Prophylactic effects of chitin microparticles on highly pathogenic H5N1 influenza virus
Identifieur interne : 000E50 ( Istex/Corpus ); précédent : 000E49; suivant : 000E51Prophylactic effects of chitin microparticles on highly pathogenic H5N1 influenza virus
Auteurs : Takeshi Ichinohe ; Noriyo Nagata ; Peter Strong ; Shin-Ichi Tamura ; Hidehiro Takahashi ; Ai Ninomiya ; Masaki Imai ; Takato Odagiri ; Masato Tashiro ; Hirofumi Sawa ; Joe Chiba ; Takeshi Kurata ; Tetsutaro Sata ; Hideki HasegawaSource :
- Journal of Medical Virology [ 0146-6615 ] ; 2007-06.
English descriptors
- Teeft :
- Adjuvant, Biron, Cervical, Cervical lymph node, Chitin, Chitin microparticles, Chitin microparticles intranasally, Chitin microparticles pretreatment, Clinical symptoms, Control group, Cytokine, Frontal lobe, Hasegawa, Hong kong, Ichinohe, Immune response, Immunol, Infection, Infectious diseases, Innate immunity, Intranasal, Intranasal administration, Intranasal application, Intranasal pretreatment, Intranasally, Ligand, Lung washes, Lymph, Mice pretreated, Microparticles, Mouse, Nasal, Nasal mucosa, Nasal wash, Nasal washes, National institute, Natural killer cells, Necrosis, Nguyen, Node, Open circles, Pretreated, Pretreatment, Prophylactic, Prophylactic effect, Prophylactic effects, Protective effect, Tumor necrosis, Tumor necrosis apoptosisinducing ligand, Tumor necrosis ligand, Unpublished data, Vaccine, Vacuum manifold, Viral, Viral challenge, Viral infection, Virol, Virus, Virus challenge, Virus infection, Virus titer, Virus titers, Wash buffer.
Abstract
Highly pathogenic avian influenza virus (H5N1) is an emerging pathogen with the potential to cause great harm to humans, and there is concern about the potential for a new influenza pandemic. This virus is resistant to the antiviral effects of interferons and tumor necrosis factor‐α. However, the mechanism of interferon‐independent protective innate immunity is not well understood. The prophylactic effects of chitin microparticles as a stimulator of innate mucosal immunity against a recently obtained strain of H5N1 influenza virus infection were examined in mice. Clinical parameters and the survival rate of mice treated by intranasal application of chitin microparticles were significantly improved compared to non‐treated mice after a lethal influenza virus challenge. Flow cytometric analysis revealed that the number of natural killer cells that expressed tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL) and that had migrated into the cervical lymph node was markedly increased (26‐fold) after intranasal treatment with chitin microparticles. In addition, the level of IL‐6 and interferon‐gamma‐inducible protein‐10 (IP‐10) in the nasal mucosa after H5N1 influenza virus challenge was decreased by prophylactic treatment with chitin microparticles. These results suggest that prophylactic intranasal administration of chitin microparticles enhanced the local accumulation of natural killer cells and suppressed hyper‐induction of cytokines, resulting in an innate immune response to prevent pathogenesis of H5N1 influenza virus. J. Med. Virol. 79: 811–819, 2007. © 2007 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/jmv.20837
Links to Exploration step
ISTEX:5543F9EE96157CFDAC3A52FB1076CDBCE1F9805BLe document en format XML
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of Infectious Diseases, Gakuen, Musashimurayama‐shi, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Strong, Peter" sort="Strong, Peter" uniqKey="Strong P" first="Peter" last="Strong">Peter Strong</name><affiliation><mods:affiliation>CMP Therapeutics Ltd., Oxford, UK</mods:affiliation></affiliation></author><author><name sortKey="Tamura, Shin Chi" sort="Tamura, Shin Chi" uniqKey="Tamura S" first="Shin-Ichi" last="Tamura">Shin-Ichi Tamura</name><affiliation><mods:affiliation>Department of Pathology, National Institute of Infectious Diseases, Gakuen, Musashimurayama‐shi, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Takahashi, Hidehiro" sort="Takahashi, Hidehiro" uniqKey="Takahashi H" first="Hidehiro" last="Takahashi">Hidehiro Takahashi</name><affiliation><mods:affiliation>Department of Pathology, National Institute of Infectious Diseases, Gakuen, Musashimurayama‐shi, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Ninomiya, Ai" sort="Ninomiya, Ai" uniqKey="Ninomiya A" first="Ai" last="Ninomiya">Ai Ninomiya</name><affiliation><mods:affiliation>Department of Virology III, National Institute of Infectious Diseases, Gakuen, Musashimurayama‐shi, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Imai, Masaki" sort="Imai, Masaki" uniqKey="Imai M" first="Masaki" last="Imai">Masaki Imai</name><affiliation><mods:affiliation>Department of Virology III, National Institute of Infectious Diseases, Gakuen, Musashimurayama‐shi, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Odagiri, Takato" sort="Odagiri, Takato" uniqKey="Odagiri T" first="Takato" last="Odagiri">Takato Odagiri</name><affiliation><mods:affiliation>Department of Virology III, National Institute of Infectious Diseases, Gakuen, Musashimurayama‐shi, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Tashiro, Masato" sort="Tashiro, Masato" uniqKey="Tashiro M" first="Masato" last="Tashiro">Masato Tashiro</name><affiliation><mods:affiliation>Department of Virology III, National Institute of Infectious Diseases, Gakuen, Musashimurayama‐shi, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Sawa, Hirofumi" sort="Sawa, Hirofumi" uniqKey="Sawa H" first="Hirofumi" last="Sawa">Hirofumi Sawa</name><affiliation><mods:affiliation>Department of Molecular Pathobiology, 21st Century COE Program for Zoonosis Control, Hokkaido University Research Center for Zoonosis Control, Kita‐ku, Sapporo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Chiba, Joe" sort="Chiba, Joe" uniqKey="Chiba J" first="Joe" last="Chiba">Joe Chiba</name><affiliation><mods:affiliation>Department of Biological Science and Technology, Tokyo University of Science, Yamazaki, Noda, Chiba, Japan</mods:affiliation></affiliation></author><author><name sortKey="Kurata, Takeshi" sort="Kurata, Takeshi" uniqKey="Kurata T" first="Takeshi" last="Kurata">Takeshi Kurata</name><affiliation><mods:affiliation>Department of Pathology, National Institute of Infectious Diseases, Gakuen, Musashimurayama‐shi, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Sata, Tetsutaro" sort="Sata, Tetsutaro" uniqKey="Sata T" first="Tetsutaro" last="Sata">Tetsutaro Sata</name><affiliation><mods:affiliation>Department of Pathology, National Institute of Infectious Diseases, Gakuen, Musashimurayama‐shi, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Hasegawa, Hideki" sort="Hasegawa, Hideki" uniqKey="Hasegawa H" first="Hideki" last="Hasegawa">Hideki Hasegawa</name><affiliation><mods:affiliation>Department of Pathology, National Institute of Infectious Diseases, Gakuen, Musashimurayama‐shi, Tokyo, Japan</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: hasegawa@nih.go.jp</mods:affiliation></affiliation><affiliation><mods:affiliation>Correspondence address: Department of Pathology, National Institute of Infectious Diseases 4‐7‐1 Gakuen, Musashimurayama‐shi, Tokyo 208‐0011, Japan.===</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:5543F9EE96157CFDAC3A52FB1076CDBCE1F9805B</idno><date when="2007" year="2007">2007</date><idno type="doi">10.1002/jmv.20837</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-JVX6427D-7/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000E50</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000E50</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Prophylactic effects of chitin microparticles on highly pathogenic H5N1 influenza virus</title><author><name sortKey="Ichinohe, Takeshi" sort="Ichinohe, Takeshi" uniqKey="Ichinohe T" first="Takeshi" last="Ichinohe">Takeshi Ichinohe</name><affiliation><mods:affiliation>Department of Pathology, National Institute of Infectious Diseases, Gakuen, Musashimurayama‐shi, Tokyo, Japan</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Biological Science and Technology, Tokyo University of Science, Yamazaki, Noda, Chiba, Japan</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: peterstrong@cmptherapeutics.com</mods:affiliation></affiliation></author><author><name sortKey="Nagata, Noriyo" sort="Nagata, Noriyo" uniqKey="Nagata N" first="Noriyo" last="Nagata">Noriyo Nagata</name><affiliation><mods:affiliation>Department of Pathology, National Institute of Infectious Diseases, Gakuen, Musashimurayama‐shi, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Strong, Peter" sort="Strong, Peter" uniqKey="Strong P" first="Peter" last="Strong">Peter Strong</name><affiliation><mods:affiliation>CMP Therapeutics Ltd., Oxford, UK</mods:affiliation></affiliation></author><author><name sortKey="Tamura, Shin Chi" sort="Tamura, Shin Chi" uniqKey="Tamura S" first="Shin-Ichi" last="Tamura">Shin-Ichi Tamura</name><affiliation><mods:affiliation>Department of Pathology, National Institute of Infectious Diseases, Gakuen, Musashimurayama‐shi, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Takahashi, Hidehiro" sort="Takahashi, Hidehiro" uniqKey="Takahashi H" first="Hidehiro" last="Takahashi">Hidehiro Takahashi</name><affiliation><mods:affiliation>Department of Pathology, National Institute of Infectious Diseases, Gakuen, Musashimurayama‐shi, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Ninomiya, Ai" sort="Ninomiya, Ai" uniqKey="Ninomiya A" first="Ai" last="Ninomiya">Ai Ninomiya</name><affiliation><mods:affiliation>Department of Virology III, National Institute of Infectious Diseases, Gakuen, Musashimurayama‐shi, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Imai, Masaki" sort="Imai, Masaki" uniqKey="Imai M" first="Masaki" last="Imai">Masaki Imai</name><affiliation><mods:affiliation>Department of Virology III, National Institute of Infectious Diseases, Gakuen, Musashimurayama‐shi, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Odagiri, Takato" sort="Odagiri, Takato" uniqKey="Odagiri T" first="Takato" last="Odagiri">Takato Odagiri</name><affiliation><mods:affiliation>Department of Virology III, National Institute of Infectious Diseases, Gakuen, Musashimurayama‐shi, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Tashiro, Masato" sort="Tashiro, Masato" uniqKey="Tashiro M" first="Masato" last="Tashiro">Masato Tashiro</name><affiliation><mods:affiliation>Department of Virology III, National Institute of Infectious Diseases, Gakuen, Musashimurayama‐shi, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Sawa, Hirofumi" sort="Sawa, Hirofumi" uniqKey="Sawa H" first="Hirofumi" last="Sawa">Hirofumi Sawa</name><affiliation><mods:affiliation>Department of Molecular Pathobiology, 21st Century COE Program for Zoonosis Control, Hokkaido University Research Center for Zoonosis Control, Kita‐ku, Sapporo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Chiba, Joe" sort="Chiba, Joe" uniqKey="Chiba J" first="Joe" last="Chiba">Joe Chiba</name><affiliation><mods:affiliation>Department of Biological Science and Technology, Tokyo University of Science, Yamazaki, Noda, Chiba, Japan</mods:affiliation></affiliation></author><author><name sortKey="Kurata, Takeshi" sort="Kurata, Takeshi" uniqKey="Kurata T" first="Takeshi" last="Kurata">Takeshi Kurata</name><affiliation><mods:affiliation>Department of Pathology, National Institute of Infectious Diseases, Gakuen, Musashimurayama‐shi, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Sata, Tetsutaro" sort="Sata, Tetsutaro" uniqKey="Sata T" first="Tetsutaro" last="Sata">Tetsutaro Sata</name><affiliation><mods:affiliation>Department of Pathology, National Institute of Infectious Diseases, Gakuen, Musashimurayama‐shi, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Hasegawa, Hideki" sort="Hasegawa, Hideki" uniqKey="Hasegawa H" first="Hideki" last="Hasegawa">Hideki Hasegawa</name><affiliation><mods:affiliation>Department of Pathology, National Institute of Infectious Diseases, Gakuen, Musashimurayama‐shi, Tokyo, Japan</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: hasegawa@nih.go.jp</mods:affiliation></affiliation><affiliation><mods:affiliation>Correspondence address: Department of Pathology, National Institute of Infectious Diseases 4‐7‐1 Gakuen, Musashimurayama‐shi, Tokyo 208‐0011, Japan.===</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Medical Virology</title><title level="j" type="alt">JOURNAL OF MEDICAL VIROLOGY</title><idno type="ISSN">0146-6615</idno><idno type="eISSN">1096-9071</idno><imprint><biblScope unit="vol">79</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="811">811</biblScope><biblScope unit="page" to="819">819</biblScope><biblScope unit="page-count">9</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-06">2007-06</date></imprint><idno type="ISSN">0146-6615</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0146-6615</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Adjuvant</term><term>Biron</term><term>Cervical</term><term>Cervical lymph node</term><term>Chitin</term><term>Chitin microparticles</term><term>Chitin microparticles intranasally</term><term>Chitin microparticles pretreatment</term><term>Clinical symptoms</term><term>Control group</term><term>Cytokine</term><term>Frontal lobe</term><term>Hasegawa</term><term>Hong kong</term><term>Ichinohe</term><term>Immune response</term><term>Immunol</term><term>Infection</term><term>Infectious diseases</term><term>Innate immunity</term><term>Intranasal</term><term>Intranasal administration</term><term>Intranasal application</term><term>Intranasal pretreatment</term><term>Intranasally</term><term>Ligand</term><term>Lung washes</term><term>Lymph</term><term>Mice pretreated</term><term>Microparticles</term><term>Mouse</term><term>Nasal</term><term>Nasal mucosa</term><term>Nasal wash</term><term>Nasal washes</term><term>National institute</term><term>Natural killer cells</term><term>Necrosis</term><term>Nguyen</term><term>Node</term><term>Open circles</term><term>Pretreated</term><term>Pretreatment</term><term>Prophylactic</term><term>Prophylactic effect</term><term>Prophylactic effects</term><term>Protective effect</term><term>Tumor necrosis</term><term>Tumor necrosis apoptosisinducing ligand</term><term>Tumor necrosis ligand</term><term>Unpublished data</term><term>Vaccine</term><term>Vacuum manifold</term><term>Viral</term><term>Viral challenge</term><term>Viral infection</term><term>Virol</term><term>Virus</term><term>Virus challenge</term><term>Virus infection</term><term>Virus titer</term><term>Virus titers</term><term>Wash buffer</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Highly pathogenic avian influenza virus (H5N1) is an emerging pathogen with the potential to cause great harm to humans, and there is concern about the potential for a new influenza pandemic. This virus is resistant to the antiviral effects of interferons and tumor necrosis factor‐α. However, the mechanism of interferon‐independent protective innate immunity is not well understood. The prophylactic effects of chitin microparticles as a stimulator of innate mucosal immunity against a recently obtained strain of H5N1 influenza virus infection were examined in mice. Clinical parameters and the survival rate of mice treated by intranasal application of chitin microparticles were significantly improved compared to non‐treated mice after a lethal influenza virus challenge. Flow cytometric analysis revealed that the number of natural killer cells that expressed tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL) and that had migrated into the cervical lymph node was markedly increased (26‐fold) after intranasal treatment with chitin microparticles. In addition, the level of IL‐6 and interferon‐gamma‐inducible protein‐10 (IP‐10) in the nasal mucosa after H5N1 influenza virus challenge was decreased by prophylactic treatment with chitin microparticles. These results suggest that prophylactic intranasal administration of chitin microparticles enhanced the local accumulation of natural killer cells and suppressed hyper‐induction of cytokines, resulting in an innate immune response to prevent pathogenesis of H5N1 influenza virus. J. Med. Virol. 79: 811–819, 2007. © 2007 Wiley‐Liss, Inc.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>chitin</json:string><json:string>microparticles</json:string><json:string>chitin microparticles</json:string><json:string>natural killer cells</json:string><json:string>virus infection</json:string><json:string>intranasally</json:string><json:string>viral</json:string><json:string>cytokine</json:string><json:string>node</json:string><json:string>cervical</json:string><json:string>prophylactic</json:string><json:string>cervical lymph node</json:string><json:string>immunol</json:string><json:string>virol</json:string><json:string>pretreatment</json:string><json:string>nasal washes</json:string><json:string>ichinohe</json:string><json:string>virus titers</json:string><json:string>tumor necrosis ligand</json:string><json:string>nguyen</json:string><json:string>hasegawa</json:string><json:string>intranasal</json:string><json:string>ligand</json:string><json:string>intranasal administration</json:string><json:string>adjuvant</json:string><json:string>biron</json:string><json:string>pretreated</json:string><json:string>vaccine</json:string><json:string>viral challenge</json:string><json:string>open circles</json:string><json:string>nasal mucosa</json:string><json:string>nasal</json:string><json:string>virus titer</json:string><json:string>prophylactic effects</json:string><json:string>national institute</json:string><json:string>mice pretreated</json:string><json:string>clinical symptoms</json:string><json:string>mouse</json:string><json:string>lymph</json:string><json:string>intranasal pretreatment</json:string><json:string>infectious diseases</json:string><json:string>tumor necrosis apoptosisinducing ligand</json:string><json:string>chitin microparticles pretreatment</json:string><json:string>virus challenge</json:string><json:string>nasal wash</json:string><json:string>wash buffer</json:string><json:string>virus</json:string><json:string>infection</json:string><json:string>necrosis</json:string><json:string>intranasal application</json:string><json:string>chitin microparticles intranasally</json:string><json:string>vacuum manifold</json:string><json:string>hong kong</json:string><json:string>innate immunity</json:string><json:string>lung washes</json:string><json:string>prophylactic effect</json:string><json:string>frontal lobe</json:string><json:string>control group</json:string><json:string>viral infection</json:string><json:string>tumor necrosis</json:string><json:string>immune response</json:string><json:string>unpublished data</json:string><json:string>protective effect</json:string></teeft></keywords><author><json:item><name>Takeshi Ichinohe</name><affiliations><json:string>Department of Pathology, National Institute of Infectious Diseases, Gakuen, Musashimurayama‐shi, Tokyo, Japan</json:string><json:string>Department of Biological Science and Technology, Tokyo University of Science, Yamazaki, Noda, Chiba, Japan</json:string><json:string>E-mail: peterstrong@cmptherapeutics.com</json:string></affiliations></json:item><json:item><name>Noriyo Nagata</name><affiliations><json:string>Department of Pathology, National Institute of Infectious Diseases, Gakuen, Musashimurayama‐shi, Tokyo, Japan</json:string></affiliations></json:item><json:item><name>Peter Strong</name><affiliations><json:string>CMP Therapeutics Ltd., Oxford, UK</json:string></affiliations></json:item><json:item><name>Shin‐ichi Tamura</name><affiliations><json:string>Department of Pathology, National Institute of Infectious Diseases, Gakuen, Musashimurayama‐shi, Tokyo, Japan</json:string></affiliations></json:item><json:item><name>Hidehiro Takahashi</name><affiliations><json:string>Department of Pathology, National Institute of Infectious Diseases, Gakuen, Musashimurayama‐shi, Tokyo, Japan</json:string></affiliations></json:item><json:item><name>Ai Ninomiya</name><affiliations><json:string>Department of Virology III, National Institute of Infectious Diseases, Gakuen, Musashimurayama‐shi, Tokyo, Japan</json:string></affiliations></json:item><json:item><name>Masaki Imai</name><affiliations><json:string>Department of Virology III, National Institute of Infectious Diseases, Gakuen, Musashimurayama‐shi, Tokyo, Japan</json:string></affiliations></json:item><json:item><name>Takato Odagiri</name><affiliations><json:string>Department of Virology III, National Institute of Infectious Diseases, Gakuen, Musashimurayama‐shi, Tokyo, Japan</json:string></affiliations></json:item><json:item><name>Masato Tashiro</name><affiliations><json:string>Department of Virology III, National Institute of Infectious Diseases, Gakuen, Musashimurayama‐shi, Tokyo, Japan</json:string></affiliations></json:item><json:item><name>Hirofumi Sawa</name><affiliations><json:string>Department of Molecular Pathobiology, 21st Century COE Program for Zoonosis Control, Hokkaido University Research Center for Zoonosis Control, Kita‐ku, Sapporo, Japan</json:string></affiliations></json:item><json:item><name>Joe Chiba</name><affiliations><json:string>Department of Biological Science and Technology, Tokyo University of Science, Yamazaki, Noda, Chiba, Japan</json:string></affiliations></json:item><json:item><name>Takeshi Kurata</name><affiliations><json:string>Department of Pathology, National Institute of Infectious Diseases, Gakuen, Musashimurayama‐shi, Tokyo, Japan</json:string></affiliations></json:item><json:item><name>Tetsutaro Sata</name><affiliations><json:string>Department of Pathology, National Institute of Infectious Diseases, Gakuen, Musashimurayama‐shi, Tokyo, Japan</json:string></affiliations></json:item><json:item><name>Hideki Hasegawa</name><affiliations><json:string>Department of Pathology, National Institute of Infectious Diseases, Gakuen, Musashimurayama‐shi, Tokyo, Japan</json:string><json:string>E-mail: hasegawa@nih.go.jp</json:string><json:string>Correspondence address: Department of Pathology, National Institute of Infectious Diseases 4‐7‐1 Gakuen, Musashimurayama‐shi, Tokyo 208‐0011, Japan.===</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>influenza virus H5N1</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>innate immunity</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>chitin</value></json:item></subject><articleId><json:string>JMV20837</json:string></articleId><arkIstex>ark:/67375/WNG-JVX6427D-7</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Highly pathogenic avian influenza virus (H5N1) is an emerging pathogen with the potential to cause great harm to humans, and there is concern about the potential for a new influenza pandemic. This virus is resistant to the antiviral effects of interferons and tumor necrosis factor‐α. However, the mechanism of interferon‐independent protective innate immunity is not well understood. The prophylactic effects of chitin microparticles as a stimulator of innate mucosal immunity against a recently obtained strain of H5N1 influenza virus infection were examined in mice. Clinical parameters and the survival rate of mice treated by intranasal application of chitin microparticles were significantly improved compared to non‐treated mice after a lethal influenza virus challenge. Flow cytometric analysis revealed that the number of natural killer cells that expressed tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL) and that had migrated into the cervical lymph node was markedly increased (26‐fold) after intranasal treatment with chitin microparticles. In addition, the level of IL‐6 and interferon‐gamma‐inducible protein‐10 (IP‐10) in the nasal mucosa after H5N1 influenza virus challenge was decreased by prophylactic treatment with chitin microparticles. These results suggest that prophylactic intranasal administration of chitin microparticles enhanced the local accumulation of natural killer cells and suppressed hyper‐induction of cytokines, resulting in an innate immune response to prevent pathogenesis of H5N1 influenza virus. J. Med. 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2006</json:string><json:string>[2007]</json:string><json:string>Cooper et al., 2001</json:string><json:string>Ichinohe et al.</json:string><json:string>Hasegawa et al., 2005</json:string><json:string>Peiris et al., 2004</json:string><json:string>Okamoto et al., 1993</json:string><json:string>Kos and Engleman, 1996</json:string><json:string>Claas et al., 1998</json:string><json:string>Seo et al., 2002</json:string><json:string>Asahi et al., 2002</json:string><json:string>Leary et al., 2006</json:string><json:string>Stein-Streilein and Guffee, 1986</json:string><json:string>de Jong et al., 2006</json:string><json:string>Shibata et al., 1997a,b, 1998</json:string><json:string>Hamajima et al., 2003</json:string><json:string>Subbarao et al., 1998</json:string><json:string>Ichinohe et al., 2005, 2006</json:string><json:string>Gazit et al., 2006</json:string><json:string>Chan et al., 2005</json:string><json:string>Biron et al., 1989</json:string><json:string>Andoniou et al., 2005</json:string><json:string>Tran et al., 2004</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-JVX6427D-7</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - virology</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - biomedical research</json:string><json:string>3 - virology</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Infectious Diseases</json:string><json:string>1 - Life Sciences</json:string><json:string>2 - Immunology and Microbiology</json:string><json:string>3 - Virology</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string><json:string>4 - pathologie 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This virus is resistant to the antiviral effects of interferons and tumor necrosis factor‐α. However, the mechanism of interferon‐independent protective innate immunity is not well understood. The prophylactic effects of chitin microparticles as a stimulator of innate mucosal immunity against a recently obtained strain of H5N1 influenza virus infection were examined in mice. Clinical parameters and the survival rate of mice treated by intranasal application of chitin microparticles were significantly improved compared to non‐treated mice after a lethal influenza virus challenge. Flow cytometric analysis revealed that the number of natural killer cells that expressed tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL) and that had migrated into the cervical lymph node was markedly increased (26‐fold) after intranasal treatment with chitin microparticles. In addition, the level of IL‐6 and interferon‐gamma‐inducible protein‐10 (IP‐10) in the nasal mucosa after H5N1 influenza virus challenge was decreased by prophylactic treatment with chitin microparticles. These results suggest that prophylactic intranasal administration of chitin microparticles enhanced the local accumulation of natural killer cells and suppressed hyper‐induction of cytokines, resulting in an innate immune response to prevent pathogenesis of H5N1 influenza virus. J. Med. Virol. 79: 811–819, 2007. © 2007 Wiley‐Liss, Inc.</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>Research Fellow of the Japanese Society for the Promotion of Science.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Prophylactic effects of chitin microparticles on highly pathogenic H5N1 influenza virus</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Prophylactic Effects of Chitin Microparticles Against H5N1</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Prophylactic effects of chitin microparticles on highly pathogenic H5N1 influenza virus</title></titleInfo><name type="personal"><namePart type="given">Takeshi</namePart><namePart type="family">Ichinohe</namePart><affiliation>Department of Pathology, National Institute of Infectious Diseases, Gakuen, Musashimurayama‐shi, Tokyo, Japan</affiliation><affiliation>Department of Biological Science and Technology, Tokyo University of Science, Yamazaki, Noda, Chiba, Japan</affiliation><description>Research Fellow of the Japanese Society for the Promotion of Science.</description><affiliation>E-mail: peterstrong@cmptherapeutics.com</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Noriyo</namePart><namePart type="family">Nagata</namePart><affiliation>Department of Pathology, National Institute of Infectious Diseases, Gakuen, Musashimurayama‐shi, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Peter</namePart><namePart type="family">Strong</namePart><affiliation>CMP Therapeutics Ltd., Oxford, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Shin‐ichi</namePart><namePart type="family">Tamura</namePart><affiliation>Department of Pathology, National Institute of Infectious Diseases, Gakuen, Musashimurayama‐shi, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hidehiro</namePart><namePart type="family">Takahashi</namePart><affiliation>Department of Pathology, National Institute of Infectious Diseases, Gakuen, Musashimurayama‐shi, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ai</namePart><namePart type="family">Ninomiya</namePart><affiliation>Department of Virology III, National Institute of Infectious Diseases, Gakuen, Musashimurayama‐shi, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Masaki</namePart><namePart type="family">Imai</namePart><affiliation>Department of Virology III, National Institute of Infectious Diseases, Gakuen, Musashimurayama‐shi, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Takato</namePart><namePart type="family">Odagiri</namePart><affiliation>Department of Virology III, National Institute of Infectious Diseases, Gakuen, Musashimurayama‐shi, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Masato</namePart><namePart type="family">Tashiro</namePart><affiliation>Department of Virology III, National Institute of Infectious Diseases, Gakuen, Musashimurayama‐shi, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hirofumi</namePart><namePart type="family">Sawa</namePart><affiliation>Department of Molecular Pathobiology, 21st Century COE Program for Zoonosis Control, Hokkaido University Research Center for Zoonosis Control, Kita‐ku, Sapporo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Joe</namePart><namePart type="family">Chiba</namePart><affiliation>Department of Biological Science and Technology, Tokyo University of Science, Yamazaki, Noda, Chiba, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Takeshi</namePart><namePart type="family">Kurata</namePart><affiliation>Department of Pathology, National Institute of Infectious Diseases, Gakuen, Musashimurayama‐shi, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Tetsutaro</namePart><namePart type="family">Sata</namePart><affiliation>Department of Pathology, National Institute of Infectious Diseases, Gakuen, Musashimurayama‐shi, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hideki</namePart><namePart type="family">Hasegawa</namePart><affiliation>Department of Pathology, National Institute of Infectious Diseases, Gakuen, Musashimurayama‐shi, Tokyo, Japan</affiliation><affiliation>E-mail: hasegawa@nih.go.jp</affiliation><affiliation>Correspondence address: Department of Pathology, National Institute of Infectious Diseases 4‐7‐1 Gakuen, Musashimurayama‐shi, Tokyo 208‐0011, Japan.===</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2007-06</dateIssued><dateValid encoding="w3cdtf">2007-02-05</dateValid><copyrightDate encoding="w3cdtf">2007</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">5</extent><extent unit="tables">0</extent><extent unit="references">35</extent><extent unit="words">1308</extent></physicalDescription><abstract lang="en">Highly pathogenic avian influenza virus (H5N1) is an emerging pathogen with the potential to cause great harm to humans, and there is concern about the potential for a new influenza pandemic. This virus is resistant to the antiviral effects of interferons and tumor necrosis factor‐α. However, the mechanism of interferon‐independent protective innate immunity is not well understood. The prophylactic effects of chitin microparticles as a stimulator of innate mucosal immunity against a recently obtained strain of H5N1 influenza virus infection were examined in mice. Clinical parameters and the survival rate of mice treated by intranasal application of chitin microparticles were significantly improved compared to non‐treated mice after a lethal influenza virus challenge. Flow cytometric analysis revealed that the number of natural killer cells that expressed tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL) and that had migrated into the cervical lymph node was markedly increased (26‐fold) after intranasal treatment with chitin microparticles. In addition, the level of IL‐6 and interferon‐gamma‐inducible protein‐10 (IP‐10) in the nasal mucosa after H5N1 influenza virus challenge was decreased by prophylactic treatment with chitin microparticles. These results suggest that prophylactic intranasal administration of chitin microparticles enhanced the local accumulation of natural killer cells and suppressed hyper‐induction of cytokines, resulting in an innate immune response to prevent pathogenesis of H5N1 influenza virus. J. Med. Virol. 79: 811–819, 2007. © 2007 Wiley‐Liss, Inc.</abstract><subject lang="en"><genre>keywords</genre><topic>influenza virus H5N1</topic><topic>innate immunity</topic><topic>chitin</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Medical Virology</title></titleInfo><titleInfo type="abbreviated"><title>J. Med. Virol.</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0146-6615</identifier><identifier type="eISSN">1096-9071</identifier><identifier type="DOI">10.1002/(ISSN)1096-9071</identifier><identifier type="PublisherID">JMV</identifier><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>79</number></detail><detail type="issue"><caption>no.</caption><number>6</number></detail><extent unit="pages"><start>811</start><end>819</end><total>9</total></extent></part></relatedItem><relatedItem type="references" displayLabel="cit1"><titleInfo><title>Interaction between conventional dendritic cells and natural killer cells is integral to the activation of effective antiviral immunity</title></titleInfo><name type="personal"><namePart type="given">CE</namePart><namePart type="family">Andoniou</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SL</namePart><namePart type="family">van Dommelen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V</namePart><namePart type="family">Voigt</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DM</namePart><namePart type="family">Andrews</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G</namePart><namePart type="family">Brizard</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Asselin‐Paturel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Delale</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KJ</namePart><namePart type="family">Stacey</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G</namePart><namePart type="family">Trinchieri</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MA</namePart><namePart type="family">Degli‐Esposti</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Andoniou CE, van Dommelen SL, Voigt V, Andrews DM, Brizard G, Asselin‐Paturel C, Delale T, Stacey KJ, Trinchieri G, Degli‐Esposti MA. 2005. Interaction between conventional dendritic cells and natural killer cells is integral to the activation of effective antiviral immunity. Nat Immunol 6: 1011–1019.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>6</number></detail><extent unit="pages"><start>1011</start><end>1019</end></extent></part><relatedItem type="host"><titleInfo><title>Nat Immunol</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>6</number></detail><extent unit="pages"><start>1011</start><end>1019</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit2"><titleInfo><title>Protection against influenza virus infection in polymeric Ig receptor knockout mice immunized intranasally with adjuvant‐combined vaccines</title></titleInfo><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Asahi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Yoshikawa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I</namePart><namePart type="family">Watanabe</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Iwasaki</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Hasegawa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Sato</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Shimada</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Nanno</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Matsuoka</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Ohwaki</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Iwakura</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Suzuki</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Aizawa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Sata</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Kurata</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Tamura</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Asahi Y, Yoshikawa T, Watanabe I, Iwasaki T, Hasegawa H, Sato Y, Shimada S, Nanno M, Matsuoka Y, Ohwaki M, Iwakura Y, Suzuki Y, Aizawa C, Sata T, Kurata T, Tamura S. 2002. Protection against influenza virus infection in polymeric Ig receptor knockout mice immunized intranasally with adjuvant‐combined vaccines. J Immunol 168: 2930–2938.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>168</number></detail><extent unit="pages"><start>2930</start><end>2938</end></extent></part><relatedItem type="host"><titleInfo><title>J Immunol</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>168</number></detail><extent unit="pages"><start>2930</start><end>2938</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit3"><titleInfo><title>Intranasal administration of adjuvant‐combined recombinant influenza virus HA vaccine protects mice from the lethal H5N1 virus infection</title></titleInfo><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Asahi‐Ozaki</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Itamura</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Ichinohe</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Strong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Tamura</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Takahashi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Sawa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Moriyama</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Tashiro</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Sata</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Kurata</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Hasegawa</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Asahi‐Ozaki Y, Itamura S, Ichinohe T, Strong P, Tamura S, Takahashi H, Sawa H, Moriyama M, Tashiro M, Sata T, Kurata T, Hasegawa H. 2006. Intranasal administration of adjuvant‐combined recombinant influenza virus HA vaccine protects mice from the lethal H5N1 virus infection. Microbes Infect 8: 2706–2714.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>8</number></detail><extent unit="pages"><start>2706</start><end>2714</end></extent></part><relatedItem type="host"><titleInfo><title>Microbes Infect</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>8</number></detail><extent unit="pages"><start>2706</start><end>2714</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit4"><titleInfo><title>Carbohydrate biopolymers enhance antibody responses to mucosally delivered vaccine antigens</title></titleInfo><name type="personal"><namePart type="given">A</namePart><namePart type="family">Bacon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Makin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PJ</namePart><namePart type="family">Sizer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I</namePart><namePart type="family">Jabbal‐Gill</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Hinchcliffe</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Illum</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Chatfield</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Roberts</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Bacon A, Makin J, Sizer PJ, Jabbal‐Gill I, Hinchcliffe M, Illum L, Chatfield S, Roberts M. 2000. Carbohydrate biopolymers enhance antibody responses to mucosally delivered vaccine antigens. Infect Immun 68: 5764–5770.</note><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>68</number></detail><extent unit="pages"><start>5764</start><end>5770</end></extent></part><relatedItem type="host"><titleInfo><title>Infect Immun</title></titleInfo><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>68</number></detail><extent unit="pages"><start>5764</start><end>5770</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit5"><titleInfo><title>Activation and function of natural killer cell responses during viral infections</title></titleInfo><name type="personal"><namePart type="given">CA</namePart><namePart type="family">Biron</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Biron CA. 1997. Activation and function of natural killer cell responses during viral infections. Curr Opin Immunol 9: 24–34.</note><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>9</number></detail><extent unit="pages"><start>24</start><end>34</end></extent></part><relatedItem type="host"><titleInfo><title>Curr Opin Immunol</title></titleInfo><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>9</number></detail><extent unit="pages"><start>24</start><end>34</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit6"><titleInfo><title>NK cells and NKT cells in innate defense against viral infections</title></titleInfo><name type="personal"><namePart type="given">CA</namePart><namePart type="family">Biron</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Brossay</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Biron CA, Brossay L. 2001. NK cells and NKT cells in innate defense against viral infections. Curr Opin Immunol 13: 458–464.</note><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>13</number></detail><extent unit="pages"><start>458</start><end>464</end></extent></part><relatedItem type="host"><titleInfo><title>Curr Opin Immunol</title></titleInfo><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>13</number></detail><extent unit="pages"><start>458</start><end>464</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit7"><titleInfo><title>Severe herpesvirus infections in an adolescent without natural killer cells</title></titleInfo><name type="personal"><namePart type="given">CA</namePart><namePart type="family">Biron</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KS</namePart><namePart type="family">Byron</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JL</namePart><namePart type="family">Sullivan</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Biron CA, Byron KS, Sullivan JL. 1989. Severe herpesvirus infections in an adolescent without natural killer cells. N Engl J Med 320: 1731–1735.</note><part><date>1989</date><detail type="volume"><caption>vol.</caption><number>320</number></detail><extent unit="pages"><start>1731</start><end>1735</end></extent></part><relatedItem type="host"><titleInfo><title>N Engl J Med</title></titleInfo><part><date>1989</date><detail type="volume"><caption>vol.</caption><number>320</number></detail><extent unit="pages"><start>1731</start><end>1735</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit8"><titleInfo><title>Natural killer cells in antiviral defense: function and regulation by innate cytokines</title></titleInfo><name type="personal"><namePart type="given">CA</namePart><namePart type="family">Biron</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KB</namePart><namePart type="family">Nguyen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GC</namePart><namePart type="family">Pien</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LP</namePart><namePart type="family">Cousens</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TP</namePart><namePart type="family">Salazar‐Mather</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Biron CA, Nguyen KB, Pien GC, Cousens LP, Salazar‐Mather TP. 1999. Natural killer cells in antiviral defense: function and regulation by innate cytokines. Annu Rev Immunol 17: 189–220.</note><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>17</number></detail><extent unit="pages"><start>189</start><end>220</end></extent></part><relatedItem type="host"><titleInfo><title>Annu Rev Immunol</title></titleInfo><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>17</number></detail><extent unit="pages"><start>189</start><end>220</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit9"><titleInfo><title>Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells</title></titleInfo><name type="personal"><namePart type="given">MC</namePart><namePart type="family">Chan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CY</namePart><namePart type="family">Cheung</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WH</namePart><namePart type="family">Chui</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SW</namePart><namePart type="family">Tsao</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JM</namePart><namePart type="family">Nicholls</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">YO</namePart><namePart type="family">Chan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RW</namePart><namePart type="family">Chan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">HT</namePart><namePart type="family">Long</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LL</namePart><namePart type="family">Poon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Guan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JS</namePart><namePart type="family">Peiris</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Chan MC, Cheung CY, Chui WH, Tsao SW, Nicholls JM, Chan YO, Chan RW, Long HT, Poon LL, Guan Y, Peiris JS. 2005. Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells. Respir Res 6: 135.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>6</number></detail><extent unit="pages"><start>135</start></extent></part><relatedItem type="host"><titleInfo><title>Respir Res</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>6</number></detail><extent unit="pages"><start>135</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit10"><titleInfo><title>Human influenza A H5N1 virus related to a highly pathogenic avian influenza virus</title></titleInfo><name type="personal"><namePart type="given">EC</namePart><namePart type="family">Claas</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AD</namePart><namePart type="family">Osterhaus</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">van Beek</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JC</namePart><namePart type="family">De Jong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GF</namePart><namePart type="family">Rimmelzwaan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DA</namePart><namePart type="family">Senne</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Krauss</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KF</namePart><namePart type="family">Shortridge</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RG</namePart><namePart type="family">Webster</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Claas EC, Osterhaus AD, van Beek R, De Jong JC, Rimmelzwaan GF, Senne DA, Krauss S, Shortridge KF, Webster RG. 1998. Human influenza A H5N1 virus related to a highly pathogenic avian influenza virus. Lancet 351: 472–477.</note><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>351</number></detail><extent unit="pages"><start>472</start><end>477</end></extent></part><relatedItem type="host"><titleInfo><title>Lancet</title></titleInfo><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>351</number></detail><extent unit="pages"><start>472</start><end>477</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit11"><titleInfo><title>The biology of human natural killer‐cell subsets</title></titleInfo><name type="personal"><namePart type="given">MA</namePart><namePart type="family">Cooper</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TA</namePart><namePart type="family">Fehniger</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MA</namePart><namePart type="family">Caligiuri</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Cooper MA, Fehniger TA, Caligiuri MA. 2001. The biology of human natural killer‐cell subsets. Trends Immunol 22: 633–640.</note><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>22</number></detail><extent unit="pages"><start>633</start><end>640</end></extent></part><relatedItem type="host"><titleInfo><title>Trends Immunol</title></titleInfo><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>22</number></detail><extent unit="pages"><start>633</start><end>640</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit12"><titleInfo><title>Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia</title></titleInfo><name type="personal"><namePart type="given">MD</namePart><namePart type="family">de Jong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CP</namePart><namePart type="family">Simmons</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TT</namePart><namePart type="family">Thanh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">VM</namePart><namePart type="family">Hien</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GJ</namePart><namePart type="family">Smith</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TN</namePart><namePart type="family">Chau</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DM</namePart><namePart type="family">Hoang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N</namePart><namePart type="family">Van Vinh Chau</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TH</namePart><namePart type="family">Khanh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">VC</namePart><namePart type="family">Dong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PT</namePart><namePart type="family">Qui</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Van Cam</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Q</namePart><namePart type="family">Ha do</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Guan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JS</namePart><namePart type="family">Peiris</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">NT</namePart><namePart type="family">Chinh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TT</namePart><namePart type="family">Hien</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Farrar</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">de Jong MD, Simmons CP, Thanh TT, Hien VM, Smith GJ, Chau TN, Hoang DM, Van Vinh Chau N, Khanh TH, Dong VC, Qui PT, Van Cam B, Ha do Q, Guan Y, Peiris JS, Chinh NT, Hien TT, Farrar J. 2006. Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia. Nat Med 12: 1203–1207.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>1203</start><end>1207</end></extent></part><relatedItem type="host"><titleInfo><title>Nat Med</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>1203</start><end>1207</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit13"><titleInfo><title>Lethal influenza infection in the absence of the natural killer cell receptor gene Ncr1</title></titleInfo><name type="personal"><namePart type="given">R</namePart><namePart type="family">Gazit</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Gruda</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Elboim</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TI</namePart><namePart type="family">Arnon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G</namePart><namePart type="family">Katz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Achdout</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Hanna</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">U</namePart><namePart type="family">Qimron</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G</namePart><namePart type="family">Landau</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Greenbaum</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Z</namePart><namePart type="family">Zakay‐Rones</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Porgador</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">O</namePart><namePart type="family">Mandelboim</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Gazit R, Gruda R, Elboim M, Arnon TI, Katz G, Achdout H, Hanna J, Qimron U, Landau G, Greenbaum E, Zakay‐Rones Z, Porgador A, Mandelboim O. 2006. Lethal influenza infection in the absence of the natural killer cell receptor gene Ncr1. Nat Immunol 7: 517–523.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>7</number></detail><extent unit="pages"><start>517</start><end>523</end></extent></part><relatedItem type="host"><titleInfo><title>Nat Immunol</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>7</number></detail><extent unit="pages"><start>517</start><end>523</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit14"><titleInfo><title>Avian influenza virus infection of children in Vietnam and Thailand</title></titleInfo><name type="personal"><namePart type="given">C</namePart><namePart type="family">Grose</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Chokephaibulkit</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Grose C, Chokephaibulkit K. 2004. Avian influenza virus infection of children in Vietnam and Thailand. Pediatr Infect Dis J 23: 793–794.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>23</number></detail><extent unit="pages"><start>793</start><end>794</end></extent></part><relatedItem type="host"><titleInfo><title>Pediatr Infect Dis J</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>23</number></detail><extent unit="pages"><start>793</start><end>794</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit15"><titleInfo><title>Chitin micro‐particles (CMP): a useful adjuvant for inducing viral specific immunity when delivered intranasally with an HIV‐DNA vaccine</title></titleInfo><name type="personal"><namePart type="given">K</namePart><namePart type="family">Hamajima</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Kojima</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Matsui</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Toda</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N</namePart><namePart type="family">Jounai</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Ozaki</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KQ</namePart><namePart type="family">Xin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Strong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Okuda</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Hamajima K, Kojima Y, Matsui K, Toda Y, Jounai N, Ozaki T, Xin KQ, Strong P, Okuda K. 2003. Chitin micro‐particles (CMP): a useful adjuvant for inducing viral specific immunity when delivered intranasally with an HIV‐DNA vaccine. Viral Immunol 16: 541–547.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>16</number></detail><extent unit="pages"><start>541</start><end>547</end></extent></part><relatedItem type="host"><titleInfo><title>Viral Immunol</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>16</number></detail><extent unit="pages"><start>541</start><end>547</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit16"><titleInfo><title>Protection against influenza virus infection by intranasal administration of hemagglutinin vaccine with chitin microparticles as an adjuvant</title></titleInfo><name type="personal"><namePart type="given">H</namePart><namePart type="family">Hasegawa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Ichinohe</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Strong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I</namePart><namePart type="family">Watanabe</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Ito</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Tamura</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Takahashi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Sawa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Chiba</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Kurata</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Sata</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Hasegawa H, Ichinohe T, Strong P, Watanabe I, Ito S, Tamura S, Takahashi H, Sawa H, Chiba J, Kurata T, Sata T. 2005. Protection against influenza virus infection by intranasal administration of hemagglutinin vaccine with chitin microparticles as an adjuvant. J Med Virol 75: 130–136.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>75</number></detail><extent unit="pages"><start>130</start><end>136</end></extent></part><relatedItem type="host"><titleInfo><title>J Med Virol</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>75</number></detail><extent unit="pages"><start>130</start><end>136</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit17"><titleInfo><title>Synthetic double‐stranded RNA poly(I:C) combined with mucosal vaccine protects against influenza virus infection</title></titleInfo><name type="personal"><namePart type="given">T</namePart><namePart type="family">Ichinohe</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I</namePart><namePart type="family">Watanabe</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Ito</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Fujii</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Moriyama</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Tamura</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Takahashi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Sawa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Chiba</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Kurata</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Sata</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Hasegawa</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ichinohe T, Watanabe I, Ito S, Fujii H, Moriyama M, Tamura S, Takahashi H, Sawa H, Chiba J, Kurata T, Sata T, Hasegawa H. 2005. Synthetic double‐stranded RNA poly(I:C) combined with mucosal vaccine protects against influenza virus infection. J Virol 79: 2910–2919.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>79</number></detail><extent unit="pages"><start>2910</start><end>2919</end></extent></part><relatedItem type="host"><titleInfo><title>J Virol</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>79</number></detail><extent unit="pages"><start>2910</start><end>2919</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit18"><titleInfo><title>Protection against influenza virus infection by intranasal vaccine with surf clam microparticles (SMP) as an adjuvant</title></titleInfo><name type="personal"><namePart type="given">T</namePart><namePart type="family">Ichinohe</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I</namePart><namePart type="family">Watanabe</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Tao</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Ito</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Kawaguchi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Tamura</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Takahashi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Sawa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Moriyama</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Chiba</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Komase</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Suzuki</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Kurata</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Sata</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Hasegawa</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ichinohe T, Watanabe I, Tao E, Ito S, Kawaguchi A, Tamura S, Takahashi H, Sawa H, Moriyama M, Chiba J, Komase K, Suzuki Y, Kurata T, Sata T, Hasegawa H. 2006. Protection against influenza virus infection by intranasal vaccine with surf clam microparticles (SMP) as an adjuvant. J Med Virol 78: 954–963.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>78</number></detail><extent unit="pages"><start>954</start><end>963</end></extent></part><relatedItem type="host"><titleInfo><title>J Med Virol</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>78</number></detail><extent unit="pages"><start>954</start><end>963</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit19"><titleInfo><title>Role of tumor necrosis factor‐related apoptosis‐inducing ligand in immune response to influenza virus infection in mice</title></titleInfo><name type="personal"><namePart type="given">E</namePart><namePart type="family">Ishikawa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Nakazawa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Yoshinari</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Minami</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ishikawa E, Nakazawa M, Yoshinari M, Minami M. 2005. Role of tumor necrosis factor‐related apoptosis‐inducing ligand in immune response to influenza virus infection in mice. J Virol 79: 7658–7663.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>79</number></detail><extent unit="pages"><start>7658</start><end>7663</end></extent></part><relatedItem type="host"><titleInfo><title>J Virol</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>79</number></detail><extent unit="pages"><start>7658</start><end>7663</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit20"><titleInfo><title>Role of natural killer cells in the generation of influenza virus‐specific cytotoxic T cells</title></titleInfo><name type="personal"><namePart type="given">FJ</namePart><namePart type="family">Kos</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">EG</namePart><namePart type="family">Engleman</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Kos FJ, Engleman EG. 1996. Role of natural killer cells in the generation of influenza virus‐specific cytotoxic T cells. Cell Immunol 173: 1–6.</note><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>173</number></detail><extent unit="pages"><start>1</start><end>6</end></extent></part><relatedItem type="host"><titleInfo><title>Cell Immunol</title></titleInfo><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>173</number></detail><extent unit="pages"><start>1</start><end>6</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit21"><titleInfo><title>Avian flu: isolation of drug‐resistant H5N1 virus</title></titleInfo><name type="personal"><namePart type="given">QM</namePart><namePart type="family">Le</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Kiso</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Someya</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">YT</namePart><namePart type="family">Sakai</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TH</namePart><namePart type="family">Nguyen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KH</namePart><namePart type="family">Nguyen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">ND</namePart><namePart type="family">Pham</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">HH</namePart><namePart type="family">Ngyen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Yamada</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Muramoto</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Horimoto</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Takada</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Goto</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Suzuki</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Suzuki</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Kawaoka</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Le QM, Kiso M, Someya K, Sakai YT, Nguyen TH, Nguyen KH, Pham ND, Ngyen HH, Yamada S, Muramoto Y, Horimoto T, Takada A, Goto H, Suzuki T, Suzuki Y, Kawaoka Y. 2005. Avian flu: isolation of drug‐resistant H5N1 virus. Nature 437: 1108.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>437</number></detail><extent unit="pages"><start>1108</start></extent></part><relatedItem type="host"><titleInfo><title>Nature</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>437</number></detail><extent unit="pages"><start>1108</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit22"><titleInfo><title>Application of polymeric N‐acetyl‐D‐glucosamine (chitin) to veterinary practice</title></titleInfo><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Okamoto</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Minami</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Matsuhashi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Sashiwa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Saimoto</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Shigemasa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Tanigawa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Tanaka</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Tokura</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Okamoto Y, Minami S, Matsuhashi A, Sashiwa H, Saimoto H, Shigemasa Y, Tanigawa T, Tanaka Y, Tokura S. 1993. Application of polymeric N‐acetyl‐D‐glucosamine (chitin) to veterinary practice. J Vet Med Sci 55: 743–747.</note><part><date>1993</date><detail type="volume"><caption>vol.</caption><number>55</number></detail><extent unit="pages"><start>743</start><end>747</end></extent></part><relatedItem type="host"><titleInfo><title>J Vet Med Sci</title></titleInfo><part><date>1993</date><detail type="volume"><caption>vol.</caption><number>55</number></detail><extent unit="pages"><start>743</start><end>747</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit23"><titleInfo><title>T cell‐ and B cell‐independent adaptive immunity mediated by natural killer cells</title></titleInfo><name type="personal"><namePart type="given">JG</namePart><namePart type="family">O'Leary</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Goodarzi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DL</namePart><namePart type="family">Drayton</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">UH</namePart><namePart type="family">von Andrian</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">O'Leary JG, Goodarzi M, Drayton DL, von Andrian UH. 2006. T cell‐ and B cell‐independent adaptive immunity mediated by natural killer cells. Nat Immunol 7: 507–516.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>7</number></detail><extent unit="pages"><start>507</start><end>516</end></extent></part><relatedItem type="host"><titleInfo><title>Nat Immunol</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>7</number></detail><extent unit="pages"><start>507</start><end>516</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit24"><titleInfo><title>Treatment with chitin microparticles is protective against lung histopathology in a murine asthma model</title></titleInfo><name type="personal"><namePart type="given">C</namePart><namePart type="family">Ozdemir</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Yazi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Aydogan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Akkoc</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">NN</namePart><namePart type="family">Bahceciler</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Strong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">IB</namePart><namePart type="family">Barlan</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ozdemir C, Yazi D, Aydogan M, Akkoc T, Bahceciler NN, Strong P, Barlan IB. 2006. Treatment with chitin microparticles is protective against lung histopathology in a murine asthma model. Clin Exp Allergy 36: 960–968.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>36</number></detail><extent unit="pages"><start>960</start><end>968</end></extent></part><relatedItem type="host"><titleInfo><title>Clin Exp Allergy</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>36</number></detail><extent unit="pages"><start>960</start><end>968</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit25"><titleInfo><title>Re‐emergence of fatal human influenza A subtype H5N1 disease</title></titleInfo><name type="personal"><namePart type="given">JS</namePart><namePart type="family">Peiris</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WC</namePart><namePart type="family">Yu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CW</namePart><namePart type="family">Leung</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CY</namePart><namePart type="family">Cheung</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WF</namePart><namePart type="family">Ng</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JM</namePart><namePart type="family">Nicholls</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TK</namePart><namePart type="family">Ng</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KH</namePart><namePart type="family">Chan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">ST</namePart><namePart type="family">Lai</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WL</namePart><namePart type="family">Lim</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KY</namePart><namePart type="family">Yuen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Guan</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Peiris JS, Yu WC, Leung CW, Cheung CY, Ng WF, Nicholls JM, Ng TK, Chan KH, Lai ST, Lim WL, Yuen KY, Guan Y. 2004. Re‐emergence of fatal human influenza A subtype H5N1 disease. Lancet 363: 617–619.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>363</number></detail><extent unit="pages"><start>617</start><end>619</end></extent></part><relatedItem type="host"><titleInfo><title>Lancet</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>363</number></detail><extent unit="pages"><start>617</start><end>619</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit26"><titleInfo><title>Lethal H5N1 influenza viruses escape host anti‐viral cytokine responses</title></titleInfo><name type="personal"><namePart type="given">SH</namePart><namePart type="family">Seo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Hoffmann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RG</namePart><namePart type="family">Webster</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Seo SH, Hoffmann E, Webster RG. 2002. Lethal H5N1 influenza viruses escape host anti‐viral cytokine responses. Nat Med 8: 950–954.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>8</number></detail><extent unit="pages"><start>950</start><end>954</end></extent></part><relatedItem type="host"><titleInfo><title>Nat Med</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>8</number></detail><extent unit="pages"><start>950</start><end>954</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit27"><titleInfo><title>Immunoregulatory roles of IL‐10 in innate immunity: IL‐10 inhibits macrophage production of IFN‐gamma‐inducing factors but enhances NK cell production of IFN‐gamma</title></titleInfo><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Shibata</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LA</namePart><namePart type="family">Foster</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Kurimoto</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Okamura</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RM</namePart><namePart type="family">Nakamura</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Kawajiri</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JP</namePart><namePart type="family">Justice</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MR</namePart><namePart type="family">Van Scott</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">QN</namePart><namePart type="family">Myrvik</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WJ</namePart><namePart type="family">Metzger</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Shibata Y, Foster LA, Kurimoto M, Okamura H, Nakamura RM, Kawajiri K, Justice JP, Van Scott MR, Myrvik QN, Metzger WJ. 1998. Immunoregulatory roles of IL‐10 in innate immunity: IL‐10 inhibits macrophage production of IFN‐gamma‐inducing factors but enhances NK cell production of IFN‐gamma. J Immunol 161: 4283–4288.</note><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>161</number></detail><extent unit="pages"><start>4283</start><end>4288</end></extent></part><relatedItem type="host"><titleInfo><title>J Immunol</title></titleInfo><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>161</number></detail><extent unit="pages"><start>4283</start><end>4288</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit28"><titleInfo><title>Alveolar macrophage priming by intravenous administration of chitin particles, polymers of N‐acetyl‐D‐glucosamine, in mice</title></titleInfo><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Shibata</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LA</namePart><namePart type="family">Foster</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WJ</namePart><namePart type="family">Metzger</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">QN</namePart><namePart type="family">Myrvik</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Shibata Y, Foster LA, Metzger WJ, Myrvik QN. 1997a. Alveolar macrophage priming by intravenous administration of chitin particles, polymers of N‐acetyl‐D‐glucosamine, in mice. Infect Immun 65: 1734–1741.</note><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>65</number></detail><extent unit="pages"><start>1734</start><end>1741</end></extent></part><relatedItem type="host"><titleInfo><title>Infect Immun</title></titleInfo><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>65</number></detail><extent unit="pages"><start>1734</start><end>1741</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit29"><titleInfo><title>Chitin particle‐induced cell‐mediated immunity is inhibited by soluble mannan: mannose receptor‐mediated phagocytosis initiates IL‐12 production</title></titleInfo><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Shibata</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WJ</namePart><namePart type="family">Metzger</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">QN</namePart><namePart type="family">Myrvik</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Shibata Y, Metzger WJ, Myrvik QN. 1997b. Chitin particle‐induced cell‐mediated immunity is inhibited by soluble mannan: mannose receptor‐mediated phagocytosis initiates IL‐12 production. J Immunol 159: 2462–2467.</note><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>159</number></detail><extent unit="pages"><start>2462</start><end>2467</end></extent></part><relatedItem type="host"><titleInfo><title>J Immunol</title></titleInfo><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>159</number></detail><extent unit="pages"><start>2462</start><end>2467</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit30"><titleInfo><title>Natural killer cells in mouse lung: surface phenotype, target preference, and response to local influenza virus infection</title></titleInfo><name type="personal"><namePart type="given">J</namePart><namePart type="family">Stein‐Streilein</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Bennett</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Mann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V</namePart><namePart type="family">Kumar</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Stein‐Streilein J, Bennett M, Mann D, Kumar V. 1983. Natural killer cells in mouse lung: surface phenotype, target preference, and response to local influenza virus infection. J Immunol 131: 2699–2704.</note><part><date>1983</date><detail type="volume"><caption>vol.</caption><number>131</number></detail><extent unit="pages"><start>2699</start><end>2704</end></extent></part><relatedItem type="host"><titleInfo><title>J Immunol</title></titleInfo><part><date>1983</date><detail type="volume"><caption>vol.</caption><number>131</number></detail><extent unit="pages"><start>2699</start><end>2704</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit31"><titleInfo><title>In vivo treatment of mice and hamsters with antibodies to asialo GM1 increases morbidity and mortality to pulmonary influenza infection</title></titleInfo><name type="personal"><namePart type="given">J</namePart><namePart type="family">Stein‐Streilein</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Guffee</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Stein‐Streilein J, Guffee J. 1986. In vivo treatment of mice and hamsters with antibodies to asialo GM1 increases morbidity and mortality to pulmonary influenza infection. J Immunol 136: 1435–1441.</note><part><date>1986</date><detail type="volume"><caption>vol.</caption><number>136</number></detail><extent unit="pages"><start>1435</start><end>1441</end></extent></part><relatedItem type="host"><titleInfo><title>J Immunol</title></titleInfo><part><date>1986</date><detail type="volume"><caption>vol.</caption><number>136</number></detail><extent unit="pages"><start>1435</start><end>1441</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit32"><titleInfo><title>Intranasal application of chitin microparticles down‐regulates symptoms of allergic hypersensitivity to Dermatophagoides pteronyssinus and Aspergillus fumigatus in murine models of allergy</title></titleInfo><name type="personal"><namePart type="given">P</namePart><namePart type="family">Strong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Clark</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Reid</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Strong P, Clark H, Reid K. 2002. Intranasal application of chitin microparticles down‐regulates symptoms of allergic hypersensitivity to Dermatophagoides pteronyssinus and Aspergillus fumigatus in murine models of allergy. Clin Exp Allergy 32: 1794–1800.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>32</number></detail><extent unit="pages"><start>1794</start><end>1800</end></extent></part><relatedItem type="host"><titleInfo><title>Clin Exp Allergy</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>32</number></detail><extent unit="pages"><start>1794</start><end>1800</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit33"><titleInfo><title>Characterization of an avian influenza A (H5N1) virus isolated from a child with a fatal respiratory illness</title></titleInfo><name type="personal"><namePart type="given">K</namePart><namePart type="family">Subbarao</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Klimov</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Katz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Regnery</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W</namePart><namePart type="family">Lim</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Hall</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Perdue</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Swayne</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Bender</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Huang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Hemphill</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Rowe</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Shaw</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">X</namePart><namePart type="family">Xu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Fukuda</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N</namePart><namePart type="family">Cox</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Subbarao K, Klimov A, Katz J, Regnery H, Lim W, Hall H, Perdue M, Swayne D, Bender C, Huang J, Hemphill M, Rowe T, Shaw M, Xu X, Fukuda K, Cox N. 1998. Characterization of an avian influenza A (H5N1) virus isolated from a child with a fatal respiratory illness. Science 279: 393–396.</note><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>279</number></detail><extent unit="pages"><start>393</start><end>396</end></extent></part><relatedItem type="host"><titleInfo><title>Science</title></titleInfo><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>279</number></detail><extent unit="pages"><start>393</start><end>396</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit34"><titleInfo><title>Avian influenza A (H5N1) in 10 patients in Vietnam</title></titleInfo><name type="personal"><namePart type="given">TH</namePart><namePart type="family">Tran</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TL</namePart><namePart type="family">Nguyen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TD</namePart><namePart type="family">Nguyen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TS</namePart><namePart type="family">Luong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PM</namePart><namePart type="family">Pham</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">VC</namePart><namePart type="family">Nguyen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TS</namePart><namePart type="family">Pham</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CD</namePart><namePart type="family">Vo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TQ</namePart><namePart type="family">Le</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TT</namePart><namePart type="family">Ngo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">BK</namePart><namePart type="family">Dao</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PP</namePart><namePart type="family">Le</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TT</namePart><namePart type="family">Nguyen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TL</namePart><namePart type="family">Hoang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">VT</namePart><namePart type="family">Cao</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TG</namePart><namePart type="family">Le</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DT</namePart><namePart type="family">Nguyen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">HN</namePart><namePart type="family">Le</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KT</namePart><namePart type="family">Nguyen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">HS</namePart><namePart type="family">Le</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">VT</namePart><namePart type="family">Le</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Christiane</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TT</namePart><namePart type="family">Tran</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Menno de</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Schultsz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Cheng</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W</namePart><namePart type="family">Lim</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Horby</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Farrar</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Tran TH, Nguyen TL, Nguyen TD, Luong TS, Pham PM, Nguyen VC, Pham TS, Vo CD, Le TQ, Ngo TT, Dao BK, Le PP, Nguyen TT, Hoang TL, Cao VT, Le TG, Nguyen DT, Le HN, Nguyen KT, Le HS, Le VT, Christiane D, Tran TT, Menno de J, Schultsz C, Cheng P, Lim W, Horby P, Farrar J. 2004. Avian influenza A (H5N1) in 10 patients in Vietnam. N Engl J Med 350: 1179–1188.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>350</number></detail><extent unit="pages"><start>1179</start><end>1188</end></extent></part><relatedItem type="host"><titleInfo><title>N Engl J Med</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>350</number></detail><extent unit="pages"><start>1179</start><end>1188</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit35"><titleInfo><title>Cumulative number of confirmed human cases of avian influenza A/(H5N1) reported to WHO</title></titleInfo><name type="corporate"><namePart>World Health Organization</namePart></name><genre>other</genre><part><date>2007</date></part></relatedItem><identifier type="istex">5543F9EE96157CFDAC3A52FB1076CDBCE1F9805B</identifier><identifier type="ark">ark:/67375/WNG-JVX6427D-7</identifier><identifier type="DOI">10.1002/jmv.20837</identifier><identifier type="ArticleID">JMV20837</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2007 Wiley‐Liss, Inc.</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Converted from (version ) to MODS version 3.6.</recordOrigin><recordCreationDate encoding="w3cdtf">2019-11-15</recordCreationDate></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-JVX6427D-7/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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