Gait variability and basal ganglia disorders: stride-to-stride variations of gait cycle timing in Parkinson's disease and Huntington's disease.
Identifieur interne : 004428 ( PubMed/Curation ); précédent : 004427; suivant : 004429Gait variability and basal ganglia disorders: stride-to-stride variations of gait cycle timing in Parkinson's disease and Huntington's disease.
Auteurs : J M Hausdorff [États-Unis] ; M E Cudkowicz ; R. Firtion ; J Y Wei ; A L GoldbergerSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1998.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Basal Ganglia (physiopathology), Basal Ganglia Diseases (diagnosis), Basal Ganglia Diseases (physiopathology), Diagnosis, Differential, Female, Gait (physiology), Humans, Huntington Disease (diagnosis), Huntington Disease (physiopathology), Locomotion (physiology), Male, Middle Aged, Neurologic Examination, Parkinson Disease (diagnosis), Parkinson Disease (physiopathology), Reaction Time (physiology), Reference Values.
- MESH :
- diagnosis : Basal Ganglia Diseases, Huntington Disease, Parkinson Disease.
- physiology : Gait, Locomotion, Reaction Time.
- physiopathology : Basal Ganglia, Basal Ganglia Diseases, Huntington Disease, Parkinson Disease.
- Adult, Aged, Aged, 80 and over, Diagnosis, Differential, Female, Humans, Male, Middle Aged, Neurologic Examination, Reference Values.
Abstract
The basal ganglia are thought to play an important role in regulating motor programs involved in gait and in the fluidity and sequencing of movement. We postulated that the ability to maintain a steady gait, with low stride-to-stride variability of gait cycle timing and its subphases, would be diminished with both Parkinson's disease (PD) and Huntington's disease (HD). To test this hypothesis, we obtained quantitative measures of stride-to-stride variability of gait cycle timing in subjects with PD (n = 15), HD (n = 20), and disease-free controls (n = 16). All measures of gait variability were significantly increased in PD and HD. In subjects with PD and HD, gait variability measures were two and three times that observed in control subjects, respectively. The degree of gait variability correlated with disease severity. In contrast, gait speed was significantly lower in PD, but not in HD, and average gait cycle duration and the time spent in many subphases of the gait cycle were similar in control subjects, HD subjects, and PD subjects. These findings are consistent with a differential control of gait variability, speed, and average gait cycle timing that may have implications for understanding the role of the basal ganglia in locomotor control and for quantitatively assessing gait in clinical settings.
DOI: 10.1002/mds.870130310
PubMed: 9613733
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Firtion</name></author><author><name sortKey="Wei, J Y" sort="Wei, J Y" uniqKey="Wei J" first="J Y" last="Wei">J Y Wei</name></author><author><name sortKey="Goldberger, A L" sort="Goldberger, A L" uniqKey="Goldberger A" first="A L" last="Goldberger">A L Goldberger</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1998">1998</date><idno type="RBID">pubmed:9613733</idno><idno type="pmid">9613733</idno><idno type="doi">10.1002/mds.870130310</idno><idno type="wicri:Area/PubMed/Corpus">004428</idno><idno type="wicri:Area/PubMed/Curation">004428</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Gait variability and basal ganglia disorders: stride-to-stride variations of gait cycle timing in Parkinson's disease and Huntington's disease.</title><author><name sortKey="Hausdorff, J M" sort="Hausdorff, J M" uniqKey="Hausdorff J" first="J M" last="Hausdorff">J M Hausdorff</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts 02215, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts 02215</wicri:regionArea></affiliation></author><author><name sortKey="Cudkowicz, M E" sort="Cudkowicz, M E" uniqKey="Cudkowicz M" first="M E" last="Cudkowicz">M E Cudkowicz</name></author><author><name sortKey="Firtion, R" sort="Firtion, R" uniqKey="Firtion R" first="R" last="Firtion">R. Firtion</name></author><author><name sortKey="Wei, J Y" sort="Wei, J Y" uniqKey="Wei J" first="J Y" last="Wei">J Y Wei</name></author><author><name sortKey="Goldberger, A L" sort="Goldberger, A L" uniqKey="Goldberger A" first="A L" last="Goldberger">A L Goldberger</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="1998" type="published">1998</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Basal Ganglia (physiopathology)</term><term>Basal Ganglia Diseases (diagnosis)</term><term>Basal Ganglia Diseases (physiopathology)</term><term>Diagnosis, Differential</term><term>Female</term><term>Gait (physiology)</term><term>Humans</term><term>Huntington Disease (diagnosis)</term><term>Huntington Disease (physiopathology)</term><term>Locomotion (physiology)</term><term>Male</term><term>Middle Aged</term><term>Neurologic Examination</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (physiopathology)</term><term>Reaction Time (physiology)</term><term>Reference Values</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Basal Ganglia Diseases</term><term>Huntington Disease</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Gait</term><term>Locomotion</term><term>Reaction Time</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Basal Ganglia</term><term>Basal Ganglia Diseases</term><term>Huntington Disease</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Diagnosis, Differential</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neurologic Examination</term><term>Reference Values</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The basal ganglia are thought to play an important role in regulating motor programs involved in gait and in the fluidity and sequencing of movement. We postulated that the ability to maintain a steady gait, with low stride-to-stride variability of gait cycle timing and its subphases, would be diminished with both Parkinson's disease (PD) and Huntington's disease (HD). To test this hypothesis, we obtained quantitative measures of stride-to-stride variability of gait cycle timing in subjects with PD (n = 15), HD (n = 20), and disease-free controls (n = 16). All measures of gait variability were significantly increased in PD and HD. In subjects with PD and HD, gait variability measures were two and three times that observed in control subjects, respectively. The degree of gait variability correlated with disease severity. In contrast, gait speed was significantly lower in PD, but not in HD, and average gait cycle duration and the time spent in many subphases of the gait cycle were similar in control subjects, HD subjects, and PD subjects. These findings are consistent with a differential control of gait variability, speed, and average gait cycle timing that may have implications for understanding the role of the basal ganglia in locomotor control and for quantitatively assessing gait in clinical settings.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">9613733</PMID><DateCreated><Year>1998</Year><Month>08</Month><Day>10</Day></DateCreated><DateCompleted><Year>1998</Year><Month>08</Month><Day>10</Day></DateCompleted><DateRevised><Year>2007</Year><Month>11</Month><Day>14</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>13</Volume><Issue>3</Issue><PubDate><Year>1998</Year><Month>May</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. 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In subjects with PD and HD, gait variability measures were two and three times that observed in control subjects, respectively. The degree of gait variability correlated with disease severity. In contrast, gait speed was significantly lower in PD, but not in HD, and average gait cycle duration and the time spent in many subphases of the gait cycle were similar in control subjects, HD subjects, and PD subjects. 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Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CitationSubset>S</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="ErratumIn"><RefSource>Mov Disord 1998 Jul;13(4):757</RefSource></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000369">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001479">Basal Ganglia</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001480">Basal Ganglia Diseases</DescriptorName><QualifierName MajorTopicYN="Y" 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UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009460">Neurologic Examination</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000175">diagnosis</QualifierName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011930">Reaction Time</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012016">Reference Values</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NASA"><Keyword MajorTopicYN="N">NASA Discipline 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