Rheumatoid arthritis in Cardinal Carlo de' Medici (1595-1666): a confirmed macroscopic, radiologic and molecular diagnosis.
Identifieur interne : 003077 ( Main/Exploration ); précédent : 003076; suivant : 003078Rheumatoid arthritis in Cardinal Carlo de' Medici (1595-1666): a confirmed macroscopic, radiologic and molecular diagnosis.
Auteurs : G. Fornaciari [Italie] ; G. Fontecchio ; L. Ventura ; F. Papola ; I. Trombetta ; V. GiuffraSource :
- Clinical and experimental rheumatology [ 0392-856X ]
Descripteurs français
- Wicri :
- geographic : Italie.
English descriptors
- KwdEn :
- MESH :
- geographic : Italy.
- history : Arthritis, Rheumatoid.
- Famous Persons, History, 17th Century, Humans, Male.
Abstract
The paleopathological study of the skeletal remains belonging to Cardinal Carlo de' Medici (1595-1666), son of Ferdinando I (1549-1609) and Cristina of Lorena (1565-1637), has been presented previously. A diagnosis of Klippel-Feil syndrome, tuberculosis and a polyarthopathy, interpreted as rheumatoid arthritis, was suggested. A revision of this case based on the analysis of the historical documents and of some radiological images of Carlo's bones has been proposed recently; according to the Authors, the Cardinal was affected by the 'Medici syndrome', a combined Psoriatic-DISH arthropathy. This revision offers us the opportunity to discuss this complex case, comparing different points of view, and to present the results of the molecular analyses carried out on Carlo's bone samples. We looked for the genetic risk factors of rheumatoid arthritis (RA) and psoriatic arthritis (PsA). We also searched for the primary candidate genes of RA and PsA, i.e. DR4 or DR1 and Cw6 or DR7 respectively, the latter predisposing also for psoriasis.
PubMed: 22152116
Affiliations:
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Fornaciari</name><affiliation wicri:level="4"><nlm:affiliation>Department of Oncology, Transplants and Advanced Technologies in Medicine, Division of Paleopathology, History of Medicine and Bioethics, University of Pisa, Italy. g.fornaciari@med.unipi.it</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Oncology, Transplants and Advanced Technologies in Medicine, Division of Paleopathology, History of Medicine and Bioethics, University of Pisa</wicri:regionArea><placeName><settlement type="city">Pise</settlement><region type="region" nuts="2">Toscane</region></placeName><orgName type="university">Université de Pise</orgName></affiliation></author><author><name sortKey="Fontecchio, G" sort="Fontecchio, G" uniqKey="Fontecchio G" first="G" last="Fontecchio">G. Fontecchio</name></author><author><name sortKey="Ventura, L" sort="Ventura, L" uniqKey="Ventura L" first="L" last="Ventura">L. 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Fornaciari</name><affiliation wicri:level="4"><nlm:affiliation>Department of Oncology, Transplants and Advanced Technologies in Medicine, Division of Paleopathology, History of Medicine and Bioethics, University of Pisa, Italy. g.fornaciari@med.unipi.it</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Oncology, Transplants and Advanced Technologies in Medicine, Division of Paleopathology, History of Medicine and Bioethics, University of Pisa</wicri:regionArea><placeName><settlement type="city">Pise</settlement><region type="region" nuts="2">Toscane</region></placeName><orgName type="university">Université de Pise</orgName></affiliation></author><author><name sortKey="Fontecchio, G" sort="Fontecchio, G" uniqKey="Fontecchio G" first="G" last="Fontecchio">G. Fontecchio</name></author><author><name sortKey="Ventura, L" sort="Ventura, L" uniqKey="Ventura L" first="L" last="Ventura">L. 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A diagnosis of Klippel-Feil syndrome, tuberculosis and a polyarthopathy, interpreted as rheumatoid arthritis, was suggested. A revision of this case based on the analysis of the historical documents and of some radiological images of Carlo's bones has been proposed recently; according to the Authors, the Cardinal was affected by the 'Medici syndrome', a combined Psoriatic-DISH arthropathy. This revision offers us the opportunity to discuss this complex case, comparing different points of view, and to present the results of the molecular analyses carried out on Carlo's bone samples. We looked for the genetic risk factors of rheumatoid arthritis (RA) and psoriatic arthritis (PsA). We also searched for the primary candidate genes of RA and PsA, i.e. DR4 or DR1 and Cw6 or DR7 respectively, the latter predisposing also for psoriasis.</div></front></TEI><affiliations><list><country><li>Italie</li></country><region><li>Toscane</li></region><settlement><li>Pise</li></settlement><orgName><li>Université de Pise</li></orgName></list><tree><noCountry><name sortKey="Fontecchio, G" sort="Fontecchio, G" uniqKey="Fontecchio G" first="G" last="Fontecchio">G. Fontecchio</name><name sortKey="Giuffra, V" sort="Giuffra, V" uniqKey="Giuffra V" first="V" last="Giuffra">V. Giuffra</name><name sortKey="Papola, F" sort="Papola, F" uniqKey="Papola F" first="F" last="Papola">F. Papola</name><name sortKey="Trombetta, I" sort="Trombetta, I" uniqKey="Trombetta I" first="I" last="Trombetta">I. Trombetta</name><name sortKey="Ventura, L" sort="Ventura, L" uniqKey="Ventura L" first="L" last="Ventura">L. Ventura</name></noCountry><country name="Italie"><region name="Toscane"><name sortKey="Fornaciari, G" sort="Fornaciari, G" uniqKey="Fornaciari G" first="G" last="Fornaciari">G. Fornaciari</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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