An estimate of the economic burden and premature deaths due to vitamin D deficiency in Canada
Identifieur interne : 001268 ( Istex/Curation ); précédent : 001267; suivant : 001269An estimate of the economic burden and premature deaths due to vitamin D deficiency in Canada
Auteurs : William B. Grant [États-Unis, Niger] ; Gerry K. Schwalfenberg [Canada] ; Stephen J. Genuis [Canada] ; Susan J. Whiting [États-Unis]Source :
- Molecular Nutrition & Food Research [ 1613-4125 ] ; 2010-08.
English descriptors
- Teeft :
- Adverse effects, Autoimmune diseases, Bacterial pneumonia, Bone diseases, Calcium supplementation, Canadian cancer society, Canadian health measures survey, Cancer incidence, Cardiovascular, Cardiovascular disease, Cardiovascular diseases, Clin, Cohort, Colorectal cancer, Death rate, Diabetes, Diabetes mellitus, Disease incidence, Economic burden, Economic burden data, Gmbh, Hazard ratio, Health canada, Health research center, Heart disease, Higher serum levels, Higher vitamin, Holick, Human skin, Insulin resistance, Intensive care unit, Kgaa, Many diseases, Many types, Maternal vitamin, Mortality rate, Mortality rates, Multiple sclerosis, Nutr, Nutrition examination survey, Observational studies, Odds ratio, Optimal level, Oral intake, Primary risk factor, Prospective study, Public health, Pulmonary disease, Randomized, Recent study, Respiratory infection subjects, Septicemia, Serum level, Serum levels, Several studies, Skin pigmentation, Skin type, Statistics canada, Steroid biochem, Supplementation, Various diseases, Various studies, Verlag, Verlag gmbh, Viral infections, Vitamin, Vitamin diseases, Weinheim, Western europe, Wintertime vitamin.
Abstract
The objective of this work is to estimate the economic burden and premature death rate in Canada attributable to low serum 25‐hydroxyvitamin D (25(OH)D) levels. Vitamin D deficiency has been linked to many diseases and conditions in addition to bone diseases, including many types of cancer, several bacterial and viral infections, autoimmune diseases, cardiovascular diseases, and adverse pregnancy outcomes. Canadians have mean serum 25(OH)D levels averaging 67 nmol/L. The journal literature was searched for papers reporting dose–response relationships for vitamin D indices and disease outcomes. The types of studies useful in this regard include randomized controlled trials, observational, cross‐sectional, and ecological studies, and meta‐analyses. The mortality rates for 2005 were obtained from Statistics Canada. The economic burden data were obtained from Health Canada. The estimated benefits in disease reduction were based on increasing the mean serum 25(OH)D level to 105 nmol/L. It is estimated that the death rate could fall by 37 000 deaths (22 300–52 300 deaths), representing 16.1% (9.7–22.7%) of annuals deaths and the economic burden by 6.9% (3.8–10.0%) or $14.4 billion ($8.0 billion–$20.1 billion) less the cost of the program. It is recommended that Canadian health policy leaders consider measures to increase serum 25(OH)D levels for all Canadians.
Url:
DOI: 10.1002/mnfr.200900420
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Vitamin D deficiency has been linked to many diseases and conditions in addition to bone diseases, including many types of cancer, several bacterial and viral infections, autoimmune diseases, cardiovascular diseases, and adverse pregnancy outcomes. Canadians have mean serum 25(OH)D levels averaging 67 nmol/L. The journal literature was searched for papers reporting dose–response relationships for vitamin D indices and disease outcomes. The types of studies useful in this regard include randomized controlled trials, observational, cross‐sectional, and ecological studies, and meta‐analyses. The mortality rates for 2005 were obtained from Statistics Canada. The economic burden data were obtained from Health Canada. The estimated benefits in disease reduction were based on increasing the mean serum 25(OH)D level to 105 nmol/L. It is estimated that the death rate could fall by 37 000 deaths (22 300–52 300 deaths), representing 16.1% (9.7–22.7%) of annuals deaths and the economic burden by 6.9% (3.8–10.0%) or $14.4 billion ($8.0 billion–$20.1 billion) less the cost of the program. It is recommended that Canadian health policy leaders consider measures to increase serum 25(OH)D levels for all Canadians.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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