Analysis of LRRK2 Gly2385Arg genetic variant in non-Chinese Asians.
Identifieur interne : 002980 ( PubMed/Checkpoint ); précédent : 002979; suivant : 002981Analysis of LRRK2 Gly2385Arg genetic variant in non-Chinese Asians.
Auteurs : Eng-King Tan [Singapour] ; Yi Zhao ; Louis Tan ; Hui-Qin Lim ; Jasinda Lee ; Yih Yuen ; Ratnagopal Pavanni ; Meng-Cheong Wong ; Stephanie Fook-Chong ; Jian-Jun LiuSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.
Descripteurs français
- Wicri :
- geographic : Inde.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Arginine (genetics), Asia, Southeastern (ethnology), Chi-Square Distribution, Female, Gene Frequency, Genotype, Glycine (genetics), Humans, India (ethnology), Male, Middle Aged, Odds Ratio, Parkinson Disease (genetics), Protein-Serine-Threonine Kinases (genetics), Risk Factors.
- MESH :
- chemical , genetics : Arginine, Glycine, Protein-Serine-Threonine Kinases.
- geographic , ethnology : Asia, Southeastern, India.
- genetics : Parkinson Disease.
- Adult, Aged, Aged, 80 and over, Chi-Square Distribution, Female, Gene Frequency, Genotype, Humans, Male, Middle Aged, Odds Ratio, Risk Factors.
Abstract
A common LRRK2 missense variant, Gly2385Arg, has been found to be a genetic risk factor for Parkinson's disease (PD) in ethnic Chinese and Japanese. However, the presence of the variant in other non-Chinese Asian patients has not been fully clarified. We performed genetic analysis of the Gly2385Arg variant in 472 non-Chinese Asian subjects in Singapore (comprising of 166 PD and 306 controls of Malay/Indian ethnicity). The frequency of the heterozygous Gly2385Arg genotype was not significantly different in PD compared with controls (1.2% vs. 0.8%, odds ratio = 2.83, 95% CI 0.40, 20.2, P = 0.3). No subjects carried the homozygous genotype. Stratification by Malay and Indian ethnicity revealed that there were two carriers each among 98 (2.0%) Malay PD and 173 (1.2%) Malay controls (odds ratio = 1.78, 95% CI 0.25, 12.8, P = 0.6), but there were no carriers among 66 Indian PD and 133 Indian controls. We demonstrated that the Gly2385Arg variant could be detected in our Malay subjects. However, its frequency was much lower than the 8 to 10% prevalence previously reported in our Singaporean and Taiwanese Chinese PD population. The relevance of Gly2385Arg as a genetic risk factor may be restricted to selected Asian races, and more studies will be needed to confirm our observations.
DOI: 10.1002/mds.21658
PubMed: 17659642
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:17659642Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Analysis of LRRK2 Gly2385Arg genetic variant in non-Chinese Asians.</title><author><name sortKey="Tan, Eng King" sort="Tan, Eng King" uniqKey="Tan E" first="Eng-King" last="Tan">Eng-King Tan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Singapore General Hospital, Singapore. gnrtek@sgh.com.sg</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Neurology, Singapore General Hospital</wicri:regionArea><wicri:noRegion>Singapore General Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Zhao, Yi" sort="Zhao, Yi" uniqKey="Zhao Y" first="Yi" last="Zhao">Yi Zhao</name></author><author><name sortKey="Tan, Louis" sort="Tan, Louis" uniqKey="Tan L" first="Louis" last="Tan">Louis Tan</name></author><author><name sortKey="Lim, Hui Qin" sort="Lim, Hui Qin" uniqKey="Lim H" first="Hui-Qin" last="Lim">Hui-Qin Lim</name></author><author><name sortKey="Lee, Jasinda" sort="Lee, Jasinda" uniqKey="Lee J" first="Jasinda" last="Lee">Jasinda Lee</name></author><author><name sortKey="Yuen, Yih" sort="Yuen, Yih" uniqKey="Yuen Y" first="Yih" last="Yuen">Yih Yuen</name></author><author><name sortKey="Pavanni, Ratnagopal" sort="Pavanni, Ratnagopal" uniqKey="Pavanni R" first="Ratnagopal" last="Pavanni">Ratnagopal Pavanni</name></author><author><name sortKey="Wong, Meng Cheong" sort="Wong, Meng Cheong" uniqKey="Wong M" first="Meng-Cheong" last="Wong">Meng-Cheong Wong</name></author><author><name sortKey="Fook Chong, Stephanie" sort="Fook Chong, Stephanie" uniqKey="Fook Chong S" first="Stephanie" last="Fook-Chong">Stephanie Fook-Chong</name></author><author><name sortKey="Liu, Jian Jun" sort="Liu, Jian Jun" uniqKey="Liu J" first="Jian-Jun" last="Liu">Jian-Jun Liu</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="doi">10.1002/mds.21658</idno><idno type="RBID">pubmed:17659642</idno><idno type="pmid">17659642</idno><idno type="wicri:Area/PubMed/Corpus">002580</idno><idno type="wicri:Area/PubMed/Curation">002580</idno><idno type="wicri:Area/PubMed/Checkpoint">002980</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Analysis of LRRK2 Gly2385Arg genetic variant in non-Chinese Asians.</title><author><name sortKey="Tan, Eng King" sort="Tan, Eng King" uniqKey="Tan E" first="Eng-King" last="Tan">Eng-King Tan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Singapore General Hospital, Singapore. gnrtek@sgh.com.sg</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Neurology, Singapore General Hospital</wicri:regionArea><wicri:noRegion>Singapore General Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Zhao, Yi" sort="Zhao, Yi" uniqKey="Zhao Y" first="Yi" last="Zhao">Yi Zhao</name></author><author><name sortKey="Tan, Louis" sort="Tan, Louis" uniqKey="Tan L" first="Louis" last="Tan">Louis Tan</name></author><author><name sortKey="Lim, Hui Qin" sort="Lim, Hui Qin" uniqKey="Lim H" first="Hui-Qin" last="Lim">Hui-Qin Lim</name></author><author><name sortKey="Lee, Jasinda" sort="Lee, Jasinda" uniqKey="Lee J" first="Jasinda" last="Lee">Jasinda Lee</name></author><author><name sortKey="Yuen, Yih" sort="Yuen, Yih" uniqKey="Yuen Y" first="Yih" last="Yuen">Yih Yuen</name></author><author><name sortKey="Pavanni, Ratnagopal" sort="Pavanni, Ratnagopal" uniqKey="Pavanni R" first="Ratnagopal" last="Pavanni">Ratnagopal Pavanni</name></author><author><name sortKey="Wong, Meng Cheong" sort="Wong, Meng Cheong" uniqKey="Wong M" first="Meng-Cheong" last="Wong">Meng-Cheong Wong</name></author><author><name sortKey="Fook Chong, Stephanie" sort="Fook Chong, Stephanie" uniqKey="Fook Chong S" first="Stephanie" last="Fook-Chong">Stephanie Fook-Chong</name></author><author><name sortKey="Liu, Jian Jun" sort="Liu, Jian Jun" uniqKey="Liu J" first="Jian-Jun" last="Liu">Jian-Jun Liu</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Arginine (genetics)</term><term>Asia, Southeastern (ethnology)</term><term>Chi-Square Distribution</term><term>Female</term><term>Gene Frequency</term><term>Genotype</term><term>Glycine (genetics)</term><term>Humans</term><term>India (ethnology)</term><term>Male</term><term>Middle Aged</term><term>Odds Ratio</term><term>Parkinson Disease (genetics)</term><term>Protein-Serine-Threonine Kinases (genetics)</term><term>Risk Factors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Arginine</term><term>Glycine</term><term>Protein-Serine-Threonine Kinases</term></keywords><keywords scheme="MESH" type="geographic" qualifier="ethnology" xml:lang="en"><term>Asia, Southeastern</term><term>India</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Chi-Square Distribution</term><term>Female</term><term>Gene Frequency</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Odds Ratio</term><term>Risk Factors</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Inde</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A common LRRK2 missense variant, Gly2385Arg, has been found to be a genetic risk factor for Parkinson's disease (PD) in ethnic Chinese and Japanese. However, the presence of the variant in other non-Chinese Asian patients has not been fully clarified. We performed genetic analysis of the Gly2385Arg variant in 472 non-Chinese Asian subjects in Singapore (comprising of 166 PD and 306 controls of Malay/Indian ethnicity). The frequency of the heterozygous Gly2385Arg genotype was not significantly different in PD compared with controls (1.2% vs. 0.8%, odds ratio = 2.83, 95% CI 0.40, 20.2, P = 0.3). No subjects carried the homozygous genotype. Stratification by Malay and Indian ethnicity revealed that there were two carriers each among 98 (2.0%) Malay PD and 173 (1.2%) Malay controls (odds ratio = 1.78, 95% CI 0.25, 12.8, P = 0.6), but there were no carriers among 66 Indian PD and 133 Indian controls. We demonstrated that the Gly2385Arg variant could be detected in our Malay subjects. However, its frequency was much lower than the 8 to 10% prevalence previously reported in our Singaporean and Taiwanese Chinese PD population. The relevance of Gly2385Arg as a genetic risk factor may be restricted to selected Asian races, and more studies will be needed to confirm our observations.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">17659642</PMID><DateCreated><Year>2007</Year><Month>10</Month><Day>01</Day></DateCreated><DateCompleted><Year>2008</Year><Month>01</Month><Day>09</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>22</Volume><Issue>12</Issue><PubDate><Year>2007</Year><Month>Sep</Month><Day>15</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Analysis of LRRK2 Gly2385Arg genetic variant in non-Chinese Asians.</ArticleTitle><Pagination><MedlinePgn>1816-8</MedlinePgn></Pagination><Abstract><AbstractText>A common LRRK2 missense variant, Gly2385Arg, has been found to be a genetic risk factor for Parkinson's disease (PD) in ethnic Chinese and Japanese. However, the presence of the variant in other non-Chinese Asian patients has not been fully clarified. We performed genetic analysis of the Gly2385Arg variant in 472 non-Chinese Asian subjects in Singapore (comprising of 166 PD and 306 controls of Malay/Indian ethnicity). The frequency of the heterozygous Gly2385Arg genotype was not significantly different in PD compared with controls (1.2% vs. 0.8%, odds ratio = 2.83, 95% CI 0.40, 20.2, P = 0.3). No subjects carried the homozygous genotype. Stratification by Malay and Indian ethnicity revealed that there were two carriers each among 98 (2.0%) Malay PD and 173 (1.2%) Malay controls (odds ratio = 1.78, 95% CI 0.25, 12.8, P = 0.6), but there were no carriers among 66 Indian PD and 133 Indian controls. We demonstrated that the Gly2385Arg variant could be detected in our Malay subjects. However, its frequency was much lower than the 8 to 10% prevalence previously reported in our Singaporean and Taiwanese Chinese PD population. The relevance of Gly2385Arg as a genetic risk factor may be restricted to selected Asian races, and more studies will be needed to confirm our observations.</AbstractText><CopyrightInformation>(c) 2007 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tan</LastName><ForeName>Eng-King</ForeName><Initials>EK</Initials><AffiliationInfo><Affiliation>Department of Neurology, Singapore General Hospital, Singapore. gnrtek@sgh.com.sg</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhao</LastName><ForeName>Yi</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Tan</LastName><ForeName>Louis</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Lim</LastName><ForeName>Hui-Qin</ForeName><Initials>HQ</Initials></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Jasinda</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Yuen</LastName><ForeName>Yih</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Pavanni</LastName><ForeName>Ratnagopal</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Wong</LastName><ForeName>Meng-Cheong</ForeName><Initials>MC</Initials></Author><Author ValidYN="Y"><LastName>Fook-Chong</LastName><ForeName>Stephanie</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Jian-Jun</ForeName><Initials>JJ</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>94ZLA3W45F</RegistryNumber><NameOfSubstance UI="D001120">Arginine</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber><NameOfSubstance UI="C495280">LRRK2 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber><NameOfSubstance UI="D017346">Protein-Serine-Threonine Kinases</NameOfSubstance></Chemical><Chemical><RegistryNumber>TE7660XO1C</RegistryNumber><NameOfSubstance UI="D005998">Glycine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000369">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001120">Arginine</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" Type="Geographic" UI="D001210">Asia, Southeastern</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000208">ethnology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D016009">Chi-Square Distribution</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005787">Gene Frequency</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005838">Genotype</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005998">Glycine</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" Type="Geographic" UI="D007194">India</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000208">ethnology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D016017">Odds Ratio</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D017346">Protein-Serine-Threonine Kinases</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012307">Risk Factors</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2007</Year><Month>7</Month><Day>31</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2008</Year><Month>1</Month><Day>10</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2007</Year><Month>7</Month><Day>31</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.21658</ArticleId><ArticleId IdType="pubmed">17659642</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Singapour</li></country></list><tree><noCountry><name sortKey="Fook Chong, Stephanie" sort="Fook Chong, Stephanie" uniqKey="Fook Chong S" first="Stephanie" last="Fook-Chong">Stephanie Fook-Chong</name><name sortKey="Lee, Jasinda" sort="Lee, Jasinda" uniqKey="Lee J" first="Jasinda" last="Lee">Jasinda Lee</name><name sortKey="Lim, Hui Qin" sort="Lim, Hui Qin" uniqKey="Lim H" first="Hui-Qin" last="Lim">Hui-Qin Lim</name><name sortKey="Liu, Jian Jun" sort="Liu, Jian Jun" uniqKey="Liu J" first="Jian-Jun" last="Liu">Jian-Jun Liu</name><name sortKey="Pavanni, Ratnagopal" sort="Pavanni, Ratnagopal" uniqKey="Pavanni R" first="Ratnagopal" last="Pavanni">Ratnagopal Pavanni</name><name sortKey="Tan, Louis" sort="Tan, Louis" uniqKey="Tan L" first="Louis" last="Tan">Louis Tan</name><name sortKey="Wong, Meng Cheong" sort="Wong, Meng Cheong" uniqKey="Wong M" first="Meng-Cheong" last="Wong">Meng-Cheong Wong</name><name sortKey="Yuen, Yih" sort="Yuen, Yih" uniqKey="Yuen Y" first="Yih" last="Yuen">Yih Yuen</name><name sortKey="Zhao, Yi" sort="Zhao, Yi" uniqKey="Zhao Y" first="Yi" last="Zhao">Yi Zhao</name></noCountry><country name="Singapour"><noRegion><name sortKey="Tan, Eng King" sort="Tan, Eng King" uniqKey="Tan E" first="Eng-King" last="Tan">Eng-King Tan</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/PubMed/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002980 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 002980 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= PubMed
|étape= Checkpoint
|type= RBID
|clé= pubmed:17659642
|texte= Analysis of LRRK2 Gly2385Arg genetic variant in non-Chinese Asians.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i -Sk "pubmed:17659642" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a MovDisordV3
| This area was generated with Dilib version V0.6.23. |  |