A Large Proportion of the Mexican Population Remained Susceptible to A(H1N1)pdm09 Infection One Year after the Emergence of 2009 Influenza Pandemic
Identifieur interne : 000920 ( Main/Exploration ); précédent : 000919; suivant : 000921A Large Proportion of the Mexican Population Remained Susceptible to A(H1N1)pdm09 Infection One Year after the Emergence of 2009 Influenza Pandemic
Auteurs : Vic Veguilla [États-Unis] ; Hugo L Pez-Gatell [Mexique] ; Irma L Pez-Martínez [Mexique] ; Rodrigo Aparicio-Antonio [Mexique] ; Gisela Barrera-Badillo [Mexique] ; Julieta Rojo-Medina [Mexique] ; Felicia Liaini Gross [États-Unis] ; Stacie N. Jefferson [États-Unis] ; Jacqueline M. Katz [États-Unis] ; Mauricio Hernández-Ávila [Mexique] ; Celia M. Alpuche-Aranda [Mexique]Source :
- PLoS ONE [ 1932-6203 ] ; 2016.
Descripteurs français
- KwdFr :
- Adulte, Américain origine mexicaine, Anticorps antiviraux (immunologie), Femelle, Grippe humaine (immunologie), Grippe humaine (épidémiologie), Humains, Mexique (épidémiologie), Mâle, Réactions croisées (immunologie), Sous-type H1N1 du virus de la grippe A (immunologie), Tests d'inhibition de l'hémagglutination (), Vaccination (), Vaccins antigrippaux (immunologie), Études séroépidémiologiques.
- MESH :
- immunologie : Anticorps antiviraux, Grippe humaine, Réactions croisées, Sous-type H1N1 du virus de la grippe A, Vaccins antigrippaux.
- épidémiologie : Grippe humaine, Mexique.
- Adulte, Américain origine mexicaine, Femelle, Humains, Mâle, Tests d'inhibition de l'hémagglutination, Vaccination, Études séroépidémiologiques.
- Wicri :
- geographic : Mexique.
English descriptors
- KwdEn :
- Adult, Antibodies, Viral (immunology), Cross Reactions (immunology), Female, Hemagglutination Inhibition Tests (methods), Humans, Influenza A Virus, H1N1 Subtype (immunology), Influenza Vaccines (immunology), Influenza, Human (epidemiology), Influenza, Human (immunology), Male, Mexican Americans, Mexico (epidemiology), Seroepidemiologic Studies, Vaccination (methods).
- MESH :
- chemical , immunology : Antibodies, Viral, Influenza Vaccines.
- geographic , epidemiology : Mexico.
- epidemiology : Influenza, Human.
- immunology : Cross Reactions, Influenza A Virus, H1N1 Subtype, Influenza, Human.
- methods : Hemagglutination Inhibition Tests, Vaccination.
- Adult, Female, Humans, Male, Mexican Americans, Seroepidemiologic Studies.
Abstract
The 2009 H1N1 influenza pandemic initially affected Mexico from April 2009 to July 2010. By August 2010, a fourth of the population had received the monovalent vaccine against the pandemic virus (A(H1N1)pdm09). To assess the proportion of the Mexican population who remained potentially susceptible to infection throughout the summer of 2010, we estimated the population seroprevalence to A(H1N1)pdm09 in a serosurvey of blood donors.
We evaluated baseline cross-reactivity to the pandemic strain and set the threshold for seropositivity using pre-pandemic (2005–2008) stored serum samples and sera from confirmed A(H1N1)pdm09 infected individuals. Between June and September 2010, a convenience sample serosurvey of adult blood donors, children, and adolescents was conducted in six states of Mexico. Sera were tested by the microneutralization (MN) and hemagglutination inhibition (HI) assays, and regarded seropositive if antibody titers were equal or exceeded 1:40 for MN and 1:20 for HI. Age-standardized seroprevalence were calculated using the 2010 National Census population.
Sera from 1,484 individuals were analyzed; 1,363 (92%) were blood donors, and 121 (8%) children or adolescents aged ≤19 years. Mean age (standard deviation) was 31.4 (11.5) years, and 276 (19%) were women. A total of 516 (35%) participants declared history of influenza vaccination after April 2009. The age-standardized seroprevalence to A(H1N1)pdm09 was 48% by the MN and 41% by the HI assays, respectively. The youngest quintile, aged 1 to 22 years, had the highest the seroprevalence; 61% (95% confidence interval [CI]: 56, 66%) for MN, and 56% (95% CI: 51, 62%) for HI.
Despite high transmission of A(H1N1)pdm09 observed immediately after its emergence and extensive vaccination, over a half of the Mexican population remained potentially susceptible to A(H1N1)pdm09 infection. Subsequent influenza seasons with high transmission of A(H1N1)pdm09, as 2011–2012 and 2013–2014, are compatible with these findings.
Url:
DOI: 10.1371/journal.pone.0150428
PubMed: 27003409
PubMed Central: 4803193
Affiliations:
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(États-Unis)</region></placeName></affiliation></author><author><name sortKey="L Pez Gatell, Hugo" sort="L Pez Gatell, Hugo" uniqKey="L Pez Gatell H" first="Hugo" last="L Pez-Gatell">Hugo L Pez-Gatell</name><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Dirección General Adjunta de Epidemiología, Secretaría de Salud, Mexico City, México</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Dirección General Adjunta de Epidemiología, Secretaría de Salud, Mexico City</wicri:regionArea><wicri:noRegion>Mexico City</wicri:noRegion></affiliation></author><author><name sortKey="L Pez Martinez, Irma" sort="L Pez Martinez, Irma" uniqKey="L Pez Martinez I" first="Irma" last="L Pez-Martínez">Irma L Pez-Martínez</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Laboratorio de Virus Respiratorios, Departamento de Virología, Instituto de Diagnóstico y Referencia Epidemiológicos, Mexico City, México</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Laboratorio de Virus Respiratorios, Departamento de Virología, Instituto de Diagnóstico y Referencia Epidemiológicos, Mexico City</wicri:regionArea><wicri:noRegion>Mexico City</wicri:noRegion></affiliation></author><author><name sortKey="Aparicio Antonio, Rodrigo" sort="Aparicio Antonio, Rodrigo" uniqKey="Aparicio Antonio R" first="Rodrigo" last="Aparicio-Antonio">Rodrigo Aparicio-Antonio</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Laboratorio de Virus Respiratorios, Departamento de Virología, Instituto de Diagnóstico y Referencia Epidemiológicos, Mexico City, México</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Laboratorio de Virus Respiratorios, Departamento de Virología, Instituto de Diagnóstico y Referencia Epidemiológicos, Mexico City</wicri:regionArea><wicri:noRegion>Mexico City</wicri:noRegion></affiliation></author><author><name sortKey="Barrera Badillo, Gisela" sort="Barrera Badillo, Gisela" uniqKey="Barrera Badillo G" first="Gisela" last="Barrera-Badillo">Gisela Barrera-Badillo</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Laboratorio de Virus Respiratorios, Departamento de Virología, Instituto de Diagnóstico y Referencia Epidemiológicos, Mexico City, México</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Laboratorio de Virus Respiratorios, Departamento de Virología, Instituto de Diagnóstico y Referencia Epidemiológicos, Mexico City</wicri:regionArea><wicri:noRegion>Mexico City</wicri:noRegion></affiliation></author><author><name sortKey="Rojo Medina, Julieta" sort="Rojo Medina, Julieta" uniqKey="Rojo Medina J" first="Julieta" last="Rojo-Medina">Julieta Rojo-Medina</name><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Centro Nacional de la Transfusión Sanguínea, Secretaría de Salud, Mexico City, México</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Centro Nacional de la Transfusión Sanguínea, Secretaría de Salud, Mexico City</wicri:regionArea><wicri:noRegion>Mexico City</wicri:noRegion></affiliation></author><author><name sortKey="Gross, Felicia Liaini" sort="Gross, Felicia Liaini" uniqKey="Gross F" first="Felicia Liaini" last="Gross">Felicia Liaini Gross</name><affiliation wicri:level="2"><nlm:aff id="aff001"><addr-line>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Jefferson, Stacie N" sort="Jefferson, Stacie N" uniqKey="Jefferson S" first="Stacie N." last="Jefferson">Stacie N. Jefferson</name><affiliation wicri:level="2"><nlm:aff id="aff001"><addr-line>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Katz, Jacqueline M" sort="Katz, Jacqueline M" uniqKey="Katz J" first="Jacqueline M." last="Katz">Jacqueline M. Katz</name><affiliation wicri:level="2"><nlm:aff id="aff001"><addr-line>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Hernandez Vila, Mauricio" sort="Hernandez Vila, Mauricio" uniqKey="Hernandez Vila M" first="Mauricio" last="Hernández-Ávila">Mauricio Hernández-Ávila</name><affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>Subsecretaría de Prevención y Promoción de la Salud, Secretaría de Salud, Mexico City, México</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Subsecretaría de Prevención y Promoción de la Salud, Secretaría de Salud, Mexico City</wicri:regionArea><wicri:noRegion>Mexico City</wicri:noRegion></affiliation></author><author><name sortKey="Alpuche Aranda, Celia M" sort="Alpuche Aranda, Celia M" uniqKey="Alpuche Aranda C" first="Celia M." last="Alpuche-Aranda">Celia M. Alpuche-Aranda</name><affiliation wicri:level="1"><nlm:aff id="aff006"><addr-line>Dirección General Adjunta del Instituto de Diagnóstico y Referencia Epidemiológicos, Mexico City, México</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Dirección General Adjunta del Instituto de Diagnóstico y Referencia Epidemiológicos, Mexico City</wicri:regionArea><wicri:noRegion>Mexico City</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Antibodies, Viral (immunology)</term><term>Cross Reactions (immunology)</term><term>Female</term><term>Hemagglutination Inhibition Tests (methods)</term><term>Humans</term><term>Influenza A Virus, H1N1 Subtype (immunology)</term><term>Influenza Vaccines (immunology)</term><term>Influenza, Human (epidemiology)</term><term>Influenza, Human (immunology)</term><term>Male</term><term>Mexican Americans</term><term>Mexico (epidemiology)</term><term>Seroepidemiologic Studies</term><term>Vaccination (methods)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Américain origine mexicaine</term><term>Anticorps antiviraux (immunologie)</term><term>Femelle</term><term>Grippe humaine (immunologie)</term><term>Grippe humaine (épidémiologie)</term><term>Humains</term><term>Mexique (épidémiologie)</term><term>Mâle</term><term>Réactions croisées (immunologie)</term><term>Sous-type H1N1 du virus de la grippe A (immunologie)</term><term>Tests d'inhibition de l'hémagglutination ()</term><term>Vaccination ()</term><term>Vaccins antigrippaux (immunologie)</term><term>Études séroépidémiologiques</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Viral</term><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Mexico</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps antiviraux</term><term>Grippe humaine</term><term>Réactions croisées</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Cross Reactions</term><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Hemagglutination Inhibition Tests</term><term>Vaccination</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Grippe humaine</term><term>Mexique</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Humans</term><term>Male</term><term>Mexican Americans</term><term>Seroepidemiologic Studies</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Américain origine mexicaine</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Tests d'inhibition de l'hémagglutination</term><term>Vaccination</term><term>Études séroépidémiologiques</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Mexique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="sec001"><title>Background</title><p>The 2009 H1N1 influenza pandemic initially affected Mexico from April 2009 to July 2010. By August 2010, a fourth of the population had received the monovalent vaccine against the pandemic virus (A(H1N1)pdm09). To assess the proportion of the Mexican population who remained potentially susceptible to infection throughout the summer of 2010, we estimated the population seroprevalence to A(H1N1)pdm09 in a serosurvey of blood donors.</p></sec><sec id="sec002"><title>Methods</title><p>We evaluated baseline cross-reactivity to the pandemic strain and set the threshold for seropositivity using pre-pandemic (2005–2008) stored serum samples and sera from confirmed A(H1N1)pdm09 infected individuals. Between June and September 2010, a convenience sample serosurvey of adult blood donors, children, and adolescents was conducted in six states of Mexico. Sera were tested by the microneutralization (MN) and hemagglutination inhibition (HI) assays, and regarded seropositive if antibody titers were equal or exceeded 1:40 for MN and 1:20 for HI. Age-standardized seroprevalence were calculated using the 2010 National Census population.</p></sec><sec id="sec003"><title>Results</title><p>Sera from 1,484 individuals were analyzed; 1,363 (92%) were blood donors, and 121 (8%) children or adolescents aged ≤19 years. Mean age (standard deviation) was 31.4 (11.5) years, and 276 (19%) were women. A total of 516 (35%) participants declared history of influenza vaccination after April 2009. The age-standardized seroprevalence to A(H1N1)pdm09 was 48% by the MN and 41% by the HI assays, respectively. The youngest quintile, aged 1 to 22 years, had the highest the seroprevalence; 61% (95% confidence interval [CI]: 56, 66%) for MN, and 56% (95% CI: 51, 62%) for HI.</p></sec><sec id="sec004"><title>Conclusions</title><p>Despite high transmission of A(H1N1)pdm09 observed immediately after its emergence and extensive vaccination, over a half of the Mexican population remained potentially susceptible to A(H1N1)pdm09 infection. Subsequent influenza seasons with high transmission of A(H1N1)pdm09, as 2011–2012 and 2013–2014, are compatible with these findings.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Chowell, G" uniqKey="Chowell G">G Chowell</name></author><author><name sortKey="Echevarria Zuno, S" uniqKey="Echevarria Zuno S">S Echevarría-Zuno</name></author><author><name sortKey="Viboud, C" uniqKey="Viboud C">C Viboud</name></author><author><name sortKey="Simonsen, L" uniqKey="Simonsen L">L Simonsen</name></author><author><name sortKey="Tamerius, J" uniqKey="Tamerius J">J Tamerius</name></author><author><name sortKey="Miller, Ma" uniqKey="Miller M">MA Miller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Broberg, Ee" uniqKey="Broberg E">EE Broberg</name></author><author><name sortKey="Nicoll, Aa" uniqKey="Nicoll A">AA Nicoll</name></author><author><name sortKey="Amato Gauci, Aa" uniqKey="Amato Gauci A">AA 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Grajales-Muñiz</name></author><author><name sortKey="Miller, Ma" uniqKey="Miller M">MA Miller</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Mexique</li><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li></region></list><tree><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Veguilla, Vic" sort="Veguilla, Vic" uniqKey="Veguilla V" first="Vic" last="Veguilla">Vic Veguilla</name></region><name sortKey="Gross, Felicia Liaini" sort="Gross, Felicia Liaini" uniqKey="Gross F" first="Felicia Liaini" last="Gross">Felicia Liaini Gross</name><name sortKey="Jefferson, Stacie N" sort="Jefferson, Stacie N" uniqKey="Jefferson S" first="Stacie N." last="Jefferson">Stacie N. Jefferson</name><name sortKey="Katz, Jacqueline M" sort="Katz, Jacqueline M" uniqKey="Katz J" first="Jacqueline M." last="Katz">Jacqueline M. Katz</name></country><country name="Mexique"><noRegion><name sortKey="L Pez Gatell, Hugo" sort="L Pez Gatell, Hugo" uniqKey="L Pez Gatell H" first="Hugo" last="L Pez-Gatell">Hugo L Pez-Gatell</name></noRegion><name sortKey="Alpuche Aranda, Celia M" sort="Alpuche Aranda, Celia M" uniqKey="Alpuche Aranda C" first="Celia M." last="Alpuche-Aranda">Celia M. Alpuche-Aranda</name><name sortKey="Aparicio Antonio, Rodrigo" sort="Aparicio Antonio, Rodrigo" uniqKey="Aparicio Antonio R" first="Rodrigo" last="Aparicio-Antonio">Rodrigo Aparicio-Antonio</name><name sortKey="Barrera Badillo, Gisela" sort="Barrera Badillo, Gisela" uniqKey="Barrera Badillo G" first="Gisela" last="Barrera-Badillo">Gisela Barrera-Badillo</name><name sortKey="Hernandez Vila, Mauricio" sort="Hernandez Vila, Mauricio" uniqKey="Hernandez Vila M" first="Mauricio" last="Hernández-Ávila">Mauricio Hernández-Ávila</name><name sortKey="L Pez Martinez, Irma" sort="L Pez Martinez, Irma" uniqKey="L Pez Martinez I" first="Irma" last="L Pez-Martínez">Irma L Pez-Martínez</name><name sortKey="Rojo Medina, Julieta" sort="Rojo Medina, Julieta" uniqKey="Rojo Medina J" first="Julieta" last="Rojo-Medina">Julieta Rojo-Medina</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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