Egg-Independent Influenza Vaccines and Vaccine Candidates
Identifieur interne : 000716 ( Main/Exploration ); précédent : 000715; suivant : 000717Egg-Independent Influenza Vaccines and Vaccine Candidates
Auteurs : Ilaria Manini ; Claudia Maria Trombetta ; Giacomo Lazzeri ; Teresa Pozzi ; Stefania Rossi ; Emanuele Montomoli [Italie]Source :
- Vaccines [ 2076-393X ] ; 2017.
Abstract
Vaccination remains the principal way to control seasonal infections and is the most effective method of reducing influenza-associated morbidity and mortality. Since the 1940s, the main method of producing influenza vaccines has been an egg-based production process. However, in the event of a pandemic, this method has a significant limitation, as the time lag from strain isolation to final dose formulation and validation is six months. Indeed, production in eggs is a relatively slow process and production yields are both unpredictable and highly variable from strain to strain. In particular, if the next influenza pandemic were to arise from an avian influenza virus, and thus reduce the egg-laying hen population, there would be a shortage of embryonated eggs available for vaccine manufacturing. Although the production of egg-derived vaccines will continue, new technological developments have generated a cell-culture-based influenza vaccine and other more recent platforms, such as synthetic influenza vaccines.
Url:
DOI: 10.3390/vaccines5030018
PubMed: 28718786
PubMed Central: 5620549
Affiliations:
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Siena, Italy;<email>trombetta@unisi.it</email> (C.M.T.);<email>giacomo.lazzeri@unisi.it</email> (G.L.);<email>teresa.pozzi@unisi.it</email> (T.P.);<email>stefania.rossi@unisi.it</email> (S.R.);<email>emanuele.montomoli@unisi.it</email> (E.M.)</nlm:aff></affiliation></author><author><name sortKey="Lazzeri, Giacomo" sort="Lazzeri, Giacomo" uniqKey="Lazzeri G" first="Giacomo" last="Lazzeri">Giacomo Lazzeri</name><affiliation><nlm:aff id="af1-vaccines-05-00018">Department of Molecular and Developmental Medicine, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy;<email>trombetta@unisi.it</email> (C.M.T.);<email>giacomo.lazzeri@unisi.it</email> (G.L.);<email>teresa.pozzi@unisi.it</email> (T.P.);<email>stefania.rossi@unisi.it</email> (S.R.);<email>emanuele.montomoli@unisi.it</email> (E.M.)</nlm:aff></affiliation></author><author><name sortKey="Pozzi, Teresa" sort="Pozzi, Teresa" uniqKey="Pozzi T" first="Teresa" last="Pozzi">Teresa Pozzi</name><affiliation><nlm:aff 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(C.M.T.);<email>giacomo.lazzeri@unisi.it</email> (G.L.);<email>teresa.pozzi@unisi.it</email> (T.P.);<email>stefania.rossi@unisi.it</email> (S.R.);<email>emanuele.montomoli@unisi.it</email> (E.M.)</nlm:aff></affiliation></author><author><name sortKey="Trombetta, Claudia Maria" sort="Trombetta, Claudia Maria" uniqKey="Trombetta C" first="Claudia Maria" last="Trombetta">Claudia Maria Trombetta</name><affiliation><nlm:aff id="af1-vaccines-05-00018">Department of Molecular and Developmental Medicine, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy;<email>trombetta@unisi.it</email> (C.M.T.);<email>giacomo.lazzeri@unisi.it</email> (G.L.);<email>teresa.pozzi@unisi.it</email> (T.P.);<email>stefania.rossi@unisi.it</email> (S.R.);<email>emanuele.montomoli@unisi.it</email> (E.M.)</nlm:aff></affiliation></author><author><name sortKey="Lazzeri, Giacomo" sort="Lazzeri, Giacomo" uniqKey="Lazzeri G" first="Giacomo" last="Lazzeri">Giacomo Lazzeri</name><affiliation><nlm:aff id="af1-vaccines-05-00018">Department of Molecular and Developmental Medicine, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy;<email>trombetta@unisi.it</email> (C.M.T.);<email>giacomo.lazzeri@unisi.it</email> (G.L.);<email>teresa.pozzi@unisi.it</email> (T.P.);<email>stefania.rossi@unisi.it</email> (S.R.);<email>emanuele.montomoli@unisi.it</email> (E.M.)</nlm:aff></affiliation></author><author><name sortKey="Pozzi, Teresa" sort="Pozzi, Teresa" uniqKey="Pozzi T" first="Teresa" last="Pozzi">Teresa Pozzi</name><affiliation><nlm:aff id="af1-vaccines-05-00018">Department of Molecular and Developmental Medicine, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy;<email>trombetta@unisi.it</email> (C.M.T.);<email>giacomo.lazzeri@unisi.it</email> (G.L.);<email>teresa.pozzi@unisi.it</email> (T.P.);<email>stefania.rossi@unisi.it</email> (S.R.);<email>emanuele.montomoli@unisi.it</email> (E.M.)</nlm:aff></affiliation></author><author><name sortKey="Rossi, Stefania" sort="Rossi, Stefania" uniqKey="Rossi S" first="Stefania" last="Rossi">Stefania Rossi</name><affiliation><nlm:aff id="af1-vaccines-05-00018">Department of Molecular and Developmental Medicine, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy;<email>trombetta@unisi.it</email> (C.M.T.);<email>giacomo.lazzeri@unisi.it</email> (G.L.);<email>teresa.pozzi@unisi.it</email> (T.P.);<email>stefania.rossi@unisi.it</email> (S.R.);<email>emanuele.montomoli@unisi.it</email> (E.M.)</nlm:aff></affiliation></author><author><name sortKey="Montomoli, Emanuele" sort="Montomoli, Emanuele" uniqKey="Montomoli E" first="Emanuele" last="Montomoli">Emanuele Montomoli</name><affiliation><nlm:aff id="af1-vaccines-05-00018">Department of Molecular and Developmental Medicine, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy;<email>trombetta@unisi.it</email> (C.M.T.);<email>giacomo.lazzeri@unisi.it</email> (G.L.);<email>teresa.pozzi@unisi.it</email> (T.P.);<email>stefania.rossi@unisi.it</email> (S.R.);<email>emanuele.montomoli@unisi.it</email> (E.M.)</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-vaccines-05-00018">VisMederi S.r.l., Strada del Petriccio e Belriguardo 35, 53100 Siena, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>VisMederi S.r.l., Strada del Petriccio e Belriguardo 35, 53100 Siena</wicri:regionArea><wicri:noRegion>53100 Siena</wicri:noRegion></affiliation></author></analytic><series><title level="j">Vaccines</title><idno type="eISSN">2076-393X</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Vaccination remains the principal way to control seasonal infections and is the most effective method of reducing influenza-associated morbidity and mortality. Since the 1940s, the main method of producing influenza vaccines has been an egg-based production process. However, in the event of a pandemic, this method has a significant limitation, as the time lag from strain isolation to final dose formulation and validation is six months. Indeed, production in eggs is a relatively slow process and production yields are both unpredictable and highly variable from strain to strain. In particular, if the next influenza pandemic were to arise from an avian influenza virus, and thus reduce the egg-laying hen population, there would be a shortage of embryonated eggs available for vaccine manufacturing. Although the production of egg-derived vaccines will continue, new technological developments have generated a cell-culture-based influenza vaccine and other more recent platforms, such as synthetic influenza vaccines.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Salomon, R" uniqKey="Salomon R">R. Salomon</name></author><author><name sortKey="Webster, R G" uniqKey="Webster R">R.G. Webster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hilleman, M R" uniqKey="Hilleman M">M.R. Hilleman</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Kistner, O" uniqKey="Kistner O">O. Kistner</name></author><author><name sortKey="Barrett, P N" uniqKey="Barrett P">P.N. Barrett</name></author><author><name sortKey="Mundt, W" uniqKey="Mundt W">W. 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Bae</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Italie</li></country></list><tree><noCountry><name sortKey="Lazzeri, Giacomo" sort="Lazzeri, Giacomo" uniqKey="Lazzeri G" first="Giacomo" last="Lazzeri">Giacomo Lazzeri</name><name sortKey="Manini, Ilaria" sort="Manini, Ilaria" uniqKey="Manini I" first="Ilaria" last="Manini">Ilaria Manini</name><name sortKey="Pozzi, Teresa" sort="Pozzi, Teresa" uniqKey="Pozzi T" first="Teresa" last="Pozzi">Teresa Pozzi</name><name sortKey="Rossi, Stefania" sort="Rossi, Stefania" uniqKey="Rossi S" first="Stefania" last="Rossi">Stefania Rossi</name><name sortKey="Trombetta, Claudia Maria" sort="Trombetta, Claudia Maria" uniqKey="Trombetta C" first="Claudia Maria" last="Trombetta">Claudia Maria Trombetta</name></noCountry><country name="Italie"><noRegion><name sortKey="Montomoli, Emanuele" sort="Montomoli, Emanuele" uniqKey="Montomoli E" first="Emanuele" last="Montomoli">Emanuele Montomoli</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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