Basic Concepts of Vaccine Immunology
Identifieur interne : 000526 ( Istex/Corpus ); précédent : 000525; suivant : 000527Basic Concepts of Vaccine Immunology
Auteurs : Jozef NautaSource :
Abstract
Abstract: Any statistician working in clinical vaccine research must have a good understanding of how vaccines work. Therefore, in this introductionairy chapter the fundamentals of vaccination, the immune system and vaccines are presented. The principle of vaccination is explained, mimicking a natural infection to prime the immune system so that it can fight of quickly infectious organisms it has encountered before. The four major infectious microorganisms are introduced: bacteria, yeasts, protozoa and viruses. It is explained how these organisms replicate, and how they are cleared from the body. The primary defence mechanism of microorganisms – antigenic variation – is discussed. A sketch of the immune system is given so that the reader will understand roughly how it works, including the distinction between the innate and the adaptive immune system. The chapter proceeds with a short section on the basics of tumour immunology. An overview is given of the several types of vaccines for viruses and bacteria, from the first generation live-attenuated vaccines to third generation vaccines like recombinant vector vaccines, DNA vaccines and virus-like particles vaccines. As an example of a parasite vaccine, the state of affairs of malaria vaccine development are discussed. Therapeutic vaccines for noninfectious diseases, a recent development, are briefly touched upon.
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DOI: 10.1007/978-3-642-14691-6_1
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Therefore, in this introductionairy chapter the fundamentals of vaccination, the immune system and vaccines are presented. The principle of vaccination is explained, mimicking a natural infection to prime the immune system so that it can fight of quickly infectious organisms it has encountered before. The four major infectious microorganisms are introduced: bacteria, yeasts, protozoa and viruses. It is explained how these organisms replicate, and how they are cleared from the body. The primary defence mechanism of microorganisms – antigenic variation – is discussed. A sketch of the immune system is given so that the reader will understand roughly how it works, including the distinction between the innate and the adaptive immune system. The chapter proceeds with a short section on the basics of tumour immunology. An overview is given of the several types of vaccines for viruses and bacteria, from the first generation live-attenuated vaccines to third generation vaccines like recombinant vector vaccines, DNA vaccines and virus-like particles vaccines. As an example of a parasite vaccine, the state of affairs of malaria vaccine development are discussed. Therapeutic vaccines for noninfectious diseases, a recent development, are briefly touched upon.</div></front></TEI><istex><corpusName>springer-ebooks</corpusName><author><json:item><name>Jozef Nauta</name><affiliations><json:string>Solvay Pharmaceuticals, Global Statistics, C.J. van Houtenlaan 36, 1381 CP, Weesp, Netherlands</json:string><json:string>E-mail: j.nautaekimp@worldonline.nl</json:string></affiliations></json:item></author><arkIstex>ark:/67375/HCB-1S4Q2FKF-W</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>chapter</json:string></originalGenre><abstract>Abstract: Any statistician working in clinical vaccine research must have a good understanding of how vaccines work. Therefore, in this introductionairy chapter the fundamentals of vaccination, the immune system and vaccines are presented. 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As an example of a parasite vaccine, the state of affairs of malaria vaccine development are discussed. 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An overview is given of the several types of vaccines for viruses and bacteria, from the first generation live-attenuated vaccines to third generation vaccines like recombinant vector vaccines, DNA vaccines and virus-like particles vaccines. As an example of a parasite vaccine, the state of affairs of malaria vaccine development are discussed. Therapeutic vaccines for noninfectious diseases, a recent development, are briefly touched upon.</p></abstract><textClass ana="subject"><keywords scheme="book-subject-collection"><list><label>SUCO11649</label><item><term>Mathematics and Statistics</term></item></list></keywords></textClass><textClass ana="subject"><keywords scheme="book-subject"><list><label>SCS</label><item><term type="Primary">Statistics</term></item><label>SCS0000X</label><item><term type="Secondary" subtype="priority-1">Statistics, general</term></item></list></keywords></textClass><langUsage><language ident="EN"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/HCB-1S4Q2FKF-W/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus springer-ebooks not found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//Springer-Verlag//DTD A++ V2.4//EN" URI="http://devel.springer.de/A++/V2.4/DTD/A++V2.4.dtd" name="istex:docType"></istex:docType><istex:document><Publisher><PublisherInfo><PublisherName>Springer Berlin Heidelberg</PublisherName><PublisherLocation>Berlin, Heidelberg</PublisherLocation><PublisherImprintName>Springer</PublisherImprintName></PublisherInfo><Book Language="En"><BookInfo BookProductType="Monograph" ContainsESM="No" Language="En" MediaType="eBook" NumberingDepth="2" NumberingStyle="ChapterContent" OutputMedium="All" TocLevels="0"><BookID>978-3-642-14691-6</BookID><BookTitle>Statistics in Clinical Vaccine Trials</BookTitle><BookDOI>10.1007/978-3-642-14691-6</BookDOI><BookTitleID>212717</BookTitleID><BookPrintISBN>978-3-642-14690-9</BookPrintISBN><BookElectronicISBN>978-3-642-14691-6</BookElectronicISBN><BookChapterCount>9</BookChapterCount><BookCopyright><CopyrightHolderName>Springer-Verlag Berlin Heidelberg</CopyrightHolderName><CopyrightYear>2011</CopyrightYear></BookCopyright><BookSubjectGroup><BookSubject Code="SCS" Type="Primary">Statistics</BookSubject><BookSubject Code="SCS0000X" Priority="1" Type="Secondary">Statistics, general</BookSubject><SubjectCollection Code="SUCO11649">Mathematics and Statistics</SubjectCollection></BookSubjectGroup></BookInfo><BookHeader><AuthorGroup><Author AffiliationIDS="AffID1"><AuthorName DisplayOrder="Western"><GivenName>Jozef</GivenName><FamilyName>Nauta</FamilyName></AuthorName><Contact><Email>j.nautaekimp@worldonline.nl</Email></Contact></Author><Affiliation ID="AffID1"><OrgDivision>, Global Statistics</OrgDivision><OrgName>Solvay Pharmaceuticals</OrgName><OrgAddress><Street>C.J. van Houtenlaan 36</Street><City>Weesp</City><Postcode>1381 CP</Postcode><Country>Netherlands</Country></OrgAddress></Affiliation></AuthorGroup></BookHeader><Chapter ID="Chap1" Language="En"><ChapterInfo ChapterType="OriginalPaper" ContainsESM="No" Language="En" NumberingDepth="2" NumberingStyle="ChapterContent" OutputMedium="All" TocLevels="0"><ChapterID>1</ChapterID><ChapterNumber>Chapter 1</ChapterNumber><ChapterDOI>10.1007/978-3-642-14691-6_1</ChapterDOI><ChapterSequenceNumber>1</ChapterSequenceNumber><ChapterTitle Language="En">Basic Concepts of Vaccine Immunology</ChapterTitle><ChapterFirstPage>1</ChapterFirstPage><ChapterLastPage>12</ChapterLastPage><ChapterCopyright><CopyrightHolderName>Springer-Verlag Berlin Heidelberg</CopyrightHolderName><CopyrightYear>2011</CopyrightYear></ChapterCopyright><ChapterHistory><RegistrationDate><Year>2010</Year><Month>7</Month><Day>20</Day></RegistrationDate><OnlineDate><Year>2010</Year><Month>9</Month><Day>8</Day></OnlineDate></ChapterHistory><ChapterGrants Type="Regular"><MetadataGrant Grant="OpenAccess"></MetadataGrant><AbstractGrant Grant="OpenAccess"></AbstractGrant><BodyPDFGrant Grant="Restricted"></BodyPDFGrant><BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant><BibliographyGrant Grant="Restricted"></BibliographyGrant><ESMGrant Grant="Restricted"></ESMGrant></ChapterGrants><ChapterContext><BookID>978-3-642-14691-6</BookID><BookTitle>Statistics in Clinical Vaccine Trials</BookTitle></ChapterContext></ChapterInfo><ChapterHeader><AuthorGroup><Author AffiliationIDS="Aff1_1" CorrespondingAffiliationID="Aff1_1"><AuthorName DisplayOrder="Western"><GivenName>Jozef</GivenName><FamilyName>Nauta</FamilyName></AuthorName><Contact><Email>j.nautaekimp@worldonline.nl</Email></Contact></Author><Affiliation ID="Aff1_1"><OrgDivision>Solvay Pharmaceuticals</OrgDivision><OrgName>Global Statistics</OrgName><OrgAddress><Street>C.J. van Houtenlaan 36</Street><Postcode>1381 CP</Postcode><City>Weesp</City><Country>Netherlands</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1_1" Language="En" OutputMedium="Online"><Heading>Abstract</Heading><Para>Any statistician working in clinical vaccine research must have a good understanding of how vaccines work. Therefore, in this introductionairy chapter the fundamentals of vaccination, the immune system and vaccines are presented. The principle of vaccination is explained, mimicking a natural infection to prime the immune system so that it can fight of quickly infectious organisms it has encountered before. The four major infectious microorganisms are introduced: bacteria, yeasts, protozoa and viruses. It is explained how these organisms replicate, and how they are cleared from the body. The primary defence mechanism of microorganisms – antigenic variation – is discussed. A sketch of the immune system is given so that the reader will understand roughly how it works, including the distinction between the innate and the adaptive immune system. The chapter proceeds with a short section on the basics of tumour immunology. An overview is given of the several types of vaccines for viruses and bacteria, from the first generation live-attenuated vaccines to third generation vaccines like recombinant vector vaccines, DNA vaccines and virus-like particles vaccines. As an example of a parasite vaccine, the state of affairs of malaria vaccine development are discussed. Therapeutic vaccines for noninfectious diseases, a recent development, are briefly touched upon.</Para></Abstract></ChapterHeader><NoBody></NoBody></Chapter></Book></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Basic Concepts of Vaccine Immunology</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Basic Concepts of Vaccine Immunology</title></titleInfo><name type="personal" displayLabel="corresp"><namePart type="given">Jozef</namePart><namePart type="family">Nauta</namePart><affiliation>Solvay Pharmaceuticals, Global Statistics, C.J. van Houtenlaan 36, 1381 CP, Weesp, Netherlands</affiliation><affiliation>E-mail: j.nautaekimp@worldonline.nl</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="chapter" displayLabel="chapter" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-CGT4WMJM-6"></genre><originInfo><publisher>Springer Berlin Heidelberg</publisher><place><placeTerm type="text">Berlin, Heidelberg</placeTerm></place><dateIssued encoding="w3cdtf">2011</dateIssued><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Abstract: Any statistician working in clinical vaccine research must have a good understanding of how vaccines work. 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An overview is given of the several types of vaccines for viruses and bacteria, from the first generation live-attenuated vaccines to third generation vaccines like recombinant vector vaccines, DNA vaccines and virus-like particles vaccines. As an example of a parasite vaccine, the state of affairs of malaria vaccine development are discussed. 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