The impact of the 2009 H1N1 influenza pandemic on pediatric patients with sickle cell disease
Identifieur interne : 000E51 ( Istex/Corpus ); précédent : 000E50; suivant : 000E52The impact of the 2009 H1N1 influenza pandemic on pediatric patients with sickle cell disease
Auteurs : Alex George ; Jennifer Benton ; Jesse Pratt ; Mi-Ok Kim ; Karen A. Kalinyak ; Theodosia A. Kalfa ; Clinton H. JoinerSource :
- Pediatric Blood & Cancer [ 1545-5009 ] ; 2011-10.
English descriptors
- Teeft :
- Acute chest syndrome, Acute illness, Admission rate, Airway, Alex george, Apical pneumothorax, Blood culture, Blood diseases institute, Brief hospital, Chronic therapy, Chronic transfusion, Chronic transfusion therapy, Cincinnati hospital, Clinical course, Common cause, Common diagnosis, Control group, Disease severity, Emergency department, Exchange transfusion, Febrile illness, Future pandemics, Guideline, Hematology clinic, Hemoglobin concentrations, Higher admission rate, Higher rate, Hydroxyurea, Hydroxyurea therapy, Initial evaluation, Laboratory data, Mechanical ventilation, Negative testing, Occult pneumonia, Oseltamivir, Oseltamivir therapy, Outpatient basis, Pain crises, Pandemic, Past complications, Past episodes, Past history, Patient characteristics, Patient population, Pediatr, Pediatr blood cancer, Pediatric patients, Pulmonary complications, Reactive, Reactive airway disease, Respiratory distress, Seasonal epidemics, Sickle, Sickle cell center, Sickle cell disease, Sickle cell disease care consortium guidelines, Sickle cell patients, Simple transfusions, Small sample size, Splenic sequestration, Statistical analysis, Transfusion, Uncomplicated courses.
Abstract
Background: Respiratory infections are associated with clinically significant illness in patients with sickle cell disease (SCD). The 2009 H1N1 pandemic was perceived as a significant threat to this population. Methods: We undertook a chart review of all patients with SCD followed at our institution to identify those with confirmed H1N1 infection. Further chart and laboratory data was collected on affected patients to analyze clinical courses and the factors that correlated with disease severity. Results: Approximately half of the patients with confirmed H1N1 infection were managed successfully on an outpatient basis with oseltamivir therapy. Among the patients admitted, the most common diagnosis was acute chest syndrome (ACS). Most admitted patients had uncomplicated clinical courses, with a median length of admission of 3 days and no mortality or requirement for mechanical ventilation. A past history of ACS or reactive airway disease correlated with a higher rate of admission and of ACS incidence during the acute illness. Chronic transfusion therapy or hydroxyurea therapy with high hemoglobin F levels had a strong inverse correlation with incidence of ACS. Conclusions: Our results indicate that that in general the impact of the H1N1 influenza pandemic on patients with SCD was mild but that past clinical history correlated with the severity of illness. Additionally, effective hydroxyurea therapy and chronic transfusion therapy appeared to be protective against the incidence of ACS. Our results suggest guidelines for the management of patients with SCD during future influenza pandemics as well as during seasonal influenza epidemics. Pediatr Blood Cancer 2011; 57: 648–653. © 2011 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/pbc.23030
Links to Exploration step
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<front><div type="abstract" xml:lang="en">Background: Respiratory infections are associated with clinically significant illness in patients with sickle cell disease (SCD). The 2009 H1N1 pandemic was perceived as a significant threat to this population. Methods: We undertook a chart review of all patients with SCD followed at our institution to identify those with confirmed H1N1 infection. Further chart and laboratory data was collected on affected patients to analyze clinical courses and the factors that correlated with disease severity. Results: Approximately half of the patients with confirmed H1N1 infection were managed successfully on an outpatient basis with oseltamivir therapy. Among the patients admitted, the most common diagnosis was acute chest syndrome (ACS). Most admitted patients had uncomplicated clinical courses, with a median length of admission of 3 days and no mortality or requirement for mechanical ventilation. A past history of ACS or reactive airway disease correlated with a higher rate of admission and of ACS incidence during the acute illness. Chronic transfusion therapy or hydroxyurea therapy with high hemoglobin F levels had a strong inverse correlation with incidence of ACS. Conclusions: Our results indicate that that in general the impact of the H1N1 influenza pandemic on patients with SCD was mild but that past clinical history correlated with the severity of illness. Additionally, effective hydroxyurea therapy and chronic transfusion therapy appeared to be protective against the incidence of ACS. Our results suggest guidelines for the management of patients with SCD during future influenza pandemics as well as during seasonal influenza epidemics. Pediatr Blood Cancer 2011; 57: 648–653. © 2011 Wiley‐Liss, Inc.</div>
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<abstract>Background: Respiratory infections are associated with clinically significant illness in patients with sickle cell disease (SCD). The 2009 H1N1 pandemic was perceived as a significant threat to this population. Methods: We undertook a chart review of all patients with SCD followed at our institution to identify those with confirmed H1N1 infection. Further chart and laboratory data was collected on affected patients to analyze clinical courses and the factors that correlated with disease severity. Results: Approximately half of the patients with confirmed H1N1 infection were managed successfully on an outpatient basis with oseltamivir therapy. Among the patients admitted, the most common diagnosis was acute chest syndrome (ACS). Most admitted patients had uncomplicated clinical courses, with a median length of admission of 3 days and no mortality or requirement for mechanical ventilation. A past history of ACS or reactive airway disease correlated with a higher rate of admission and of ACS incidence during the acute illness. Chronic transfusion therapy or hydroxyurea therapy with high hemoglobin F levels had a strong inverse correlation with incidence of ACS. Conclusions: Our results indicate that that in general the impact of the H1N1 influenza pandemic on patients with SCD was mild but that past clinical history correlated with the severity of illness. Additionally, effective hydroxyurea therapy and chronic transfusion therapy appeared to be protective against the incidence of ACS. Our results suggest guidelines for the management of patients with SCD during future influenza pandemics as well as during seasonal influenza epidemics. Pediatr Blood Cancer 2011; 57: 648–653. © 2011 Wiley‐Liss, Inc.</abstract>
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<p>Respiratory infections are associated with clinically significant illness in patients with sickle cell disease (SCD). The 2009 H1N1 pandemic was perceived as a significant threat to this population.</p>
<head>Methods</head>
<p>We undertook a chart review of all patients with SCD followed at our institution to identify those with confirmed H1N1 infection. Further chart and laboratory data was collected on affected patients to analyze clinical courses and the factors that correlated with disease severity.</p>
<head>Results</head>
<p>Approximately half of the patients with confirmed H1N1 infection were managed successfully on an outpatient basis with oseltamivir therapy. Among the patients admitted, the most common diagnosis was acute chest syndrome (ACS). Most admitted patients had uncomplicated clinical courses, with a median length of admission of 3 days and no mortality or requirement for mechanical ventilation. A past history of ACS or reactive airway disease correlated with a higher rate of admission and of ACS incidence during the acute illness. Chronic transfusion therapy or hydroxyurea therapy with high hemoglobin F levels had a strong inverse correlation with incidence of ACS.</p>
<head>Conclusions</head>
<p>Our results indicate that that in general the impact of the H1N1 influenza pandemic on patients with SCD was mild but that past clinical history correlated with the severity of illness. Additionally, effective hydroxyurea therapy and chronic transfusion therapy appeared to be protective against the incidence of ACS. Our results suggest guidelines for the management of patients with SCD during future influenza pandemics as well as during seasonal influenza epidemics. Pediatr Blood Cancer 2011; 57: 648–653. © 2011 Wiley‐Liss, Inc.</p>
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<p>Approximately half of the patients with confirmed H1N1 infection were managed successfully on an outpatient basis with oseltamivir therapy. Among the patients admitted, the most common diagnosis was acute chest syndrome (ACS). Most admitted patients had uncomplicated clinical courses, with a median length of admission of 3 days and no mortality or requirement for mechanical ventilation. A past history of ACS or reactive airway disease correlated with a higher rate of admission and of ACS incidence during the acute illness. Chronic transfusion therapy or hydroxyurea therapy with high hemoglobin F levels had a strong inverse correlation with incidence of ACS.</p>
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<abstract lang="en">Background: Respiratory infections are associated with clinically significant illness in patients with sickle cell disease (SCD). The 2009 H1N1 pandemic was perceived as a significant threat to this population. Methods: We undertook a chart review of all patients with SCD followed at our institution to identify those with confirmed H1N1 infection. Further chart and laboratory data was collected on affected patients to analyze clinical courses and the factors that correlated with disease severity. Results: Approximately half of the patients with confirmed H1N1 infection were managed successfully on an outpatient basis with oseltamivir therapy. Among the patients admitted, the most common diagnosis was acute chest syndrome (ACS). Most admitted patients had uncomplicated clinical courses, with a median length of admission of 3 days and no mortality or requirement for mechanical ventilation. A past history of ACS or reactive airway disease correlated with a higher rate of admission and of ACS incidence during the acute illness. Chronic transfusion therapy or hydroxyurea therapy with high hemoglobin F levels had a strong inverse correlation with incidence of ACS. Conclusions: Our results indicate that that in general the impact of the H1N1 influenza pandemic on patients with SCD was mild but that past clinical history correlated with the severity of illness. Additionally, effective hydroxyurea therapy and chronic transfusion therapy appeared to be protective against the incidence of ACS. Our results suggest guidelines for the management of patients with SCD during future influenza pandemics as well as during seasonal influenza epidemics. Pediatr Blood Cancer 2011; 57: 648–653. © 2011 Wiley‐Liss, Inc.</abstract>
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</titleInfo>
<name type="personal"><namePart type="given">RP</namePart>
<namePart type="family">Hebbel</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">GM</namePart>
<namePart type="family">Vercellotti</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">KA</namePart>
<namePart type="family">Nath</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Hebbel RP, Vercellotti GM, Nath KA. A systems biology consideration of the vasculopathy of sickle cell disease: The need for multi‐modality chemo‐prophylaxis. Cardiovasc Haematol Disorders‐Drug Targets 2009; 9: 271–292.</note>
<part><date>2009</date>
<detail type="volume"><caption>vol.</caption>
<number>9</number>
</detail>
<extent unit="pages"><start>271</start>
<end>292</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Cardiovasc Haematol Disorders‐Drug Targets</title>
</titleInfo>
<part><date>2009</date>
<detail type="volume"><caption>vol.</caption>
<number>9</number>
</detail>
<extent unit="pages"><start>271</start>
<end>292</end>
</extent>
</part>
</relatedItem>
<identifier type="ISSN">0096-0802</identifier>
<identifier type="ISSN">1096-911X</identifier>
<part><date point="end">2003</date>
<detail type="volume"><caption>last vol.</caption>
<number>41</number>
</detail>
<detail type="issue"><caption>last no.</caption>
<number>6</number>
</detail>
</part>
</relatedItem>
<relatedItem type="references" displayLabel="cit4"><titleInfo><title>Pulmonary complications of sickle cell disease</title>
</titleInfo>
<name type="personal"><namePart type="given">MT</namePart>
<namePart type="family">Gladwin</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">E</namePart>
<namePart type="family">Vichinsky</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Gladwin MT, Vichinsky E. Pulmonary complications of sickle cell disease. N Engl J Med 2008; 359: 2254–2265.</note>
<part><date>2008</date>
<detail type="volume"><caption>vol.</caption>
<number>359</number>
</detail>
<extent unit="pages"><start>2254</start>
<end>2265</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>N Engl J Med</title>
</titleInfo>
<part><date>2008</date>
<detail type="volume"><caption>vol.</caption>
<number>359</number>
</detail>
<extent unit="pages"><start>2254</start>
<end>2265</end>
</extent>
</part>
</relatedItem>
<identifier type="ISSN">0096-0802</identifier>
<identifier type="ISSN">1096-911X</identifier>
<part><date point="end">2003</date>
<detail type="volume"><caption>last vol.</caption>
<number>41</number>
</detail>
<detail type="issue"><caption>last no.</caption>
<number>6</number>
</detail>
</part>
</relatedItem>
<relatedItem type="references" displayLabel="cit5"><titleInfo><title>Pulmonary complications of sickle cell disease in children</title>
</titleInfo>
<name type="personal"><namePart type="given">JB</namePart>
<namePart type="family">Caboot</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JL</namePart>
<namePart type="family">Allen</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Caboot JB, Allen JL. Pulmonary complications of sickle cell disease in children. Curr Opin Pediatr 2008; 20: 279–287.</note>
<part><date>2008</date>
<detail type="volume"><caption>vol.</caption>
<number>20</number>
</detail>
<extent unit="pages"><start>279</start>
<end>287</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Curr Opin Pediatr</title>
</titleInfo>
<part><date>2008</date>
<detail type="volume"><caption>vol.</caption>
<number>20</number>
</detail>
<extent unit="pages"><start>279</start>
<end>287</end>
</extent>
</part>
</relatedItem>
<identifier type="ISSN">0096-0802</identifier>
<identifier type="ISSN">1096-911X</identifier>
<part><date point="end">2003</date>
<detail type="volume"><caption>last vol.</caption>
<number>41</number>
</detail>
<detail type="issue"><caption>last no.</caption>
<number>6</number>
</detail>
</part>
</relatedItem>
<relatedItem type="references" displayLabel="cit6"><titleInfo><title>The acute chest syndrome</title>
</titleInfo>
<name type="personal"><namePart type="given">CS</namePart>
<namePart type="family">Johnson</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Johnson CS. The acute chest syndrome. Hematol Oncol Clin N Am 2005; 19: 857–879.</note>
<part><date>2005</date>
<detail type="volume"><caption>vol.</caption>
<number>19</number>
</detail>
<extent unit="pages"><start>857</start>
<end>879</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Hematol Oncol Clin N Am</title>
</titleInfo>
<part><date>2005</date>
<detail type="volume"><caption>vol.</caption>
<number>19</number>
</detail>
<extent unit="pages"><start>857</start>
<end>879</end>
</extent>
</part>
</relatedItem>
<identifier type="ISSN">0096-0802</identifier>
<identifier type="ISSN">1096-911X</identifier>
<part><date point="end">2003</date>
<detail type="volume"><caption>last vol.</caption>
<number>41</number>
</detail>
<detail type="issue"><caption>last no.</caption>
<number>6</number>
</detail>
</part>
</relatedItem>
<relatedItem type="references" displayLabel="cit7"><titleInfo><title>Burden of influenza‐related hospitalizations among children with sickle cell disease</title>
</titleInfo>
<name type="personal"><namePart type="given">DG</namePart>
<namePart type="family">Bundy</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JJ</namePart>
<namePart type="family">Strouse</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JF</namePart>
<namePart type="family">Casella</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Bundy DG, Strouse JJ, Casella JF, et al. Burden of influenza‐related hospitalizations among children with sickle cell disease. Pediatrics 2010; 125: 234–241.</note>
<part><date>2010</date>
<detail type="volume"><caption>vol.</caption>
<number>125</number>
</detail>
<extent unit="pages"><start>234</start>
<end>241</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Pediatrics</title>
</titleInfo>
<part><date>2010</date>
<detail type="volume"><caption>vol.</caption>
<number>125</number>
</detail>
<extent unit="pages"><start>234</start>
<end>241</end>
</extent>
</part>
</relatedItem>
<identifier type="ISSN">0096-0802</identifier>
<identifier type="ISSN">1096-911X</identifier>
<part><date point="end">2003</date>
<detail type="volume"><caption>last vol.</caption>
<number>41</number>
</detail>
<detail type="issue"><caption>last no.</caption>
<number>6</number>
</detail>
</part>
</relatedItem>
<relatedItem type="references" displayLabel="cit8"><titleInfo><title>Clinical Aspects of Pandemic 2009 Influenza A (H1N1) Virus Infection</title>
</titleInfo>
<name type="personal"><namePart type="given">E</namePart>
<namePart type="family">Bautista</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">T</namePart>
<namePart type="family">Chotpitayasunondh</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Z</namePart>
<namePart type="family">Gao</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Bautista E, Chotpitayasunondh T, Gao Z, et al. Clinical Aspects of Pandemic 2009 Influenza A (H1N1) Virus Infection. N Engl J Med 2010; 362: 1708–1719.</note>
<part><date>2010</date>
<detail type="volume"><caption>vol.</caption>
<number>362</number>
</detail>
<extent unit="pages"><start>1708</start>
<end>1719</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>N Engl J Med</title>
</titleInfo>
<part><date>2010</date>
<detail type="volume"><caption>vol.</caption>
<number>362</number>
</detail>
<extent unit="pages"><start>1708</start>
<end>1719</end>
</extent>
</part>
</relatedItem>
<identifier type="ISSN">0096-0802</identifier>
<identifier type="ISSN">1096-911X</identifier>
<part><date point="end">2003</date>
<detail type="volume"><caption>last vol.</caption>
<number>41</number>
</detail>
<detail type="issue"><caption>last no.</caption>
<number>6</number>
</detail>
</part>
</relatedItem>
<relatedItem type="references" displayLabel="cit9"><titleInfo><title>Pandemic influenza A (H1N1) virus infections in children with sickle cell disease</title>
</titleInfo>
<name type="personal"><namePart type="given">B</namePart>
<namePart type="family">Inusa</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Zuckerman</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">N</namePart>
<namePart type="family">Gadong</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Inusa B, Zuckerman M, Gadong N, et al. Pandemic influenza A (H1N1) virus infections in children with sickle cell disease. Blood 2010; 115: 2329.</note>
<part><date>2010</date>
<detail type="volume"><caption>vol.</caption>
<number>115</number>
</detail>
<extent unit="pages"><start>2329</start>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Blood</title>
</titleInfo>
<part><date>2010</date>
<detail type="volume"><caption>vol.</caption>
<number>115</number>
</detail>
<extent unit="pages"><start>2329</start>
</extent>
</part>
</relatedItem>
<identifier type="ISSN">0096-0802</identifier>
<identifier type="ISSN">1096-911X</identifier>
<part><date point="end">2003</date>
<detail type="volume"><caption>last vol.</caption>
<number>41</number>
</detail>
<detail type="issue"><caption>last no.</caption>
<number>6</number>
</detail>
</part>
</relatedItem>
<relatedItem type="references" displayLabel="cit10"><titleInfo><title>Severe pandemic H1N1 and seasonal influenza in children and young adults with sickle cell disease</title>
</titleInfo>
<name type="personal"><namePart type="given">JJ</namePart>
<namePart type="family">Strouse</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">ME</namePart>
<namePart type="family">Reller</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">DG</namePart>
<namePart type="family">Bundy</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Strouse JJ, Reller ME, Bundy DG, et al. Severe pandemic H1N1 and seasonal influenza in children and young adults with sickle cell disease. Blood 2010; 116: 3431–3434.</note>
<part><date>2010</date>
<detail type="volume"><caption>vol.</caption>
<number>116</number>
</detail>
<extent unit="pages"><start>3431</start>
<end>3434</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Blood</title>
</titleInfo>
<part><date>2010</date>
<detail type="volume"><caption>vol.</caption>
<number>116</number>
</detail>
<extent unit="pages"><start>3431</start>
<end>3434</end>
</extent>
</part>
</relatedItem>
<identifier type="ISSN">0096-0802</identifier>
<identifier type="ISSN">1096-911X</identifier>
<part><date point="end">2003</date>
<detail type="volume"><caption>last vol.</caption>
<number>41</number>
</detail>
<detail type="issue"><caption>last no.</caption>
<number>6</number>
</detail>
</part>
</relatedItem>
<relatedItem type="references" displayLabel="cit11"><titleInfo><title>Sickle cell disease in children and adolescents: Diagnosis, guidelines for comprehensive care, and care paths and protocols for management of acute and chronic complications</title>
</titleInfo>
<name type="personal"><namePart type="given">PA</namePart>
<namePart type="family">Lane</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">GR</namePart>
<namePart type="family">Buchanan</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JJ</namePart>
<namePart type="family">Hutter</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>other</genre>
<identifier type="ISSN">0096-0802</identifier>
<identifier type="ISSN">1096-911X</identifier>
<part><date point="end">2003</date>
<detail type="volume"><caption>last vol.</caption>
<number>41</number>
</detail>
<detail type="issue"><caption>last no.</caption>
<number>6</number>
</detail>
</part>
</relatedItem>
<relatedItem type="references" displayLabel="cit12"><titleInfo><title>Updated Interim Recommendations for the Use of Antiviral Medications in the Treatment and Prevention of Influenza for the 2009–2010 Season</title>
</titleInfo>
<genre>other</genre>
<identifier type="ISSN">0096-0802</identifier>
<identifier type="ISSN">1096-911X</identifier>
<part><date point="end">2003</date>
<detail type="volume"><caption>last vol.</caption>
<number>41</number>
</detail>
<detail type="issue"><caption>last no.</caption>
<number>6</number>
</detail>
</part>
</relatedItem>
<relatedItem type="references" displayLabel="cit13"><titleInfo><title>Blood transfusions for treating acute chest syndrome in people with sickle cell disease</title>
</titleInfo>
<name type="personal"><namePart type="given">D</namePart>
<namePart type="family">Alhashimi</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Z</namePart>
<namePart type="family">Fedorowicz</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">F</namePart>
<namePart type="family">Alhashimi</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Alhashimi D, Fedorowicz Z, Alhashimi F, et al. Blood transfusions for treating acute chest syndrome in people with sickle cell disease. Cochrane Database Syst Rev 2010; Art. No.: CD007843. DOI: 10.1002/14651858.CD007843.pub2.</note>
<part><date>2010</date>
</part>
<relatedItem type="host"><titleInfo><title>Cochrane Database Syst Rev</title>
</titleInfo>
<part><date>2010</date>
</part>
</relatedItem>
<identifier type="ISSN">0096-0802</identifier>
<identifier type="ISSN">1096-911X</identifier>
<part><date point="end">2003</date>
<detail type="volume"><caption>last vol.</caption>
<number>41</number>
</detail>
<detail type="issue"><caption>last no.</caption>
<number>6</number>
</detail>
</part>
</relatedItem>
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