Analysis of LRRK2 Gly2385Arg genetic variant in non-Chinese Asians.
Identifieur interne : 002580 ( PubMed/Curation ); précédent : 002579; suivant : 002581Analysis of LRRK2 Gly2385Arg genetic variant in non-Chinese Asians.
Auteurs : Eng-King Tan [Singapour] ; Yi Zhao ; Louis Tan ; Hui-Qin Lim ; Jasinda Lee ; Yih Yuen ; Ratnagopal Pavanni ; Meng-Cheong Wong ; Stephanie Fook-Chong ; Jian-Jun LiuSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.
Descripteurs français
- Wicri :
- geographic : Inde.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Arginine (genetics), Asia, Southeastern (ethnology), Chi-Square Distribution, Female, Gene Frequency, Genotype, Glycine (genetics), Humans, India (ethnology), Male, Middle Aged, Odds Ratio, Parkinson Disease (genetics), Protein-Serine-Threonine Kinases (genetics), Risk Factors.
- MESH :
- chemical , genetics : Arginine, Glycine, Protein-Serine-Threonine Kinases.
- geographic , ethnology : Asia, Southeastern, India.
- genetics : Parkinson Disease.
- Adult, Aged, Aged, 80 and over, Chi-Square Distribution, Female, Gene Frequency, Genotype, Humans, Male, Middle Aged, Odds Ratio, Risk Factors.
Abstract
A common LRRK2 missense variant, Gly2385Arg, has been found to be a genetic risk factor for Parkinson's disease (PD) in ethnic Chinese and Japanese. However, the presence of the variant in other non-Chinese Asian patients has not been fully clarified. We performed genetic analysis of the Gly2385Arg variant in 472 non-Chinese Asian subjects in Singapore (comprising of 166 PD and 306 controls of Malay/Indian ethnicity). The frequency of the heterozygous Gly2385Arg genotype was not significantly different in PD compared with controls (1.2% vs. 0.8%, odds ratio = 2.83, 95% CI 0.40, 20.2, P = 0.3). No subjects carried the homozygous genotype. Stratification by Malay and Indian ethnicity revealed that there were two carriers each among 98 (2.0%) Malay PD and 173 (1.2%) Malay controls (odds ratio = 1.78, 95% CI 0.25, 12.8, P = 0.6), but there were no carriers among 66 Indian PD and 133 Indian controls. We demonstrated that the Gly2385Arg variant could be detected in our Malay subjects. However, its frequency was much lower than the 8 to 10% prevalence previously reported in our Singaporean and Taiwanese Chinese PD population. The relevance of Gly2385Arg as a genetic risk factor may be restricted to selected Asian races, and more studies will be needed to confirm our observations.
DOI: 10.1002/mds.21658
PubMed: 17659642
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<author><name sortKey="Tan, Eng King" sort="Tan, Eng King" uniqKey="Tan E" first="Eng-King" last="Tan">Eng-King Tan</name>
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<wicri:regionArea>Department of Neurology, Singapore General Hospital</wicri:regionArea>
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<author><name sortKey="Zhao, Yi" sort="Zhao, Yi" uniqKey="Zhao Y" first="Yi" last="Zhao">Yi Zhao</name>
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<author><name sortKey="Tan, Louis" sort="Tan, Louis" uniqKey="Tan L" first="Louis" last="Tan">Louis Tan</name>
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<author><name sortKey="Lim, Hui Qin" sort="Lim, Hui Qin" uniqKey="Lim H" first="Hui-Qin" last="Lim">Hui-Qin Lim</name>
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<author><name sortKey="Fook Chong, Stephanie" sort="Fook Chong, Stephanie" uniqKey="Fook Chong S" first="Stephanie" last="Fook-Chong">Stephanie Fook-Chong</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Analysis of LRRK2 Gly2385Arg genetic variant in non-Chinese Asians.</title>
<author><name sortKey="Tan, Eng King" sort="Tan, Eng King" uniqKey="Tan E" first="Eng-King" last="Tan">Eng-King Tan</name>
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<author><name sortKey="Tan, Louis" sort="Tan, Louis" uniqKey="Tan L" first="Louis" last="Tan">Louis Tan</name>
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<author><name sortKey="Lee, Jasinda" sort="Lee, Jasinda" uniqKey="Lee J" first="Jasinda" last="Lee">Jasinda Lee</name>
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<author><name sortKey="Yuen, Yih" sort="Yuen, Yih" uniqKey="Yuen Y" first="Yih" last="Yuen">Yih Yuen</name>
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<author><name sortKey="Pavanni, Ratnagopal" sort="Pavanni, Ratnagopal" uniqKey="Pavanni R" first="Ratnagopal" last="Pavanni">Ratnagopal Pavanni</name>
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<author><name sortKey="Wong, Meng Cheong" sort="Wong, Meng Cheong" uniqKey="Wong M" first="Meng-Cheong" last="Wong">Meng-Cheong Wong</name>
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<author><name sortKey="Fook Chong, Stephanie" sort="Fook Chong, Stephanie" uniqKey="Fook Chong S" first="Stephanie" last="Fook-Chong">Stephanie Fook-Chong</name>
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<term>Aged, 80 and over</term>
<term>Arginine (genetics)</term>
<term>Asia, Southeastern (ethnology)</term>
<term>Chi-Square Distribution</term>
<term>Female</term>
<term>Gene Frequency</term>
<term>Genotype</term>
<term>Glycine (genetics)</term>
<term>Humans</term>
<term>India (ethnology)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Odds Ratio</term>
<term>Parkinson Disease (genetics)</term>
<term>Protein-Serine-Threonine Kinases (genetics)</term>
<term>Risk Factors</term>
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<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Chi-Square Distribution</term>
<term>Female</term>
<term>Gene Frequency</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
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<front><div type="abstract" xml:lang="en">A common LRRK2 missense variant, Gly2385Arg, has been found to be a genetic risk factor for Parkinson's disease (PD) in ethnic Chinese and Japanese. However, the presence of the variant in other non-Chinese Asian patients has not been fully clarified. We performed genetic analysis of the Gly2385Arg variant in 472 non-Chinese Asian subjects in Singapore (comprising of 166 PD and 306 controls of Malay/Indian ethnicity). The frequency of the heterozygous Gly2385Arg genotype was not significantly different in PD compared with controls (1.2% vs. 0.8%, odds ratio = 2.83, 95% CI 0.40, 20.2, P = 0.3). No subjects carried the homozygous genotype. Stratification by Malay and Indian ethnicity revealed that there were two carriers each among 98 (2.0%) Malay PD and 173 (1.2%) Malay controls (odds ratio = 1.78, 95% CI 0.25, 12.8, P = 0.6), but there were no carriers among 66 Indian PD and 133 Indian controls. We demonstrated that the Gly2385Arg variant could be detected in our Malay subjects. However, its frequency was much lower than the 8 to 10% prevalence previously reported in our Singaporean and Taiwanese Chinese PD population. The relevance of Gly2385Arg as a genetic risk factor may be restricted to selected Asian races, and more studies will be needed to confirm our observations.</div>
</front>
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<Abstract><AbstractText>A common LRRK2 missense variant, Gly2385Arg, has been found to be a genetic risk factor for Parkinson's disease (PD) in ethnic Chinese and Japanese. However, the presence of the variant in other non-Chinese Asian patients has not been fully clarified. We performed genetic analysis of the Gly2385Arg variant in 472 non-Chinese Asian subjects in Singapore (comprising of 166 PD and 306 controls of Malay/Indian ethnicity). The frequency of the heterozygous Gly2385Arg genotype was not significantly different in PD compared with controls (1.2% vs. 0.8%, odds ratio = 2.83, 95% CI 0.40, 20.2, P = 0.3). No subjects carried the homozygous genotype. Stratification by Malay and Indian ethnicity revealed that there were two carriers each among 98 (2.0%) Malay PD and 173 (1.2%) Malay controls (odds ratio = 1.78, 95% CI 0.25, 12.8, P = 0.6), but there were no carriers among 66 Indian PD and 133 Indian controls. We demonstrated that the Gly2385Arg variant could be detected in our Malay subjects. However, its frequency was much lower than the 8 to 10% prevalence previously reported in our Singaporean and Taiwanese Chinese PD population. The relevance of Gly2385Arg as a genetic risk factor may be restricted to selected Asian races, and more studies will be needed to confirm our observations.</AbstractText>
<CopyrightInformation>(c) 2007 Movement Disorder Society.</CopyrightInformation>
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