Modulation of potential respiratory pathogens by pH1N1 viral infection.
Identifieur interne : 001305 ( Main/Exploration ); précédent : 001304; suivant : 001306Modulation of potential respiratory pathogens by pH1N1 viral infection.
Auteurs : R K-K Leung [République populaire de Chine] ; J-W Zhou ; W. Guan ; S-K Li ; Z-F Yang ; S K-W TsuiSource :
- Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases [ 1469-0691 ] ; 2013.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Bactéries (), Bactéries (génétique), Bactéries (isolement et purification), Bactéries (pathogénicité), Chimiotaxie (génétique), Chimiotaxie (physiologie), Chine (épidémiologie), Co-infection (microbiologie), Co-infection (virologie), Co-infection (épidémiologie), Femelle, Grippe humaine (microbiologie), Grippe humaine (virologie), Grippe humaine (épidémiologie), Humains, Jeune adulte, Microbiote, Mâle, Partie orale du pharynx (microbiologie), Partie orale du pharynx (virologie), Pneumopathie bactérienne (microbiologie), Pneumopathie bactérienne (virologie), Pneumopathie bactérienne (épidémiologie), Pseudomonas (physiologie), Sous-type H1N1 du virus de la grippe A (physiologie), Sujet âgé.
- MESH :
- génétique : Bactéries, Chimiotaxie.
- isolement et purification : Bactéries.
- microbiologie : Co-infection, Grippe humaine, Partie orale du pharynx, Pneumopathie bactérienne.
- pathogénicité : Bactéries.
- physiologie : Chimiotaxie, Pseudomonas, Sous-type H1N1 du virus de la grippe A.
- virologie : Co-infection, Grippe humaine, Partie orale du pharynx, Pneumopathie bactérienne.
- épidémiologie : Chine, Co-infection, Grippe humaine, Pneumopathie bactérienne.
- Adolescent, Adulte, Adulte d'âge moyen, Bactéries, Femelle, Humains, Jeune adulte, Microbiote, Mâle, Sujet âgé.
- Wicri :
- geographic : République populaire de Chine.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Bacteria (classification), Bacteria (genetics), Bacteria (isolation & purification), Bacteria (pathogenicity), Chemotaxis (genetics), Chemotaxis (physiology), China (epidemiology), Coinfection (epidemiology), Coinfection (microbiology), Coinfection (virology), Female, Humans, Influenza A Virus, H1N1 Subtype (physiology), Influenza, Human (epidemiology), Influenza, Human (microbiology), Influenza, Human (virology), Male, Microbiota, Middle Aged, Oropharynx (microbiology), Oropharynx (virology), Pneumonia, Bacterial (epidemiology), Pneumonia, Bacterial (microbiology), Pneumonia, Bacterial (virology), Pseudomonas (physiology), Young Adult.
- MESH :
- geographic , epidemiology : China.
- classification : Bacteria.
- epidemiology : Coinfection, Influenza, Human, Pneumonia, Bacterial.
- genetics : Bacteria, Chemotaxis.
- isolation & purification : Bacteria.
- microbiology : Coinfection, Influenza, Human, Oropharynx, Pneumonia, Bacterial.
- pathogenicity : Bacteria.
- physiology : Chemotaxis, Influenza A Virus, H1N1 Subtype, Pseudomonas.
- virology : Coinfection, Influenza, Human, Oropharynx, Pneumonia, Bacterial.
- Adolescent, Adult, Aged, Female, Humans, Male, Microbiota, Middle Aged, Young Adult.
Abstract
While much effort has been made to characterize influenza A pdm09 virus (pH1N1), the flu that was responsible for the fourth influenza pandemic, there is a lack of study on the composition of bacteria that lead to secondary infection. In this study, we recruited pneumonia patients with and without pH1N1 infection and characterized their oropharyngeal microbiota by the unbiased high-throughput sequencing method. While there were no significant differences in common bacterial pneumonia-causative agents (Acinetobacter and Streptococcus species), previously unreported Pseudomonas species equipped with chemotaxis and flagellar assembly genes significantly increased (>20-fold) in the pH1N1-infected group. Bacillus and Ralstonia species that also increased significantly (5-10-fold) were also found to possess similar signaling and motility genes. In contrast, no such genes were found in oral commensal Prevotella, Veillonella and Neisseria species, which decreased significantly, or in either Acinetobacter or 10 out of 21 Streptococcus species, including Streptococcus pneumoniae. Our results support the notion that pH1N1 infection provides a niche for previously unnoticed potential respiratory pathogens that were able to access the lower respiratory tract with weakened immunity.
DOI: 10.1111/1469-0691.12054
PubMed: 23167452
Affiliations:
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Le document en format XML
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<term>Adult</term>
<term>Aged</term>
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<term>Bacteria (genetics)</term>
<term>Bacteria (isolation & purification)</term>
<term>Bacteria (pathogenicity)</term>
<term>Chemotaxis (genetics)</term>
<term>Chemotaxis (physiology)</term>
<term>China (epidemiology)</term>
<term>Coinfection (epidemiology)</term>
<term>Coinfection (microbiology)</term>
<term>Coinfection (virology)</term>
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<term>Humans</term>
<term>Influenza A Virus, H1N1 Subtype (physiology)</term>
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<term>Oropharynx (virology)</term>
<term>Pneumonia, Bacterial (epidemiology)</term>
<term>Pneumonia, Bacterial (microbiology)</term>
<term>Pneumonia, Bacterial (virology)</term>
<term>Pseudomonas (physiology)</term>
<term>Young Adult</term>
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<term>Adulte d'âge moyen</term>
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<term>Bactéries (isolement et purification)</term>
<term>Bactéries (pathogénicité)</term>
<term>Chimiotaxie (génétique)</term>
<term>Chimiotaxie (physiologie)</term>
<term>Chine (épidémiologie)</term>
<term>Co-infection (microbiologie)</term>
<term>Co-infection (virologie)</term>
<term>Co-infection (épidémiologie)</term>
<term>Femelle</term>
<term>Grippe humaine (microbiologie)</term>
<term>Grippe humaine (virologie)</term>
<term>Grippe humaine (épidémiologie)</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Microbiote</term>
<term>Mâle</term>
<term>Partie orale du pharynx (microbiologie)</term>
<term>Partie orale du pharynx (virologie)</term>
<term>Pneumopathie bactérienne (microbiologie)</term>
<term>Pneumopathie bactérienne (virologie)</term>
<term>Pneumopathie bactérienne (épidémiologie)</term>
<term>Pseudomonas (physiologie)</term>
<term>Sous-type H1N1 du virus de la grippe A (physiologie)</term>
<term>Sujet âgé</term>
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<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coinfection</term>
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<term>Pneumonia, Bacterial</term>
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<term>Chemotaxis</term>
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<term>Chimiotaxie</term>
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<keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Co-infection</term>
<term>Grippe humaine</term>
<term>Partie orale du pharynx</term>
<term>Pneumopathie bactérienne</term>
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<keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Coinfection</term>
<term>Influenza, Human</term>
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<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Chimiotaxie</term>
<term>Pseudomonas</term>
<term>Sous-type H1N1 du virus de la grippe A</term>
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<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Chemotaxis</term>
<term>Influenza A Virus, H1N1 Subtype</term>
<term>Pseudomonas</term>
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<term>Grippe humaine</term>
<term>Partie orale du pharynx</term>
<term>Pneumopathie bactérienne</term>
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<term>Femelle</term>
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<front><div type="abstract" xml:lang="en">While much effort has been made to characterize influenza A pdm09 virus (pH1N1), the flu that was responsible for the fourth influenza pandemic, there is a lack of study on the composition of bacteria that lead to secondary infection. In this study, we recruited pneumonia patients with and without pH1N1 infection and characterized their oropharyngeal microbiota by the unbiased high-throughput sequencing method. While there were no significant differences in common bacterial pneumonia-causative agents (Acinetobacter and Streptococcus species), previously unreported Pseudomonas species equipped with chemotaxis and flagellar assembly genes significantly increased (>20-fold) in the pH1N1-infected group. Bacillus and Ralstonia species that also increased significantly (5-10-fold) were also found to possess similar signaling and motility genes. In contrast, no such genes were found in oral commensal Prevotella, Veillonella and Neisseria species, which decreased significantly, or in either Acinetobacter or 10 out of 21 Streptococcus species, including Streptococcus pneumoniae. Our results support the notion that pH1N1 infection provides a niche for previously unnoticed potential respiratory pathogens that were able to access the lower respiratory tract with weakened immunity. </div>
</front>
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<affiliations><list><country><li>République populaire de Chine</li>
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<name sortKey="Tsui, S K W" sort="Tsui, S K W" uniqKey="Tsui S" first="S K-W" last="Tsui">S K-W Tsui</name>
<name sortKey="Yang, Z F" sort="Yang, Z F" uniqKey="Yang Z" first="Z-F" last="Yang">Z-F Yang</name>
<name sortKey="Zhou, J W" sort="Zhou, J W" uniqKey="Zhou J" first="J-W" last="Zhou">J-W Zhou</name>
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<country name="République populaire de Chine"><noRegion><name sortKey="Leung, R K K" sort="Leung, R K K" uniqKey="Leung R" first="R K-K" last="Leung">R K-K Leung</name>
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