7000 year-old tuberculosis cases from Hungary - Osteological and biomolecular evidence.
Identifieur interne : 000E22 ( Ncbi/Merge ); précédent : 000E21; suivant : 000E237000 year-old tuberculosis cases from Hungary - Osteological and biomolecular evidence.
Auteurs : Muriel Masson [Hongrie] ; Zsolt Bereczki [Hongrie] ; Erika Molnár [Hongrie] ; Helen D. Donoghue [Royaume-Uni] ; David E. Minnikin [Royaume-Uni] ; Oona Y-C Lee [Royaume-Uni] ; Houdini H T. Wu [Royaume-Uni] ; Gurdyal S. Besra [Royaume-Uni] ; Ian D. Bull [Royaume-Uni] ; György Pálfi [Hongrie]Source :
- Tuberculosis (Edinburgh, Scotland) [ 1873-281X ] ; 2015.
Descripteurs français
- Wicri :
- geographic : Hongrie.
English descriptors
- KwdEn :
- Adolescent, Biomarkers (analysis), DNA, Bacterial (genetics), Female, History, Ancient, Humans, Hungary, Infant, Lipids (analysis), Male, Mycobacterium tuberculosis (genetics), Paleopathology, Tuberculosis, Osteoarticular (genetics), Tuberculosis, Osteoarticular (history), Tuberculosis, Spinal (history), Young Adult.
- MESH :
- chemical , analysis : Biomarkers, Lipids.
- chemical , genetics : DNA, Bacterial.
- geographic : Hungary.
- genetics : Mycobacterium tuberculosis, Tuberculosis, Osteoarticular.
- history : Tuberculosis, Osteoarticular, Tuberculosis, Spinal.
- Adolescent, Female, History, Ancient, Humans, Infant, Male, Paleopathology, Young Adult.
Abstract
This study derives from the macroscopic analysis of a Late Neolithic population from Hungary. Remains were recovered from a tell settlement at Hódmezővásárhely-Gorzsa from graves within the settlement as well as pits, ditches, houses and as stray finds. One of the most important discoveries from these remains was evidence of tuberculosis. Pathological analysis of the seventy-one individuals revealed numerous cases of infections and non-specific stress indicators on juveniles and adults, metabolic diseases on juveniles, and evidence of trauma and mechanical changes on adults. Several cases showed potential signs of tuberculosis and further analyses were undertaken, including biomolecular studies. The five individuals were all very young adults and included a striking case of Hypertrophic Pulmonary Osteopathy (HPO) with rib changes, one case with resorptive lesions on the vertebrae, two cases with hypervascularisation on the vertebrae and periosteal remodelling on the ribs, and one case with abnormal blood vessel impressions and a possible lesion on the endocranial surface of the skull. The initial macroscopic diagnosis of these five cases was confirmed by lipid biomarker analyses, and three of them were corroborated by DNA analysis. At present, these 7000-year-old individuals are among the oldest palaeopathological and palaeomicrobiological cases of tuberculosis worldwide.
DOI: 10.1016/j.tube.2015.02.007
PubMed: 25736538
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pubmed:25736538Le document en format XML
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<term>History, Ancient</term>
<term>Humans</term>
<term>Hungary</term>
<term>Infant</term>
<term>Lipids (analysis)</term>
<term>Male</term>
<term>Mycobacterium tuberculosis (genetics)</term>
<term>Paleopathology</term>
<term>Tuberculosis, Osteoarticular (genetics)</term>
<term>Tuberculosis, Osteoarticular (history)</term>
<term>Tuberculosis, Spinal (history)</term>
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<front><div type="abstract" xml:lang="en">This study derives from the macroscopic analysis of a Late Neolithic population from Hungary. Remains were recovered from a tell settlement at Hódmezővásárhely-Gorzsa from graves within the settlement as well as pits, ditches, houses and as stray finds. One of the most important discoveries from these remains was evidence of tuberculosis. Pathological analysis of the seventy-one individuals revealed numerous cases of infections and non-specific stress indicators on juveniles and adults, metabolic diseases on juveniles, and evidence of trauma and mechanical changes on adults. Several cases showed potential signs of tuberculosis and further analyses were undertaken, including biomolecular studies. The five individuals were all very young adults and included a striking case of Hypertrophic Pulmonary Osteopathy (HPO) with rib changes, one case with resorptive lesions on the vertebrae, two cases with hypervascularisation on the vertebrae and periosteal remodelling on the ribs, and one case with abnormal blood vessel impressions and a possible lesion on the endocranial surface of the skull. The initial macroscopic diagnosis of these five cases was confirmed by lipid biomarker analyses, and three of them were corroborated by DNA analysis. At present, these 7000-year-old individuals are among the oldest palaeopathological and palaeomicrobiological cases of tuberculosis worldwide.</div>
</front>
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<Abstract><AbstractText>This study derives from the macroscopic analysis of a Late Neolithic population from Hungary. Remains were recovered from a tell settlement at Hódmezővásárhely-Gorzsa from graves within the settlement as well as pits, ditches, houses and as stray finds. One of the most important discoveries from these remains was evidence of tuberculosis. Pathological analysis of the seventy-one individuals revealed numerous cases of infections and non-specific stress indicators on juveniles and adults, metabolic diseases on juveniles, and evidence of trauma and mechanical changes on adults. Several cases showed potential signs of tuberculosis and further analyses were undertaken, including biomolecular studies. The five individuals were all very young adults and included a striking case of Hypertrophic Pulmonary Osteopathy (HPO) with rib changes, one case with resorptive lesions on the vertebrae, two cases with hypervascularisation on the vertebrae and periosteal remodelling on the ribs, and one case with abnormal blood vessel impressions and a possible lesion on the endocranial surface of the skull. The initial macroscopic diagnosis of these five cases was confirmed by lipid biomarker analyses, and three of them were corroborated by DNA analysis. At present, these 7000-year-old individuals are among the oldest palaeopathological and palaeomicrobiological cases of tuberculosis worldwide.</AbstractText>
<CopyrightInformation>Copyright © 2015 Elsevier Ltd. All rights reserved.</CopyrightInformation>
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<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Masson</LastName>
<ForeName>Muriel</ForeName>
<Initials>M</Initials>
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</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Bereczki</LastName>
<ForeName>Zsolt</ForeName>
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<AffiliationInfo><Affiliation>Department of Biological Anthropology, University of Szeged, Szeged, Hungary. Electronic address: bereczki.zsolt@bio.u-szeged.hu.</Affiliation>
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<Author ValidYN="Y"><LastName>Molnár</LastName>
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</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Lee</LastName>
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</Author>
<Author ValidYN="Y"><LastName>Wu</LastName>
<ForeName>Houdini H T</ForeName>
<Initials>HH</Initials>
<AffiliationInfo><Affiliation>Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, UK. Electronic address: h.wu.2@bham.ac.uk.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Besra</LastName>
<ForeName>Gurdyal S</ForeName>
<Initials>GS</Initials>
<AffiliationInfo><Affiliation>Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, UK. Electronic address: g.besra@bham.ac.uk.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bull</LastName>
<ForeName>Ian D</ForeName>
<Initials>ID</Initials>
<AffiliationInfo><Affiliation>Organic Geochemistry Unit, School of Chemistry, University of Bristol, Bristol, UK. Electronic address: ian.d.bull@bristol.ac.uk.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pálfi</LastName>
<ForeName>György</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Department of Biological Anthropology, University of Szeged, Szeged, Hungary. Electronic address: palfigy@bio.u-szeged.hu.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>MR/K012118/1</GrantID>
<Agency>Medical Research Council</Agency>
<Country>United Kingdom</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016456">Historical Article</PublicationType>
<PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2015</Year>
<Month>02</Month>
<Day>12</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Scotland</Country>
<MedlineTA>Tuberculosis (Edinb)</MedlineTA>
<NlmUniqueID>100971555</NlmUniqueID>
<ISSNLinking>1472-9792</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D015415">Biomarkers</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D004269">DNA, Bacterial</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D008055">Lipids</NameOfSubstance>
</Chemical>
</ChemicalList>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015415" MajorTopicYN="N">Biomarkers</DescriptorName>
<QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName>
</MeshHeading>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D049690" MajorTopicYN="N">History, Ancient</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006814" MajorTopicYN="N" Type="Geographic">Hungary</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008055" MajorTopicYN="N">Lipids</DescriptorName>
<QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009169" MajorTopicYN="N">Mycobacterium tuberculosis</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010164" MajorTopicYN="N">Paleopathology</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014394" MajorTopicYN="N">Tuberculosis, Osteoarticular</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000266" MajorTopicYN="Y">history</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014399" MajorTopicYN="N">Tuberculosis, Spinal</DescriptorName>
<QualifierName UI="Q000266" MajorTopicYN="N">history</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Hungary</Keyword>
<Keyword MajorTopicYN="N">Lipid biomarkers</Keyword>
<Keyword MajorTopicYN="N">Neolithic</Keyword>
<Keyword MajorTopicYN="N">Tuberculosis</Keyword>
<Keyword MajorTopicYN="N">aDNA</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2015</Year>
<Month>3</Month>
<Day>5</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<PubMedPubDate PubStatus="pubmed"><Year>2015</Year>
<Month>3</Month>
<Day>5</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2016</Year>
<Month>3</Month>
<Day>26</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">25736538</ArticleId>
<ArticleId IdType="pii">S1472-9792(15)00008-6</ArticleId>
<ArticleId IdType="doi">10.1016/j.tube.2015.02.007</ArticleId>
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</pubmed>
<affiliations><list><country><li>Hongrie</li>
<li>Royaume-Uni</li>
</country>
<region><li>Angleterre</li>
<li>Grand Londres</li>
<li>Midlands de l'Ouest</li>
</region>
<settlement><li>Birmingham</li>
<li>Londres</li>
</settlement>
<orgName><li>University College de Londres</li>
<li>Université de Birmingham</li>
</orgName>
</list>
<tree><country name="Hongrie"><noRegion><name sortKey="Masson, Muriel" sort="Masson, Muriel" uniqKey="Masson M" first="Muriel" last="Masson">Muriel Masson</name>
</noRegion>
<name sortKey="Bereczki, Zsolt" sort="Bereczki, Zsolt" uniqKey="Bereczki Z" first="Zsolt" last="Bereczki">Zsolt Bereczki</name>
<name sortKey="Molnar, Erika" sort="Molnar, Erika" uniqKey="Molnar E" first="Erika" last="Molnár">Erika Molnár</name>
<name sortKey="Palfi, Gyorgy" sort="Palfi, Gyorgy" uniqKey="Palfi G" first="György" last="Pálfi">György Pálfi</name>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Donoghue, Helen D" sort="Donoghue, Helen D" uniqKey="Donoghue H" first="Helen D" last="Donoghue">Helen D. Donoghue</name>
</region>
<name sortKey="Besra, Gurdyal S" sort="Besra, Gurdyal S" uniqKey="Besra G" first="Gurdyal S" last="Besra">Gurdyal S. Besra</name>
<name sortKey="Bull, Ian D" sort="Bull, Ian D" uniqKey="Bull I" first="Ian D" last="Bull">Ian D. Bull</name>
<name sortKey="Lee, Oona Y C" sort="Lee, Oona Y C" uniqKey="Lee O" first="Oona Y-C" last="Lee">Oona Y-C Lee</name>
<name sortKey="Minnikin, David E" sort="Minnikin, David E" uniqKey="Minnikin D" first="David E" last="Minnikin">David E. Minnikin</name>
<name sortKey="Wu, Houdini H T" sort="Wu, Houdini H T" uniqKey="Wu H" first="Houdini H T" last="Wu">Houdini H T. Wu</name>
</country>
</tree>
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