Hypokinesia in Parkinson's disease: influence of age, disease severity, and disease duration.
Identifieur interne : 004967 ( PubMed/Corpus ); précédent : 004966; suivant : 004968Hypokinesia in Parkinson's disease: influence of age, disease severity, and disease duration.
Auteurs : J J Van Hilten ; E A Braat ; E A Van Der Velde ; H A Middelkoop ; J G Van Dijk ; G J Lighart ; R A RoosSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1995.
English descriptors
- KwdEn :
- Activities of Daily Living (classification), Adult, Aged, Aged, 80 and over, Antiparkinson Agents (therapeutic use), Circadian Rhythm (drug effects), Circadian Rhythm (physiology), Drug Therapy, Combination, Female, Humans, Hypokinesia (classification), Hypokinesia (diagnosis), Hypokinesia (drug therapy), Levodopa (therapeutic use), Male, Middle Aged, Motor Activity (drug effects), Motor Activity (physiology), Muscle Rigidity (classification), Muscle Rigidity (diagnosis), Muscle Rigidity (drug therapy), Neurologic Examination (drug effects), Parkinson Disease (classification), Parkinson Disease (diagnosis), Parkinson Disease (drug therapy).
- MESH :
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- classification : Activities of Daily Living, Hypokinesia, Muscle Rigidity, Parkinson Disease.
- diagnosis : Hypokinesia, Muscle Rigidity, Parkinson Disease.
- drug effects : Circadian Rhythm, Motor Activity, Neurologic Examination.
- drug therapy : Hypokinesia, Muscle Rigidity, Parkinson Disease.
- physiology : Circadian Rhythm, Motor Activity.
- Adult, Aged, Aged, 80 and over, Drug Therapy, Combination, Female, Humans, Male, Middle Aged.
Abstract
The aim of this cross-sectional study was to compare the role of aging in measures reflecting diurnal activity and immobility in 60 parkinsonian patients with predominant features of hypokinesia and rigidity and 100 healthy subjects aged 50 to 98 years. In the patients, we also studied the relation between disease duration and subjective and objective measures of disease severity. Motor activity was recorded during 5 successive days at home with a wrist-worn activity monitor. For each subject, two mean measures reflecting the diurnal activity level and the relative proportion of activity and immobility were calculated. Diurnal measures of activity revealed in both groups a prominent absolute reduction of activity and an increase of the time spent without movement ("immobility") with advancing age. Parkinsonian patients showed significantly lower values for both motor-activity measures than did the healthy subjects. The rate of the age-related decline of both diurnal activity measures in both groups, however, is comparable. Disease duration showed no relation with subjective and objective measures reflecting disease severity. This study shows that if care is taken to control for disease severity, the rate of the age-related decline of measures reflecting diurnal activity and immobility is similar in both groups. The lack of relation between disease duration and subjective and objective measures of disease severity suggests that the rate of progression of Parkinson's disease can be reliably studied only by means of longitudinal studies.
DOI: 10.1002/mds.870100404
PubMed: 7565821
Links to Exploration step
pubmed:7565821Le document en format XML
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<author><name sortKey="Braat, E A" sort="Braat, E A" uniqKey="Braat E" first="E A" last="Braat">E A Braat</name>
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<author><name sortKey="Van Der Velde, E A" sort="Van Der Velde, E A" uniqKey="Van Der Velde E" first="E A" last="Van Der Velde">E A Van Der Velde</name>
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<author><name sortKey="Middelkoop, H A" sort="Middelkoop, H A" uniqKey="Middelkoop H" first="H A" last="Middelkoop">H A Middelkoop</name>
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<author><name sortKey="Van Dijk, J G" sort="Van Dijk, J G" uniqKey="Van Dijk J" first="J G" last="Van Dijk">J G Van Dijk</name>
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<author><name sortKey="Lighart, G J" sort="Lighart, G J" uniqKey="Lighart G" first="G J" last="Lighart">G J Lighart</name>
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<author><name sortKey="Van Der Velde, E A" sort="Van Der Velde, E A" uniqKey="Van Der Velde E" first="E A" last="Van Der Velde">E A Van Der Velde</name>
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<term>Aged</term>
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<term>Antiparkinson Agents (therapeutic use)</term>
<term>Circadian Rhythm (drug effects)</term>
<term>Circadian Rhythm (physiology)</term>
<term>Drug Therapy, Combination</term>
<term>Female</term>
<term>Humans</term>
<term>Hypokinesia (classification)</term>
<term>Hypokinesia (diagnosis)</term>
<term>Hypokinesia (drug therapy)</term>
<term>Levodopa (therapeutic use)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Motor Activity (drug effects)</term>
<term>Motor Activity (physiology)</term>
<term>Muscle Rigidity (classification)</term>
<term>Muscle Rigidity (diagnosis)</term>
<term>Muscle Rigidity (drug therapy)</term>
<term>Neurologic Examination (drug effects)</term>
<term>Parkinson Disease (classification)</term>
<term>Parkinson Disease (diagnosis)</term>
<term>Parkinson Disease (drug therapy)</term>
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<term>Levodopa</term>
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<term>Hypokinesia</term>
<term>Muscle Rigidity</term>
<term>Parkinson Disease</term>
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<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Hypokinesia</term>
<term>Muscle Rigidity</term>
<term>Parkinson Disease</term>
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<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Circadian Rhythm</term>
<term>Motor Activity</term>
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<term>Muscle Rigidity</term>
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<term>Motor Activity</term>
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<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Drug Therapy, Combination</term>
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<term>Humans</term>
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<front><div type="abstract" xml:lang="en">The aim of this cross-sectional study was to compare the role of aging in measures reflecting diurnal activity and immobility in 60 parkinsonian patients with predominant features of hypokinesia and rigidity and 100 healthy subjects aged 50 to 98 years. In the patients, we also studied the relation between disease duration and subjective and objective measures of disease severity. Motor activity was recorded during 5 successive days at home with a wrist-worn activity monitor. For each subject, two mean measures reflecting the diurnal activity level and the relative proportion of activity and immobility were calculated. Diurnal measures of activity revealed in both groups a prominent absolute reduction of activity and an increase of the time spent without movement ("immobility") with advancing age. Parkinsonian patients showed significantly lower values for both motor-activity measures than did the healthy subjects. The rate of the age-related decline of both diurnal activity measures in both groups, however, is comparable. Disease duration showed no relation with subjective and objective measures reflecting disease severity. This study shows that if care is taken to control for disease severity, the rate of the age-related decline of measures reflecting diurnal activity and immobility is similar in both groups. The lack of relation between disease duration and subjective and objective measures of disease severity suggests that the rate of progression of Parkinson's disease can be reliably studied only by means of longitudinal studies.</div>
</front>
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<Abstract><AbstractText>The aim of this cross-sectional study was to compare the role of aging in measures reflecting diurnal activity and immobility in 60 parkinsonian patients with predominant features of hypokinesia and rigidity and 100 healthy subjects aged 50 to 98 years. In the patients, we also studied the relation between disease duration and subjective and objective measures of disease severity. Motor activity was recorded during 5 successive days at home with a wrist-worn activity monitor. For each subject, two mean measures reflecting the diurnal activity level and the relative proportion of activity and immobility were calculated. Diurnal measures of activity revealed in both groups a prominent absolute reduction of activity and an increase of the time spent without movement ("immobility") with advancing age. Parkinsonian patients showed significantly lower values for both motor-activity measures than did the healthy subjects. The rate of the age-related decline of both diurnal activity measures in both groups, however, is comparable. Disease duration showed no relation with subjective and objective measures reflecting disease severity. This study shows that if care is taken to control for disease severity, the rate of the age-related decline of measures reflecting diurnal activity and immobility is similar in both groups. The lack of relation between disease duration and subjective and objective measures of disease severity suggests that the rate of progression of Parkinson's disease can be reliably studied only by means of longitudinal studies.</AbstractText>
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