Human Dendritic Cell Response Signatures Distinguish 1918, Pandemic, and Seasonal H1N1 Influenza Viruses.
Identifieur interne : 000638 ( PubMed/Checkpoint ); précédent : 000637; suivant : 000639Human Dendritic Cell Response Signatures Distinguish 1918, Pandemic, and Seasonal H1N1 Influenza Viruses.
Auteurs : Boris M. Hartmann [États-Unis] ; Juilee Thakar [États-Unis] ; Randy A. Albrecht [États-Unis] ; Stefan Avey [États-Unis] ; Elena Zaslavsky [États-Unis] ; Nada Marjanovic [États-Unis] ; Maria Chikina [États-Unis] ; Miguel Fribourg [États-Unis] ; Fernand Hayot [États-Unis] ; Mirco Schmolke [Suisse] ; Hailong Meng [États-Unis] ; James Wetmur [États-Unis] ; Adolfo García-Sastre [États-Unis] ; Steven H. Kleinstein [États-Unis] ; Stuart C. Sealfon [États-Unis]Source :
- Journal of virology [ 1098-5514 ] ; 2015.
Descripteurs français
- KwdFr :
- Analyse de profil d'expression de gènes, Cellules dendritiques (immunologie), Cellules dendritiques (virologie), Europe (épidémiologie), Facteur de transcription NF-kappa B (génétique), Facteur de transcription NF-kappa B (immunologie), Facteurs temps, Grippe humaine (génétique), Grippe humaine (histoire), Grippe humaine (immunologie), Grippe humaine (épidémiologie), Histoire du 20ème siècle, Histoire du 21ème siècle, Humains, Interactions hôte-pathogène, Interférons (génétique), Interférons (immunologie), Pandémie de grippe de 1918-1919 (histoire), Pandémies, Recombinaison génétique, Régulation de l'expression des gènes, Saisons, Sous-type H1N1 du virus de la grippe A (génétique), Sous-type H1N1 du virus de la grippe A (immunologie), Transduction du signal, Variation des antigènes, Virus recombinants (génétique), Virus recombinants (immunologie), Épidémiologie moléculaire, États-Unis d'Amérique (épidémiologie).
- MESH :
- génétique : Facteur de transcription NF-kappa B, Grippe humaine, Interférons, Sous-type H1N1 du virus de la grippe A, Virus recombinants.
- histoire : Grippe humaine, Pandémie de grippe de 1918-1919.
- immunologie : Cellules dendritiques, Facteur de transcription NF-kappa B, Grippe humaine, Interférons, Sous-type H1N1 du virus de la grippe A, Virus recombinants.
- virologie : Cellules dendritiques.
- épidémiologie : Europe, Grippe humaine, États-Unis d'Amérique.
- Analyse de profil d'expression de gènes, Facteurs temps, Histoire du 20ème siècle, Histoire du 21ème siècle, Humains, Interactions hôte-pathogène, Pandémies, Recombinaison génétique, Régulation de l'expression des gènes, Saisons, Transduction du signal, Variation des antigènes, Épidémiologie moléculaire.
- Wicri :
- geographic : États-Unis.
English descriptors
- KwdEn :
- Antigenic Variation, Dendritic Cells (immunology), Dendritic Cells (virology), Europe (epidemiology), Gene Expression Profiling, Gene Expression Regulation, History, 20th Century, History, 21st Century, Host-Pathogen Interactions, Humans, Influenza A Virus, H1N1 Subtype (genetics), Influenza A Virus, H1N1 Subtype (immunology), Influenza Pandemic, 1918-1919 (history), Influenza, Human (epidemiology), Influenza, Human (genetics), Influenza, Human (history), Influenza, Human (immunology), Interferons (genetics), Interferons (immunology), Molecular Epidemiology, NF-kappa B (genetics), NF-kappa B (immunology), Pandemics, Reassortant Viruses (genetics), Reassortant Viruses (immunology), Recombination, Genetic, Seasons, Signal Transduction, Time Factors, United States (epidemiology).
- MESH :
- chemical , genetics : Interferons, NF-kappa B.
- geographic , epidemiology : Europe, United States.
- epidemiology : Influenza, Human.
- genetics : Influenza A Virus, H1N1 Subtype, Influenza, Human, Reassortant Viruses.
- history : Influenza Pandemic, 1918-1919, Influenza, Human.
- immunology : Dendritic Cells, Influenza A Virus, H1N1 Subtype, Influenza, Human, Interferons, NF-kappa B, Reassortant Viruses.
- virology : Dendritic Cells.
- Antigenic Variation, Gene Expression Profiling, Gene Expression Regulation, History, 20th Century, History, 21st Century, Host-Pathogen Interactions, Humans, Molecular Epidemiology, Pandemics, Recombination, Genetic, Seasons, Signal Transduction, Time Factors.
Abstract
Influenza viruses continue to present global threats to human health. Antigenic drift and shift, genetic reassortment, and cross-species transmission generate new strains with differences in epidemiology and clinical severity. We compared the temporal transcriptional responses of human dendritic cells (DC) to infection with two pandemic (A/Brevig Mission/1/1918, A/California/4/2009) and two seasonal (A/New Caledonia/20/1999, A/Texas/36/1991) H1N1 influenza viruses. Strain-specific response differences included stronger activation of NF-κB following infection with A/New Caledonia/20/1999 and a unique cluster of genes expressed following infection with A/Brevig Mission/1/1918. A common antiviral program showing strain-specific timing was identified in the early DC response and found to correspond with reported transcript changes in blood during symptomatic human influenza virus infection. Comparison of the global responses to the seasonal and pandemic strains showed that a dramatic divergence occurred after 4 h, with only the seasonal strains inducing widespread mRNA loss.
DOI: 10.1128/JVI.01523-15
PubMed: 26223639
Affiliations:
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pubmed:26223639Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Human Dendritic Cell Response Signatures Distinguish 1918, Pandemic, and Seasonal H1N1 Influenza Viruses.</title>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Thakar, Juilee" sort="Thakar, Juilee" uniqKey="Thakar J" first="Juilee" last="Thakar">Juilee Thakar</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Avey, Stefan" sort="Avey, Stefan" uniqKey="Avey S" first="Stefan" last="Avey">Stefan Avey</name>
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<author><name sortKey="Zaslavsky, Elena" sort="Zaslavsky, Elena" uniqKey="Zaslavsky E" first="Elena" last="Zaslavsky">Elena Zaslavsky</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA Center for Translational Systems Biology, Icahn School of Medicine at Mount Sinai, New York, New York</wicri:regionArea>
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<author><name sortKey="Marjanovic, Nada" sort="Marjanovic, Nada" uniqKey="Marjanovic N" first="Nada" last="Marjanovic">Nada Marjanovic</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
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<author><name sortKey="Chikina, Maria" sort="Chikina, Maria" uniqKey="Chikina M" first="Maria" last="Chikina">Maria Chikina</name>
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<author><name sortKey="Fribourg, Miguel" sort="Fribourg, Miguel" uniqKey="Fribourg M" first="Miguel" last="Fribourg">Miguel Fribourg</name>
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<author><name sortKey="Hayot, Fernand" sort="Hayot, Fernand" uniqKey="Hayot F" first="Fernand" last="Hayot">Fernand Hayot</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA Center for Translational Systems Biology, Icahn School of Medicine at Mount Sinai, New York, New York</wicri:regionArea>
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<author><name sortKey="Schmolke, Mirco" sort="Schmolke, Mirco" uniqKey="Schmolke M" first="Mirco" last="Schmolke">Mirco Schmolke</name>
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<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Department of Microbiology and Molecular Medicine, University of Geneva, Geneva</wicri:regionArea>
<orgName type="university">Université de Genève</orgName>
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<author><name sortKey="Meng, Hailong" sort="Meng, Hailong" uniqKey="Meng H" first="Hailong" last="Meng">Hailong Meng</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology, Yale School of Medicine, New Haven, Connecticut</wicri:regionArea>
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<author><name sortKey="Wetmur, James" sort="Wetmur, James" uniqKey="Wetmur J" first="James" last="Wetmur">James Wetmur</name>
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<wicri:regionArea>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
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<author><name sortKey="Garcia Sastre, Adolfo" sort="Garcia Sastre, Adolfo" uniqKey="Garcia Sastre A" first="Adolfo" last="García-Sastre">Adolfo García-Sastre</name>
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<wicri:regionArea>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA Global Health & Emerging Pathogens Institute at Icahn School of Medicine, New York, New York, USA Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York</wicri:regionArea>
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<author><name sortKey="Kleinstein, Steven H" sort="Kleinstein, Steven H" uniqKey="Kleinstein S" first="Steven H" last="Kleinstein">Steven H. Kleinstein</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Yale School of Medicine, New Haven, Connecticut, USA Interdepartmental Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, USA steven.kleinstein@yale.edu stuart.sealfon@mssm.edu.</nlm:affiliation>
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<author><name sortKey="Sealfon, Stuart C" sort="Sealfon, Stuart C" uniqKey="Sealfon S" first="Stuart C" last="Sealfon">Stuart C. Sealfon</name>
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<country wicri:rule="url">États-Unis</country>
<wicri:regionArea>Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA Center for Translational Systems Biology, Icahn School of Medicine at Mount Sinai, New York, New York</wicri:regionArea>
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<series><title level="j">Journal of virology</title>
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<front><div type="abstract" xml:lang="en">Influenza viruses continue to present global threats to human health. Antigenic drift and shift, genetic reassortment, and cross-species transmission generate new strains with differences in epidemiology and clinical severity. We compared the temporal transcriptional responses of human dendritic cells (DC) to infection with two pandemic (A/Brevig Mission/1/1918, A/California/4/2009) and two seasonal (A/New Caledonia/20/1999, A/Texas/36/1991) H1N1 influenza viruses. Strain-specific response differences included stronger activation of NF-κB following infection with A/New Caledonia/20/1999 and a unique cluster of genes expressed following infection with A/Brevig Mission/1/1918. A common antiviral program showing strain-specific timing was identified in the early DC response and found to correspond with reported transcript changes in blood during symptomatic human influenza virus infection. Comparison of the global responses to the seasonal and pandemic strains showed that a dramatic divergence occurred after 4 h, with only the seasonal strains inducing widespread mRNA loss.</div>
</front>
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<DateCompleted><Year>2015</Year>
<Month>12</Month>
<Day>16</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>03</Month>
<Day>06</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1098-5514</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>89</Volume>
<Issue>20</Issue>
<PubDate><Year>2015</Year>
<Month>Oct</Month>
</PubDate>
</JournalIssue>
<Title>Journal of virology</Title>
<ISOAbbreviation>J. Virol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Human Dendritic Cell Response Signatures Distinguish 1918, Pandemic, and Seasonal H1N1 Influenza Viruses.</ArticleTitle>
<Pagination><MedlinePgn>10190-205</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1128/JVI.01523-15</ELocationID>
<Abstract><AbstractText Label="UNLABELLED">Influenza viruses continue to present global threats to human health. Antigenic drift and shift, genetic reassortment, and cross-species transmission generate new strains with differences in epidemiology and clinical severity. We compared the temporal transcriptional responses of human dendritic cells (DC) to infection with two pandemic (A/Brevig Mission/1/1918, A/California/4/2009) and two seasonal (A/New Caledonia/20/1999, A/Texas/36/1991) H1N1 influenza viruses. Strain-specific response differences included stronger activation of NF-κB following infection with A/New Caledonia/20/1999 and a unique cluster of genes expressed following infection with A/Brevig Mission/1/1918. A common antiviral program showing strain-specific timing was identified in the early DC response and found to correspond with reported transcript changes in blood during symptomatic human influenza virus infection. Comparison of the global responses to the seasonal and pandemic strains showed that a dramatic divergence occurred after 4 h, with only the seasonal strains inducing widespread mRNA loss.</AbstractText>
<AbstractText Label="IMPORTANCE" NlmCategory="OBJECTIVE">Continuously evolving influenza viruses present a global threat to human health; however, these host responses display strain-dependent differences that are incompletely understood. Thus, we conducted a detailed comparative study assessing the immune responses of human DC to infection with two pandemic and two seasonal H1N1 influenza strains. We identified in the immune response to viral infection both common and strain-specific features. Among the stain-specific elements were a time shift of the interferon-stimulated gene response, selective induction of NF-κB signaling by one of the seasonal strains, and massive RNA degradation as early as 4 h postinfection by the seasonal, but not the pandemic, viruses. These findings illuminate new aspects of the distinct differences in the immune responses to pandemic and seasonal influenza viruses.</AbstractText>
<CopyrightInformation>Copyright © 2015, American Society for Microbiology. All Rights Reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hartmann</LastName>
<ForeName>Boris M</ForeName>
<Initials>BM</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA Center for Translational Systems Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Thakar</LastName>
<ForeName>Juilee</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Pathology, Yale School of Medicine, New Haven, Connecticut, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Albrecht</LastName>
<ForeName>Randy A</ForeName>
<Initials>RA</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA Global Health & Emerging Pathogens Institute at Icahn School of Medicine, New York, New York, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Avey</LastName>
<ForeName>Stefan</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Interdepartmental Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zaslavsky</LastName>
<ForeName>Elena</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA Center for Translational Systems Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Marjanovic</LastName>
<ForeName>Nada</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chikina</LastName>
<ForeName>Maria</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fribourg</LastName>
<ForeName>Miguel</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hayot</LastName>
<ForeName>Fernand</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA Center for Translational Systems Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Schmolke</LastName>
<ForeName>Mirco</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology and Molecular Medicine, University of Geneva, Geneva, Switzerland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Meng</LastName>
<ForeName>Hailong</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Department of Pathology, Yale School of Medicine, New Haven, Connecticut, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wetmur</LastName>
<ForeName>James</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>García-Sastre</LastName>
<ForeName>Adolfo</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA Global Health & Emerging Pathogens Institute at Icahn School of Medicine, New York, New York, USA Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kleinstein</LastName>
<ForeName>Steven H</ForeName>
<Initials>SH</Initials>
<AffiliationInfo><Affiliation>Department of Pathology, Yale School of Medicine, New Haven, Connecticut, USA Interdepartmental Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, USA steven.kleinstein@yale.edu stuart.sealfon@mssm.edu.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sealfon</LastName>
<ForeName>Stuart C</ForeName>
<Initials>SC</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA Center for Translational Systems Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA steven.kleinstein@yale.edu stuart.sealfon@mssm.edu.</Affiliation>
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<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U19 AI117873</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>HHSN272201000054C</GrantID>
<Agency>PHS HHS</Agency>
<Country>United States</Country>
</Grant>
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<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
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<ArticleDate DateType="Electronic"><Year>2015</Year>
<Month>07</Month>
<Day>29</Day>
</ArticleDate>
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<MedlineTA>J Virol</MedlineTA>
<NlmUniqueID>0113724</NlmUniqueID>
<ISSNLinking>0022-538X</ISSNLinking>
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</Chemical>
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<ReferenceList><Reference><Citation>Genome Res. 2003 Aug;13(8):1863-72</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12902380</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Med. 2006 Oct;12(10):1203-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16964257</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2006 Jul;80(13):6295-304</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16775317</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 2007;35(15):5232-41</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17675303</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Chest. 1998 Aug;114(2):452-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9726729</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2006 Oct 5;443(7111):578-81</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17006449</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Leukoc Biol. 1996 Jan;59(1):61-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8558069</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2011 Apr 28;472(7344):481-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21478870</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Hepatology. 2014 Apr;59(4):1262-72</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23929627</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biomed Environ Sci. 2010 Aug;23(4):259-66</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20934112</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Top Microbiol Immunol. 2014;378:129-47</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24728596</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Pathog. 2011 Sep;7(9):e1002225</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21909272</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Vaccine. 2007 Jun 28;25(27):5086-96</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17544181</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunity. 2015 Sep 15;43(3):605-14</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26362267</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Immunol. 2007 Nov;8(11):1188-93</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17952044</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Leukoc Biol. 2001 Jun;69(6):912-20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11404376</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gen Virol. 2008 Oct;89(Pt 10):2359-2376</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18796704</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2011 Mar 1;186(5):3006-14</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21270393</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Opin Immunol. 2004 Feb;16(1):21-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14734106</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Pathog. 2007 Oct 5;3(10):1414-21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17922571</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2000 Feb 15;164(4):1753-60</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10657621</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMC Immunol. 2015 Aug 14;16:46</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26272204</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cytokine. 2013 Apr;62(1):151-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23434273</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2010 Feb;84(3):1414-22</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19939920</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Med. 2001 Dec;7(12):1306-12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11726970</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Genet. 2011 Aug;7(8):e1002234</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21901105</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2011;6(10):e26050</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22022504</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Blood. 2002 Apr 15;99(8):2913-21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11929782</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genome Res. 2004 Apr;14(4):708-15</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15060014</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2007 Jul;81(13):7011-21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17442719</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Respir Physiol Neurobiol. 2011 Jan 31;175(1):185-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21075220</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Respir Cell Mol Biol. 2012 Aug;47(2):149-57</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22383584</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2012 Sep;86(17):9361-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22718834</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Front Immunol. 2014 Feb 26;5:73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24616721</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Invest. 1998 Feb 1;101(3):643-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9449698</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Emerg Infect Dis. 2006 Jan;12(1):15-22</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16494711</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2011 Feb 08;6(2):e16614</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21347441</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):8107-12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24778238</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Infect Dis. 2003 Jul 15;188(2):257-66</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12854081</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2010 Jul;84(14):6909-22</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20444891</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2011 Nov;85(21):11235-41</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21880744</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genome Biol. 2004;5(10):R80</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15461798</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 2003 Jan 1;31(1):374-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12520026</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Comput Biol. 2008 Mar 21;4(3):e1000021</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18369420</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Curr. 2009 Aug 21;1:RRN1006</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20029605</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2007 Apr 17;104(16):6806-11</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17426143</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>MMWR Morb Mortal Wkly Rep. 2010 Aug 27;59(33):1057-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20798667</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>mBio. 2014 Feb 04;5(1):e01102-13</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24496798</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet Infect Dis. 2012 Sep;12(9):687-95</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22738893</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cell Biol. 1990 May;10(5):2327-34</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2183031</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2009 Dec 14;4(12):e8072</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20011590</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Respir Res. 2010 Oct 28;11:147</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21029402</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Microbiol. 2011 Jul 11;9(8):590-603</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21747392</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur J Immunol. 2002 Nov;32(11):3050-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12385024</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Infect Dis. 2010 May 15;201(10):1509-16</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20377412</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2010 May;84(9):4442-50</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20181699</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 2003 Jul 1;31(13):3576-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12824369</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2010 May 6;362(18):1708-19</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20445182</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2003 Jul;77(13):7214-24</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12805420</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W501-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15980522</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Exp Med. 2006 Mar 20;203(3):689-97</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16533883</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Bull Hist Med. 2002 Spring;76(1):105-15</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11875246</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Leukoc Biol. 2006 Nov;80(5):994-1000</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16912071</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
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