Chimpanzee adenovirus vector-based avian influenza vaccine completely protects mice against lethal challenge of H5N1.
Identifieur interne : 000903 ( Main/Exploration ); précédent : 000902; suivant : 000904Chimpanzee adenovirus vector-based avian influenza vaccine completely protects mice against lethal challenge of H5N1.
Auteurs : Tao Cheng [République populaire de Chine] ; Xiang Wang [République populaire de Chine] ; Yufeng Song [République populaire de Chine] ; Xinying Tang [République populaire de Chine] ; Chao Zhang [République populaire de Chine] ; Hongbo Zhang [République populaire de Chine] ; Xia Jin [République populaire de Chine] ; Dongming Zhou [République populaire de Chine]Source :
- Vaccine [ 1873-2518 ] ; 2016.
Descripteurs français
- KwdFr :
- Adénovirus simiens, Animaux, Anticorps antiviraux (sang), Anticorps neutralisants (sang), Cellules HEK293, Femelle, Glycoprotéine hémagglutinine du virus influenza (immunologie), Humains, Immunisation passive, Immunité cellulaire, Immunité humorale, Infections à Orthomyxoviridae (), Lymphocytes T CD8+ (immunologie), Pan troglodytes, Souris, Souris de lignée BALB C, Souris de lignée ICR, Sous-type H5N1 du virus de la grippe A, Vaccins antigrippaux (immunologie).
- MESH :
- immunologie : Glycoprotéine hémagglutinine du virus influenza, Lymphocytes T CD8+, Vaccins antigrippaux.
- sang : Anticorps antiviraux, Anticorps neutralisants.
- Adénovirus simiens, Animaux, Cellules HEK293, Femelle, Humains, Immunisation passive, Immunité cellulaire, Immunité humorale, Infections à Orthomyxoviridae, Pan troglodytes, Souris, Souris de lignée BALB C, Souris de lignée ICR, Sous-type H5N1 du virus de la grippe A.
English descriptors
- KwdEn :
- Adenoviruses, Simian, Animals, Antibodies, Neutralizing (blood), Antibodies, Viral (blood), CD8-Positive T-Lymphocytes (immunology), Female, HEK293 Cells, Hemagglutinin Glycoproteins, Influenza Virus (immunology), Humans, Immunity, Cellular, Immunity, Humoral, Immunization, Passive, Influenza A Virus, H5N1 Subtype, Influenza Vaccines (immunology), Mice, Mice, Inbred BALB C, Mice, Inbred ICR, Orthomyxoviridae Infections (prevention & control), Pan troglodytes.
- MESH :
- chemical , blood : Antibodies, Neutralizing, Antibodies, Viral.
- immunology : CD8-Positive T-Lymphocytes, Hemagglutinin Glycoproteins, Influenza Virus, Influenza Vaccines.
- prevention & control : Orthomyxoviridae Infections.
- Adenoviruses, Simian, Animals, Female, HEK293 Cells, Humans, Immunity, Cellular, Immunity, Humoral, Immunization, Passive, Influenza A Virus, H5N1 Subtype, Mice, Mice, Inbred BALB C, Mice, Inbred ICR, Pan troglodytes.
Abstract
Highly pathogenic avian H5N1 viruses may give rise to the next influenza pandemic due to their reassortment and mutation of the genome. Vaccine against this virus is important for coping with its potential threat. Chimpanzee adenovirus (Ad) vectors are a novel type of vaccine vectors that share the advantages of human serotype Ad vectors but without being affected by pre-existing human neutralizing antibody to the vaccine vector. Based on a replication-deficient chimpanzee Ad vector, AdC7, we generated a novel H5N1 vaccine candidate AdC7-H5HA that expresses H5N1 Hemagglutinin(HA). When tested in mice, the vaccine significantly reduced the virus load and pathological lesions in the lung tissues, and conferred complete protection against lethal challenge by a homologous virus. Mechanistically, the AdC7-H5HA vaccine can induce both HA-specific humoral and cell-mediated immune responses in mice. Also, sera transfer experiments demonstrated that neutralizing antibodies alone could provide protection. In conclusion, our results show that chimpanzee Ad vector expressing influenza virus HA may represent a promising vaccine candidate for H5N1 viruses and other influenza virus subtypes.
DOI: 10.1016/j.vaccine.2016.08.066
PubMed: 27576071
Affiliations:
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Le document en format XML
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<term>Animals</term>
<term>Antibodies, Neutralizing (blood)</term>
<term>Antibodies, Viral (blood)</term>
<term>CD8-Positive T-Lymphocytes (immunology)</term>
<term>Female</term>
<term>HEK293 Cells</term>
<term>Hemagglutinin Glycoproteins, Influenza Virus (immunology)</term>
<term>Humans</term>
<term>Immunity, Cellular</term>
<term>Immunity, Humoral</term>
<term>Immunization, Passive</term>
<term>Influenza A Virus, H5N1 Subtype</term>
<term>Influenza Vaccines (immunology)</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Mice, Inbred ICR</term>
<term>Orthomyxoviridae Infections (prevention & control)</term>
<term>Pan troglodytes</term>
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<term>Animaux</term>
<term>Anticorps antiviraux (sang)</term>
<term>Anticorps neutralisants (sang)</term>
<term>Cellules HEK293</term>
<term>Femelle</term>
<term>Glycoprotéine hémagglutinine du virus influenza (immunologie)</term>
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<term>Immunisation passive</term>
<term>Immunité cellulaire</term>
<term>Immunité humorale</term>
<term>Infections à Orthomyxoviridae ()</term>
<term>Lymphocytes T CD8+ (immunologie)</term>
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<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Souris de lignée ICR</term>
<term>Sous-type H5N1 du virus de la grippe A</term>
<term>Vaccins antigrippaux (immunologie)</term>
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<term>Antibodies, Viral</term>
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<term>Lymphocytes T CD8+</term>
<term>Vaccins antigrippaux</term>
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<term>Influenza Vaccines</term>
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<term>Cellules HEK293</term>
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<term>Humains</term>
<term>Immunisation passive</term>
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<front><div type="abstract" xml:lang="en">Highly pathogenic avian H5N1 viruses may give rise to the next influenza pandemic due to their reassortment and mutation of the genome. Vaccine against this virus is important for coping with its potential threat. Chimpanzee adenovirus (Ad) vectors are a novel type of vaccine vectors that share the advantages of human serotype Ad vectors but without being affected by pre-existing human neutralizing antibody to the vaccine vector. Based on a replication-deficient chimpanzee Ad vector, AdC7, we generated a novel H5N1 vaccine candidate AdC7-H5HA that expresses H5N1 Hemagglutinin(HA). When tested in mice, the vaccine significantly reduced the virus load and pathological lesions in the lung tissues, and conferred complete protection against lethal challenge by a homologous virus. Mechanistically, the AdC7-H5HA vaccine can induce both HA-specific humoral and cell-mediated immune responses in mice. Also, sera transfer experiments demonstrated that neutralizing antibodies alone could provide protection. In conclusion, our results show that chimpanzee Ad vector expressing influenza virus HA may represent a promising vaccine candidate for H5N1 viruses and other influenza virus subtypes.</div>
</front>
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<name sortKey="Tang, Xinying" sort="Tang, Xinying" uniqKey="Tang X" first="Xinying" last="Tang">Xinying Tang</name>
<name sortKey="Wang, Xiang" sort="Wang, Xiang" uniqKey="Wang X" first="Xiang" last="Wang">Xiang Wang</name>
<name sortKey="Zhang, Chao" sort="Zhang, Chao" uniqKey="Zhang C" first="Chao" last="Zhang">Chao Zhang</name>
<name sortKey="Zhang, Hongbo" sort="Zhang, Hongbo" uniqKey="Zhang H" first="Hongbo" last="Zhang">Hongbo Zhang</name>
<name sortKey="Zhou, Dongming" sort="Zhou, Dongming" uniqKey="Zhou D" first="Dongming" last="Zhou">Dongming Zhou</name>
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