PandemieGrippaleV1, Main, Exploration, bibRecord, 000B60

Human Dendritic Cell Response Signatures Distinguish 1918, Pandemic, and Seasonal H1N1 Influenza Viruses.

Identifieur interne : 000B60 ( Main/Exploration ); précédent : 000B59; suivant : 000B61

Human Dendritic Cell Response Signatures Distinguish 1918, Pandemic, and Seasonal H1N1 Influenza Viruses.

Auteurs : Boris M. Hartmann [États-Unis] ; Juilee Thakar [États-Unis] ; Randy A. Albrecht [États-Unis] ; Stefan Avey [États-Unis] ; Elena Zaslavsky [États-Unis] ; Nada Marjanovic [États-Unis] ; Maria Chikina [États-Unis] ; Miguel Fribourg [États-Unis] ; Fernand Hayot [États-Unis] ; Mirco Schmolke [Suisse] ; Hailong Meng [États-Unis] ; James Wetmur [États-Unis] ; Adolfo García-Sastre [États-Unis] ; Steven H. Kleinstein [États-Unis] ; Stuart C. Sealfon [États-Unis]

Source :

Journal of virology [ 1098-5514 ] ; 2015.

RBID : pubmed:26223639

Descripteurs français

English descriptors

KwdEn :
- Antigenic Variation, Dendritic Cells (immunology), Dendritic Cells (virology), Europe (epidemiology), Gene Expression Profiling, Gene Expression Regulation, History, 20th Century, History, 21st Century, Host-Pathogen Interactions, Humans, Influenza A Virus, H1N1 Subtype (genetics), Influenza A Virus, H1N1 Subtype (immunology), Influenza Pandemic, 1918-1919 (history), Influenza, Human (epidemiology), Influenza, Human (genetics), Influenza, Human (history), Influenza, Human (immunology), Interferons (genetics), Interferons (immunology), Molecular Epidemiology, NF-kappa B (genetics), NF-kappa B (immunology), Pandemics, Reassortant Viruses (genetics), Reassortant Viruses (immunology), Recombination, Genetic, Seasons, Signal Transduction, Time Factors, United States (epidemiology).
MESH :
- chemical , genetics : Interferons, NF-kappa B.
- geographic , epidemiology : Europe, United States.
- epidemiology : Influenza, Human.
- genetics : Influenza A Virus, H1N1 Subtype, Influenza, Human, Reassortant Viruses.
- history : Influenza Pandemic, 1918-1919, Influenza, Human.
- immunology : Dendritic Cells, Influenza A Virus, H1N1 Subtype, Influenza, Human, Interferons, NF-kappa B, Reassortant Viruses.
- virology : Dendritic Cells.
- Antigenic Variation, Gene Expression Profiling, Gene Expression Regulation, History, 20th Century, History, 21st Century, Host-Pathogen Interactions, Humans, Molecular Epidemiology, Pandemics, Recombination, Genetic, Seasons, Signal Transduction, Time Factors.

Abstract

Influenza viruses continue to present global threats to human health. Antigenic drift and shift, genetic reassortment, and cross-species transmission generate new strains with differences in epidemiology and clinical severity. We compared the temporal transcriptional responses of human dendritic cells (DC) to infection with two pandemic (A/Brevig Mission/1/1918, A/California/4/2009) and two seasonal (A/New Caledonia/20/1999, A/Texas/36/1991) H1N1 influenza viruses. Strain-specific response differences included stronger activation of NF-κB following infection with A/New Caledonia/20/1999 and a unique cluster of genes expressed following infection with A/Brevig Mission/1/1918. A common antiviral program showing strain-specific timing was identified in the early DC response and found to correspond with reported transcript changes in blood during symptomatic human influenza virus infection. Comparison of the global responses to the seasonal and pandemic strains showed that a dramatic divergence occurred after 4 h, with only the seasonal strains inducing widespread mRNA loss.

DOI: 10.1128/JVI.01523-15
PubMed: 26223639

Affiliations:

Le document en format XML

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<author><name sortKey="Fribourg, Miguel" sort="Fribourg, Miguel" uniqKey="Fribourg M" first="Miguel" last="Fribourg">Miguel Fribourg</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Human Dendritic Cell Response Signatures Distinguish 1918, Pandemic, and Seasonal H1N1 Influenza Viruses.</title>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Avey, Stefan" sort="Avey, Stefan" uniqKey="Avey S" first="Stefan" last="Avey">Stefan Avey</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Marjanovic, Nada" sort="Marjanovic, Nada" uniqKey="Marjanovic N" first="Nada" last="Marjanovic">Nada Marjanovic</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Meng, Hailong" sort="Meng, Hailong" uniqKey="Meng H" first="Hailong" last="Meng">Hailong Meng</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA Global Health & Emerging Pathogens Institute at Icahn School of Medicine, New York, New York, USA Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
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<author><name sortKey="Kleinstein, Steven H" sort="Kleinstein, Steven H" uniqKey="Kleinstein S" first="Steven H" last="Kleinstein">Steven H. Kleinstein</name>
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<placeName><region type="state">Connecticut</region>
</placeName>
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<author><name sortKey="Sealfon, Stuart C" sort="Sealfon, Stuart C" uniqKey="Sealfon S" first="Stuart C" last="Sealfon">Stuart C. Sealfon</name>
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<wicri:regionArea>Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA Center for Translational Systems Biology, Icahn School of Medicine at Mount Sinai, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of virology</title>
<idno type="eISSN">1098-5514</idno>
<imprint><date when="2015" type="published">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antigenic Variation</term>
<term>Dendritic Cells (immunology)</term>
<term>Dendritic Cells (virology)</term>
<term>Europe (epidemiology)</term>
<term>Gene Expression Profiling</term>
<term>Gene Expression Regulation</term>
<term>History, 20th Century</term>
<term>History, 21st Century</term>
<term>Host-Pathogen Interactions</term>
<term>Humans</term>
<term>Influenza A Virus, H1N1 Subtype (genetics)</term>
<term>Influenza A Virus, H1N1 Subtype (immunology)</term>
<term>Influenza Pandemic, 1918-1919 (history)</term>
<term>Influenza, Human (epidemiology)</term>
<term>Influenza, Human (genetics)</term>
<term>Influenza, Human (history)</term>
<term>Influenza, Human (immunology)</term>
<term>Interferons (genetics)</term>
<term>Interferons (immunology)</term>
<term>Molecular Epidemiology</term>
<term>NF-kappa B (genetics)</term>
<term>NF-kappa B (immunology)</term>
<term>Pandemics</term>
<term>Reassortant Viruses (genetics)</term>
<term>Reassortant Viruses (immunology)</term>
<term>Recombination, Genetic</term>
<term>Seasons</term>
<term>Signal Transduction</term>
<term>Time Factors</term>
<term>United States (epidemiology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de profil d'expression de gènes</term>
<term>Cellules dendritiques (immunologie)</term>
<term>Cellules dendritiques (virologie)</term>
<term>Europe (épidémiologie)</term>
<term>Facteur de transcription NF-kappa B (génétique)</term>
<term>Facteur de transcription NF-kappa B (immunologie)</term>
<term>Facteurs temps</term>
<term>Grippe humaine (génétique)</term>
<term>Grippe humaine (histoire)</term>
<term>Grippe humaine (immunologie)</term>
<term>Grippe humaine (épidémiologie)</term>
<term>Histoire du 20ème siècle</term>
<term>Histoire du 21ème siècle</term>
<term>Humains</term>
<term>Interactions hôte-pathogène</term>
<term>Interférons (génétique)</term>
<term>Interférons (immunologie)</term>
<term>Pandémie de grippe de 1918-1919 (histoire)</term>
<term>Pandémies</term>
<term>Recombinaison génétique</term>
<term>Régulation de l'expression des gènes</term>
<term>Saisons</term>
<term>Sous-type H1N1 du virus de la grippe A (génétique)</term>
<term>Sous-type H1N1 du virus de la grippe A (immunologie)</term>
<term>Transduction du signal</term>
<term>Variation des antigènes</term>
<term>Virus recombinants (génétique)</term>
<term>Virus recombinants (immunologie)</term>
<term>Épidémiologie moléculaire</term>
<term>États-Unis d'Amérique (épidémiologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Interferons</term>
<term>NF-kappa B</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Europe</term>
<term>United States</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term>
<term>Influenza, Human</term>
<term>Reassortant Viruses</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Facteur de transcription NF-kappa B</term>
<term>Grippe humaine</term>
<term>Interférons</term>
<term>Sous-type H1N1 du virus de la grippe A</term>
<term>Virus recombinants</term>
</keywords>
<keywords scheme="MESH" qualifier="histoire" xml:lang="fr"><term>Grippe humaine</term>
<term>Pandémie de grippe de 1918-1919</term>
</keywords>
<keywords scheme="MESH" qualifier="history" xml:lang="en"><term>Influenza Pandemic, 1918-1919</term>
<term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Cellules dendritiques</term>
<term>Facteur de transcription NF-kappa B</term>
<term>Grippe humaine</term>
<term>Interférons</term>
<term>Sous-type H1N1 du virus de la grippe A</term>
<term>Virus recombinants</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Dendritic Cells</term>
<term>Influenza A Virus, H1N1 Subtype</term>
<term>Influenza, Human</term>
<term>Interferons</term>
<term>NF-kappa B</term>
<term>Reassortant Viruses</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Cellules dendritiques</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Dendritic Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Europe</term>
<term>Grippe humaine</term>
<term>États-Unis d'Amérique</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Antigenic Variation</term>
<term>Gene Expression Profiling</term>
<term>Gene Expression Regulation</term>
<term>History, 20th Century</term>
<term>History, 21st Century</term>
<term>Host-Pathogen Interactions</term>
<term>Humans</term>
<term>Molecular Epidemiology</term>
<term>Pandemics</term>
<term>Recombination, Genetic</term>
<term>Seasons</term>
<term>Signal Transduction</term>
<term>Time Factors</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Analyse de profil d'expression de gènes</term>
<term>Facteurs temps</term>
<term>Histoire du 20ème siècle</term>
<term>Histoire du 21ème siècle</term>
<term>Humains</term>
<term>Interactions hôte-pathogène</term>
<term>Pandémies</term>
<term>Recombinaison génétique</term>
<term>Régulation de l'expression des gènes</term>
<term>Saisons</term>
<term>Transduction du signal</term>
<term>Variation des antigènes</term>
<term>Épidémiologie moléculaire</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>États-Unis</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Influenza viruses continue to present global threats to human health. Antigenic drift and shift, genetic reassortment, and cross-species transmission generate new strains with differences in epidemiology and clinical severity. We compared the temporal transcriptional responses of human dendritic cells (DC) to infection with two pandemic (A/Brevig Mission/1/1918, A/California/4/2009) and two seasonal (A/New Caledonia/20/1999, A/Texas/36/1991) H1N1 influenza viruses. Strain-specific response differences included stronger activation of NF-κB following infection with A/New Caledonia/20/1999 and a unique cluster of genes expressed following infection with A/Brevig Mission/1/1918. A common antiviral program showing strain-specific timing was identified in the early DC response and found to correspond with reported transcript changes in blood during symptomatic human influenza virus infection. Comparison of the global responses to the seasonal and pandemic strains showed that a dramatic divergence occurred after 4 h, with only the seasonal strains inducing widespread mRNA loss.</div>
</front>
</TEI>
<affiliations><list><country><li>Suisse</li>
<li>États-Unis</li>
</country>
<region><li>Canton de Genève</li>
<li>Connecticut</li>
<li>État de New York</li>
</region>
<settlement><li>Genève</li>
</settlement>
<orgName><li>Université de Genève</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="État de New York"><name sortKey="Hartmann, Boris M" sort="Hartmann, Boris M" uniqKey="Hartmann B" first="Boris M" last="Hartmann">Boris M. Hartmann</name>
</region>
<name sortKey="Albrecht, Randy A" sort="Albrecht, Randy A" uniqKey="Albrecht R" first="Randy A" last="Albrecht">Randy A. Albrecht</name>
<name sortKey="Avey, Stefan" sort="Avey, Stefan" uniqKey="Avey S" first="Stefan" last="Avey">Stefan Avey</name>
<name sortKey="Chikina, Maria" sort="Chikina, Maria" uniqKey="Chikina M" first="Maria" last="Chikina">Maria Chikina</name>
<name sortKey="Fribourg, Miguel" sort="Fribourg, Miguel" uniqKey="Fribourg M" first="Miguel" last="Fribourg">Miguel Fribourg</name>
<name sortKey="Garcia Sastre, Adolfo" sort="Garcia Sastre, Adolfo" uniqKey="Garcia Sastre A" first="Adolfo" last="García-Sastre">Adolfo García-Sastre</name>
<name sortKey="Hayot, Fernand" sort="Hayot, Fernand" uniqKey="Hayot F" first="Fernand" last="Hayot">Fernand Hayot</name>
<name sortKey="Kleinstein, Steven H" sort="Kleinstein, Steven H" uniqKey="Kleinstein S" first="Steven H" last="Kleinstein">Steven H. Kleinstein</name>
<name sortKey="Marjanovic, Nada" sort="Marjanovic, Nada" uniqKey="Marjanovic N" first="Nada" last="Marjanovic">Nada Marjanovic</name>
<name sortKey="Meng, Hailong" sort="Meng, Hailong" uniqKey="Meng H" first="Hailong" last="Meng">Hailong Meng</name>
<name sortKey="Sealfon, Stuart C" sort="Sealfon, Stuart C" uniqKey="Sealfon S" first="Stuart C" last="Sealfon">Stuart C. Sealfon</name>
<name sortKey="Thakar, Juilee" sort="Thakar, Juilee" uniqKey="Thakar J" first="Juilee" last="Thakar">Juilee Thakar</name>
<name sortKey="Wetmur, James" sort="Wetmur, James" uniqKey="Wetmur J" first="James" last="Wetmur">James Wetmur</name>
<name sortKey="Zaslavsky, Elena" sort="Zaslavsky, Elena" uniqKey="Zaslavsky E" first="Elena" last="Zaslavsky">Elena Zaslavsky</name>
</country>
<country name="Suisse"><region name="Canton de Genève"><name sortKey="Schmolke, Mirco" sort="Schmolke, Mirco" uniqKey="Schmolke M" first="Mirco" last="Schmolke">Mirco Schmolke</name>
</region>
</country>
</tree>
</affiliations>
</record>

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Serveur d'exploration sur les pandémies grippales

Human Dendritic Cell Response Signatures Distinguish 1918, Pandemic, and Seasonal H1N1 Influenza Viruses.

Human Dendritic Cell Response Signatures Distinguish 1918, Pandemic, and Seasonal H1N1 Influenza Viruses.

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