An estimate of the economic burden and premature deaths due to vitamin D deficiency in Canada
Identifieur interne : 001268 ( Istex/Corpus ); précédent : 001267; suivant : 001269An estimate of the economic burden and premature deaths due to vitamin D deficiency in Canada
Auteurs : William B. Grant ; Gerry K. Schwalfenberg ; Stephen J. Genuis ; Susan J. WhitingSource :
- Molecular Nutrition & Food Research [ 1613-4125 ] ; 2010-08.
English descriptors
- Teeft :
- Adverse effects, Autoimmune diseases, Bacterial pneumonia, Bone diseases, Calcium supplementation, Canadian cancer society, Canadian health measures survey, Cancer incidence, Cardiovascular, Cardiovascular disease, Cardiovascular diseases, Clin, Cohort, Colorectal cancer, Death rate, Diabetes, Diabetes mellitus, Disease incidence, Economic burden, Economic burden data, Gmbh, Hazard ratio, Health canada, Health research center, Heart disease, Higher serum levels, Higher vitamin, Holick, Human skin, Insulin resistance, Intensive care unit, Kgaa, Many diseases, Many types, Maternal vitamin, Mortality rate, Mortality rates, Multiple sclerosis, Nutr, Nutrition examination survey, Observational studies, Odds ratio, Optimal level, Oral intake, Primary risk factor, Prospective study, Public health, Pulmonary disease, Randomized, Recent study, Respiratory infection subjects, Septicemia, Serum level, Serum levels, Several studies, Skin pigmentation, Skin type, Statistics canada, Steroid biochem, Supplementation, Various diseases, Various studies, Verlag, Verlag gmbh, Viral infections, Vitamin, Vitamin diseases, Weinheim, Western europe, Wintertime vitamin.
Abstract
The objective of this work is to estimate the economic burden and premature death rate in Canada attributable to low serum 25‐hydroxyvitamin D (25(OH)D) levels. Vitamin D deficiency has been linked to many diseases and conditions in addition to bone diseases, including many types of cancer, several bacterial and viral infections, autoimmune diseases, cardiovascular diseases, and adverse pregnancy outcomes. Canadians have mean serum 25(OH)D levels averaging 67 nmol/L. The journal literature was searched for papers reporting dose–response relationships for vitamin D indices and disease outcomes. The types of studies useful in this regard include randomized controlled trials, observational, cross‐sectional, and ecological studies, and meta‐analyses. The mortality rates for 2005 were obtained from Statistics Canada. The economic burden data were obtained from Health Canada. The estimated benefits in disease reduction were based on increasing the mean serum 25(OH)D level to 105 nmol/L. It is estimated that the death rate could fall by 37 000 deaths (22 300–52 300 deaths), representing 16.1% (9.7–22.7%) of annuals deaths and the economic burden by 6.9% (3.8–10.0%) or $14.4 billion ($8.0 billion–$20.1 billion) less the cost of the program. It is recommended that Canadian health policy leaders consider measures to increase serum 25(OH)D levels for all Canadians.
Url:
DOI: 10.1002/mnfr.200900420
Links to Exploration step
ISTEX:1DF0524B6255993A32A7DF38E7C1D70D682EE83DLe document en format XML
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Vitamin D deficiency has been linked to many diseases and conditions in addition to bone diseases, including many types of cancer, several bacterial and viral infections, autoimmune diseases, cardiovascular diseases, and adverse pregnancy outcomes. Canadians have mean serum 25(OH)D levels averaging 67 nmol/L. The journal literature was searched for papers reporting dose–response relationships for vitamin D indices and disease outcomes. The types of studies useful in this regard include randomized controlled trials, observational, cross‐sectional, and ecological studies, and meta‐analyses. The mortality rates for 2005 were obtained from Statistics Canada. The economic burden data were obtained from Health Canada. The estimated benefits in disease reduction were based on increasing the mean serum 25(OH)D level to 105 nmol/L. It is estimated that the death rate could fall by 37 000 deaths (22 300–52 300 deaths), representing 16.1% (9.7–22.7%) of annuals deaths and the economic burden by 6.9% (3.8–10.0%) or $14.4 billion ($8.0 billion–$20.1 billion) less the cost of the program. It is recommended that Canadian health policy leaders consider measures to increase serum 25(OH)D levels for all Canadians.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>nutr</json:string><json:string>vitamin</json:string><json:string>economic burden</json:string><json:string>clin</json:string><json:string>supplementation</json:string><json:string>verlag gmbh</json:string><json:string>weinheim</json:string><json:string>kgaa</json:string><json:string>gmbh</json:string><json:string>verlag</json:string><json:string>serum levels</json:string><json:string>holick</json:string><json:string>cohort</json:string><json:string>randomized</json:string><json:string>septicemia</json:string><json:string>serum level</json:string><json:string>cancer incidence</json:string><json:string>cardiovascular</json:string><json:string>cardiovascular diseases</json:string><json:string>mortality rates</json:string><json:string>multiple sclerosis</json:string><json:string>maternal vitamin</json:string><json:string>public health</json:string><json:string>oral intake</json:string><json:string>vitamin diseases</json:string><json:string>viral infections</json:string><json:string>mortality rate</json:string><json:string>steroid biochem</json:string><json:string>higher vitamin</json:string><json:string>many diseases</json:string><json:string>diabetes mellitus</json:string><json:string>calcium supplementation</json:string><json:string>recent study</json:string><json:string>statistics canada</json:string><json:string>autoimmune diseases</json:string><json:string>higher serum levels</json:string><json:string>many types</json:string><json:string>adverse effects</json:string><json:string>several studies</json:string><json:string>canadian health measures survey</json:string><json:string>optimal level</json:string><json:string>various studies</json:string><json:string>cardiovascular disease</json:string><json:string>hazard ratio</json:string><json:string>skin pigmentation</json:string><json:string>prospective study</json:string><json:string>nutrition examination survey</json:string><json:string>odds ratio</json:string><json:string>heart disease</json:string><json:string>observational studies</json:string><json:string>various diseases</json:string><json:string>disease incidence</json:string><json:string>insulin resistance</json:string><json:string>primary risk factor</json:string><json:string>bone diseases</json:string><json:string>bacterial pneumonia</json:string><json:string>respiratory infection subjects</json:string><json:string>economic burden data</json:string><json:string>intensive care unit</json:string><json:string>health canada</json:string><json:string>skin type</json:string><json:string>canadian cancer society</json:string><json:string>health research center</json:string><json:string>western europe</json:string><json:string>human skin</json:string><json:string>death rate</json:string><json:string>wintertime vitamin</json:string><json:string>colorectal cancer</json:string><json:string>pulmonary disease</json:string><json:string>diabetes</json:string></teeft></keywords><author><json:item><name>William B. 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The economic burden data were obtained from Health Canada. The estimated benefits in disease reduction were based on increasing the mean serum 25(OH)D level to 105 nmol/L. It is estimated that the death rate could fall by 37 000 deaths (22 300–52 300 deaths), representing 16.1% (9.7–22.7%) of annuals deaths and the economic burden by 6.9% (3.8–10.0%) or $14.4 billion ($8.0 billion–$20.1 billion) less the cost of the program. It is recommended that Canadian health policy leaders consider measures to increase serum 25(OH)D levels for all Canadians.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="kwd1">Cancer</term><term xml:id="kwd2">Cardiovascular disease</term><term xml:id="kwd3">Infectious disease</term><term xml:id="kwd4">Pregnancy outcomes</term><term xml:id="kwd5">Vitamin D</term></keywords><keywords rend="articleCategory"><term>Review</term></keywords><keywords rend="tocHeading1"><term>Reviews</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc><revisionDesc><change when="2019-12-20" who="#istex" xml:id="pub2tei">formatting</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-H9GZD1NR-P/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>WILEY‐VCH Verlag</publisherName><publisherLoc>Weinheim</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1613-4133</doi><issn type="print">1613-4125</issn><issn type="electronic">1613-4133</issn><idGroup><id type="product" value="MNFR"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOLECULAR NUTRITION FOOD RESEARCH">Molecular Nutrition & Food Research</title><title type="short">Mol. 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Vitamin D deficiency has been linked to many diseases and conditions in addition to bone diseases, including many types of cancer, several bacterial and viral infections, autoimmune diseases, cardiovascular diseases, and adverse pregnancy outcomes. Canadians have mean serum 25(OH)D levels averaging 67 nmol/L. The journal literature was searched for papers reporting dose–response relationships for vitamin D indices and disease outcomes. The types of studies useful in this regard include randomized controlled trials, observational, cross‐sectional, and ecological studies, and meta‐analyses. The mortality rates for 2005 were obtained from Statistics Canada. The economic burden data were obtained from Health Canada. The estimated benefits in disease reduction were based on increasing the mean serum 25(OH)D level to 105 nmol/L. It is estimated that the death rate could fall by 37 000 deaths (22 300–52 300 deaths), representing 16.1% (9.7–22.7%) of annuals deaths and the economic burden by 6.9% (3.8–10.0%) or $14.4 billion ($8.0 billion–$20.1 billion) less the cost of the program. It is recommended that Canadian health policy leaders consider measures to increase serum 25(OH)D levels for all Canadians.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>An estimate of the economic burden and premature deaths due to vitamin D deficiency in Canada</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>An estimate of the economic burden and premature deaths due to vitamin D deficiency in Canada</title></titleInfo><name type="personal"><namePart type="given">William B.</namePart><namePart type="family">Grant</namePart><affiliation>Sunlight, Nutrition, and Health Research Center (SUNARC), San Francisco, CA, USA</affiliation><affiliation>E-mail: wbgrant@infionline.net</affiliation><affiliation>Correspondence address: Sunlight, Nutrition, and Health Research Center (SUNARC), P. O. Box 641603, San Francisco, CA 94164‐1603, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gerry K.</namePart><namePart type="family">Schwalfenberg</namePart><affiliation>Department of Family Medicine, University of Alberta, Edmonton, Alb., Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Stephen J.</namePart><namePart type="family">Genuis</namePart><affiliation>Department of Obstetrics and Gynecology, University of Alberta, Edmonton, Alb., Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Susan J.</namePart><namePart type="family">Whiting</namePart><affiliation>College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="review-article" displayLabel="reviewArticle" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-L5L7X3NF-P">review-article</genre><originInfo><publisher>WILEY‐VCH Verlag</publisher><place><placeTerm type="text">Weinheim</placeTerm></place><dateIssued encoding="w3cdtf">2010-08</dateIssued><dateCaptured encoding="w3cdtf">2009-08-28</dateCaptured><dateValid encoding="w3cdtf">2009-11-20</dateValid><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">0</extent><extent unit="tables">4</extent><extent unit="references">91</extent></physicalDescription><abstract lang="en">The objective of this work is to estimate the economic burden and premature death rate in Canada attributable to low serum 25‐hydroxyvitamin D (25(OH)D) levels. Vitamin D deficiency has been linked to many diseases and conditions in addition to bone diseases, including many types of cancer, several bacterial and viral infections, autoimmune diseases, cardiovascular diseases, and adverse pregnancy outcomes. Canadians have mean serum 25(OH)D levels averaging 67 nmol/L. The journal literature was searched for papers reporting dose–response relationships for vitamin D indices and disease outcomes. The types of studies useful in this regard include randomized controlled trials, observational, cross‐sectional, and ecological studies, and meta‐analyses. The mortality rates for 2005 were obtained from Statistics Canada. The economic burden data were obtained from Health Canada. The estimated benefits in disease reduction were based on increasing the mean serum 25(OH)D level to 105 nmol/L. It is estimated that the death rate could fall by 37 000 deaths (22 300–52 300 deaths), representing 16.1% (9.7–22.7%) of annuals deaths and the economic burden by 6.9% (3.8–10.0%) or $14.4 billion ($8.0 billion–$20.1 billion) less the cost of the program. It is recommended that Canadian health policy leaders consider measures to increase serum 25(OH)D levels for all Canadians.</abstract><note type="funding">Vitamin D Society (Canada)</note><note type="funding">UV Foundation (McLean, VA)</note><note type="funding">Sunlight Research Forum (Veldhoven)</note><note type="funding">Bio‐Tech‐Pharmacal (Fayetteville, AR)</note><note type="funding">Dairy Farmers, Yoplait, and IADSA</note><subject lang="en"><genre>keywords</genre><topic>Cancer</topic><topic>Cardiovascular disease</topic><topic>Infectious disease</topic><topic>Pregnancy outcomes</topic><topic>Vitamin D</topic></subject><relatedItem type="host"><titleInfo><title>Molecular Nutrition & Food Research</title></titleInfo><titleInfo type="abbreviated"><title>Mol. Nutr. Food Res.</title></titleInfo><name type="personal"><namePart type="given">William B.</namePart><namePart type="family">Grant</namePart></name><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>Review</topic><topic>Reviews</topic></subject><identifier type="ISSN">1613-4125</identifier><identifier type="eISSN">1613-4133</identifier><identifier type="DOI">10.1002/(ISSN)1613-4133</identifier><identifier type="PublisherID">MNFR</identifier><part><date>2010</date><detail type="title"><title>The Vitamin D Revolution</title></detail><detail type="volume"><caption>vol.</caption><number>54</number></detail><detail type="issue"><caption>no.</caption><number>8</number></detail><extent unit="pages"><start>1172</start><end>1181</end><total>10</total></extent></part></relatedItem><relatedItem type="references" displayLabel="cit1"><titleInfo><title>The role of vitamin D in cancer prevention</title></titleInfo><name type="personal"><namePart type="given">C. 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