Prophylactic effects of chitin microparticles on highly pathogenic H5N1 influenza virus
Identifieur interne : 000E50 ( Istex/Corpus ); précédent : 000E49; suivant : 000E51Prophylactic effects of chitin microparticles on highly pathogenic H5N1 influenza virus
Auteurs : Takeshi Ichinohe ; Noriyo Nagata ; Peter Strong ; Shin-Ichi Tamura ; Hidehiro Takahashi ; Ai Ninomiya ; Masaki Imai ; Takato Odagiri ; Masato Tashiro ; Hirofumi Sawa ; Joe Chiba ; Takeshi Kurata ; Tetsutaro Sata ; Hideki HasegawaSource :
- Journal of Medical Virology [ 0146-6615 ] ; 2007-06.
English descriptors
- Teeft :
- Adjuvant, Biron, Cervical, Cervical lymph node, Chitin, Chitin microparticles, Chitin microparticles intranasally, Chitin microparticles pretreatment, Clinical symptoms, Control group, Cytokine, Frontal lobe, Hasegawa, Hong kong, Ichinohe, Immune response, Immunol, Infection, Infectious diseases, Innate immunity, Intranasal, Intranasal administration, Intranasal application, Intranasal pretreatment, Intranasally, Ligand, Lung washes, Lymph, Mice pretreated, Microparticles, Mouse, Nasal, Nasal mucosa, Nasal wash, Nasal washes, National institute, Natural killer cells, Necrosis, Nguyen, Node, Open circles, Pretreated, Pretreatment, Prophylactic, Prophylactic effect, Prophylactic effects, Protective effect, Tumor necrosis, Tumor necrosis apoptosisinducing ligand, Tumor necrosis ligand, Unpublished data, Vaccine, Vacuum manifold, Viral, Viral challenge, Viral infection, Virol, Virus, Virus challenge, Virus infection, Virus titer, Virus titers, Wash buffer.
Abstract
Highly pathogenic avian influenza virus (H5N1) is an emerging pathogen with the potential to cause great harm to humans, and there is concern about the potential for a new influenza pandemic. This virus is resistant to the antiviral effects of interferons and tumor necrosis factor‐α. However, the mechanism of interferon‐independent protective innate immunity is not well understood. The prophylactic effects of chitin microparticles as a stimulator of innate mucosal immunity against a recently obtained strain of H5N1 influenza virus infection were examined in mice. Clinical parameters and the survival rate of mice treated by intranasal application of chitin microparticles were significantly improved compared to non‐treated mice after a lethal influenza virus challenge. Flow cytometric analysis revealed that the number of natural killer cells that expressed tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL) and that had migrated into the cervical lymph node was markedly increased (26‐fold) after intranasal treatment with chitin microparticles. In addition, the level of IL‐6 and interferon‐gamma‐inducible protein‐10 (IP‐10) in the nasal mucosa after H5N1 influenza virus challenge was decreased by prophylactic treatment with chitin microparticles. These results suggest that prophylactic intranasal administration of chitin microparticles enhanced the local accumulation of natural killer cells and suppressed hyper‐induction of cytokines, resulting in an innate immune response to prevent pathogenesis of H5N1 influenza virus. J. Med. Virol. 79: 811–819, 2007. © 2007 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/jmv.20837
Links to Exploration step
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<front><div type="abstract" xml:lang="en">Highly pathogenic avian influenza virus (H5N1) is an emerging pathogen with the potential to cause great harm to humans, and there is concern about the potential for a new influenza pandemic. This virus is resistant to the antiviral effects of interferons and tumor necrosis factor‐α. However, the mechanism of interferon‐independent protective innate immunity is not well understood. The prophylactic effects of chitin microparticles as a stimulator of innate mucosal immunity against a recently obtained strain of H5N1 influenza virus infection were examined in mice. Clinical parameters and the survival rate of mice treated by intranasal application of chitin microparticles were significantly improved compared to non‐treated mice after a lethal influenza virus challenge. Flow cytometric analysis revealed that the number of natural killer cells that expressed tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL) and that had migrated into the cervical lymph node was markedly increased (26‐fold) after intranasal treatment with chitin microparticles. In addition, the level of IL‐6 and interferon‐gamma‐inducible protein‐10 (IP‐10) in the nasal mucosa after H5N1 influenza virus challenge was decreased by prophylactic treatment with chitin microparticles. These results suggest that prophylactic intranasal administration of chitin microparticles enhanced the local accumulation of natural killer cells and suppressed hyper‐induction of cytokines, resulting in an innate immune response to prevent pathogenesis of H5N1 influenza virus. J. Med. Virol. 79: 811–819, 2007. © 2007 Wiley‐Liss, Inc.</div>
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<p>Highly pathogenic avian influenza virus (H5N1) is an emerging pathogen with the potential to cause great harm to humans, and there is concern about the potential for a new influenza pandemic. This virus is resistant to the antiviral effects of interferons and tumor necrosis factor‐α. However, the mechanism of interferon‐independent protective innate immunity is not well understood. The prophylactic effects of chitin microparticles as a stimulator of innate mucosal immunity against a recently obtained strain of H5N1 influenza virus infection were examined in mice. Clinical parameters and the survival rate of mice treated by intranasal application of chitin microparticles were significantly improved compared to non‐treated mice after a lethal influenza virus challenge. Flow cytometric analysis revealed that the number of natural killer cells that expressed tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL) and that had migrated into the cervical lymph node was markedly increased (26‐fold) after intranasal treatment with chitin microparticles. In addition, the level of IL‐6 and interferon‐gamma‐inducible protein‐10 (IP‐10) in the nasal mucosa after H5N1 influenza virus challenge was decreased by prophylactic treatment with chitin microparticles. These results suggest that prophylactic intranasal administration of chitin microparticles enhanced the local accumulation of natural killer cells and suppressed hyper‐induction of cytokines, resulting in an innate immune response to prevent pathogenesis of H5N1 influenza virus. J. Med. Virol. 79: 811–819, 2007. © 2007 Wiley‐Liss, Inc.</p>
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<titleGroup><title type="main" xml:lang="en">Prophylactic effects of chitin microparticles on highly pathogenic H5N1 influenza virus</title>
<title type="short" xml:lang="en">Prophylactic Effects of Chitin Microparticles Against H5N1</title>
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<keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">influenza virus H5N1</keyword>
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<abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title>
<p>Highly pathogenic avian influenza virus (H5N1) is an emerging pathogen with the potential to cause great harm to humans, and there is concern about the potential for a new influenza pandemic. This virus is resistant to the antiviral effects of interferons and tumor necrosis factor‐α. However, the mechanism of interferon‐independent protective innate immunity is not well understood. The prophylactic effects of chitin microparticles as a stimulator of innate mucosal immunity against a recently obtained strain of H5N1 influenza virus infection were examined in mice. Clinical parameters and the survival rate of mice treated by intranasal application of chitin microparticles were significantly improved compared to non‐treated mice after a lethal influenza virus challenge. Flow cytometric analysis revealed that the number of natural killer cells that expressed tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL) and that had migrated into the cervical lymph node was markedly increased (26‐fold) after intranasal treatment with chitin microparticles. In addition, the level of IL‐6 and interferon‐gamma‐inducible protein‐10 (IP‐10) in the nasal mucosa after H5N1 influenza virus challenge was decreased by prophylactic treatment with chitin microparticles. These results suggest that prophylactic intranasal administration of chitin microparticles enhanced the local accumulation of natural killer cells and suppressed hyper‐induction of cytokines, resulting in an innate immune response to prevent pathogenesis of H5N1 influenza virus. J. Med. Virol. 79: 811–819, 2007. © 2007 Wiley‐Liss, Inc.</p>
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<noteGroup><note xml:id="fn1"><p>Research Fellow of the Japanese Society for the Promotion of Science.</p>
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<name type="personal"><namePart type="given">Takeshi</namePart>
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<affiliation>Department of Pathology, National Institute of Infectious Diseases, Gakuen, Musashimurayama‐shi, Tokyo, Japan</affiliation>
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<name type="personal"><namePart type="given">Shin‐ichi</namePart>
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<name type="personal"><namePart type="given">Hidehiro</namePart>
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<name type="personal"><namePart type="given">Ai</namePart>
<namePart type="family">Ninomiya</namePart>
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<name type="personal"><namePart type="given">Masaki</namePart>
<namePart type="family">Imai</namePart>
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<name type="personal"><namePart type="given">Takato</namePart>
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<name type="personal"><namePart type="given">Masato</namePart>
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<name type="personal"><namePart type="given">Hirofumi</namePart>
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<name type="personal"><namePart type="given">Takeshi</namePart>
<namePart type="family">Kurata</namePart>
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<name type="personal"><namePart type="given">Tetsutaro</namePart>
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<name type="personal"><namePart type="given">Hideki</namePart>
<namePart type="family">Hasegawa</namePart>
<affiliation>Department of Pathology, National Institute of Infectious Diseases, Gakuen, Musashimurayama‐shi, Tokyo, Japan</affiliation>
<affiliation>E-mail: hasegawa@nih.go.jp</affiliation>
<affiliation>Correspondence address: Department of Pathology, National Institute of Infectious Diseases 4‐7‐1 Gakuen, Musashimurayama‐shi, Tokyo 208‐0011, Japan.===</affiliation>
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<abstract lang="en">Highly pathogenic avian influenza virus (H5N1) is an emerging pathogen with the potential to cause great harm to humans, and there is concern about the potential for a new influenza pandemic. This virus is resistant to the antiviral effects of interferons and tumor necrosis factor‐α. However, the mechanism of interferon‐independent protective innate immunity is not well understood. The prophylactic effects of chitin microparticles as a stimulator of innate mucosal immunity against a recently obtained strain of H5N1 influenza virus infection were examined in mice. Clinical parameters and the survival rate of mice treated by intranasal application of chitin microparticles were significantly improved compared to non‐treated mice after a lethal influenza virus challenge. Flow cytometric analysis revealed that the number of natural killer cells that expressed tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL) and that had migrated into the cervical lymph node was markedly increased (26‐fold) after intranasal treatment with chitin microparticles. In addition, the level of IL‐6 and interferon‐gamma‐inducible protein‐10 (IP‐10) in the nasal mucosa after H5N1 influenza virus challenge was decreased by prophylactic treatment with chitin microparticles. These results suggest that prophylactic intranasal administration of chitin microparticles enhanced the local accumulation of natural killer cells and suppressed hyper‐induction of cytokines, resulting in an innate immune response to prevent pathogenesis of H5N1 influenza virus. J. Med. Virol. 79: 811–819, 2007. © 2007 Wiley‐Liss, Inc.</abstract>
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