No Lewy pathology in monkeys with over 10 years of severe MPTP Parkinsonism.
Identifieur interne : 001C57 ( PubMed/Corpus ); précédent : 001C56; suivant : 001C58No Lewy pathology in monkeys with over 10 years of severe MPTP Parkinsonism.
Auteurs : Glenda Halliday ; Maria Trinidad Herrero ; Karen Murphy ; Heather Mccann ; Francisco Ros-Bernal ; Carlos Barcia ; Hideo Mori ; Francisco J. Blesa ; José A. ObesoSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2009.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Tyrosine 3-Monooxygenase, alpha-Synuclein.
- metabolism : MPTP Poisoning.
- pathology : Lewy Bodies, MPTP Poisoning.
- Animals, Disease Models, Animal, Disease Progression, Longitudinal Studies, Macaca fascicularis.
Abstract
The recent knowledge that 10 years after transplantation surviving human fetal neurons adopt the histopathology of Parkinson's disease suggests that Lewy body formation takes a decade to achieve. To determine whether similar histopathology occurs in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-primate models over a similar timeframe, the brains of two adult monkeys made parkinsonian in their youth with intermittent injections of MPTP were studied. Despite substantial nigral degeneration and increased alpha-synuclein immunoreactivity within surviving neurons, there was no evidence of Lewy body formation. This suggests that MPTP-induced oxidative stress and inflammation per se are not sufficient for Lewy body formation, or Lewy bodies are human specific.
DOI: 10.1002/mds.22481
PubMed: 19526568
Links to Exploration step
pubmed:19526568Le document en format XML
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<author><name sortKey="Halliday, Glenda" sort="Halliday, Glenda" uniqKey="Halliday G" first="Glenda" last="Halliday">Glenda Halliday</name>
<affiliation><nlm:affiliation>Prince of Wales Medical Research Institute and School of Medical Sciences, Faculty of Medicine University of New South Wales, Sydney, Australia. g.halliday@powmri.edu.au</nlm:affiliation>
</affiliation>
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<author><name sortKey="Herrero, Maria Trinidad" sort="Herrero, Maria Trinidad" uniqKey="Herrero M" first="Maria Trinidad" last="Herrero">Maria Trinidad Herrero</name>
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<author><name sortKey="Murphy, Karen" sort="Murphy, Karen" uniqKey="Murphy K" first="Karen" last="Murphy">Karen Murphy</name>
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<author><name sortKey="Mccann, Heather" sort="Mccann, Heather" uniqKey="Mccann H" first="Heather" last="Mccann">Heather Mccann</name>
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<author><name sortKey="Ros Bernal, Francisco" sort="Ros Bernal, Francisco" uniqKey="Ros Bernal F" first="Francisco" last="Ros-Bernal">Francisco Ros-Bernal</name>
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<author><name sortKey="Barcia, Carlos" sort="Barcia, Carlos" uniqKey="Barcia C" first="Carlos" last="Barcia">Carlos Barcia</name>
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<author><name sortKey="Mori, Hideo" sort="Mori, Hideo" uniqKey="Mori H" first="Hideo" last="Mori">Hideo Mori</name>
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<author><name sortKey="Blesa, Francisco J" sort="Blesa, Francisco J" uniqKey="Blesa F" first="Francisco J" last="Blesa">Francisco J. Blesa</name>
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<author><name sortKey="Obeso, Jose A" sort="Obeso, Jose A" uniqKey="Obeso J" first="José A" last="Obeso">José A. Obeso</name>
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<author><name sortKey="Murphy, Karen" sort="Murphy, Karen" uniqKey="Murphy K" first="Karen" last="Murphy">Karen Murphy</name>
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<author><name sortKey="Mccann, Heather" sort="Mccann, Heather" uniqKey="Mccann H" first="Heather" last="Mccann">Heather Mccann</name>
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<author><name sortKey="Ros Bernal, Francisco" sort="Ros Bernal, Francisco" uniqKey="Ros Bernal F" first="Francisco" last="Ros-Bernal">Francisco Ros-Bernal</name>
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<author><name sortKey="Blesa, Francisco J" sort="Blesa, Francisco J" uniqKey="Blesa F" first="Francisco J" last="Blesa">Francisco J. Blesa</name>
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<author><name sortKey="Obeso, Jose A" sort="Obeso, Jose A" uniqKey="Obeso J" first="José A" last="Obeso">José A. Obeso</name>
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<term>Disease Progression</term>
<term>Lewy Bodies (pathology)</term>
<term>Longitudinal Studies</term>
<term>MPTP Poisoning (metabolism)</term>
<term>MPTP Poisoning (pathology)</term>
<term>Macaca fascicularis</term>
<term>Tyrosine 3-Monooxygenase (metabolism)</term>
<term>alpha-Synuclein (metabolism)</term>
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<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Tyrosine 3-Monooxygenase</term>
<term>alpha-Synuclein</term>
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<term>MPTP Poisoning</term>
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<term>Disease Models, Animal</term>
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<front><div type="abstract" xml:lang="en">The recent knowledge that 10 years after transplantation surviving human fetal neurons adopt the histopathology of Parkinson's disease suggests that Lewy body formation takes a decade to achieve. To determine whether similar histopathology occurs in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-primate models over a similar timeframe, the brains of two adult monkeys made parkinsonian in their youth with intermittent injections of MPTP were studied. Despite substantial nigral degeneration and increased alpha-synuclein immunoreactivity within surviving neurons, there was no evidence of Lewy body formation. This suggests that MPTP-induced oxidative stress and inflammation per se are not sufficient for Lewy body formation, or Lewy bodies are human specific.</div>
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<Abstract><AbstractText>The recent knowledge that 10 years after transplantation surviving human fetal neurons adopt the histopathology of Parkinson's disease suggests that Lewy body formation takes a decade to achieve. To determine whether similar histopathology occurs in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-primate models over a similar timeframe, the brains of two adult monkeys made parkinsonian in their youth with intermittent injections of MPTP were studied. Despite substantial nigral degeneration and increased alpha-synuclein immunoreactivity within surviving neurons, there was no evidence of Lewy body formation. This suggests that MPTP-induced oxidative stress and inflammation per se are not sufficient for Lewy body formation, or Lewy bodies are human specific.</AbstractText>
<CopyrightInformation>Copyright 2009 Movement Disorder Society.</CopyrightInformation>
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