7000 year-old tuberculosis cases from Hungary - Osteological and biomolecular evidence.
Identifieur interne : 000192 ( Main/Merge ); précédent : 000191; suivant : 0001937000 year-old tuberculosis cases from Hungary - Osteological and biomolecular evidence.
Auteurs : Muriel Masson [Hongrie] ; Zsolt Bereczki [Hongrie] ; Erika Molnár [Hongrie] ; Helen D. Donoghue [Royaume-Uni] ; David E. Minnikin [Royaume-Uni] ; Oona Y-C Lee [Royaume-Uni] ; Houdini H T. Wu [Royaume-Uni] ; Gurdyal S. Besra [Royaume-Uni] ; Ian D. Bull [Royaume-Uni] ; György Pálfi [Hongrie]Source :
- Tuberculosis (Edinburgh, Scotland) [ 1873-281X ] ; 2015.
Descripteurs français
- Wicri :
- geographic : Hongrie.
English descriptors
- KwdEn :
- Adolescent, Biomarkers (analysis), DNA, Bacterial (genetics), Female, History, Ancient, Humans, Hungary, Infant, Lipids (analysis), Male, Mycobacterium tuberculosis (genetics), Paleopathology, Tuberculosis, Osteoarticular (genetics), Tuberculosis, Osteoarticular (history), Tuberculosis, Spinal (history), Young Adult.
- MESH :
- chemical , analysis : Biomarkers, Lipids.
- chemical , genetics : DNA, Bacterial.
- geographic : Hungary.
- genetics : Mycobacterium tuberculosis, Tuberculosis, Osteoarticular.
- history : Tuberculosis, Osteoarticular, Tuberculosis, Spinal.
- Adolescent, Female, History, Ancient, Humans, Infant, Male, Paleopathology, Young Adult.
Abstract
This study derives from the macroscopic analysis of a Late Neolithic population from Hungary. Remains were recovered from a tell settlement at Hódmezővásárhely-Gorzsa from graves within the settlement as well as pits, ditches, houses and as stray finds. One of the most important discoveries from these remains was evidence of tuberculosis. Pathological analysis of the seventy-one individuals revealed numerous cases of infections and non-specific stress indicators on juveniles and adults, metabolic diseases on juveniles, and evidence of trauma and mechanical changes on adults. Several cases showed potential signs of tuberculosis and further analyses were undertaken, including biomolecular studies. The five individuals were all very young adults and included a striking case of Hypertrophic Pulmonary Osteopathy (HPO) with rib changes, one case with resorptive lesions on the vertebrae, two cases with hypervascularisation on the vertebrae and periosteal remodelling on the ribs, and one case with abnormal blood vessel impressions and a possible lesion on the endocranial surface of the skull. The initial macroscopic diagnosis of these five cases was confirmed by lipid biomarker analyses, and three of them were corroborated by DNA analysis. At present, these 7000-year-old individuals are among the oldest palaeopathological and palaeomicrobiological cases of tuberculosis worldwide.
DOI: 10.1016/j.tube.2015.02.007
PubMed: 25736538
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Donoghue</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Clinical Microbiology and Centre for the History of Medicine, University College London, London, UK. Electronic address: h.donoghue@ucl.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Clinical Microbiology and Centre for the History of Medicine, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Minnikin, David E" sort="Minnikin, David E" uniqKey="Minnikin D" first="David E" last="Minnikin">David E. Minnikin</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, UK. 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Electronic address: h.wu.2@bham.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName><orgName type="university">Université de Birmingham</orgName></affiliation></author><author><name sortKey="Besra, Gurdyal S" sort="Besra, Gurdyal S" uniqKey="Besra G" first="Gurdyal S" last="Besra">Gurdyal S. Besra</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, UK. Electronic address: g.besra@bham.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName><orgName type="university">Université de Birmingham</orgName></affiliation></author><author><name sortKey="Bull, Ian D" sort="Bull, Ian D" uniqKey="Bull I" first="Ian D" last="Bull">Ian D. Bull</name><affiliation wicri:level="1"><nlm:affiliation>Organic Geochemistry Unit, School of Chemistry, University of Bristol, Bristol, UK. Electronic address: ian.d.bull@bristol.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Organic Geochemistry Unit, School of Chemistry, University of Bristol, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Palfi, Gyorgy" sort="Palfi, Gyorgy" uniqKey="Palfi G" first="György" last="Pálfi">György Pálfi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological Anthropology, University of Szeged, Szeged, Hungary. 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Electronic address: mmasson@bio.u-szeged.hu.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Biological Anthropology, University of Szeged, Szeged</wicri:regionArea><wicri:noRegion>Szeged</wicri:noRegion></affiliation></author><author><name sortKey="Bereczki, Zsolt" sort="Bereczki, Zsolt" uniqKey="Bereczki Z" first="Zsolt" last="Bereczki">Zsolt Bereczki</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological Anthropology, University of Szeged, Szeged, Hungary. Electronic address: bereczki.zsolt@bio.u-szeged.hu.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Biological Anthropology, University of Szeged, Szeged</wicri:regionArea><wicri:noRegion>Szeged</wicri:noRegion></affiliation></author><author><name sortKey="Molnar, Erika" sort="Molnar, Erika" uniqKey="Molnar E" first="Erika" last="Molnár">Erika Molnár</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological Anthropology, University of Szeged, Szeged, Hungary. Electronic address: balinte@bio.u-szeged.hu.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Biological Anthropology, University of Szeged, Szeged</wicri:regionArea><wicri:noRegion>Szeged</wicri:noRegion></affiliation></author><author><name sortKey="Donoghue, Helen D" sort="Donoghue, Helen D" uniqKey="Donoghue H" first="Helen D" last="Donoghue">Helen D. Donoghue</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Clinical Microbiology and Centre for the History of Medicine, University College London, London, UK. Electronic address: h.donoghue@ucl.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Clinical Microbiology and Centre for the History of Medicine, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Minnikin, David E" sort="Minnikin, David E" uniqKey="Minnikin D" first="David E" last="Minnikin">David E. Minnikin</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, UK. Electronic address: d.e.minnikin@bham.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName><orgName type="university">Université de Birmingham</orgName></affiliation></author><author><name sortKey="Lee, Oona Y C" sort="Lee, Oona Y C" uniqKey="Lee O" first="Oona Y-C" last="Lee">Oona Y-C Lee</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, UK. Electronic address: o.y.lee@bham.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName><orgName type="university">Université de Birmingham</orgName></affiliation></author><author><name sortKey="Wu, Houdini H T" sort="Wu, Houdini H T" uniqKey="Wu H" first="Houdini H T" last="Wu">Houdini H T. Wu</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, UK. Electronic address: h.wu.2@bham.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName><orgName type="university">Université de Birmingham</orgName></affiliation></author><author><name sortKey="Besra, Gurdyal S" sort="Besra, Gurdyal S" uniqKey="Besra G" first="Gurdyal S" last="Besra">Gurdyal S. Besra</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, UK. Electronic address: g.besra@bham.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName><orgName type="university">Université de Birmingham</orgName></affiliation></author><author><name sortKey="Bull, Ian D" sort="Bull, Ian D" uniqKey="Bull I" first="Ian D" last="Bull">Ian D. Bull</name><affiliation wicri:level="1"><nlm:affiliation>Organic Geochemistry Unit, School of Chemistry, University of Bristol, Bristol, UK. Electronic address: ian.d.bull@bristol.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Organic Geochemistry Unit, School of Chemistry, University of Bristol, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Palfi, Gyorgy" sort="Palfi, Gyorgy" uniqKey="Palfi G" first="György" last="Pálfi">György Pálfi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological Anthropology, University of Szeged, Szeged, Hungary. Electronic address: palfigy@bio.u-szeged.hu.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Biological Anthropology, University of Szeged, Szeged</wicri:regionArea><wicri:noRegion>Szeged</wicri:noRegion></affiliation></author></analytic><series><title level="j">Tuberculosis (Edinburgh, Scotland)</title><idno type="eISSN">1873-281X</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Biomarkers (analysis)</term><term>DNA, Bacterial (genetics)</term><term>Female</term><term>History, Ancient</term><term>Humans</term><term>Hungary</term><term>Infant</term><term>Lipids (analysis)</term><term>Male</term><term>Mycobacterium tuberculosis (genetics)</term><term>Paleopathology</term><term>Tuberculosis, Osteoarticular (genetics)</term><term>Tuberculosis, Osteoarticular (history)</term><term>Tuberculosis, Spinal (history)</term><term>Young Adult</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Biomarkers</term><term>Lipids</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>DNA, Bacterial</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Hungary</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Mycobacterium tuberculosis</term><term>Tuberculosis, Osteoarticular</term></keywords><keywords scheme="MESH" qualifier="history" xml:lang="en"><term>Tuberculosis, Osteoarticular</term><term>Tuberculosis, Spinal</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Female</term><term>History, Ancient</term><term>Humans</term><term>Infant</term><term>Male</term><term>Paleopathology</term><term>Young Adult</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Hongrie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study derives from the macroscopic analysis of a Late Neolithic population from Hungary. Remains were recovered from a tell settlement at Hódmezővásárhely-Gorzsa from graves within the settlement as well as pits, ditches, houses and as stray finds. One of the most important discoveries from these remains was evidence of tuberculosis. Pathological analysis of the seventy-one individuals revealed numerous cases of infections and non-specific stress indicators on juveniles and adults, metabolic diseases on juveniles, and evidence of trauma and mechanical changes on adults. Several cases showed potential signs of tuberculosis and further analyses were undertaken, including biomolecular studies. The five individuals were all very young adults and included a striking case of Hypertrophic Pulmonary Osteopathy (HPO) with rib changes, one case with resorptive lesions on the vertebrae, two cases with hypervascularisation on the vertebrae and periosteal remodelling on the ribs, and one case with abnormal blood vessel impressions and a possible lesion on the endocranial surface of the skull. The initial macroscopic diagnosis of these five cases was confirmed by lipid biomarker analyses, and three of them were corroborated by DNA analysis. At present, these 7000-year-old individuals are among the oldest palaeopathological and palaeomicrobiological cases of tuberculosis worldwide.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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