Modulation of potential respiratory pathogens by pH1N1 viral infection.
Identifieur interne : 000968 ( PubMed/Checkpoint ); précédent : 000967; suivant : 000969Modulation of potential respiratory pathogens by pH1N1 viral infection.
Auteurs : R K-K Leung [République populaire de Chine] ; J-W Zhou ; W. Guan ; S-K Li ; Z-F Yang ; S K-W TsuiSource :
- Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases [ 1469-0691 ] ; 2013.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Bactéries (), Bactéries (génétique), Bactéries (isolement et purification), Bactéries (pathogénicité), Chimiotaxie (génétique), Chimiotaxie (physiologie), Chine (épidémiologie), Co-infection (microbiologie), Co-infection (virologie), Co-infection (épidémiologie), Femelle, Grippe humaine (microbiologie), Grippe humaine (virologie), Grippe humaine (épidémiologie), Humains, Jeune adulte, Microbiote, Mâle, Partie orale du pharynx (microbiologie), Partie orale du pharynx (virologie), Pneumopathie bactérienne (microbiologie), Pneumopathie bactérienne (virologie), Pneumopathie bactérienne (épidémiologie), Pseudomonas (physiologie), Sous-type H1N1 du virus de la grippe A (physiologie), Sujet âgé.
- MESH :
- génétique : Bactéries, Chimiotaxie.
- isolement et purification : Bactéries.
- microbiologie : Co-infection, Grippe humaine, Partie orale du pharynx, Pneumopathie bactérienne.
- pathogénicité : Bactéries.
- physiologie : Chimiotaxie, Pseudomonas, Sous-type H1N1 du virus de la grippe A.
- virologie : Co-infection, Grippe humaine, Partie orale du pharynx, Pneumopathie bactérienne.
- épidémiologie : Chine, Co-infection, Grippe humaine, Pneumopathie bactérienne.
- Adolescent, Adulte, Adulte d'âge moyen, Bactéries, Femelle, Humains, Jeune adulte, Microbiote, Mâle, Sujet âgé.
- Wicri :
- geographic : République populaire de Chine.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Bacteria (classification), Bacteria (genetics), Bacteria (isolation & purification), Bacteria (pathogenicity), Chemotaxis (genetics), Chemotaxis (physiology), China (epidemiology), Coinfection (epidemiology), Coinfection (microbiology), Coinfection (virology), Female, Humans, Influenza A Virus, H1N1 Subtype (physiology), Influenza, Human (epidemiology), Influenza, Human (microbiology), Influenza, Human (virology), Male, Microbiota, Middle Aged, Oropharynx (microbiology), Oropharynx (virology), Pneumonia, Bacterial (epidemiology), Pneumonia, Bacterial (microbiology), Pneumonia, Bacterial (virology), Pseudomonas (physiology), Young Adult.
- MESH :
- geographic , epidemiology : China.
- classification : Bacteria.
- epidemiology : Coinfection, Influenza, Human, Pneumonia, Bacterial.
- genetics : Bacteria, Chemotaxis.
- isolation & purification : Bacteria.
- microbiology : Coinfection, Influenza, Human, Oropharynx, Pneumonia, Bacterial.
- pathogenicity : Bacteria.
- physiology : Chemotaxis, Influenza A Virus, H1N1 Subtype, Pseudomonas.
- virology : Coinfection, Influenza, Human, Oropharynx, Pneumonia, Bacterial.
- Adolescent, Adult, Aged, Female, Humans, Male, Microbiota, Middle Aged, Young Adult.
Abstract
While much effort has been made to characterize influenza A pdm09 virus (pH1N1), the flu that was responsible for the fourth influenza pandemic, there is a lack of study on the composition of bacteria that lead to secondary infection. In this study, we recruited pneumonia patients with and without pH1N1 infection and characterized their oropharyngeal microbiota by the unbiased high-throughput sequencing method. While there were no significant differences in common bacterial pneumonia-causative agents (Acinetobacter and Streptococcus species), previously unreported Pseudomonas species equipped with chemotaxis and flagellar assembly genes significantly increased (>20-fold) in the pH1N1-infected group. Bacillus and Ralstonia species that also increased significantly (5-10-fold) were also found to possess similar signaling and motility genes. In contrast, no such genes were found in oral commensal Prevotella, Veillonella and Neisseria species, which decreased significantly, or in either Acinetobacter or 10 out of 21 Streptococcus species, including Streptococcus pneumoniae. Our results support the notion that pH1N1 infection provides a niche for previously unnoticed potential respiratory pathogens that were able to access the lower respiratory tract with weakened immunity.
DOI: 10.1111/1469-0691.12054
PubMed: 23167452
Affiliations:
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Human</term><term>Oropharynx</term><term>Pneumonia, Bacterial</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Chine</term><term>Co-infection</term><term>Grippe humaine</term><term>Pneumopathie bactérienne</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Microbiota</term><term>Middle Aged</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Bactéries</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Microbiote</term><term>Mâle</term><term>Sujet âgé</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>République populaire de Chine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">While much effort has been made to characterize influenza A pdm09 virus (pH1N1), the flu that was responsible for the fourth influenza pandemic, there is a lack of study on the composition of bacteria that lead to secondary infection. In this study, we recruited pneumonia patients with and without pH1N1 infection and characterized their oropharyngeal microbiota by the unbiased high-throughput sequencing method. While there were no significant differences in common bacterial pneumonia-causative agents (Acinetobacter and Streptococcus species), previously unreported Pseudomonas species equipped with chemotaxis and flagellar assembly genes significantly increased (>20-fold) in the pH1N1-infected group. Bacillus and Ralstonia species that also increased significantly (5-10-fold) were also found to possess similar signaling and motility genes. In contrast, no such genes were found in oral commensal Prevotella, Veillonella and Neisseria species, which decreased significantly, or in either Acinetobacter or 10 out of 21 Streptococcus species, including Streptococcus pneumoniae. Our results support the notion that pH1N1 infection provides a niche for previously unnoticed potential respiratory pathogens that were able to access the lower respiratory tract with weakened immunity. </div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23167452</PMID><DateCompleted><Year>2014</Year><Month>07</Month><Day>14</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>11</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1469-0691</ISSN><JournalIssue CitedMedium="Internet"><Volume>19</Volume><Issue>10</Issue><PubDate><Year>2013</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases</Title><ISOAbbreviation>Clin. Microbiol. Infect.</ISOAbbreviation></Journal><ArticleTitle>Modulation of potential respiratory pathogens by pH1N1 viral infection.</ArticleTitle><Pagination><MedlinePgn>930-5</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/1469-0691.12054</ELocationID><Abstract><AbstractText>While much effort has been made to characterize influenza A pdm09 virus (pH1N1), the flu that was responsible for the fourth influenza pandemic, there is a lack of study on the composition of bacteria that lead to secondary infection. In this study, we recruited pneumonia patients with and without pH1N1 infection and characterized their oropharyngeal microbiota by the unbiased high-throughput sequencing method. While there were no significant differences in common bacterial pneumonia-causative agents (Acinetobacter and Streptococcus species), previously unreported Pseudomonas species equipped with chemotaxis and flagellar assembly genes significantly increased (>20-fold) in the pH1N1-infected group. Bacillus and Ralstonia species that also increased significantly (5-10-fold) were also found to possess similar signaling and motility genes. In contrast, no such genes were found in oral commensal Prevotella, Veillonella and Neisseria species, which decreased significantly, or in either Acinetobacter or 10 out of 21 Streptococcus species, including Streptococcus pneumoniae. Our results support the notion that pH1N1 infection provides a niche for previously unnoticed potential respiratory pathogens that were able to access the lower respiratory tract with weakened immunity. </AbstractText><CopyrightInformation>© 2012 The Authors Clinical Microbiology and Infection © 2012 European Society of Clinical Microbiology and Infectious Diseases.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Leung</LastName><ForeName>R K-K</ForeName><Initials>RK</Initials><AffiliationInfo><Affiliation>Hong Kong Bioinformatics Centre, The Chinese University of Hong Kong, Hong Kong, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhou</LastName><ForeName>J-W</ForeName><Initials>JW</Initials></Author><Author ValidYN="Y"><LastName>Guan</LastName><ForeName>W</ForeName><Initials>W</Initials></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>S-K</ForeName><Initials>SK</Initials></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Z-F</ForeName><Initials>ZF</Initials></Author><Author ValidYN="Y"><LastName>Tsui</LastName><ForeName>S K-W</ForeName><Initials>SK</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2012</Year><Month>11</Month><Day>20</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Clin Microbiol Infect</MedlineTA><NlmUniqueID>9516420</NlmUniqueID><ISSNLinking>1198-743X</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001419" MajorTopicYN="N">Bacteria</DescriptorName><QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName><QualifierName UI="Q000472" MajorTopicYN="Y">pathogenicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002633" MajorTopicYN="N">Chemotaxis</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002681" MajorTopicYN="N" Type="Geographic">China</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D060085" MajorTopicYN="N">Coinfection</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053118" MajorTopicYN="N">Influenza A Virus, H1N1 Subtype</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D064307" MajorTopicYN="N">Microbiota</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009960" MajorTopicYN="N">Oropharynx</DescriptorName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018410" MajorTopicYN="N">Pneumonia, Bacterial</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011549" MajorTopicYN="N">Pseudomonas</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Cell motility</Keyword><Keyword MajorTopicYN="N">chemotaxis</Keyword><Keyword MajorTopicYN="N">microbiota</Keyword><Keyword MajorTopicYN="N">pH1N1</Keyword><Keyword MajorTopicYN="N">pneumonia</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2012</Year><Month>04</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2012</Year><Month>09</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2012</Year><Month>09</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>11</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>11</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>7</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">23167452</ArticleId><ArticleId IdType="doi">10.1111/1469-0691.12054</ArticleId><ArticleId IdType="pii">S1198-743X(14)62977-3</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Sha Tin</li></settlement><orgName><li>Université chinoise de Hong Kong</li></orgName></list><tree><noCountry><name sortKey="Guan, W" sort="Guan, W" uniqKey="Guan W" first="W" last="Guan">W. Guan</name><name sortKey="Li, S K" sort="Li, S K" uniqKey="Li S" first="S-K" last="Li">S-K Li</name><name sortKey="Tsui, S K W" sort="Tsui, S K W" uniqKey="Tsui S" first="S K-W" last="Tsui">S K-W Tsui</name><name sortKey="Yang, Z F" sort="Yang, Z F" uniqKey="Yang Z" first="Z-F" last="Yang">Z-F Yang</name><name sortKey="Zhou, J W" sort="Zhou, J W" uniqKey="Zhou J" first="J-W" last="Zhou">J-W Zhou</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Leung, R K K" sort="Leung, R K K" uniqKey="Leung R" first="R K-K" last="Leung">R K-K Leung</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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