Rheumatoid arthritis in Cardinal Carlo de' Medici (1595-1666): a confirmed macroscopic, radiologic and molecular diagnosis.
Identifieur interne : 000B48 ( Ncbi/Merge ); précédent : 000B47; suivant : 000B49Rheumatoid arthritis in Cardinal Carlo de' Medici (1595-1666): a confirmed macroscopic, radiologic and molecular diagnosis.
Auteurs : G. Fornaciari [Italie] ; G. Fontecchio ; L. Ventura ; F. Papola ; I. Trombetta ; V. GiuffraSource :
- Clinical and experimental rheumatology [ 0392-856X ]
Descripteurs français
- Wicri :
- geographic : Italie.
English descriptors
- KwdEn :
- MESH :
- geographic : Italy.
- history : Arthritis, Rheumatoid.
- Famous Persons, History, 17th Century, Humans, Male.
Abstract
The paleopathological study of the skeletal remains belonging to Cardinal Carlo de' Medici (1595-1666), son of Ferdinando I (1549-1609) and Cristina of Lorena (1565-1637), has been presented previously. A diagnosis of Klippel-Feil syndrome, tuberculosis and a polyarthopathy, interpreted as rheumatoid arthritis, was suggested. A revision of this case based on the analysis of the historical documents and of some radiological images of Carlo's bones has been proposed recently; according to the Authors, the Cardinal was affected by the 'Medici syndrome', a combined Psoriatic-DISH arthropathy. This revision offers us the opportunity to discuss this complex case, comparing different points of view, and to present the results of the molecular analyses carried out on Carlo's bone samples. We looked for the genetic risk factors of rheumatoid arthritis (RA) and psoriatic arthritis (PsA). We also searched for the primary candidate genes of RA and PsA, i.e. DR4 or DR1 and Cw6 or DR7 respectively, the latter predisposing also for psoriasis.
PubMed: 22152116
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Fornaciari</name><affiliation wicri:level="4"><nlm:affiliation>Department of Oncology, Transplants and Advanced Technologies in Medicine, Division of Paleopathology, History of Medicine and Bioethics, University of Pisa, Italy. g.fornaciari@med.unipi.it</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Oncology, Transplants and Advanced Technologies in Medicine, Division of Paleopathology, History of Medicine and Bioethics, University of Pisa</wicri:regionArea><placeName><settlement type="city">Pise</settlement><region type="region" nuts="2">Toscane</region></placeName><orgName type="university">Université de Pise</orgName></affiliation></author><author><name sortKey="Fontecchio, G" sort="Fontecchio, G" uniqKey="Fontecchio G" first="G" last="Fontecchio">G. Fontecchio</name></author><author><name sortKey="Ventura, L" sort="Ventura, L" uniqKey="Ventura L" first="L" last="Ventura">L. Ventura</name></author><author><name sortKey="Papola, F" sort="Papola, F" uniqKey="Papola F" first="F" last="Papola">F. Papola</name></author><author><name sortKey="Trombetta, I" sort="Trombetta, I" uniqKey="Trombetta I" first="I" last="Trombetta">I. Trombetta</name></author><author><name sortKey="Giuffra, V" sort="Giuffra, V" uniqKey="Giuffra V" first="V" last="Giuffra">V. Giuffra</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>2012 Jan-Feb</MedlineDate></PubDate></date><idno type="RBID">pubmed:22152116</idno><idno type="pmid">22152116</idno><idno type="wicri:Area/PubMed/Corpus">000299</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000299</idno><idno type="wicri:Area/PubMed/Curation">000299</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000299</idno><idno type="wicri:Area/PubMed/Checkpoint">000299</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000299</idno><idno type="wicri:Area/Ncbi/Merge">000B48</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Rheumatoid arthritis in Cardinal Carlo de' Medici (1595-1666): a confirmed macroscopic, radiologic and molecular diagnosis.</title><author><name sortKey="Fornaciari, G" sort="Fornaciari, G" uniqKey="Fornaciari G" first="G" last="Fornaciari">G. Fornaciari</name><affiliation wicri:level="4"><nlm:affiliation>Department of Oncology, Transplants and Advanced Technologies in Medicine, Division of Paleopathology, History of Medicine and Bioethics, University of Pisa, Italy. g.fornaciari@med.unipi.it</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Oncology, Transplants and Advanced Technologies in Medicine, Division of Paleopathology, History of Medicine and Bioethics, University of Pisa</wicri:regionArea><placeName><settlement type="city">Pise</settlement><region type="region" nuts="2">Toscane</region></placeName><orgName type="university">Université de Pise</orgName></affiliation></author><author><name sortKey="Fontecchio, G" sort="Fontecchio, G" uniqKey="Fontecchio G" first="G" last="Fontecchio">G. Fontecchio</name></author><author><name sortKey="Ventura, L" sort="Ventura, L" uniqKey="Ventura L" first="L" last="Ventura">L. Ventura</name></author><author><name sortKey="Papola, F" sort="Papola, F" uniqKey="Papola F" first="F" last="Papola">F. Papola</name></author><author><name sortKey="Trombetta, I" sort="Trombetta, I" uniqKey="Trombetta I" first="I" last="Trombetta">I. Trombetta</name></author><author><name sortKey="Giuffra, V" sort="Giuffra, V" uniqKey="Giuffra V" first="V" last="Giuffra">V. Giuffra</name></author></analytic><series><title level="j">Clinical and experimental rheumatology</title><idno type="ISSN">0392-856X</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Arthritis, Rheumatoid (history)</term><term>Famous Persons</term><term>History, 17th Century</term><term>Humans</term><term>Italy</term><term>Male</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Italy</term></keywords><keywords scheme="MESH" qualifier="history" xml:lang="en"><term>Arthritis, Rheumatoid</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Famous Persons</term><term>History, 17th Century</term><term>Humans</term><term>Male</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Italie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The paleopathological study of the skeletal remains belonging to Cardinal Carlo de' Medici (1595-1666), son of Ferdinando I (1549-1609) and Cristina of Lorena (1565-1637), has been presented previously. A diagnosis of Klippel-Feil syndrome, tuberculosis and a polyarthopathy, interpreted as rheumatoid arthritis, was suggested. A revision of this case based on the analysis of the historical documents and of some radiological images of Carlo's bones has been proposed recently; according to the Authors, the Cardinal was affected by the 'Medici syndrome', a combined Psoriatic-DISH arthropathy. This revision offers us the opportunity to discuss this complex case, comparing different points of view, and to present the results of the molecular analyses carried out on Carlo's bone samples. We looked for the genetic risk factors of rheumatoid arthritis (RA) and psoriatic arthritis (PsA). We also searched for the primary candidate genes of RA and PsA, i.e. DR4 or DR1 and Cw6 or DR7 respectively, the latter predisposing also for psoriasis.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22152116</PMID><DateCreated><Year>2012</Year><Month>03</Month><Day>13</Day></DateCreated><DateCompleted><Year>2012</Year><Month>07</Month><Day>19</Day></DateCompleted><DateRevised><Year>2017</Year><Month>01</Month><Day>12</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0392-856X</ISSN><JournalIssue CitedMedium="Print"><Volume>30</Volume><Issue>1</Issue><PubDate><MedlineDate>2012 Jan-Feb</MedlineDate></PubDate></JournalIssue><Title>Clinical and experimental rheumatology</Title><ISOAbbreviation>Clin. Exp. Rheumatol.</ISOAbbreviation></Journal><ArticleTitle>Rheumatoid arthritis in Cardinal Carlo de' Medici (1595-1666): a confirmed macroscopic, radiologic and molecular diagnosis.</ArticleTitle><Pagination><MedlinePgn>12-22</MedlinePgn></Pagination><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">The paleopathological study of the skeletal remains belonging to Cardinal Carlo de' Medici (1595-1666), son of Ferdinando I (1549-1609) and Cristina of Lorena (1565-1637), has been presented previously. A diagnosis of Klippel-Feil syndrome, tuberculosis and a polyarthopathy, interpreted as rheumatoid arthritis, was suggested. A revision of this case based on the analysis of the historical documents and of some radiological images of Carlo's bones has been proposed recently; according to the Authors, the Cardinal was affected by the 'Medici syndrome', a combined Psoriatic-DISH arthropathy. This revision offers us the opportunity to discuss this complex case, comparing different points of view, and to present the results of the molecular analyses carried out on Carlo's bone samples. We looked for the genetic risk factors of rheumatoid arthritis (RA) and psoriatic arthritis (PsA). We also searched for the primary candidate genes of RA and PsA, i.e. DR4 or DR1 and Cw6 or DR7 respectively, the latter predisposing also for psoriasis.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">An original molecular protocol was applied to achieve an aDNA uncontaminated by exogenous sources and almost intact, starting from one of the Cardinal's rib pieces. The allele risk factors for both diseases were identified by PCR-SSP assay as HLA genotyping methodology.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Our data assigned Carlo the genotype DRB1*04/*11 for HLA-DRB locus and Cw*04/*12 for HLA-C locus.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Since Carlo was infected by M. tuberculosis during infancy and was carrying the DR4 variant but not the Cw6, he surely had a predisposition to RA, not to PsA and/or psoriasis. The diagnosis of RA is thus confirmed.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Fornaciari</LastName><ForeName>G</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Oncology, Transplants and Advanced Technologies in Medicine, Division of Paleopathology, History of Medicine and Bioethics, University of Pisa, Italy. g.fornaciari@med.unipi.it</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fontecchio</LastName><ForeName>G</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Ventura</LastName><ForeName>L</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Papola</LastName><ForeName>F</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Trombetta</LastName><ForeName>I</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Giuffra</LastName><ForeName>V</ForeName><Initials>V</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D019215">Biography</PublicationType><PublicationType UI="D016456">Historical Article</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2012</Year><Month>03</Month><Day>06</Day></ArticleDate></Article><MedlineJournalInfo><Country>Italy</Country><MedlineTA>Clin Exp Rheumatol</MedlineTA><NlmUniqueID>8308521</NlmUniqueID><ISSNLinking>0392-856X</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D001172" MajorTopicYN="N">Arthritis, Rheumatoid</DescriptorName><QualifierName UI="Q000266" MajorTopicYN="Y">history</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005197" MajorTopicYN="Y">Famous Persons</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D049670" MajorTopicYN="N">History, 17th Century</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007558" MajorTopicYN="N" Type="Geographic">Italy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading></MeshHeadingList><PersonalNameSubjectList><PersonalNameSubject><LastName>de' Medici</LastName><ForeName>Carlo</ForeName><Initials>C</Initials></PersonalNameSubject></PersonalNameSubjectList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2011</Year><Month>07</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2011</Year><Month>09</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>12</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>12</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>7</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">22152116</ArticleId><ArticleId IdType="pii">5258</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Italie</li></country><region><li>Toscane</li></region><settlement><li>Pise</li></settlement><orgName><li>Université de Pise</li></orgName></list><tree><noCountry><name sortKey="Fontecchio, G" sort="Fontecchio, G" uniqKey="Fontecchio G" first="G" last="Fontecchio">G. Fontecchio</name><name sortKey="Giuffra, V" sort="Giuffra, V" uniqKey="Giuffra V" first="V" last="Giuffra">V. Giuffra</name><name sortKey="Papola, F" sort="Papola, F" uniqKey="Papola F" first="F" last="Papola">F. Papola</name><name sortKey="Trombetta, I" sort="Trombetta, I" uniqKey="Trombetta I" first="I" last="Trombetta">I. Trombetta</name><name sortKey="Ventura, L" sort="Ventura, L" uniqKey="Ventura L" first="L" last="Ventura">L. Ventura</name></noCountry><country name="Italie"><region name="Toscane"><name sortKey="Fornaciari, G" sort="Fornaciari, G" uniqKey="Fornaciari G" first="G" last="Fornaciari">G. Fornaciari</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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