Prophylaxis and treatment of influenza encephalitis in an experimental mouse model
Identifieur interne : 000987 ( Istex/Corpus ); précédent : 000986; suivant : 000988Prophylaxis and treatment of influenza encephalitis in an experimental mouse model
Auteurs : Masayoshi Shinjoh ; Takashi Yoshikawa ; Yixing Li ; Kyoko Shiraishi ; Hideaki Ueki ; Kuniaki NeromeSource :
- Journal of Medical Virology [ 0146-6615 ] ; 2002-07.
Abstract
A mouse model study using mouse brain‐adapted influenza A virus was performed to establish the prophylaxis and treatment of influenza encephalitis and encephalopathy. All mice died after intranasal inoculation of the brain‐adapted influenza A virus (H7N3), and the pathological findings indicated the presence of significant encephalitis. Viral antigen was also detected in the brain, both pathologically and virologically. By contrast, infected mice immunized with inactivated vaccine of the same strain did not lose weight, which is an indicator of the overall condition of the mice, and all of them survived. Similarly, antiserum treatment in the early period (0–1 day post‐infection) resulted in 100% survival, and no pathological findings were observed in the brain. However, mice treated with antiserum 3 days post‐infection showed encephalitis with viral antigens in both glial cells and neurocytes. Although amantadine treatment for 4 days delayed weight loss, it did not prevent death from encephalitis. These results show vaccination and early antiserum treatment to be highly effective, whereas 4‐day treatment of amantadine was not very effective in treating or preventing influenza encephalitis. The life‐prolonging effect of amantadine, however, suggests that use of amantadine together with other treatments may inhibit the progression of encephalitis. J. Med. Virol. 67:406–417, 2002. © 2002 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/jmv.10088
Links to Exploration step
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<front><div type="abstract" xml:lang="en">A mouse model study using mouse brain‐adapted influenza A virus was performed to establish the prophylaxis and treatment of influenza encephalitis and encephalopathy. All mice died after intranasal inoculation of the brain‐adapted influenza A virus (H7N3), and the pathological findings indicated the presence of significant encephalitis. Viral antigen was also detected in the brain, both pathologically and virologically. By contrast, infected mice immunized with inactivated vaccine of the same strain did not lose weight, which is an indicator of the overall condition of the mice, and all of them survived. Similarly, antiserum treatment in the early period (0–1 day post‐infection) resulted in 100% survival, and no pathological findings were observed in the brain. However, mice treated with antiserum 3 days post‐infection showed encephalitis with viral antigens in both glial cells and neurocytes. Although amantadine treatment for 4 days delayed weight loss, it did not prevent death from encephalitis. These results show vaccination and early antiserum treatment to be highly effective, whereas 4‐day treatment of amantadine was not very effective in treating or preventing influenza encephalitis. The life‐prolonging effect of amantadine, however, suggests that use of amantadine together with other treatments may inhibit the progression of encephalitis. J. Med. Virol. 67:406–417, 2002. © 2002 Wiley‐Liss, Inc.</div>
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<p>A mouse model study using mouse brain‐adapted influenza A virus was performed to establish the prophylaxis and treatment of influenza encephalitis and encephalopathy. All mice died after intranasal inoculation of the brain‐adapted influenza A virus (H7N3), and the pathological findings indicated the presence of significant encephalitis. Viral antigen was also detected in the brain, both pathologically and virologically. By contrast, infected mice immunized with inactivated vaccine of the same strain did not lose weight, which is an indicator of the overall condition of the mice, and all of them survived. Similarly, antiserum treatment in the early period (0–1 day post‐infection) resulted in 100% survival, and no pathological findings were observed in the brain. However, mice treated with antiserum 3 days post‐infection showed encephalitis with viral antigens in both glial cells and neurocytes. Although amantadine treatment for 4 days delayed weight loss, it did not prevent death from encephalitis. These results show vaccination and early antiserum treatment to be highly effective, whereas 4‐day treatment of amantadine was not very effective in treating or preventing influenza encephalitis. The life‐prolonging effect of amantadine, however, suggests that use of amantadine together with other treatments may inhibit the progression of encephalitis. J. Med. Virol. 67:406–417, 2002. © 2002 Wiley‐Liss, Inc.</p>
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<abstract lang="en">A mouse model study using mouse brain‐adapted influenza A virus was performed to establish the prophylaxis and treatment of influenza encephalitis and encephalopathy. All mice died after intranasal inoculation of the brain‐adapted influenza A virus (H7N3), and the pathological findings indicated the presence of significant encephalitis. Viral antigen was also detected in the brain, both pathologically and virologically. By contrast, infected mice immunized with inactivated vaccine of the same strain did not lose weight, which is an indicator of the overall condition of the mice, and all of them survived. Similarly, antiserum treatment in the early period (0–1 day post‐infection) resulted in 100% survival, and no pathological findings were observed in the brain. However, mice treated with antiserum 3 days post‐infection showed encephalitis with viral antigens in both glial cells and neurocytes. Although amantadine treatment for 4 days delayed weight loss, it did not prevent death from encephalitis. These results show vaccination and early antiserum treatment to be highly effective, whereas 4‐day treatment of amantadine was not very effective in treating or preventing influenza encephalitis. The life‐prolonging effect of amantadine, however, suggests that use of amantadine together with other treatments may inhibit the progression of encephalitis. J. Med. Virol. 67:406–417, 2002. © 2002 Wiley‐Liss, Inc.</abstract>
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<relatedItem type="references" displayLabel="cit1"><titleInfo><title>Equilibrium sedimentation of influenza virus in caesium chloride density gradients</title>
</titleInfo>
<name type="personal"><namePart type="given">RD</namePart>
<namePart type="family">Barry</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Barry RD. 1960. Equilibrium sedimentation of influenza virus in caesium chloride density gradients. Aust J Exp Biol 38: 499–508.</note>
<part><date>1960</date>
<detail type="volume"><caption>vol.</caption>
<number>38</number>
</detail>
<extent unit="pages"><start>499</start>
<end>508</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Aust J Exp Biol</title>
</titleInfo>
<part><date>1960</date>
<detail type="volume"><caption>vol.</caption>
<number>38</number>
</detail>
<extent unit="pages"><start>499</start>
<end>508</end>
</extent>
</part>
</relatedItem>
</relatedItem>
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</titleInfo>
<name type="corporate"><namePart>Centers for Diseases Control and Preventions</namePart>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Centers for Diseases Control and Preventions. 1998. Prevention and control of influenza: Recommendations of the advisory committee on immunization practices (ACIP);. MMWR 47: 1–26.</note>
<part><date>1998</date>
<detail type="volume"><caption>vol.</caption>
<number>47</number>
</detail>
<extent unit="pages"><start>1</start>
<end>26</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>MMWR</title>
</titleInfo>
<part><date>1998</date>
<detail type="volume"><caption>vol.</caption>
<number>47</number>
</detail>
<extent unit="pages"><start>1</start>
<end>26</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit3"><titleInfo><title>Flu and the American expeditionary force</title>
</titleInfo>
<name type="personal"><namePart type="given">AW</namePart>
<namePart type="family">Crosby</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>book-chapter</genre>
<relatedItem type="host"><titleInfo><title>Epidemic and peace 1918</title>
</titleInfo>
<originInfo><publisher>Greenwood Press</publisher>
<place><placeTerm type="text">Westport, CT</placeTerm>
</place>
</originInfo>
<part><date>1976</date>
<extent unit="pages"><start>145</start>
<end>170</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit4"><titleInfo><title>Efficacy of combination therapy with AMN, thymosin, α1 and α/β interferon in mice infected with influenza A virus</title>
</titleInfo>
<name type="personal"><namePart type="given">C</namePart>
<namePart type="family">D'Agostini</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">AT</namePart>
<namePart type="family">Palamara</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">C</namePart>
<namePart type="family">Favalli</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Sivilia</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">G</namePart>
<namePart type="family">Febbravo</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">C</namePart>
<namePart type="family">Bue</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">E</namePart>
<namePart type="family">Garaci</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">D'Agostini C, Palamara AT, Favalli C, Sivilia M, Febbravo G, Bue C, Garaci E. 1996. Efficacy of combination therapy with AMN, thymosin, α1 and α/β interferon in mice infected with influenza A virus. Int J Immunopharmacol 18: 95–102.</note>
<part><date>1996</date>
<detail type="volume"><caption>vol.</caption>
<number>18</number>
</detail>
<extent unit="pages"><start>95</start>
<end>102</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Int J Immunopharmacol</title>
</titleInfo>
<part><date>1996</date>
<detail type="volume"><caption>vol.</caption>
<number>18</number>
</detail>
<extent unit="pages"><start>95</start>
<end>102</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit5"><titleInfo><title>Influenza A virus associated with acute encephalopathy</title>
</titleInfo>
<name type="personal"><namePart type="given">L</namePart>
<namePart type="family">Delorme</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">PJ</namePart>
<namePart type="family">Middleton</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Delorme L, Middleton PJ. 1979. Influenza A virus associated with acute encephalopathy. Am J Dis Child 133: 822–824.</note>
<part><date>1979</date>
<detail type="volume"><caption>vol.</caption>
<number>133</number>
</detail>
<extent unit="pages"><start>822</start>
<end>824</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Am J Dis Child</title>
</titleInfo>
<part><date>1979</date>
<detail type="volume"><caption>vol.</caption>
<number>133</number>
</detail>
<extent unit="pages"><start>822</start>
<end>824</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit6"><titleInfo><title>Animal influenza</title>
</titleInfo>
<name type="personal"><namePart type="given">BC</namePart>
<namePart type="family">Easterday</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>book-chapter</genre>
<relatedItem type="host"><titleInfo><title>The influenza viruses and influenza</title>
</titleInfo>
<originInfo><publisher>Academic Press</publisher>
<place><placeTerm type="text">Orlando, FL</placeTerm>
</place>
</originInfo>
<part><date>1975</date>
<extent unit="pages"><start>449</start>
<end>481</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit7"><titleInfo><title>Encephalopathy and pericarditis during an outbreak of influenza</title>
</titleInfo>
<name type="personal"><namePart type="given">JS</namePart>
<namePart type="family">Edelen</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">TR</namePart>
<namePart type="family">Bender</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">TDY</namePart>
<namePart type="family">Chin</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Edelen JS, Bender TR, Chin TDY. 1974. Encephalopathy and pericarditis during an outbreak of influenza. Am J Epidemiol 100: 79–84.</note>
<part><date>1974</date>
<detail type="volume"><caption>vol.</caption>
<number>100</number>
</detail>
<extent unit="pages"><start>79</start>
<end>84</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Am J Epidemiol</title>
</titleInfo>
<part><date>1974</date>
<detail type="volume"><caption>vol.</caption>
<number>100</number>
</detail>
<extent unit="pages"><start>79</start>
<end>84</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit8"><titleInfo><title>Clinical effectiveness of influenza vaccination in Manitoba</title>
</titleInfo>
<name type="personal"><namePart type="given">DS</namePart>
<namePart type="family">Fedson</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">A</namePart>
<namePart type="family">Wajda</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JP</namePart>
<namePart type="family">Nicol</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">GW</namePart>
<namePart type="family">Hammond</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">DL</namePart>
<namePart type="family">Kaiser</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">LL</namePart>
<namePart type="family">Roos</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Fedson DS, Wajda A, Nicol JP, Hammond GW, Kaiser DL, Roos LL. 1993. Clinical effectiveness of influenza vaccination in Manitoba. JAMA 270: 1956–1961.</note>
<part><date>1994</date>
<detail type="volume"><caption>vol.</caption>
<number>270</number>
</detail>
<extent unit="pages"><start>1956</start>
<end>1961</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>JAMA</title>
</titleInfo>
<part><date>1994</date>
<detail type="volume"><caption>vol.</caption>
<number>270</number>
</detail>
<extent unit="pages"><start>1956</start>
<end>1961</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit9"><titleInfo><title>Influenzal encephalopathy and postinfluenzal encephalitis</title>
</titleInfo>
<name type="personal"><namePart type="given">TH</namePart>
<namePart type="family">Flewett</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JG</namePart>
<namePart type="family">Hoult</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Flewett TH, Hoult JG. 1958. Influenzal encephalopathy and postinfluenzal encephalitis. Lancet 2: 11–15.</note>
<part><date>1958</date>
<detail type="volume"><caption>vol.</caption>
<number>2</number>
</detail>
<extent unit="pages"><start>11</start>
<end>15</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Lancet</title>
</titleInfo>
<part><date>1958</date>
<detail type="volume"><caption>vol.</caption>
<number>2</number>
</detail>
<extent unit="pages"><start>11</start>
<end>15</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit10"><titleInfo><title>PCR on cerebrospinal fluid to show influenza‐associated acute encephalopathy or encephalitis</title>
</titleInfo>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Fujimoto</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Kobayashi</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">O</namePart>
<namePart type="family">Uemura</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Iwasa</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">T</namePart>
<namePart type="family">Ando</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">T</namePart>
<namePart type="family">Katoh</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">C</namePart>
<namePart type="family">Nakamura</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">N</namePart>
<namePart type="family">Maki</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">H</namePart>
<namePart type="family">Togari</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Y</namePart>
<namePart type="family">Wada</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Fujimoto S, Kobayashi M, Uemura O, Iwasa M, Ando T, Katoh T, Nakamura C, Maki N, Togari H, Wada Y. 1998. PCR on cerebrospinal fluid to show influenza‐associated acute encephalopathy or encephalitis. Lancet 352: 873–875.</note>
<part><date>1998</date>
<detail type="volume"><caption>vol.</caption>
<number>352</number>
</detail>
<extent unit="pages"><start>873</start>
<end>875</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Lancet</title>
</titleInfo>
<part><date>1998</date>
<detail type="volume"><caption>vol.</caption>
<number>352</number>
</detail>
<extent unit="pages"><start>873</start>
<end>875</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit11"><titleInfo><title>Biological heterogeneity, including systemic replication in mice, of H5N1 influenza A virus isolates from human in Hong Kong</title>
</titleInfo>
<name type="personal"><namePart type="given">P</namePart>
<namePart type="family">Gao</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Watanabe</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">T</namePart>
<namePart type="family">Ito</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">H</namePart>
<namePart type="family">Goto</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Krisna</namePart>
<namePart type="family">Wells</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Mcgregor</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">AJ</namePart>
<namePart type="family">Cooley</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Y</namePart>
<namePart type="family">Kawaoka</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Gao P, Watanabe S, Ito T, Goto H, Wells Krisna, Mcgregor M, Cooley AJ, Kawaoka Y. 1999. Biological heterogeneity, including systemic replication in mice, of H5N1 influenza A virus isolates from human in Hong Kong. J Virol 73: 3184–3189.</note>
<part><date>1999</date>
<detail type="volume"><caption>vol.</caption>
<number>73</number>
</detail>
<extent unit="pages"><start>3184</start>
<end>3189</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Virol</title>
</titleInfo>
<part><date>1999</date>
<detail type="volume"><caption>vol.</caption>
<number>73</number>
</detail>
<extent unit="pages"><start>3184</start>
<end>3189</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit12"><titleInfo><title>The role of interferon in influenza virus tissue tropism</title>
</titleInfo>
<name type="personal"><namePart type="given">A</namePart>
<namePart type="family">Garcia‐Sastre</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">RK</namePart>
<namePart type="family">Durbin</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">H</namePart>
<namePart type="family">Zheng</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">P</namePart>
<namePart type="family">Palese</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">R</namePart>
<namePart type="family">Gertner</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">DE</namePart>
<namePart type="family">Levy</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JE</namePart>
<namePart type="family">Durbin</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Garcia‐Sastre A, Durbin RK, Zheng H, Palese P, Gertner R, Levy DE, Durbin JE. 1998. The role of interferon in influenza virus tissue tropism. J Virol 72: 8550–8558.</note>
<part><date>1998</date>
<detail type="volume"><caption>vol.</caption>
<number>72</number>
</detail>
<extent unit="pages"><start>8550</start>
<end>8558</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Virol</title>
</titleInfo>
<part><date>1998</date>
<detail type="volume"><caption>vol.</caption>
<number>72</number>
</detail>
<extent unit="pages"><start>8550</start>
<end>8558</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit13"><titleInfo><title>Aerozol and intraperitoneal administration of ribavirin and ribavirin triacetate: pharmacokinetics and protection of mice against intracerebral infection with influenza A/WSN virus</title>
</titleInfo>
<name type="personal"><namePart type="given">BE</namePart>
<namePart type="family">Gilbert</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">PR</namePart>
<namePart type="family">Wyde</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">SZ</namePart>
<namePart type="family">Wilson</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">RK</namePart>
<namePart type="family">Robins</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Gilbert BE, Wyde PR, Wilson SZ, Robins RK. 1991. Aerozol and intraperitoneal administration of ribavirin and ribavirin triacetate: pharmacokinetics and protection of mice against intracerebral infection with influenza A/WSN virus. Antimicrob Agents Chemother 35: 1448–1453.</note>
<part><date>1991</date>
<detail type="volume"><caption>vol.</caption>
<number>35</number>
</detail>
<extent unit="pages"><start>1448</start>
<end>1453</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Antimicrob Agents Chemother</title>
</titleInfo>
<part><date>1991</date>
<detail type="volume"><caption>vol.</caption>
<number>35</number>
</detail>
<extent unit="pages"><start>1448</start>
<end>1453</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit14"><titleInfo><title>Maturation of influenza A virus hemagglutinin—estimates of the pH encountered during transport and its regulation by the M2 protein</title>
</titleInfo>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Grambas</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">AJ</namePart>
<namePart type="family">Hay</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Grambas S, Hay AJ. 1992. Maturation of influenza A virus hemagglutinin—estimates of the pH encountered during transport and its regulation by the M2 protein. Virology 190: 11–18.</note>
<part><date>1992</date>
<detail type="volume"><caption>vol.</caption>
<number>190</number>
</detail>
<extent unit="pages"><start>11</start>
<end>18</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Virology</title>
</titleInfo>
<part><date>1992</date>
<detail type="volume"><caption>vol.</caption>
<number>190</number>
</detail>
<extent unit="pages"><start>11</start>
<end>18</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit15"><titleInfo><title>Characterization of influenza A/HongKong/156/97 (H5N1) virus in a mouse model and protective effect of zanamivir on H5N1 infection in mice</title>
</titleInfo>
<name type="personal"><namePart type="given">LV</namePart>
<namePart type="family">Gubareva</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JA</namePart>
<namePart type="family">McCullers</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">RC</namePart>
<namePart type="family">Bethell</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">RG</namePart>
<namePart type="family">Webster</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Gubareva LV, McCullers JA, Bethell RC, Webster RG. 1998. Characterization of influenza A/HongKong/156/97 (H5N1) virus in a mouse model and protective effect of zanamivir on H5N1 infection in mice. J Infect Dis 178: 1592–1596.</note>
<part><date>1998</date>
<detail type="volume"><caption>vol.</caption>
<number>178</number>
</detail>
<extent unit="pages"><start>1592</start>
<end>1596</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Infect Dis</title>
</titleInfo>
<part><date>1998</date>
<detail type="volume"><caption>vol.</caption>
<number>178</number>
</detail>
<extent unit="pages"><start>1592</start>
<end>1596</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit16"><titleInfo><title>The molecular basis of the specific anti‐influenza action of AMN</title>
</titleInfo>
<name type="personal"><namePart type="given">AJ</namePart>
<namePart type="family">Hay</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">AJ</namePart>
<namePart type="family">Wolstenholme</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JJ</namePart>
<namePart type="family">Skehel</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MH</namePart>
<namePart type="family">Smith</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Hay AJ, Wolstenholme AJ, Skehel JJ, Smith MH. 1985. The molecular basis of the specific anti‐influenza action of AMN. EMBO J 4: 3021–3024.</note>
<part><date>1985</date>
<detail type="volume"><caption>vol.</caption>
<number>4</number>
</detail>
<extent unit="pages"><start>3021</start>
<end>3024</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>EMBO J</title>
</titleInfo>
<part><date>1985</date>
<detail type="volume"><caption>vol.</caption>
<number>4</number>
</detail>
<extent unit="pages"><start>3021</start>
<end>3024</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit17"><titleInfo><title>Emergence and transmission of influenza A viruses resistant to AMN and rimantadine</title>
</titleInfo>
<name type="personal"><namePart type="given">FG</namePart>
<namePart type="family">Hayden</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">AJ</namePart>
<namePart type="family">Hay</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Hayden FG, Hay AJ. 1992. Emergence and transmission of influenza A viruses resistant to AMN and rimantadine. Curr Top Microbiol Immunol 176: 119–130.</note>
<part><date>1992</date>
<detail type="volume"><caption>vol.</caption>
<number>176</number>
</detail>
<extent unit="pages"><start>119</start>
<end>130</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Curr Top Microbiol Immunol</title>
</titleInfo>
<part><date>1992</date>
<detail type="volume"><caption>vol.</caption>
<number>176</number>
</detail>
<extent unit="pages"><start>119</start>
<end>130</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit18"><titleInfo><title>Neurologic disorders after Asian influenza</title>
</titleInfo>
<name type="personal"><namePart type="given">FA</namePart>
<namePart type="family">Horner</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Horner FA. 1958. Neurologic disorders after Asian influenza. N Engl J Med 258: 983–985.</note>
<part><date>1958</date>
<detail type="volume"><caption>vol.</caption>
<number>258</number>
</detail>
<extent unit="pages"><start>983</start>
<end>985</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>N Engl J Med</title>
</titleInfo>
<part><date>1958</date>
<detail type="volume"><caption>vol.</caption>
<number>258</number>
</detail>
<extent unit="pages"><start>983</start>
<end>985</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit19"><titleInfo><title>Detection of influenza virus RNA by reverse transcription‐PCR and postinflammatory cytokines in influenza‐virus‐asssociated encephalopathy</title>
</titleInfo>
<name type="personal"><namePart type="given">Y</namePart>
<namePart type="family">Ito</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">T</namePart>
<namePart type="family">Ichiyama</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">H</namePart>
<namePart type="family">Kimura</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Shibata</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">N</namePart>
<namePart type="family">Ishiwada</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">H</namePart>
<namePart type="family">Kuroki</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Furukawa</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">T</namePart>
<namePart type="family">Morishima</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Ito Y, Ichiyama T, Kimura H, Shibata M, Ishiwada N, Kuroki H, Furukawa S, Morishima T. 1999. Detection of influenza virus RNA by reverse transcription‐PCR and postinflammatory cytokines in influenza‐virus‐asssociated encephalopathy. J Med Virol 58: 420–425.</note>
<part><date>1999</date>
<detail type="volume"><caption>vol.</caption>
<number>58</number>
</detail>
<extent unit="pages"><start>420</start>
<end>425</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Med Virol</title>
</titleInfo>
<part><date>1999</date>
<detail type="volume"><caption>vol.</caption>
<number>58</number>
</detail>
<extent unit="pages"><start>420</start>
<end>425</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit20"><titleInfo><title>Growth impairment resulting from expression of influenza virus M2 protein in Saccharomyces cerevisiae; identification of a novel inhibitor of influenza virus</title>
</titleInfo>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Kurtz</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">G</namePart>
<namePart type="family">Luo</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">KM</namePart>
<namePart type="family">Hahnenberger</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">C</namePart>
<namePart type="family">Brooks</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">O</namePart>
<namePart type="family">Gecha</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">K</namePart>
<namePart type="family">Ingalls</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">K</namePart>
<namePart type="family">Numata</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Krystal</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Kurtz S, Luo G, Hahnenberger KM, Brooks C, Gecha O, Ingalls K, Numata K, Krystal M. 1995. Growth impairment resulting from expression of influenza virus M2 protein in Saccharomyces cerevisiae; identification of a novel inhibitor of influenza virus. Antimicrob Agents Chemother 39: 2204–2209.</note>
<part><date>1995</date>
<detail type="volume"><caption>vol.</caption>
<number>39</number>
</detail>
<extent unit="pages"><start>2204</start>
<end>2209</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Antimicrob Agents Chemother</title>
</titleInfo>
<part><date>1995</date>
<detail type="volume"><caption>vol.</caption>
<number>39</number>
</detail>
<extent unit="pages"><start>2204</start>
<end>2209</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit21"><titleInfo><title>Phylogenetic analysis of the entire genome of influenza A (H3N2) viruses from Japan: evidence for genetic reassortment of the six internal genes</title>
</titleInfo>
<name type="personal"><namePart type="given">SE</namePart>
<namePart type="family">Lindstrom</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Y</namePart>
<namePart type="family">Hiromoto</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">R</namePart>
<namePart type="family">Nerome</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">K</namePart>
<namePart type="family">Omoe</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Sugita</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Y</namePart>
<namePart type="family">Yamazaki</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">T</namePart>
<namePart type="family">Takahashi</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">K</namePart>
<namePart type="family">Nerome</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Lindstrom SE, Hiromoto Y, Nerome R, Omoe K, Sugita S, Yamazaki Y, Takahashi T, Nerome K. 1998. Phylogenetic analysis of the entire genome of influenza A (H3N2) viruses from Japan: evidence for genetic reassortment of the six internal genes. J Virol 72: 8021–8031.</note>
<part><date>1998</date>
<detail type="volume"><caption>vol.</caption>
<number>72</number>
</detail>
<extent unit="pages"><start>8021</start>
<end>8031</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Virol</title>
</titleInfo>
<part><date>1998</date>
<detail type="volume"><caption>vol.</caption>
<number>72</number>
</detail>
<extent unit="pages"><start>8021</start>
<end>8031</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit22"><titleInfo><title>A mouse model for the evaluation of pathogenesis and immunity to influenza A (H5N1) viruses isolated from humans</title>
</titleInfo>
<name type="personal"><namePart type="given">X</namePart>
<namePart type="family">Lu</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">TM</namePart>
<namePart type="family">Tumpey</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">T</namePart>
<namePart type="family">Morken</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">SR</namePart>
<namePart type="family">Zaki</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">NJ</namePart>
<namePart type="family">Cox</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JM</namePart>
<namePart type="family">Katz</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Lu X, Tumpey TM, Morken T, Zaki SR, Cox NJ, Katz JM. 1999. A mouse model for the evaluation of pathogenesis and immunity to influenza A (H5N1) viruses isolated from humans. J Virol 73: 5903–5911.</note>
<part><date>1999</date>
<detail type="volume"><caption>vol.</caption>
<number>73</number>
</detail>
<extent unit="pages"><start>5903</start>
<end>5911</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Virol</title>
</titleInfo>
<part><date>1999</date>
<detail type="volume"><caption>vol.</caption>
<number>73</number>
</detail>
<extent unit="pages"><start>5903</start>
<end>5911</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit23"><titleInfo><title>Nucleotide sequence of RNA segment 7 and the predicted amino acid sequence of M1 and M2 proteins of FPV/Weybridge (H7N7) and WSN (H1N1) influenza virus</title>
</titleInfo>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Markushin</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">H</namePart>
<namePart type="family">Ghiasi</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">N</namePart>
<namePart type="family">Sokolov</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">A</namePart>
<namePart type="family">Shilov</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">B</namePart>
<namePart type="family">Sinitsin</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">D</namePart>
<namePart type="family">Brown</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">A</namePart>
<namePart type="family">Klimov</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">D</namePart>
<namePart type="family">Nayak</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Markushin S, Ghiasi H, Sokolov N, Shilov A, Sinitsin B, Brown D, Klimov A, Nayak D. 1988. Nucleotide sequence of RNA segment 7 and the predicted amino acid sequence of M1 and M2 proteins of FPV/Weybridge (H7N7) and WSN (H1N1) influenza virus. Virus Res 10: 263–271.</note>
<part><date>1988</date>
<detail type="volume"><caption>vol.</caption>
<number>10</number>
</detail>
<extent unit="pages"><start>263</start>
<end>271</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Virus Res</title>
</titleInfo>
<part><date>1988</date>
<detail type="volume"><caption>vol.</caption>
<number>10</number>
</detail>
<extent unit="pages"><start>263</start>
<end>271</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit24"><titleInfo><title>Antiviral and adjuvant activity of immunomodulator adamantylamide dipeptide</title>
</titleInfo>
<name type="personal"><namePart type="given">KN</namePart>
<namePart type="family">Masihi</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">B</namePart>
<namePart type="family">Rohde‐Schulz</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">K</namePart>
<namePart type="family">Masek</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">B</namePart>
<namePart type="family">Palache</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Masihi KN, Rohde‐Schulz B, Masek K, Palache B. 1992. Antiviral and adjuvant activity of immunomodulator adamantylamide dipeptide. Adv Exp Med Biol 319: 275–286.</note>
<part><date>1992</date>
<detail type="volume"><caption>vol.</caption>
<number>319</number>
</detail>
<extent unit="pages"><start>275</start>
<end>286</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Adv Exp Med Biol</title>
</titleInfo>
<part><date>1992</date>
<detail type="volume"><caption>vol.</caption>
<number>319</number>
</detail>
<extent unit="pages"><start>275</start>
<end>286</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit25"><titleInfo><title>Neurological disorders associated with Asian influenza</title>
</titleInfo>
<name type="personal"><namePart type="given">B</namePart>
<namePart type="family">McConkey</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">RA</namePart>
<namePart type="family">Daws</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">McConkey B, Daws RA. 1958. Neurological disorders associated with Asian influenza. Lancet 2: 15–17.</note>
<part><date>1958</date>
<detail type="volume"><caption>vol.</caption>
<number>2</number>
</detail>
<extent unit="pages"><start>15</start>
<end>17</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Lancet</title>
</titleInfo>
<part><date>1958</date>
<detail type="volume"><caption>vol.</caption>
<number>2</number>
</detail>
<extent unit="pages"><start>15</start>
<end>17</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit26"><titleInfo><title>Orthomyxoviruses</title>
</titleInfo>
<name type="personal"><namePart type="given">BR</namePart>
<namePart type="family">Murphy</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">RG</namePart>
<namePart type="family">Webster</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>book-chapter</genre>
<relatedItem type="host"><titleInfo><title>Field's virology</title>
</titleInfo>
<originInfo><publisher>Lippincott‐Raven</publisher>
<place><placeTerm type="text">Philadelphia</placeTerm>
</place>
</originInfo>
<part><date>1996</date>
<extent unit="pages"><start>1397</start>
<end>1445</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit27"><titleInfo><title>Neurovirulence of influenza virus in mice. II. Mechanism of virulence as studied in a neuroblastoma cell line</title>
</titleInfo>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Nakajima</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">A</namePart>
<namePart type="family">Sugiura</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Nakajima S, Sugiura A. 1980. Neurovirulence of influenza virus in mice. II. Mechanism of virulence as studied in a neuroblastoma cell line. Virology 101: 450–457.</note>
<part><date>1980</date>
<detail type="volume"><caption>vol.</caption>
<number>101</number>
</detail>
<extent unit="pages"><start>450</start>
<end>457</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Virology</title>
</titleInfo>
<part><date>1980</date>
<detail type="volume"><caption>vol.</caption>
<number>101</number>
</detail>
<extent unit="pages"><start>450</start>
<end>457</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit28"><titleInfo><title>The effectiveness of vaccination against influenza in healthy, working adults</title>
</titleInfo>
<name type="personal"><namePart type="given">KL</namePart>
<namePart type="family">Nichol</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">A</namePart>
<namePart type="family">Lind</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">KL</namePart>
<namePart type="family">Margolis</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Murdoch</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">R</namePart>
<namePart type="family">McFadden</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Hauge</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Magnan</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Drake</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Nichol KL, Lind A, Margolis KL, Murdoch M, McFadden R, Hauge M, Magnan S, Drake M. 1995. The effectiveness of vaccination against influenza in healthy, working adults. N Engl J Med 333: 889–893.</note>
<part><date>1995</date>
<detail type="volume"><caption>vol.</caption>
<number>333</number>
</detail>
<extent unit="pages"><start>889</start>
<end>893</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>N Engl J Med</title>
</titleInfo>
<part><date>1995</date>
<detail type="volume"><caption>vol.</caption>
<number>333</number>
</detail>
<extent unit="pages"><start>889</start>
<end>893</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit29"><titleInfo><title>In vivo selection of an influenza A2 strain resistant to AMN</title>
</titleInfo>
<name type="personal"><namePart type="given">JS</namePart>
<namePart type="family">Oxford</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">IS</namePart>
<namePart type="family">Logan</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">CW</namePart>
<namePart type="family">Potter</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Oxford JS, Logan IS, Potter CW. 1970. In vivo selection of an influenza A2 strain resistant to AMN. Nature 226: 82–83.</note>
<part><date>1970</date>
<detail type="volume"><caption>vol.</caption>
<number>226</number>
</detail>
<extent unit="pages"><start>82</start>
<end>83</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Nature</title>
</titleInfo>
<part><date>1970</date>
<detail type="volume"><caption>vol.</caption>
<number>226</number>
</detail>
<extent unit="pages"><start>82</start>
<end>83</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit30"><titleInfo><title>Human infection with influenza H9N2</title>
</titleInfo>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Peiris</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">KY</namePart>
<namePart type="family">Yuen</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">CW</namePart>
<namePart type="family">Leung</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">KH</namePart>
<namePart type="family">Chan</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">PL</namePart>
<namePart type="family">Ip</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">RW</namePart>
<namePart type="family">Lai</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">WK</namePart>
<namePart type="family">Orr</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">KF</namePart>
<namePart type="family">Shortridge</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Peiris M, Yuen KY, Leung CW, Chan KH, Ip PL, Lai RW, Orr WK, Shortridge KF. 1999. Human infection with influenza H9N2. Lancet 354: 916–917.</note>
<part><date>1999</date>
<detail type="volume"><caption>vol.</caption>
<number>354</number>
</detail>
<extent unit="pages"><start>916</start>
<end>917</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Lancet</title>
</titleInfo>
<part><date>1999</date>
<detail type="volume"><caption>vol.</caption>
<number>354</number>
</detail>
<extent unit="pages"><start>916</start>
<end>917</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit31"><titleInfo><title>Effective prophylaxis of influenza A virus pneumonia in mice by topical passive immunotherapy with polyvalent human immunoglobulins or F(ab′) fragments</title>
</titleInfo>
<name type="personal"><namePart type="given">F</namePart>
<namePart type="family">Ramisse</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">FX</namePart>
<namePart type="family">Deramoudt</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Szatanik</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">A</namePart>
<namePart type="family">Blanchi</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">P</namePart>
<namePart type="family">Binder</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">C</namePart>
<namePart type="family">Hannoun</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JM</namePart>
<namePart type="family">Alonso</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Ramisse F, Deramoudt FX, Szatanik M, Blanchi A, Binder P, Hannoun C, Alonso JM. 1998. Effective prophylaxis of influenza A virus pneumonia in mice by topical passive immunotherapy with polyvalent human immunoglobulins or F(ab′) fragments. Clin Exp Immunol 111: 583–587.</note>
<part><date>1998</date>
<detail type="volume"><caption>vol.</caption>
<number>111</number>
</detail>
<extent unit="pages"><start>583</start>
<end>587</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Clin Exp Immunol</title>
</titleInfo>
<part><date>1998</date>
<detail type="volume"><caption>vol.</caption>
<number>111</number>
</detail>
<extent unit="pages"><start>583</start>
<end>587</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit32"><titleInfo><title>1918 influenza, encephalitis lethargica, parkinsonism</title>
</titleInfo>
<name type="personal"><namePart type="given">RT</namePart>
<namePart type="family">Ravenholt</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">WH</namePart>
<namePart type="family">Foege</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Ravenholt RT, Foege WH. 1982. 1918 influenza, encephalitis lethargica, parkinsonism. Lancet 2: 860–864.</note>
<part><date>1982</date>
<detail type="volume"><caption>vol.</caption>
<number>2</number>
</detail>
<extent unit="pages"><start>860</start>
<end>864</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Lancet</title>
</titleInfo>
<part><date>1982</date>
<detail type="volume"><caption>vol.</caption>
<number>2</number>
</detail>
<extent unit="pages"><start>860</start>
<end>864</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit33"><titleInfo><title>Pathogenesis of neurovirulent influenza A virus infection in mice—route of entry of virus into brain determines infection of different populations of cells</title>
</titleInfo>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Reinacher</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">J</namePart>
<namePart type="family">Bonin</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">O</namePart>
<namePart type="family">Narayan</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">C</namePart>
<namePart type="family">Scholtissek</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Reinacher M, Bonin J, Narayan O, Scholtissek C. 1983. Pathogenesis of neurovirulent influenza A virus infection in mice—route of entry of virus into brain determines infection of different populations of cells. Lab Invest 49: 686–692.</note>
<part><date>1983</date>
<detail type="volume"><caption>vol.</caption>
<number>49</number>
</detail>
<extent unit="pages"><start>686</start>
<end>692</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Lab Invest</title>
</titleInfo>
<part><date>1983</date>
<detail type="volume"><caption>vol.</caption>
<number>49</number>
</detail>
<extent unit="pages"><start>686</start>
<end>692</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit34"><titleInfo><title>Influenza A virus associated neurological disorders in Jamaica</title>
</titleInfo>
<name type="personal"><namePart type="given">E</namePart>
<namePart type="family">Rose</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">P</namePart>
<namePart type="family">Prabhakar</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Rose E, Prabhakar P. 1982. Influenza A virus associated neurological disorders in Jamaica. West Indian Med J 31: 29–33.</note>
<part><date>1982</date>
<detail type="volume"><caption>vol.</caption>
<number>31</number>
</detail>
<extent unit="pages"><start>29</start>
<end>33</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>West Indian Med J</title>
</titleInfo>
<part><date>1982</date>
<detail type="volume"><caption>vol.</caption>
<number>31</number>
</detail>
<extent unit="pages"><start>29</start>
<end>33</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit35"><titleInfo><title>The specific inhibition of influenza A virus maturation by AMN; An electron microscopic examination</title>
</titleInfo>
<name type="personal"><namePart type="given">RWH</namePart>
<namePart type="family">Ruigrok</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">EMA</namePart>
<namePart type="family">Hirst</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">AJ</namePart>
<namePart type="family">Hay</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Ruigrok RWH, Hirst EMA, Hay AJ. 1991. The specific inhibition of influenza A virus maturation by AMN; An electron microscopic examination. J Gen Virol 72: 191–194.</note>
<part><date>1991</date>
<detail type="volume"><caption>vol.</caption>
<number>72</number>
</detail>
<extent unit="pages"><start>191</start>
<end>194</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Gen Virol</title>
</titleInfo>
<part><date>1991</date>
<detail type="volume"><caption>vol.</caption>
<number>72</number>
</detail>
<extent unit="pages"><start>191</start>
<end>194</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit36"><titleInfo><title>Inhibition of influenza virus replication in mice by GG167 (4‐guanidino‐2,4‐dideoxy‐2,3‐dehydro‐N‐acetylneuraminic acid) is consistent with extracellular activity of viral neuraminidase (sialidase)</title>
</titleInfo>
<name type="personal"><namePart type="given">DM</namePart>
<namePart type="family">Ryan</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">J</namePart>
<namePart type="family">Ticehurst</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MH</namePart>
<namePart type="family">Dempsey</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">CR</namePart>
<namePart type="family">Penn</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Ryan DM, Ticehurst J, Dempsey MH, Penn CR. 1994. Inhibition of influenza virus replication in mice by GG167 (4‐guanidino‐2,4‐dideoxy‐2,3‐dehydro‐N‐acetylneuraminic acid) is consistent with extracellular activity of viral neuraminidase (sialidase);. Antimicrob Agents Chemother 38: 2270–2275.</note>
<part><date>1994</date>
<detail type="volume"><caption>vol.</caption>
<number>38</number>
</detail>
<extent unit="pages"><start>2270</start>
<end>2275</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Antimicrob Agents Chemother</title>
</titleInfo>
<part><date>1994</date>
<detail type="volume"><caption>vol.</caption>
<number>38</number>
</detail>
<extent unit="pages"><start>2270</start>
<end>2275</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit37"><titleInfo><title>Influenza type A‐associated encephalopathy with bilateral thalamic necrosis in Japan</title>
</titleInfo>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Shinjoh</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Bamba</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">K</namePart>
<namePart type="family">Jozaki</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">E</namePart>
<namePart type="family">Takahashi</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">G</namePart>
<namePart type="family">Koinuma</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">N</namePart>
<namePart type="family">Sugaya</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Shinjoh M, Bamba M, Jozaki K, Takahashi E, Koinuma G, Sugaya N. 2000. Influenza type A‐associated encephalopathy with bilateral thalamic necrosis in Japan. Clin Infect Dis 31: 611–613.</note>
<part><date>2000</date>
<detail type="volume"><caption>vol.</caption>
<number>31</number>
</detail>
<extent unit="pages"><start>611</start>
<end>613</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Clin Infect Dis</title>
</titleInfo>
<part><date>2000</date>
<detail type="volume"><caption>vol.</caption>
<number>31</number>
</detail>
<extent unit="pages"><start>611</start>
<end>613</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit38"><titleInfo><title>Avian influenza virus intranasally inoculated infects the central nervous system of mice through the general visceral afferent nerve</title>
</titleInfo>
<name type="personal"><namePart type="given">K</namePart>
<namePart type="family">Shinya</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">A</namePart>
<namePart type="family">Shimada</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">T</namePart>
<namePart type="family">Ito</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">K</namePart>
<namePart type="family">Otsuki</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">T</namePart>
<namePart type="family">Morita</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">H</namePart>
<namePart type="family">Tanaka</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">A</namePart>
<namePart type="family">Takada</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">H</namePart>
<namePart type="family">Kida</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">T</namePart>
<namePart type="family">Uemura</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Shinya K, Shimada A, Ito T, Otsuki K, Morita T, Tanaka H, Takada A, Kida H, Uemura T. 2000. Avian influenza virus intranasally inoculated infects the central nervous system of mice through the general visceral afferent nerve. Arch Virol 145: 187–195.</note>
<part><date>2000</date>
<detail type="volume"><caption>vol.</caption>
<number>145</number>
</detail>
<extent unit="pages"><start>187</start>
<end>195</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Arch Virol</title>
</titleInfo>
<part><date>2000</date>
<detail type="volume"><caption>vol.</caption>
<number>145</number>
</detail>
<extent unit="pages"><start>187</start>
<end>195</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit39"><titleInfo><title>AMN therapy for influenza type A‐associated encephalopathy</title>
</titleInfo>
<name type="personal"><namePart type="given">N</namePart>
<namePart type="family">Sugaya</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Miura</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Sugaya N, Miura M. 1999. AMN therapy for influenza type A‐associated encephalopathy. Pediatr Infect Dis J 18: 734.</note>
<part><date>1999</date>
<detail type="volume"><caption>vol.</caption>
<number>18</number>
</detail>
<extent unit="pages"><start>734</start>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Pediatr Infect Dis J</title>
</titleInfo>
<part><date>1999</date>
<detail type="volume"><caption>vol.</caption>
<number>18</number>
</detail>
<extent unit="pages"><start>734</start>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit40"><titleInfo><title>Efficacy of inactivated vaccine in preventing antigenically drifted influenza type A and well‐matched type B</title>
</titleInfo>
<name type="personal"><namePart type="given">N</namePart>
<namePart type="family">Sugaya</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">K</namePart>
<namePart type="family">Nerome</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Ishida</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Matsumoto</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">K</namePart>
<namePart type="family">Mitamura</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Nirasawa</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Sugaya N, Nerome K, Ishida M, Matsumoto M, Mitamura K, Nirasawa M. 1994. Efficacy of inactivated vaccine in preventing antigenically drifted influenza type A and well‐matched type B. JAMA 272: 1122–1126.</note>
<part><date>1994</date>
<detail type="volume"><caption>vol.</caption>
<number>272</number>
</detail>
<extent unit="pages"><start>1122</start>
<end>1126</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>JAMA</title>
</titleInfo>
<part><date>1994</date>
<detail type="volume"><caption>vol.</caption>
<number>272</number>
</detail>
<extent unit="pages"><start>1122</start>
<end>1126</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit41"><titleInfo><title>Neurovirulence of influenza virus in mice. I. Neurovirulence of reconbinants between virulent and avirulent virus strains</title>
</titleInfo>
<name type="personal"><namePart type="given">A</namePart>
<namePart type="family">Sugiura</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Ueda</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Sugiura A, Ueda M. 1980. Neurovirulence of influenza virus in mice. I. Neurovirulence of reconbinants between virulent and avirulent virus strains. Virology 101: 440–449.</note>
<part><date>1980</date>
<detail type="volume"><caption>vol.</caption>
<number>101</number>
</detail>
<extent unit="pages"><start>440</start>
<end>449</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Virology</title>
</titleInfo>
<part><date>1980</date>
<detail type="volume"><caption>vol.</caption>
<number>101</number>
</detail>
<extent unit="pages"><start>440</start>
<end>449</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit42"><titleInfo><title>Specific structural alteration of the influenza haemagglutinin by AMN</title>
</titleInfo>
<name type="personal"><namePart type="given">RJ</namePart>
<namePart type="family">Sugrue</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">G</namePart>
<namePart type="family">Bahadur</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MC</namePart>
<namePart type="family">Zambon</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Hall‐Smith</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">AR</namePart>
<namePart type="family">Douglas</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">AJ</namePart>
<namePart type="family">Hay</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Sugrue RJ, Bahadur G, Zambon MC, Hall‐Smith M, Douglas AR, Hay AJ. 1990. Specific structural alteration of the influenza haemagglutinin by AMN. EMBO J 9: 3469–3476.</note>
<part><date>1990</date>
<detail type="volume"><caption>vol.</caption>
<number>9</number>
</detail>
<extent unit="pages"><start>3469</start>
<end>3476</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>EMBO J</title>
</titleInfo>
<part><date>1990</date>
<detail type="volume"><caption>vol.</caption>
<number>9</number>
</detail>
<extent unit="pages"><start>3469</start>
<end>3476</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit43"><titleInfo><title>Excess mortality from influenza epidemics in Japan, 1980–1994. [In Japanese.]</title>
</titleInfo>
<name type="personal"><namePart type="given">T</namePart>
<namePart type="family">Tachibana</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">K</namePart>
<namePart type="family">Kawaminami</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Minowa</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Tachibana T, Kawaminami K, Minowa M. 1999. Excess mortality from influenza epidemics in Japan, 1980–1994. [In Japanese.]; Nippon Koshu Eisei Zassi 46: 263–274.</note>
<part><date>1999</date>
<detail type="volume"><caption>vol.</caption>
<number>46</number>
</detail>
<extent unit="pages"><start>263</start>
<end>274</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Nippon Koshu Eisei Zassi</title>
</titleInfo>
<part><date>1999</date>
<detail type="volume"><caption>vol.</caption>
<number>46</number>
</detail>
<extent unit="pages"><start>263</start>
<end>274</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit44"><titleInfo><title>The substantia nigra is a major target for neurovirulent influenza A virus</title>
</titleInfo>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Takahashi</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">T</namePart>
<namePart type="family">Yamada</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Nakajima</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">K</namePart>
<namePart type="family">Nakajima</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">T</namePart>
<namePart type="family">Yamamoto</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">H</namePart>
<namePart type="family">Okada</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Takahashi M, Yamada T, Nakajima S, Nakajima K, Yamamoto T, Okada H. 1995. The substantia nigra is a major target for neurovirulent influenza A virus. J Exp Med 181: 2161–2169.</note>
<part><date>1995</date>
<detail type="volume"><caption>vol.</caption>
<number>181</number>
</detail>
<extent unit="pages"><start>2161</start>
<end>2169</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Exp Med</title>
</titleInfo>
<part><date>1995</date>
<detail type="volume"><caption>vol.</caption>
<number>181</number>
</detail>
<extent unit="pages"><start>2161</start>
<end>2169</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit45"><titleInfo><title>Isolation of influenza virus “A/Hong Kong/1/68 (H3N2)” from liquor cerebrospinalis of patients with CNS involvement. [In German.]</title>
</titleInfo>
<name type="personal"><namePart type="given">O</namePart>
<namePart type="family">Thraenhart</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">G</namePart>
<namePart type="family">Schley</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">E</namePart>
<namePart type="family">Kuwert</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Thraenhart O, Schley G, Kuwert E. 1975. Isolation of influenza virus “A/Hong Kong/1/68 (H3N2)” from liquor cerebrospinalis of patients with CNS involvement. [In German.]; Med Klin 70: 1910–1914.</note>
<part><date>1975</date>
<detail type="volume"><caption>vol.</caption>
<number>70</number>
</detail>
<extent unit="pages"><start>1910</start>
<end>1914</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Med Klin</title>
</titleInfo>
<part><date>1975</date>
<detail type="volume"><caption>vol.</caption>
<number>70</number>
</detail>
<extent unit="pages"><start>1910</start>
<end>1914</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit46"><titleInfo><title>Antivirals for the chemoprophylaxis and treatment of influenza</title>
</titleInfo>
<name type="personal"><namePart type="given">LP</namePart>
<namePart type="family">Van Voris</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">PM</namePart>
<namePart type="family">Newell</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Van Voris LP, Newell PM. 1992. Antivirals for the chemoprophylaxis and treatment of influenza. Semin Respir Infect 7: 61–70.</note>
<part><date>1992</date>
<detail type="volume"><caption>vol.</caption>
<number>7</number>
</detail>
<extent unit="pages"><start>61</start>
<end>70</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Semin Respir Infect</title>
</titleInfo>
<part><date>1992</date>
<detail type="volume"><caption>vol.</caption>
<number>7</number>
</detail>
<extent unit="pages"><start>61</start>
<end>70</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit47"><titleInfo><title>AMN and ribavirin aerosol treatment of influenza A and B infection in mice</title>
</titleInfo>
<name type="personal"><namePart type="given">SZ</namePart>
<namePart type="family">Wilson</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">V</namePart>
<namePart type="family">Knight</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">PR</namePart>
<namePart type="family">Wyde</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Drake</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">RB</namePart>
<namePart type="family">Couch</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Wilson SZ, Knight V, Wyde PR, Drake S, Couch RB. 1980. AMN and ribavirin aerosol treatment of influenza A and B infection in mice. Antimicrob Agents Chemother 17: 642–648.</note>
<part><date>1980</date>
<detail type="volume"><caption>vol.</caption>
<number>17</number>
</detail>
<extent unit="pages"><start>642</start>
<end>648</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Antimicrob Agents Chemother</title>
</titleInfo>
<part><date>1980</date>
<detail type="volume"><caption>vol.</caption>
<number>17</number>
</detail>
<extent unit="pages"><start>642</start>
<end>648</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit48"><titleInfo><title>Clinical features and rapid viral diagnosis of human disease associated with avian influenza A H5N1 virus</title>
</titleInfo>
<name type="personal"><namePart type="given">KY</namePart>
<namePart type="family">Yuen</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">PKS</namePart>
<namePart type="family">Chan</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Peiris</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">DNC</namePart>
<namePart type="family">Tsang</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">TL</namePart>
<namePart type="family">Que</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">KF</namePart>
<namePart type="family">Shortridge</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">PT</namePart>
<namePart type="family">Cheung</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">WK</namePart>
<namePart type="family">To</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">EFT</namePart>
<namePart type="family">Ho</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">R</namePart>
<namePart type="family">Sung</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">AFB</namePart>
<namePart type="family">Cheng</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="corporate"><namePart>members of the H5N1 study group</namePart>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Yuen KY, Chan PKS, Peiris M, Tsang DNC, Que TL, Shortridge KF, Cheung PT, To WK, Ho EFT, Sung R, Cheng AFB, members of the H5N1 study group. 1998. Clinical features and rapid viral diagnosis of human disease associated with avian influenza A H5N1 virus. Lancet 351: 467–471.</note>
<part><date>1998</date>
<detail type="volume"><caption>vol.</caption>
<number>351</number>
</detail>
<extent unit="pages"><start>467</start>
<end>471</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Lancet</title>
</titleInfo>
<part><date>1998</date>
<detail type="volume"><caption>vol.</caption>
<number>351</number>
</detail>
<extent unit="pages"><start>467</start>
<end>471</end>
</extent>
</part>
</relatedItem>
</relatedItem>
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