Prophylaxis and treatment of influenza encephalitis in an experimental mouse model
Identifieur interne : 001C23 ( Istex/Checkpoint ); précédent : 001C22; suivant : 001C24Prophylaxis and treatment of influenza encephalitis in an experimental mouse model
Auteurs : Masayoshi Shinjoh [Japon] ; Takashi Yoshikawa [Japon] ; Yixing Li [Japon] ; Kyoko Shiraishi [Japon] ; Hideaki Ueki [Japon] ; Kuniaki Nerome [Japon]Source :
- Journal of Medical Virology [ 0146-6615 ] ; 2002-07.
Abstract
A mouse model study using mouse brain‐adapted influenza A virus was performed to establish the prophylaxis and treatment of influenza encephalitis and encephalopathy. All mice died after intranasal inoculation of the brain‐adapted influenza A virus (H7N3), and the pathological findings indicated the presence of significant encephalitis. Viral antigen was also detected in the brain, both pathologically and virologically. By contrast, infected mice immunized with inactivated vaccine of the same strain did not lose weight, which is an indicator of the overall condition of the mice, and all of them survived. Similarly, antiserum treatment in the early period (0–1 day post‐infection) resulted in 100% survival, and no pathological findings were observed in the brain. However, mice treated with antiserum 3 days post‐infection showed encephalitis with viral antigens in both glial cells and neurocytes. Although amantadine treatment for 4 days delayed weight loss, it did not prevent death from encephalitis. These results show vaccination and early antiserum treatment to be highly effective, whereas 4‐day treatment of amantadine was not very effective in treating or preventing influenza encephalitis. The life‐prolonging effect of amantadine, however, suggests that use of amantadine together with other treatments may inhibit the progression of encephalitis. J. Med. Virol. 67:406–417, 2002. © 2002 Wiley‐Liss, Inc.
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DOI: 10.1002/jmv.10088
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type="abstract" xml:lang="en">A mouse model study using mouse brain‐adapted influenza A virus was performed to establish the prophylaxis and treatment of influenza encephalitis and encephalopathy. All mice died after intranasal inoculation of the brain‐adapted influenza A virus (H7N3), and the pathological findings indicated the presence of significant encephalitis. Viral antigen was also detected in the brain, both pathologically and virologically. By contrast, infected mice immunized with inactivated vaccine of the same strain did not lose weight, which is an indicator of the overall condition of the mice, and all of them survived. Similarly, antiserum treatment in the early period (0–1 day post‐infection) resulted in 100% survival, and no pathological findings were observed in the brain. However, mice treated with antiserum 3 days post‐infection showed encephalitis with viral antigens in both glial cells and neurocytes. Although amantadine treatment for 4 days delayed weight loss, it did not prevent death from encephalitis. These results show vaccination and early antiserum treatment to be highly effective, whereas 4‐day treatment of amantadine was not very effective in treating or preventing influenza encephalitis. The life‐prolonging effect of amantadine, however, suggests that use of amantadine together with other treatments may inhibit the progression of encephalitis. J. Med. Virol. 67:406–417, 2002. © 2002 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>Japon</li></country><region><li>Région de Kantō</li></region><settlement><li>Tokyo</li></settlement></list><tree><country name="Japon"><region name="Région de Kantō"><name sortKey="Shinjoh, Masayoshi" sort="Shinjoh, Masayoshi" uniqKey="Shinjoh M" first="Masayoshi" last="Shinjoh">Masayoshi Shinjoh</name></region><name sortKey="Li, Yixing" sort="Li, Yixing" uniqKey="Li Y" first="Yixing" last="Li">Yixing Li</name><name sortKey="Nerome, Kuniaki" sort="Nerome, Kuniaki" uniqKey="Nerome K" first="Kuniaki" last="Nerome">Kuniaki Nerome</name><name sortKey="Shinjoh, Masayoshi" sort="Shinjoh, Masayoshi" uniqKey="Shinjoh M" first="Masayoshi" last="Shinjoh">Masayoshi Shinjoh</name><name sortKey="Shinjoh, Masayoshi" sort="Shinjoh, Masayoshi" uniqKey="Shinjoh M" first="Masayoshi" last="Shinjoh">Masayoshi Shinjoh</name><name sortKey="Shinjoh, Masayoshi" sort="Shinjoh, Masayoshi" uniqKey="Shinjoh M" first="Masayoshi" last="Shinjoh">Masayoshi Shinjoh</name><name sortKey="Shiraishi, Kyoko" sort="Shiraishi, Kyoko" uniqKey="Shiraishi K" first="Kyoko" last="Shiraishi">Kyoko Shiraishi</name><name sortKey="Ueki, Hideaki" sort="Ueki, Hideaki" uniqKey="Ueki H" first="Hideaki" last="Ueki">Hideaki Ueki</name><name sortKey="Yoshikawa, Takashi" sort="Yoshikawa, Takashi" uniqKey="Yoshikawa T" first="Takashi" last="Yoshikawa">Takashi Yoshikawa</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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