Trabecular bone microarchitecture during growth : three-dimensional normal and pathological variability analyzed by μCT-scan
Identifieur interne : 000008 ( Hal/Curation ); précédent : 000007; suivant : 000009Trabecular bone microarchitecture during growth : three-dimensional normal and pathological variability analyzed by μCT-scan
Auteurs : Antony Colombo [France]Source :
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Abstract
Medical imaging and 3D reconstructions are used increasingly by anthropologists; they allow both investigating and preserving internal structures. Study of trabecular bone microarchitecture allows understanding variability of human skeleton at a smaller scale. This variability is observed and characterized in terms of normal growth and maturation according to age and sex, and for several pathological conditions. μCT scans of proximal metaphysis of humerus from 43 immature individuals (coming from 3 identified skeletons collections and representing all periods of age development) and 8 paleopathological cases (corresponding to 5 different etiologies) have been analyzed to quantify bone microarchitecture. Our results show that this microarchitecture varies during and between different phases of growth. Correlations with age are highlighted, even if they do not sufficiently explain the observed variability in order to represent specific age estimators; it nevertheless appears that the variations observed between the different volumes of interest could characterize different periods of growth. The measured variables showed significant sex differences only during the adolescence period, but they cannot be used, in the present state, for sex determination. The study of the trabecular bone microarchitecture of pathological individuals attests of the abnormal development of bone and therefore of their pathological status.
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Study of trabecular bone microarchitecture allows understanding variability of human skeleton at a smaller scale. This variability is observed and characterized in terms of normal growth and maturation according to age and sex, and for several pathological conditions. μCT scans of proximal metaphysis of humerus from 43 immature individuals (coming from 3 identified skeletons collections and representing all periods of age development) and 8 paleopathological cases (corresponding to 5 different etiologies) have been analyzed to quantify bone microarchitecture. Our results show that this microarchitecture varies during and between different phases of growth. Correlations with age are highlighted, even if they do not sufficiently explain the observed variability in order to represent specific age estimators; it nevertheless appears that the variations observed between the different volumes of interest could characterize different periods of growth. The measured variables showed significant sex differences only during the adolescence period, but they cannot be used, in the present state, for sex determination. The study of the trabecular bone microarchitecture of pathological individuals attests of the abnormal development of bone and therefore of their pathological status.</div></front></TEI><hal api="V3"><titleStmt><title xml:lang="en">Trabecular bone microarchitecture during growth : three-dimensional normal and pathological variability analyzed by μCT-scan</title><title xml:lang="fr">La micro-architecture de l'os trabéculaire en croissance : variabilité tridimensionnelle normale et pathologique analysée par microtomodensitométrie</title><author role="aut"><persName><forename type="first">Antony</forename><surname>Colombo</surname></persName><idno type="halauthorid">1173935</idno><idno type="IdRef">http://www.idref.fr/185906346</idno><affiliation ref="#struct-680"></affiliation></author><editor role="depositor"><persName><forename>ABES</forename><surname>STAR</surname></persName><email type="md5">f5aa7f563b02bb6adbba7496989af39a</email><email type="domain">abes.fr</email></editor></titleStmt><editionStmt><edition n="v1" type="current"><date type="whenSubmitted">2015-06-08 16:22:05</date><date type="whenModified">2016-05-27 04:43:26</date><date type="whenReleased">2015-06-08 16:23:03</date><date type="whenProduced">2014-12-15</date><date type="whenEndEmbargoed">2015-06-08</date><ref type="file" target="https://tel.archives-ouvertes.fr/tel-01161557/document"><date notBefore="2015-06-08"></date></ref><ref type="file" subtype="author" n="1" target="https://tel.archives-ouvertes.fr/tel-01161557/file/COLOMBO_ANTONY_2014.pdf"><date notBefore="2015-06-08"></date></ref></edition><respStmt><resp>contributor</resp><name key="131274"><persName><forename>ABES</forename><surname>STAR</surname></persName><email type="md5">f5aa7f563b02bb6adbba7496989af39a</email><email type="domain">abes.fr</email></name></respStmt></editionStmt><publicationStmt><distributor>CCSD</distributor><idno type="halId">tel-01161557</idno><idno type="halUri">https://tel.archives-ouvertes.fr/tel-01161557</idno><idno type="halBibtex">colombo:tel-01161557</idno><idno type="halRefHtml">Anthropologie biologique. Université de Bordeaux, 2014. Français. <NNT : 2014BORD0291></idno><idno type="halRef">Anthropologie biologique. Université de Bordeaux, 2014. Français. <NNT : 2014BORD0291></idno></publicationStmt><seriesStmt><idno type="stamp" n="STAR">STAR - Dépôt national des thèses électroniques</idno><idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno><idno type="stamp" n="U-BORDEAUX">Université de Bordeaux</idno><idno type="stamp" n="SHS">Sciences de l'Homme et de la Société</idno></seriesStmt><notesStmt></notesStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Trabecular bone microarchitecture during growth : three-dimensional normal and pathological variability analyzed by μCT-scan</title><title xml:lang="fr">La micro-architecture de l'os trabéculaire en croissance : variabilité tridimensionnelle normale et pathologique analysée par microtomodensitométrie</title><author role="aut"><persName><forename type="first">Antony</forename><surname>Colombo</surname></persName><idno type="halauthorid">1173935</idno><idno type="IdRef">http://www.idref.fr/185906346</idno><affiliation ref="#struct-680"></affiliation></author></analytic><monogr><idno type="nnt">2014BORD0291</idno><imprint><date type="dateDefended">2014-12-15</date></imprint><authority type="institution">Université de Bordeaux</authority><authority type="school">École doctorale Sciences et Environnements (Pessac, Gironde)</authority><authority type="supervisor">Hélène Coqueugniot</authority><authority type="supervisor">Olivier Dutour</authority><authority type="jury">Anne-Marie Tillier [Président]</authority><authority type="jury">Jean-Jacques Hublin [Rapporteur]</authority><authority type="jury">Frank Rühli [Rapporteur]</authority><authority type="jury">Alain Froment</authority><authority type="jury">György Pálfi</authority><authority type="jury">Michel Panuel</authority><authority type="jury">Bruno Dutailly</authority></monogr></biblStruct></sourceDesc><profileDesc><langUsage><language ident="fr">French</language></langUsage><textClass><keywords scheme="author"><term xml:lang="en">Humerus</term><term xml:lang="en">Paleopathology</term><term xml:lang="en">Human growth and maturation</term><term xml:lang="en">Children</term><term xml:lang="en">Auxology</term><term xml:lang="en"> μCT-scan</term><term xml:lang="en">Trabecular bon e</term><term xml:lang="en">Microarchitecture</term><term xml:lang="fr">Microtomodensitométrie</term><term xml:lang="fr">Os trabéculaire</term><term xml:lang="fr">Micro-architecture</term><term xml:lang="fr">Croissance et maturation</term><term xml:lang="fr">Auxologie</term><term xml:lang="fr">Enfants</term><term xml:lang="fr">Paléopathologie</term></keywords><classCode scheme="halDomain" n="shs.anthro-bio">Humanities and Social Sciences/Biological anthropology</classCode><classCode scheme="halTypology" n="THESE">Theses</classCode></textClass><abstract xml:lang="en">Medical imaging and 3D reconstructions are used increasingly by anthropologists; they allow both investigating and preserving internal structures. Study of trabecular bone microarchitecture allows understanding variability of human skeleton at a smaller scale. This variability is observed and characterized in terms of normal growth and maturation according to age and sex, and for several pathological conditions. μCT scans of proximal metaphysis of humerus from 43 immature individuals (coming from 3 identified skeletons collections and representing all periods of age development) and 8 paleopathological cases (corresponding to 5 different etiologies) have been analyzed to quantify bone microarchitecture. Our results show that this microarchitecture varies during and between different phases of growth. Correlations with age are highlighted, even if they do not sufficiently explain the observed variability in order to represent specific age estimators; it nevertheless appears that the variations observed between the different volumes of interest could characterize different periods of growth. The measured variables showed significant sex differences only during the adolescence period, but they cannot be used, in the present state, for sex determination. The study of the trabecular bone microarchitecture of pathological individuals attests of the abnormal development of bone and therefore of their pathological status.</abstract><abstract xml:lang="fr">L’imagerie médicale et la 3D, en pleine expansion dans le champ de l'anthropologie biologique, permettent d’explorer les structures internes tout en les préservant. L’étude de la micro-architecture osseuse trabéculaire permet d’appréhender la variabilité de l'os humain à une échelle jusqu'à présent peu explorée. Dans le cadre de cette recherche, cette variabilité est analysée et caractérisée en termes de croissance et de maturation, en fonction des critères individuels d’âge et de sexe, ainsi que dans des contextes pathologiques variés. Les images microtomodensitométriques des métaphyses humérales proximales de 43 sujets immatures (provenant de 3 collections ostéologiques de référence et couvrant l’ensemble des âges du développement) et celles de 8 cas paléopathologiques (représentant 5 étiologies différentes) ont été analysées pour quantifier la micro-architecture osseuse trabéculaire. Nos résultats montrent que cette micro-architecture varie pendant et entre les différentes phases de la croissance. Des corrélations avec l’âge sont mises en évidence, si elles n’expliquent pas suffisamment la variabilité observée pour en faire des estimateurs d'âge précis, il apparaît néanmoins que les variations relevées entre les différents volumes d’intérêt pourraient caractériser différentes périodes de la croissance. Les variables mesurées présentent des différences sexuelles significatives pendant l’adolescence, mais ne peuvent pas en l'état être utilisées pour la diagnose sexuelle. L'étude de la microarchitecture trabéculaire osseuse des sujets pathologiques atteste d’un développement anormal de l’os et donc du statut pathologique de l’individu observé.</abstract></profileDesc></hal></record>Pour manipuler ce document sous Unix (Dilib)
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