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Trabecular bone microarchitecture during growth : three-dimensional normal and pathological variability analyzed by μCT-scan

Identifieur interne : 000193 ( Main/Exploration ); précédent : 000192; suivant : 000194

Trabecular bone microarchitecture during growth : three-dimensional normal and pathological variability analyzed by μCT-scan

Auteurs : Antony Colombo [France]

Source :

RBID : Hal:tel-01161557

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English descriptors

Abstract

Medical imaging and 3D reconstructions are used increasingly by anthropologists; they allow both investigating and preserving internal structures. Study of trabecular bone microarchitecture allows understanding variability of human skeleton at a smaller scale. This variability is observed and characterized in terms of normal growth and maturation according to age and sex, and for several pathological conditions. μCT scans of proximal metaphysis of humerus from 43 immature individuals (coming from 3 identified skeletons collections and representing all periods of age development) and 8 paleopathological cases (corresponding to 5 different etiologies) have been analyzed to quantify bone microarchitecture. Our results show that this microarchitecture varies during and between different phases of growth. Correlations with age are highlighted, even if they do not sufficiently explain the observed variability in order to represent specific age estimators; it nevertheless appears that the variations observed between the different volumes of interest could characterize different periods of growth. The measured variables showed significant sex differences only during the adolescence period, but they cannot be used, in the present state, for sex determination. The study of the trabecular bone microarchitecture of pathological individuals attests of the abnormal development of bone and therefore of their pathological status.

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Le document en format XML

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