PandemieGrippaleV1, Main, Curation, bibRecord, 000793

Comparative Analysis Between Flaviviruses Reveals Specific Neural Stem Cell Tropism for Zika Virus in the Mouse Developing Neocortex.

Identifieur interne : 000793 ( Main/Curation ); précédent : 000792; suivant : 000794

Comparative Analysis Between Flaviviruses Reveals Specific Neural Stem Cell Tropism for Zika Virus in the Mouse Developing Neocortex.

Auteurs : Jean-Baptiste Brault [France] ; Cécile Khou [France] ; Justine Basset [France] ; Laure Coquand [France] ; Vincent Fraisier [France] ; Marie-Pascale Frenkiel [France] ; Bruno Goud [France] ; Jean-Claude Manuguerra [France] ; Nathalie Pardigon [France] ; Alexandre D. Baffet [France]

Source :

EBioMedicine [ 2352-3964 ] ; 2016-08.

RBID : Hal:pasteur-01441052

English descriptors

mix :
- Flavivirus, mouse neocortex, neural stem cell, Zika virus.

Abstract

The recent Zika outbreak in South America and French Polynesia was associated with an epidemic of microcephaly, a disease characterized by a reduced size of the cerebral cortex. Other members of the Flavivirus genus, including West Nile virus (WNV), can cause encephalitis but were not demonstrated to cause microcephaly. It remains unclear whether Zika virus (ZIKV) and other flaviviruses may infect different cell populations in the developing neocortex and lead to distinct developmental defects. Here, we describe an assay to infect mouse E15 embryonic brain slices with ZIKV, WNV and dengue virus serotype 4 (DENV-4). We show that this tissue is able to support viral replication of ZIKV and WNV, but not DENV-4. Cell fate analysis reveals a remarkable tropism of ZIKV infection for neural stem cells. Closely related WNV displays a very different tropism of infection, with a bias towards neurons. We further show that ZIKV infection, but not WNV infection, impairs cell cycle progression of neural stem cells. Both viruses inhibited apoptosis at early stages of infection. This work establishes a powerful comparative approach to identify ZIKV-specific alterations in the developing neocortex and reveals specific preferential infection of neural stem cells by ZIKV.

Url:

https://hal-pasteur.archives-ouvertes.fr/pasteur-01441052

DOI: 10.1016/j.ebiom.2016.07.018

Links toward previous steps (curation, corpus...)

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Hal:pasteur-01441052

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en">Comparative Analysis Between Flaviviruses Reveals Specific Neural Stem Cell Tropism for Zika Virus in the Mouse Developing Neocortex.</title>
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<country>France</country>
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</author>
<author><name sortKey="Coquand, Laure" sort="Coquand, Laure" uniqKey="Coquand L" first="Laure" last="Coquand">Laure Coquand</name>
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<author><name sortKey="Fraisier, Vincent" sort="Fraisier, Vincent" uniqKey="Fraisier V" first="Vincent" last="Fraisier">Vincent Fraisier</name>
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          <orgName>Compartimentation et dynamique cellulaires</orgName>
          <orgName type="acronym">CDC</orgName>
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<author><name sortKey="Frenkiel, Marie Pascale" sort="Frenkiel, Marie Pascale" uniqKey="Frenkiel M" first="Marie-Pascale" last="Frenkiel">Marie-Pascale Frenkiel</name>
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<author><name sortKey="Goud, Bruno" sort="Goud, Bruno" uniqKey="Goud B" first="Bruno" last="Goud">Bruno Goud</name>
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<author><name sortKey="Manuguerra, Jean Claude" sort="Manuguerra, Jean Claude" uniqKey="Manuguerra J" first="Jean-Claude" last="Manuguerra">Jean-Claude Manuguerra</name>
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<author><name sortKey="Pardigon, Nathalie" sort="Pardigon, Nathalie" uniqKey="Pardigon N" first="Nathalie" last="Pardigon">Nathalie Pardigon</name>
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<author><name sortKey="Baffet, Alexandre D" sort="Baffet, Alexandre D" uniqKey="Baffet A" first="Alexandre D" last="Baffet">Alexandre D. Baffet</name>
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          <orgName>Compartimentation et dynamique cellulaires</orgName>
          <orgName type="acronym">CDC</orgName>
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          <orgName>Centre National de la Recherche Scientifique</orgName>
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          <desc>            <address>              <addrLine> 26 rue d'Ulm - 75248 Paris Cedex 05 - France</addrLine>
              <country key="FR"></country>
            </address>
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          </desc>
        </org>
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          <orgName type="acronym">UPMC</orgName>
          <date type="end">2017-12-31</date>
          <desc>            <address>              <addrLine>4 place Jussieu - 75005 Paris</addrLine>
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<country>France</country>
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</author>
</analytic>
<idno type="DOI">10.1016/j.ebiom.2016.07.018</idno>
<series><title level="j">EBioMedicine</title>
<idno type="ISSN">2352-3964</idno>
<imprint><date type="datePub">2016-08</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term> Flavivirus</term>
<term> mouse neocortex</term>
<term> neural stem cell</term>
<term>Zika virus</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">              <p>The recent Zika outbreak in South America and French Polynesia was associated with an epidemic of microcephaly, a disease characterized by a reduced size of the cerebral cortex. Other members of the Flavivirus genus, including West Nile virus (WNV), can cause encephalitis but were not demonstrated to cause microcephaly. It remains unclear whether Zika virus (ZIKV) and other flaviviruses may infect different cell populations in the developing neocortex and lead to distinct developmental defects. Here, we describe an assay to infect mouse E15 embryonic brain slices with ZIKV, WNV and dengue virus serotype 4 (DENV-4). We show that this tissue is able to support viral replication of ZIKV and WNV, but not DENV-4. Cell fate analysis reveals a remarkable tropism of ZIKV infection for neural stem cells. Closely related WNV displays a very different tropism of infection, with a bias towards neurons. We further show that ZIKV infection, but not WNV infection, impairs cell cycle progression of neural stem cells. Both viruses inhibited apoptosis at early stages of infection. This work establishes a powerful comparative approach to identify ZIKV-specific alterations in the developing neocortex and reveals specific preferential infection of neural stem cells by ZIKV.</p>
            </div>
</front>
</TEI>
</record>

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Comparative Analysis Between Flaviviruses Reveals Specific Neural Stem Cell Tropism for Zika Virus in the Mouse Developing Neocortex.

Comparative Analysis Between Flaviviruses Reveals Specific Neural Stem Cell Tropism for Zika Virus in the Mouse Developing Neocortex.

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