunology : Immunity, Maternally-Acquired, Influenza A Virus, H5N1 Subtype, Influenza Vaccines, Orthomyxoviridae Infections, Vaccines, Inactivated.
- prevention & control : Orthomyxoviridae Infections.
- chemical , therapeutic use : Influenza Vaccines, Vaccines, Inactivated.
- Age Factors, Animals, Dose-Response Relationship, Immunologic, Female, Mice, Mice, Inbred BALB C.
Abstract
H5N1 influenza virus is one of the viruses that can potentially cause an influenza pandemic. Protection of newborns against influenza virus infection could be effectively provided by maternal immunization. In this study, female mice were immunized with H5N1 HA DNA vaccine or inactivated whole-virion vaccine, and the protection provided by maternal antibodies in their offspring against a lethal homologous influenza virus challenge was compared. The results showed that maternal antibodies, whether induced by a DNA vaccine or an inactivated vaccine, could completely protect offspring aged 1-4 weeks from a lethal influenza virus challenge. Breast-feeding was the major route of transfer for maternal antibodies. Milk-derived antibodies were able to effectively protect the offspring aged 1-4 weeks from lethal influenza virus infection, whereas maternal antibodies transferred through the placenta only partially protected the offspring 1-2 weeks of age. The milk- and placenta-transferred IgG2a antibody levels in offspring from their mothers, whether vaccinated with DNA vaccine or inactivated vaccine, were higher than the IgG1 levels. Our results indicated that maternal vaccination with HA DNA, as well as with whole-virion inactivated vaccine, could offer effective protection to offspring against H5N1 influenza virus infection.
DOI: 10.1007/s00705-013-1621-y
PubMed: 23385327
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000A93
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :000A93
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000A50
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :001581
Links to Exploration step
pubmed:23385327Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Comparison of protection against H5N1 influenza virus in mouse offspring provided by maternal vaccination with HA DNA and inactivated vaccine.</title><author><name sortKey="Zhang, Fenghua" sort="Zhang, Fenghua" uniqKey="Zhang F" first="Fenghua" last="Zhang">Fenghua Zhang</name><affiliation wicri:level="1"><nlm:affiliation>College of Life Sciences, Hunan Normal University, Changsha, 410081 Hunan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Life Sciences, Hunan Normal University, Changsha, 410081 Hunan</wicri:regionArea><wicri:noRegion>410081 Hunan</wicri:noRegion></affiliation></author><author><name sortKey="Fang, Fang" sort="Fang, Fang" uniqKey="Fang F" first="Fang" last="Fang">Fang Fang</name></author><author><name sortKey="Chang, Haiyan" sort="Chang, Haiyan" uniqKey="Chang H" first="Haiyan" last="Chang">Haiyan Chang</name></author><author><name sortKey="Peng, Bo" sort="Peng, Bo" uniqKey="Peng B" first="Bo" last="Peng">Bo Peng</name></author><author><name sortKey="Wu, Jian" sort="Wu, Jian" uniqKey="Wu J" first="Jian" last="Wu">Jian Wu</name></author><author><name sortKey="Chen, Jianjun" sort="Chen, Jianjun" uniqKey="Chen J" first="Jianjun" last="Chen">Jianjun Chen</name></author><author><name sortKey="Wang, Hanzhong" sort="Wang, Hanzhong" uniqKey="Wang H" first="Hanzhong" last="Wang">Hanzhong Wang</name></author><author><name sortKey="Chen, Ze" sort="Chen, Ze" uniqKey="Chen Z" first="Ze" last="Chen">Ze Chen</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23385327</idno><idno type="pmid">23385327</idno><idno type="doi">10.1007/s00705-013-1621-y</idno><idno type="wicri:Area/PubMed/Corpus">000A93</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000A93</idno><idno type="wicri:Area/PubMed/Curation">000A93</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000A93</idno><idno type="wicri:Area/PubMed/Checkpoint">000A50</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000A50</idno><idno type="wicri:Area/Ncbi/Merge">001581</idno><idno type="wicri:Area/Ncbi/Curation">001581</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Comparison of protection against H5N1 influenza virus in mouse offspring provided by maternal vaccination with HA DNA and inactivated vaccine.</title><author><name sortKey="Zhang, Fenghua" sort="Zhang, Fenghua" uniqKey="Zhang F" first="Fenghua" last="Zhang">Fenghua Zhang</name><affiliation wicri:level="1"><nlm:affiliation>College of Life Sciences, Hunan Normal University, Changsha, 410081 Hunan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Life Sciences, Hunan Normal University, Changsha, 410081 Hunan</wicri:regionArea><wicri:noRegion>410081 Hunan</wicri:noRegion></affiliation></author><author><name sortKey="Fang, Fang" sort="Fang, Fang" uniqKey="Fang F" first="Fang" last="Fang">Fang Fang</name></author><author><name sortKey="Chang, Haiyan" sort="Chang, Haiyan" uniqKey="Chang H" first="Haiyan" last="Chang">Haiyan Chang</name></author><author><name sortKey="Peng, Bo" sort="Peng, Bo" uniqKey="Peng B" first="Bo" last="Peng">Bo Peng</name></author><author><name sortKey="Wu, Jian" sort="Wu, Jian" uniqKey="Wu J" first="Jian" last="Wu">Jian Wu</name></author><author><name sortKey="Chen, Jianjun" sort="Chen, Jianjun" uniqKey="Chen J" first="Jianjun" last="Chen">Jianjun Chen</name></author><author><name sortKey="Wang, Hanzhong" sort="Wang, Hanzhong" uniqKey="Wang H" first="Hanzhong" last="Wang">Hanzhong Wang</name></author><author><name sortKey="Chen, Ze" sort="Chen, Ze" uniqKey="Chen Z" first="Ze" last="Chen">Ze Chen</name></author></analytic><series><title level="j">Archives of virology</title><idno type="eISSN">1432-8798</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age Factors</term><term>Animals</term><term>Antibodies, Viral (blood)</term><term>Dose-Response Relationship, Immunologic</term><term>Female</term><term>Immunity, Maternally-Acquired (immunology)</term><term>Influenza A Virus, H5N1 Subtype (immunology)</term><term>Influenza Vaccines (administration & dosage)</term><term>Influenza Vaccines (immunology)</term><term>Influenza Vaccines (therapeutic use)</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Orthomyxoviridae Infections (immunology)</term><term>Orthomyxoviridae Infections (prevention & control)</term><term>Vaccines, Inactivated (immunology)</term><term>Vaccines, Inactivated (therapeutic use)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antiviraux (sang)</term><term>Facteurs de l'âge</term><term>Femelle</term><term>Immunité acquise d'origine maternelle (immunologie)</term><term>Infections à Orthomyxoviridae ()</term><term>Infections à Orthomyxoviridae (immunologie)</term><term>Relation dose-réponse (immunologie)</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Sous-type H5N1 du virus de la grippe A (immunologie)</term><term>Vaccins antigrippaux (administration et posologie)</term><term>Vaccins antigrippaux (immunologie)</term><term>Vaccins antigrippaux (usage thérapeutique)</term><term>Vaccins inactivés (immunologie)</term><term>Vaccins inactivés (usage thérapeutique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Immunité acquise d'origine maternelle</term><term>Infections à Orthomyxoviridae</term><term>Sous-type H5N1 du virus de la grippe A</term><term>Vaccins antigrippaux</term><term>Vaccins inactivés</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Immunity, Maternally-Acquired</term><term>Influenza A Virus, H5N1 Subtype</term><term>Influenza Vaccines</term><term>Orthomyxoviridae Infections</term><term>Vaccines, Inactivated</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Influenza Vaccines</term><term>Vaccines, Inactivated</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Vaccins antigrippaux</term><term>Vaccins inactivés</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Age Factors</term><term>Animals</term><term>Dose-Response Relationship, Immunologic</term><term>Female</term><term>Mice</term><term>Mice, Inbred BALB C</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Facteurs de l'âge</term><term>Femelle</term><term>Infections à Orthomyxoviridae</term><term>Relation dose-réponse (immunologie)</term><term>Souris</term><term>Souris de lignée BALB C</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">H5N1 influenza virus is one of the viruses that can potentially cause an influenza pandemic. Protection of newborns against influenza virus infection could be effectively provided by maternal immunization. In this study, female mice were immunized with H5N1 HA DNA vaccine or inactivated whole-virion vaccine, and the protection provided by maternal antibodies in their offspring against a lethal homologous influenza virus challenge was compared. The results showed that maternal antibodies, whether induced by a DNA vaccine or an inactivated vaccine, could completely protect offspring aged 1-4 weeks from a lethal influenza virus challenge. Breast-feeding was the major route of transfer for maternal antibodies. Milk-derived antibodies were able to effectively protect the offspring aged 1-4 weeks from lethal influenza virus infection, whereas maternal antibodies transferred through the placenta only partially protected the offspring 1-2 weeks of age. The milk- and placenta-transferred IgG2a antibody levels in offspring from their mothers, whether vaccinated with DNA vaccine or inactivated vaccine, were higher than the IgG1 levels. Our results indicated that maternal vaccination with HA DNA, as well as with whole-virion inactivated vaccine, could offer effective protection to offspring against H5N1 influenza virus infection.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/PandemieGrippaleV1/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001581 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 001581 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= PandemieGrippaleV1
|flux= Ncbi
|étape= Curation
|type= RBID
|clé= pubmed:23385327
|texte= Comparison of protection against H5N1 influenza virus in mouse offspring provided by maternal vaccination with HA DNA and inactivated vaccine.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:23385327" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \
| NlmPubMed2Wicri -a PandemieGrippaleV1
| This area was generated with Dilib version V0.6.34. |  |