Deep brain stimulation of the subthalamic nucleus improves intrinsic alertness in Parkinson's disease.
Identifieur interne : 001C49 ( PubMed/Curation ); précédent : 001C48; suivant : 001C50Deep brain stimulation of the subthalamic nucleus improves intrinsic alertness in Parkinson's disease.
Auteurs : Bruno Fimm [Allemagne] ; Ines A. Heber ; Volker A. Coenen ; Christoph Fromm ; Johannes Noth ; Martin KronenbuergerSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2009.
English descriptors
- KwdEn :
- Adult, Aged, Antiparkinson Agents (pharmacology), Antiparkinson Agents (therapeutic use), Attention (drug effects), Attention (physiology), Combined Modality Therapy, Deep Brain Stimulation, Female, Frontal Lobe (drug effects), Frontal Lobe (physiopathology), Humans, Male, Mental Processes (drug effects), Mental Processes (physiology), Middle Aged, Motor Activity (drug effects), Motor Activity (physiology), Neuropsychological Tests, Parietal Lobe (drug effects), Parietal Lobe (physiopathology), Parkinson Disease (drug therapy), Parkinson Disease (psychology), Parkinson Disease (therapy), Psychomotor Performance (drug effects), Psychomotor Performance (physiology), Random Allocation, Severity of Illness Index, Subthalamic Nucleus (drug effects), Subthalamic Nucleus (physiopathology).
- MESH :
- chemical , pharmacology : Antiparkinson Agents.
- chemical , therapeutic use : Antiparkinson Agents.
- drug effects : Attention, Frontal Lobe, Mental Processes, Motor Activity, Parietal Lobe, Psychomotor Performance, Subthalamic Nucleus.
- drug therapy : Parkinson Disease.
- physiology : Attention, Mental Processes, Motor Activity, Psychomotor Performance.
- physiopathology : Frontal Lobe, Parietal Lobe, Subthalamic Nucleus.
- psychology : Parkinson Disease.
- therapy : Parkinson Disease.
- Adult, Aged, Combined Modality Therapy, Deep Brain Stimulation, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Random Allocation, Severity of Illness Index.
Abstract
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a treatment option for patients with Parkinson's disease (PD) in the advanced stage. Besides motor improvement, DBS of the STN may also modulate cognitive and attentional functions of the basal ganglia. In our study, 13 patients with PD and bilateral DBS of the STN were assessed with DBS switched on and off by the use of a wide range of neuropsychological tasks. This included reasoning, cognitive flexibility, phonemic and semantic word fluency, verbal and nonverbal short-term memory, learning, delayed verbal memory recall, and stimulus-response incompatibility. Special emphasis was put on basic attentional functions, in particular intrinsic and phasic alertness as well as visual search. DBS significantly improved intrinsic alertness, whereas phasic alertness and other neuropsychological domains were not affected. Additionally, the effects on intrinsic alertness were independent of motor improvements by DBS. The findings suggest that DBS modulates the fronto-parietal network of alertness.
DOI: 10.1002/mds.22580
PubMed: 19533754
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001C49
Links to Exploration step
pubmed:19533754Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Deep brain stimulation of the subthalamic nucleus improves intrinsic alertness in Parkinson's disease.</title>
<author><name sortKey="Fimm, Bruno" sort="Fimm, Bruno" uniqKey="Fimm B" first="Bruno" last="Fimm">Bruno Fimm</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University Hospital RWTH Aachen, Germany. fimm@neuropsych.rwth-aachen.de</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University Hospital RWTH Aachen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Heber, Ines A" sort="Heber, Ines A" uniqKey="Heber I" first="Ines A" last="Heber">Ines A. Heber</name>
</author>
<author><name sortKey="Coenen, Volker A" sort="Coenen, Volker A" uniqKey="Coenen V" first="Volker A" last="Coenen">Volker A. Coenen</name>
</author>
<author><name sortKey="Fromm, Christoph" sort="Fromm, Christoph" uniqKey="Fromm C" first="Christoph" last="Fromm">Christoph Fromm</name>
</author>
<author><name sortKey="Noth, Johannes" sort="Noth, Johannes" uniqKey="Noth J" first="Johannes" last="Noth">Johannes Noth</name>
</author>
<author><name sortKey="Kronenbuerger, Martin" sort="Kronenbuerger, Martin" uniqKey="Kronenbuerger M" first="Martin" last="Kronenbuerger">Martin Kronenbuerger</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2009">2009</date>
<idno type="doi">10.1002/mds.22580</idno>
<idno type="RBID">pubmed:19533754</idno>
<idno type="pmid">19533754</idno>
<idno type="wicri:Area/PubMed/Corpus">001C49</idno>
<idno type="wicri:Area/PubMed/Curation">001C49</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Deep brain stimulation of the subthalamic nucleus improves intrinsic alertness in Parkinson's disease.</title>
<author><name sortKey="Fimm, Bruno" sort="Fimm, Bruno" uniqKey="Fimm B" first="Bruno" last="Fimm">Bruno Fimm</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University Hospital RWTH Aachen, Germany. fimm@neuropsych.rwth-aachen.de</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University Hospital RWTH Aachen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Heber, Ines A" sort="Heber, Ines A" uniqKey="Heber I" first="Ines A" last="Heber">Ines A. Heber</name>
</author>
<author><name sortKey="Coenen, Volker A" sort="Coenen, Volker A" uniqKey="Coenen V" first="Volker A" last="Coenen">Volker A. Coenen</name>
</author>
<author><name sortKey="Fromm, Christoph" sort="Fromm, Christoph" uniqKey="Fromm C" first="Christoph" last="Fromm">Christoph Fromm</name>
</author>
<author><name sortKey="Noth, Johannes" sort="Noth, Johannes" uniqKey="Noth J" first="Johannes" last="Noth">Johannes Noth</name>
</author>
<author><name sortKey="Kronenbuerger, Martin" sort="Kronenbuerger, Martin" uniqKey="Kronenbuerger M" first="Martin" last="Kronenbuerger">Martin Kronenbuerger</name>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2009" type="published">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Antiparkinson Agents (pharmacology)</term>
<term>Antiparkinson Agents (therapeutic use)</term>
<term>Attention (drug effects)</term>
<term>Attention (physiology)</term>
<term>Combined Modality Therapy</term>
<term>Deep Brain Stimulation</term>
<term>Female</term>
<term>Frontal Lobe (drug effects)</term>
<term>Frontal Lobe (physiopathology)</term>
<term>Humans</term>
<term>Male</term>
<term>Mental Processes (drug effects)</term>
<term>Mental Processes (physiology)</term>
<term>Middle Aged</term>
<term>Motor Activity (drug effects)</term>
<term>Motor Activity (physiology)</term>
<term>Neuropsychological Tests</term>
<term>Parietal Lobe (drug effects)</term>
<term>Parietal Lobe (physiopathology)</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Parkinson Disease (psychology)</term>
<term>Parkinson Disease (therapy)</term>
<term>Psychomotor Performance (drug effects)</term>
<term>Psychomotor Performance (physiology)</term>
<term>Random Allocation</term>
<term>Severity of Illness Index</term>
<term>Subthalamic Nucleus (drug effects)</term>
<term>Subthalamic Nucleus (physiopathology)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiparkinson Agents</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Attention</term>
<term>Frontal Lobe</term>
<term>Mental Processes</term>
<term>Motor Activity</term>
<term>Parietal Lobe</term>
<term>Psychomotor Performance</term>
<term>Subthalamic Nucleus</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Attention</term>
<term>Mental Processes</term>
<term>Motor Activity</term>
<term>Psychomotor Performance</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Frontal Lobe</term>
<term>Parietal Lobe</term>
<term>Subthalamic Nucleus</term>
</keywords>
<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Combined Modality Therapy</term>
<term>Deep Brain Stimulation</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neuropsychological Tests</term>
<term>Random Allocation</term>
<term>Severity of Illness Index</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a treatment option for patients with Parkinson's disease (PD) in the advanced stage. Besides motor improvement, DBS of the STN may also modulate cognitive and attentional functions of the basal ganglia. In our study, 13 patients with PD and bilateral DBS of the STN were assessed with DBS switched on and off by the use of a wide range of neuropsychological tasks. This included reasoning, cognitive flexibility, phonemic and semantic word fluency, verbal and nonverbal short-term memory, learning, delayed verbal memory recall, and stimulus-response incompatibility. Special emphasis was put on basic attentional functions, in particular intrinsic and phasic alertness as well as visual search. DBS significantly improved intrinsic alertness, whereas phasic alertness and other neuropsychological domains were not affected. Additionally, the effects on intrinsic alertness were independent of motor improvements by DBS. The findings suggest that DBS modulates the fronto-parietal network of alertness.</div>
</front>
</TEI>
<pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">19533754</PMID>
<DateCreated><Year>2009</Year>
<Month>09</Month>
<Day>01</Day>
</DateCreated>
<DateCompleted><Year>2010</Year>
<Month>01</Month>
<Day>15</Day>
</DateCompleted>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>24</Volume>
<Issue>11</Issue>
<PubDate><Year>2009</Year>
<Month>Aug</Month>
<Day>15</Day>
</PubDate>
</JournalIssue>
<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
<ISOAbbreviation>Mov. Disord.</ISOAbbreviation>
</Journal>
<ArticleTitle>Deep brain stimulation of the subthalamic nucleus improves intrinsic alertness in Parkinson's disease.</ArticleTitle>
<Pagination><MedlinePgn>1613-20</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.22580</ELocationID>
<Abstract><AbstractText>Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a treatment option for patients with Parkinson's disease (PD) in the advanced stage. Besides motor improvement, DBS of the STN may also modulate cognitive and attentional functions of the basal ganglia. In our study, 13 patients with PD and bilateral DBS of the STN were assessed with DBS switched on and off by the use of a wide range of neuropsychological tasks. This included reasoning, cognitive flexibility, phonemic and semantic word fluency, verbal and nonverbal short-term memory, learning, delayed verbal memory recall, and stimulus-response incompatibility. Special emphasis was put on basic attentional functions, in particular intrinsic and phasic alertness as well as visual search. DBS significantly improved intrinsic alertness, whereas phasic alertness and other neuropsychological domains were not affected. Additionally, the effects on intrinsic alertness were independent of motor improvements by DBS. The findings suggest that DBS modulates the fronto-parietal network of alertness.</AbstractText>
<CopyrightInformation>2009 Movement Disorder Society.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Fimm</LastName>
<ForeName>Bruno</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, University Hospital RWTH Aachen, Germany. fimm@neuropsych.rwth-aachen.de</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Heber</LastName>
<ForeName>Ines A</ForeName>
<Initials>IA</Initials>
</Author>
<Author ValidYN="Y"><LastName>Coenen</LastName>
<ForeName>Volker A</ForeName>
<Initials>VA</Initials>
</Author>
<Author ValidYN="Y"><LastName>Fromm</LastName>
<ForeName>Christoph</ForeName>
<Initials>C</Initials>
</Author>
<Author ValidYN="Y"><LastName>Noth</LastName>
<ForeName>Johannes</ForeName>
<Initials>J</Initials>
</Author>
<Author ValidYN="Y"><LastName>Kronenbuerger</LastName>
<ForeName>Martin</ForeName>
<Initials>M</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Mov Disord</MedlineTA>
<NlmUniqueID>8610688</NlmUniqueID>
<ISSNLinking>0885-3185</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000978">Antiparkinson Agents</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D000978">Antiparkinson Agents</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000494">pharmacology</QualifierName>
<QualifierName MajorTopicYN="N" UI="Q000627">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D001288">Attention</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName>
<QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D003131">Combined Modality Therapy</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="Y" UI="D046690">Deep Brain Stimulation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D005625">Frontal Lobe</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName>
<QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D008606">Mental Processes</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName>
<QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D009043">Motor Activity</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName>
<QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D009483">Neuropsychological Tests</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D010296">Parietal Lobe</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName>
<QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000188">drug therapy</QualifierName>
<QualifierName MajorTopicYN="N" UI="Q000523">psychology</QualifierName>
<QualifierName MajorTopicYN="Y" UI="Q000628">therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D011597">Psychomotor Performance</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName>
<QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D011897">Random Allocation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D012720">Severity of Illness Index</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D020531">Subthalamic Nucleus</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName>
<QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2009</Year>
<Month>6</Month>
<Day>18</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2009</Year>
<Month>6</Month>
<Day>18</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2010</Year>
<Month>1</Month>
<Day>16</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="doi">10.1002/mds.22580</ArticleId>
<ArticleId IdType="pubmed">19533754</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/PubMed/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001C49 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 001C49 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= PubMed |étape= Curation |type= RBID |clé= pubmed:19533754 |texte= Deep brain stimulation of the subthalamic nucleus improves intrinsic alertness in Parkinson's disease. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i -Sk "pubmed:19533754" \ | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \ | NlmPubMed2Wicri -a MovDisordV3
This area was generated with Dilib version V0.6.23. |