MovDisordV3, PubMed, Corpus, bibRecord, 002068

A comparative study of odor identification and odor discrimination deficits in Parkinson's disease.

Identifieur interne : 002068 ( PubMed/Corpus ); précédent : 002067; suivant : 002069

A comparative study of odor identification and odor discrimination deficits in Parkinson's disease.

Auteurs : Sanne Boesveldt ; Dagmar Verbaan ; Dirk L. Knol ; Martine Visser ; Stephanie M. Van Rooden ; Jacobus J. Van Hilten ; Henk W. Berendse

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2008.

RBID : pubmed:18759360

English descriptors

KwdEn :
- Adult, Aged, Aged, 80 and over, Analysis of Variance, Discrimination (Psychology) (physiology), Female, Humans, Male, Middle Aged, Odors, Olfaction Disorders (etiology), Olfactory Perception (physiology), Parkinson Disease (complications), ROC Curve, Sensory Thresholds.
MESH :
- complications : Parkinson Disease.
- etiology : Olfaction Disorders.
- physiology : Discrimination (Psychology), Olfactory Perception.
- Adult, Aged, Aged, 80 and over, Analysis of Variance, Female, Humans, Male, Middle Aged, Odors, ROC Curve, Sensory Thresholds.

Abstract

The aim of this study was to compare the characteristics of odor discrimination and odor identification deficits in a large population of patients with Parkinson's disease (PD) and to determine which of these olfactory tests best distinguishes between patients with PD and control subjects. Olfactory performance was assessed in 404 patients with PD and 150 controls, using the odor identification and discrimination parts of the Sniffin' Sticks battery. Mean identification and discrimination scores in patients with PD were significantly lower than in controls. Linear regression analysis using a 95% confidence interval revealed that, relative to the performance of controls, 65.0% of patients with PD had an impairment in odor identification, whereas 42.1% of patients were impaired on the odor discrimination task. ROC curves revealed a higher sensitivity and specificity for odor identification than for odor discrimination in separating patients from controls. In patients with PD, odor discrimination performance decreased with increasing disease duration, whereas odor identification was not correlated with disease stage or duration. In PD, odor identification is more frequently impaired than odor discrimination and allows a better discrimination between patients and controls. Although an odor identification deficit is generally believed to be independent of disease progression, the impairment in odor discrimination appears to increase with disease duration.

DOI: 10.1002/mds.22155
PubMed: 18759360

Links to Exploration step

pubmed:18759360

Le document en format XML

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<author><name sortKey="Verbaan, Dagmar" sort="Verbaan, Dagmar" uniqKey="Verbaan D" first="Dagmar" last="Verbaan">Dagmar Verbaan</name>
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<author><name sortKey="Knol, Dirk L" sort="Knol, Dirk L" uniqKey="Knol D" first="Dirk L" last="Knol">Dirk L. Knol</name>
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<author><name sortKey="Visser, Martine" sort="Visser, Martine" uniqKey="Visser M" first="Martine" last="Visser">Martine Visser</name>
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<front><div type="abstract" xml:lang="en">The aim of this study was to compare the characteristics of odor discrimination and odor identification deficits in a large population of patients with Parkinson's disease (PD) and to determine which of these olfactory tests best distinguishes between patients with PD and control subjects. Olfactory performance was assessed in 404 patients with PD and 150 controls, using the odor identification and discrimination parts of the Sniffin' Sticks battery. Mean identification and discrimination scores in patients with PD were significantly lower than in controls. Linear regression analysis using a 95% confidence interval revealed that, relative to the performance of controls, 65.0% of patients with PD had an impairment in odor identification, whereas 42.1% of patients were impaired on the odor discrimination task. ROC curves revealed a higher sensitivity and specificity for odor identification than for odor discrimination in separating patients from controls. In patients with PD, odor discrimination performance decreased with increasing disease duration, whereas odor identification was not correlated with disease stage or duration. In PD, odor identification is more frequently impaired than odor discrimination and allows a better discrimination between patients and controls. Although an odor identification deficit is generally believed to be independent of disease progression, the impairment in odor discrimination appears to increase with disease duration.</div>
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<Abstract><AbstractText>The aim of this study was to compare the characteristics of odor discrimination and odor identification deficits in a large population of patients with Parkinson's disease (PD) and to determine which of these olfactory tests best distinguishes between patients with PD and control subjects. Olfactory performance was assessed in 404 patients with PD and 150 controls, using the odor identification and discrimination parts of the Sniffin' Sticks battery. Mean identification and discrimination scores in patients with PD were significantly lower than in controls. Linear regression analysis using a 95% confidence interval revealed that, relative to the performance of controls, 65.0% of patients with PD had an impairment in odor identification, whereas 42.1% of patients were impaired on the odor discrimination task. ROC curves revealed a higher sensitivity and specificity for odor identification than for odor discrimination in separating patients from controls. In patients with PD, odor discrimination performance decreased with increasing disease duration, whereas odor identification was not correlated with disease stage or duration. In PD, odor identification is more frequently impaired than odor discrimination and allows a better discrimination between patients and controls. Although an odor identification deficit is generally believed to be independent of disease progression, the impairment in odor discrimination appears to increase with disease duration.</AbstractText>
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A comparative study of odor identification and odor discrimination deficits in Parkinson's disease.

A comparative study of odor identification and odor discrimination deficits in Parkinson's disease.

Source :

English descriptors

Abstract

Links to Exploration step

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