Mild parkinsonian signs are associated with increased risk of dementia in a prospective, population-based study of elders.
Identifieur interne : 001A18 ( PubMed/Curation ); précédent : 001A17; suivant : 001A19Mild parkinsonian signs are associated with increased risk of dementia in a prospective, population-based study of elders.
Auteurs : Elan D. Louis [États-Unis] ; Ming X. Tang ; Nicole SchupfSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2010.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Aging (psychology), Dementia (diagnosis), Dementia (epidemiology), Dementia (etiology), Female, Follow-Up Studies, Humans, Incidence, Male, Muscle Rigidity (physiopathology), Neuropsychological Tests, New York City (epidemiology), Parkinson Disease (complications), Parkinson Disease (epidemiology), Parkinson Disease (physiopathology), Population Groups, Proportional Hazards Models, Prospective Studies, Psychiatric Status Rating Scales, Risk Factors, Severity of Illness Index, Tremor (physiopathology).
- MESH :
- geographic , epidemiology : New York City.
- complications : Parkinson Disease.
- diagnosis : Dementia.
- epidemiology : Dementia, Parkinson Disease.
- etiology : Dementia.
- physiopathology : Muscle Rigidity, Parkinson Disease, Tremor.
- psychology : Aging.
- Aged, Aged, 80 and over, Female, Follow-Up Studies, Humans, Incidence, Male, Neuropsychological Tests, Population Groups, Proportional Hazards Models, Prospective Studies, Psychiatric Status Rating Scales, Risk Factors, Severity of Illness Index.
Abstract
There is some evidence that mild parkinsonian signs (MPSs) are associated with increased risk of dementia, suggesting that MPS could be an early biomarker for dementia. Our aims, in a new cohort, were to determine whether (1) baseline MPS are a predictor of incident dementia and (2) there is an interaction between MPS and other baseline risk factors for dementia (i.e., the presence of both together greatly elevates the risk of dementia) was the objective. In a prospective, longitudinal study of community-dwelling elders in northern Manhattan, NY, Parkinsonian signs were rated with an abbreviated Unified Parkinson's Disease Rating Scale. Risk of incident dementia was assessed using Cox proportional hazards models. There were 1,851 participants (mean follow-up = 3.7 years). Participants with baseline MPS were twice as likely to develop dementia as participants without MPS: 16.3% versus 7.7%, unadjusted hazards ratio (HR) = 2.24 (P< 0.001), adjusted HR = 1.98 (P < 0.001). MPS were divided into three subtypes: adjusted HR(axial dysfunction) = 2.45 (P < 0.001), adjusted HR(tremor) = 2.38 (P = 0.006), and adjusted HR(rigidity) = 1.16 (P = 0.58). When MPS were treated as a continuous variable, the adjusted HR = 1.15 (P = 0.001). There were no interactions between MPS and other baseline risk factors for dementia, including gender, education, race, family history of dementia, stroke, and apolipoprotein E-e4. Baseline MPS seems to be a predictor of incident dementia. These motor signs might, therefore, serve as a useful biomarker for emerging dementia.
DOI: 10.1002/mds.22943
PubMed: 20077482
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pubmed:20077482Le document en format XML
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<front><div type="abstract" xml:lang="en">There is some evidence that mild parkinsonian signs (MPSs) are associated with increased risk of dementia, suggesting that MPS could be an early biomarker for dementia. Our aims, in a new cohort, were to determine whether (1) baseline MPS are a predictor of incident dementia and (2) there is an interaction between MPS and other baseline risk factors for dementia (i.e., the presence of both together greatly elevates the risk of dementia) was the objective. In a prospective, longitudinal study of community-dwelling elders in northern Manhattan, NY, Parkinsonian signs were rated with an abbreviated Unified Parkinson's Disease Rating Scale. Risk of incident dementia was assessed using Cox proportional hazards models. There were 1,851 participants (mean follow-up = 3.7 years). Participants with baseline MPS were twice as likely to develop dementia as participants without MPS: 16.3% versus 7.7%, unadjusted hazards ratio (HR) = 2.24 (P< 0.001), adjusted HR = 1.98 (P < 0.001). MPS were divided into three subtypes: adjusted HR(axial dysfunction) = 2.45 (P < 0.001), adjusted HR(tremor) = 2.38 (P = 0.006), and adjusted HR(rigidity) = 1.16 (P = 0.58). When MPS were treated as a continuous variable, the adjusted HR = 1.15 (P = 0.001). There were no interactions between MPS and other baseline risk factors for dementia, including gender, education, race, family history of dementia, stroke, and apolipoprotein E-e4. Baseline MPS seems to be a predictor of incident dementia. These motor signs might, therefore, serve as a useful biomarker for emerging dementia.</div>
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<CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2003 Jul 8;61(1):24-8</RefSource>
<PMID Version="1">12847151</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neurobiol Aging. 2010 Sep;31(9):1593-600</RefSource>
<PMID Version="1">18963256</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Arch Neurol. 2004 Aug;61(8):1273-6</RefSource>
<PMID Version="1">15313847</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Br J Psychiatry. 1968 Jul;114(512):797-811</RefSource>
<PMID Version="1">5662937</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neurology. 1974 Nov;24(11):1019-25</RefSource>
<PMID Version="1">4473151</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neurology. 1984 Jul;34(7):939-44</RefSource>
<PMID Version="1">6610841</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Arch Neurol. 1992 May;49(5):453-60</RefSource>
<PMID Version="1">1580806</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Annu Rev Public Health. 1992;13:431-49</RefSource>
<PMID Version="1">1599598</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Am Geriatr Soc. 2000 Apr;48(4):422-5</RefSource>
<PMID Version="1">10798470</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neurology. 2001 Jan 9;56(1):49-56</RefSource>
<PMID Version="1">11148235</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Aging (Milano). 2001 Jun;13(3):143-62</RefSource>
<PMID Version="1">11442298</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Arch Neurol. 2001 Dec;58(12):1985-92</RefSource>
<PMID Version="1">11735772</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neurology. 2001 Dec 26;57(12):2236-42</RefSource>
<PMID Version="1">11756603</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Am J Epidemiol. 2002 Sep 1;156(5):445-53</RefSource>
<PMID Version="1">12196314</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Arch Neurol. 2003 Apr;60(4):539-44</RefSource>
<PMID Version="1">12707067</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Am J Prev Med. 1994 Mar-Apr;10(2):77-84</RefSource>
<PMID Version="1">8037935</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Am J Public Health. 1995 Sep;85(9):1280-4</RefSource>
<PMID Version="1">7661240</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Am J Epidemiol. 1995 Oct 15;142(8):820-7</RefSource>
<PMID Version="1">7572958</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>N Engl J Med. 1996 Jan 11;334(2):71-6</RefSource>
<PMID Version="1">8531961</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Ann Neurol. 1997 Mar;41(3):368-74</RefSource>
<PMID Version="1">9066358</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neurology. 1997 May;48(5):1277-81</RefSource>
<PMID Version="1">9153457</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Arch Neurol. 1999 Mar;56(3):334-7</RefSource>
<PMID Version="1">10190824</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Gerontol A Biol Sci Med Sci. 1999 Apr;54(4):M191-6</RefSource>
<PMID Version="1">10219010</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Arch Neurol. 2005 Feb;62(2):297-302</RefSource>
<PMID Version="1">15710859</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neurology. 2005 Apr 12;64(7):1157-61</RefSource>
<PMID Version="1">15824340</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neurology. 2005 Apr 26;64(8):1397-403</RefSource>
<PMID Version="1">15851730</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2006 Mar;21(3):411-6</RefSource>
<PMID Version="1">16211605</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Arch Neurol. 2006 May;63(5):717-22</RefSource>
<PMID Version="1">16682541</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Exp Aging Res. 2007 Jan-Mar;33(1):59-76</RefSource>
<PMID Version="1">17132564</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neurology. 2007 Jan 30;68(5):326-37</RefSource>
<PMID Version="1">17261678</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2007 Aug 15;22(11):1573-80</RefSource>
<PMID Version="1">17516478</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neural Transm. 2007;114(10):1355-61</RefSource>
<PMID Version="1">17641815</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Affect Disord. 2008 Jan;105(1-3):273-7</RefSource>
<PMID Version="1">17532052</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2008 Mar 15;23(4):524-30</RefSource>
<PMID Version="1">18098296</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neuropsychology. 2008 May;22(3):400-11</RefSource>
<PMID Version="1">18444718</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neurology. 2008 May 6;70(19 Pt 2):1842-9</RefSource>
<PMID Version="1">18401023</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Arch Neurol. 2009 Feb;66(2):216-25</RefSource>
<PMID Version="1">19204158</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neurology. 2009 Aug 25;73(8):621-5</RefSource>
<PMID Version="1">19704081</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2004 Mar;19(3):268-72</RefSource>
<PMID Version="1">15022180</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
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