Movement Disorders (revue)

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No Lewy pathology in monkeys with over 10 years of severe MPTP Parkinsonism.

Identifieur interne : 001C89 ( PubMed/Checkpoint ); précédent : 001C88; suivant : 001C90

No Lewy pathology in monkeys with over 10 years of severe MPTP Parkinsonism.

Auteurs : Glenda Halliday [Australie] ; Maria Trinidad Herrero ; Karen Murphy ; Heather Mccann ; Francisco Ros-Bernal ; Carlos Barcia ; Hideo Mori ; Francisco J. Blesa ; José A. Obeso

Source :

RBID : pubmed:19526568

English descriptors

Abstract

The recent knowledge that 10 years after transplantation surviving human fetal neurons adopt the histopathology of Parkinson's disease suggests that Lewy body formation takes a decade to achieve. To determine whether similar histopathology occurs in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-primate models over a similar timeframe, the brains of two adult monkeys made parkinsonian in their youth with intermittent injections of MPTP were studied. Despite substantial nigral degeneration and increased alpha-synuclein immunoreactivity within surviving neurons, there was no evidence of Lewy body formation. This suggests that MPTP-induced oxidative stress and inflammation per se are not sufficient for Lewy body formation, or Lewy bodies are human specific.

DOI: 10.1002/mds.22481
PubMed: 19526568


Affiliations:


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pubmed:19526568

Le document en format XML

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