Chimpanzee adenovirus vector-based avian influenza vaccine completely protects mice against lethal challenge of H5N1.
Identifieur interne : 000527 ( PubMed/Checkpoint ); précédent : 000526; suivant : 000528Chimpanzee adenovirus vector-based avian influenza vaccine completely protects mice against lethal challenge of H5N1.
Auteurs : Tao Cheng [République populaire de Chine] ; Xiang Wang [République populaire de Chine] ; Yufeng Song [République populaire de Chine] ; Xinying Tang [République populaire de Chine] ; Chao Zhang [République populaire de Chine] ; Hongbo Zhang [République populaire de Chine] ; Xia Jin [République populaire de Chine] ; Dongming Zhou [République populaire de Chine]Source :
- Vaccine [ 1873-2518 ] ; 2016.
Descripteurs français
- KwdFr :
- Adénovirus simiens, Animaux, Anticorps antiviraux (sang), Anticorps neutralisants (sang), Cellules HEK293, Femelle, Glycoprotéine hémagglutinine du virus influenza (immunologie), Humains, Immunisation passive, Immunité cellulaire, Immunité humorale, Infections à Orthomyxoviridae (), Lymphocytes T CD8+ (immunologie), Pan troglodytes, Souris, Souris de lignée BALB C, Souris de lignée ICR, Sous-type H5N1 du virus de la grippe A, Vaccins antigrippaux (immunologie).
- MESH :
- immunologie : Glycoprotéine hémagglutinine du virus influenza, Lymphocytes T CD8+, Vaccins antigrippaux.
- sang : Anticorps antiviraux, Anticorps neutralisants.
- Adénovirus simiens, Animaux, Cellules HEK293, Femelle, Humains, Immunisation passive, Immunité cellulaire, Immunité humorale, Infections à Orthomyxoviridae, Pan troglodytes, Souris, Souris de lignée BALB C, Souris de lignée ICR, Sous-type H5N1 du virus de la grippe A.
English descriptors
- KwdEn :
- Adenoviruses, Simian, Animals, Antibodies, Neutralizing (blood), Antibodies, Viral (blood), CD8-Positive T-Lymphocytes (immunology), Female, HEK293 Cells, Hemagglutinin Glycoproteins, Influenza Virus (immunology), Humans, Immunity, Cellular, Immunity, Humoral, Immunization, Passive, Influenza A Virus, H5N1 Subtype, Influenza Vaccines (immunology), Mice, Mice, Inbred BALB C, Mice, Inbred ICR, Orthomyxoviridae Infections (prevention & control), Pan troglodytes.
- MESH :
- chemical , blood : Antibodies, Neutralizing, Antibodies, Viral.
- immunology : CD8-Positive T-Lymphocytes, Hemagglutinin Glycoproteins, Influenza Virus, Influenza Vaccines.
- prevention & control : Orthomyxoviridae Infections.
- Adenoviruses, Simian, Animals, Female, HEK293 Cells, Humans, Immunity, Cellular, Immunity, Humoral, Immunization, Passive, Influenza A Virus, H5N1 Subtype, Mice, Mice, Inbred BALB C, Mice, Inbred ICR, Pan troglodytes.
Abstract
Highly pathogenic avian H5N1 viruses may give rise to the next influenza pandemic due to their reassortment and mutation of the genome. Vaccine against this virus is important for coping with its potential threat. Chimpanzee adenovirus (Ad) vectors are a novel type of vaccine vectors that share the advantages of human serotype Ad vectors but without being affected by pre-existing human neutralizing antibody to the vaccine vector. Based on a replication-deficient chimpanzee Ad vector, AdC7, we generated a novel H5N1 vaccine candidate AdC7-H5HA that expresses H5N1 Hemagglutinin(HA). When tested in mice, the vaccine significantly reduced the virus load and pathological lesions in the lung tissues, and conferred complete protection against lethal challenge by a homologous virus. Mechanistically, the AdC7-H5HA vaccine can induce both HA-specific humoral and cell-mediated immune responses in mice. Also, sera transfer experiments demonstrated that neutralizing antibodies alone could provide protection. In conclusion, our results show that chimpanzee Ad vector expressing influenza virus HA may represent a promising vaccine candidate for H5N1 viruses and other influenza virus subtypes.
DOI: 10.1016/j.vaccine.2016.08.066
PubMed: 27576071
Affiliations:
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pubmed:27576071Le document en format XML
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last="Wang">Xiang Wang</name><affiliation wicri:level="1"><nlm:affiliation>Vaccine Research Center, Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Vaccine Research Center, Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031</wicri:regionArea><wicri:noRegion>Shanghai 200031</wicri:noRegion></affiliation></author><author><name sortKey="Song, Yufeng" sort="Song, Yufeng" uniqKey="Song Y" first="Yufeng" last="Song">Yufeng Song</name><affiliation wicri:level="1"><nlm:affiliation>Vaccine Research Center, Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Vaccine 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Electronic address: xjin@ips.ac.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Vaccine Research Center, Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031</wicri:regionArea><wicri:noRegion>Shanghai 200031</wicri:noRegion></affiliation></author><author><name sortKey="Zhou, Dongming" sort="Zhou, Dongming" uniqKey="Zhou D" first="Dongming" last="Zhou">Dongming Zhou</name><affiliation wicri:level="1"><nlm:affiliation>Vaccine Research Center, Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China. Electronic address: dmzhou@sibs.ac.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Vaccine Research Center, Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031</wicri:regionArea><wicri:noRegion>Shanghai 200031</wicri:noRegion></affiliation></author></analytic><series><title level="j">Vaccine</title><idno type="eISSN">1873-2518</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenoviruses, Simian</term><term>Animals</term><term>Antibodies, Neutralizing (blood)</term><term>Antibodies, Viral (blood)</term><term>CD8-Positive T-Lymphocytes (immunology)</term><term>Female</term><term>HEK293 Cells</term><term>Hemagglutinin Glycoproteins, Influenza Virus (immunology)</term><term>Humans</term><term>Immunity, Cellular</term><term>Immunity, Humoral</term><term>Immunization, Passive</term><term>Influenza A Virus, H5N1 Subtype</term><term>Influenza Vaccines (immunology)</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Mice, Inbred ICR</term><term>Orthomyxoviridae Infections (prevention & control)</term><term>Pan troglodytes</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adénovirus simiens</term><term>Animaux</term><term>Anticorps antiviraux (sang)</term><term>Anticorps neutralisants (sang)</term><term>Cellules HEK293</term><term>Femelle</term><term>Glycoprotéine hémagglutinine du virus influenza (immunologie)</term><term>Humains</term><term>Immunisation passive</term><term>Immunité cellulaire</term><term>Immunité humorale</term><term>Infections à Orthomyxoviridae ()</term><term>Lymphocytes T CD8+ (immunologie)</term><term>Pan troglodytes</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Souris de lignée ICR</term><term>Sous-type H5N1 du virus de la grippe A</term><term>Vaccins antigrippaux (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Neutralizing</term><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Glycoprotéine hémagglutinine du virus influenza</term><term>Lymphocytes T CD8+</term><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>CD8-Positive T-Lymphocytes</term><term>Hemagglutinin Glycoproteins, Influenza Virus</term><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term><term>Anticorps neutralisants</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adenoviruses, Simian</term><term>Animals</term><term>Female</term><term>HEK293 Cells</term><term>Humans</term><term>Immunity, Cellular</term><term>Immunity, Humoral</term><term>Immunization, Passive</term><term>Influenza A Virus, H5N1 Subtype</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Mice, Inbred ICR</term><term>Pan troglodytes</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adénovirus simiens</term><term>Animaux</term><term>Cellules HEK293</term><term>Femelle</term><term>Humains</term><term>Immunisation passive</term><term>Immunité cellulaire</term><term>Immunité humorale</term><term>Infections à Orthomyxoviridae</term><term>Pan troglodytes</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Souris de lignée ICR</term><term>Sous-type H5N1 du virus de la grippe A</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Highly pathogenic avian H5N1 viruses may give rise to the next influenza pandemic due to their reassortment and mutation of the genome. Vaccine against this virus is important for coping with its potential threat. Chimpanzee adenovirus (Ad) vectors are a novel type of vaccine vectors that share the advantages of human serotype Ad vectors but without being affected by pre-existing human neutralizing antibody to the vaccine vector. Based on a replication-deficient chimpanzee Ad vector, AdC7, we generated a novel H5N1 vaccine candidate AdC7-H5HA that expresses H5N1 Hemagglutinin(HA). When tested in mice, the vaccine significantly reduced the virus load and pathological lesions in the lung tissues, and conferred complete protection against lethal challenge by a homologous virus. Mechanistically, the AdC7-H5HA vaccine can induce both HA-specific humoral and cell-mediated immune responses in mice. Also, sera transfer experiments demonstrated that neutralizing antibodies alone could provide protection. In conclusion, our results show that chimpanzee Ad vector expressing influenza virus HA may represent a promising vaccine candidate for H5N1 viruses and other influenza virus subtypes.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27576071</PMID><DateCompleted><Year>2017</Year><Month>12</Month><Day>06</Day></DateCompleted><DateRevised><Year>2017</Year><Month>12</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-2518</ISSN><JournalIssue CitedMedium="Internet"><Volume>34</Volume><Issue>41</Issue><PubDate><Year>2016</Year><Month>09</Month><Day>22</Day></PubDate></JournalIssue><Title>Vaccine</Title><ISOAbbreviation>Vaccine</ISOAbbreviation></Journal><ArticleTitle>Chimpanzee adenovirus vector-based avian influenza vaccine completely protects mice against lethal challenge of H5N1.</ArticleTitle><Pagination><MedlinePgn>4875-4883</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0264-410X(16)30762-9</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.vaccine.2016.08.066</ELocationID><Abstract><AbstractText>Highly pathogenic avian H5N1 viruses may give rise to the next influenza pandemic due to their reassortment and mutation of the genome. Vaccine against this virus is important for coping with its potential threat. Chimpanzee adenovirus (Ad) vectors are a novel type of vaccine vectors that share the advantages of human serotype Ad vectors but without being affected by pre-existing human neutralizing antibody to the vaccine vector. Based on a replication-deficient chimpanzee Ad vector, AdC7, we generated a novel H5N1 vaccine candidate AdC7-H5HA that expresses H5N1 Hemagglutinin(HA). When tested in mice, the vaccine significantly reduced the virus load and pathological lesions in the lung tissues, and conferred complete protection against lethal challenge by a homologous virus. Mechanistically, the AdC7-H5HA vaccine can induce both HA-specific humoral and cell-mediated immune responses in mice. Also, sera transfer experiments demonstrated that neutralizing antibodies alone could provide protection. In conclusion, our results show that chimpanzee Ad vector expressing influenza virus HA may represent a promising vaccine candidate for H5N1 viruses and other influenza virus subtypes.</AbstractText><CopyrightInformation>Copyright © 2016 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Cheng</LastName><ForeName>Tao</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Vaccine Research Center, Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Xiang</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Vaccine Research Center, Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Song</LastName><ForeName>Yufeng</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Vaccine Research Center, Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tang</LastName><ForeName>Xinying</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Vaccine Research Center, Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Chao</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Vaccine Research Center, Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Hongbo</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Vaccine Research Center, Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jin</LastName><ForeName>Xia</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Vaccine Research Center, Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China. Electronic address: xjin@ips.ac.cn.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhou</LastName><ForeName>Dongming</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Vaccine Research Center, Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China. Electronic address: dmzhou@sibs.ac.cn.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>08</Month><Day>26</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Vaccine</MedlineTA><NlmUniqueID>8406899</NlmUniqueID><ISSNLinking>0264-410X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D057134">Antibodies, Neutralizing</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000914">Antibodies, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019267">Hemagglutinin Glycoproteins, Influenza Virus</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007252">Influenza Vaccines</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000261" MajorTopicYN="Y">Adenoviruses, Simian</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D057134" MajorTopicYN="N">Antibodies, Neutralizing</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000914" MajorTopicYN="N">Antibodies, Viral</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018414" MajorTopicYN="N">CD8-Positive T-Lymphocytes</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName 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MajorTopicYN="Y">Vaccine</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>03</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>08</Month><Day>03</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>08</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>8</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>9</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>12</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27576071</ArticleId><ArticleId IdType="pii">S0264-410X(16)30762-9</ArticleId><ArticleId IdType="doi">10.1016/j.vaccine.2016.08.066</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Cheng, Tao" sort="Cheng, Tao" uniqKey="Cheng T" first="Tao" last="Cheng">Tao Cheng</name></noRegion><name sortKey="Jin, Xia" sort="Jin, Xia" uniqKey="Jin X" first="Xia" last="Jin">Xia Jin</name><name sortKey="Song, Yufeng" sort="Song, Yufeng" uniqKey="Song Y" first="Yufeng" last="Song">Yufeng Song</name><name sortKey="Tang, Xinying" sort="Tang, Xinying" uniqKey="Tang X" first="Xinying" last="Tang">Xinying Tang</name><name sortKey="Wang, Xiang" sort="Wang, Xiang" uniqKey="Wang X" first="Xiang" last="Wang">Xiang Wang</name><name sortKey="Zhang, Chao" sort="Zhang, Chao" uniqKey="Zhang C" first="Chao" last="Zhang">Chao Zhang</name><name sortKey="Zhang, Hongbo" sort="Zhang, Hongbo" uniqKey="Zhang H" first="Hongbo" last="Zhang">Hongbo Zhang</name><name sortKey="Zhou, Dongming" sort="Zhou, Dongming" uniqKey="Zhou D" first="Dongming" last="Zhou">Dongming Zhou</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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