Catechol-O-methyltransferase val158met and cognitive function in Parkinson's disease.
Identifieur interne : 001A01 ( PubMed/Checkpoint ); précédent : 001A00; suivant : 001A02Catechol-O-methyltransferase val158met and cognitive function in Parkinson's disease.
Auteurs : Jeroen Hoogland [Pays-Bas] ; Rob M A. De Bie ; Caroline H. Williams-Gray ; Dino Muslimovi ; Ben Schmand ; Bart PostSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2010.
English descriptors
- KwdEn :
- Age Factors, Aged, Analysis of Variance, Attention (physiology), Catechol O-Methyltransferase (genetics), Cognition (physiology), Cognition Disorders (genetics), Cognition Disorders (physiopathology), Cognition Disorders (psychology), Executive Function (physiology), Female, Genotype, Humans, Male, Middle Aged, Neuropsychological Tests, Parkinson Disease (genetics), Parkinson Disease (physiopathology), Parkinson Disease (psychology), Polymorphism, Single Nucleotide, Sex Factors.
- MESH :
- chemical , genetics : Catechol O-Methyltransferase.
- genetics : Cognition Disorders, Parkinson Disease.
- physiology : Attention, Cognition, Executive Function.
- physiopathology : Cognition Disorders, Parkinson Disease.
- psychology : Cognition Disorders, Parkinson Disease.
- Age Factors, Aged, Analysis of Variance, Female, Genotype, Humans, Male, Middle Aged, Neuropsychological Tests, Polymorphism, Single Nucleotide, Sex Factors.
Abstract
Cognitive dysfunction is one of the most incapacitating non-motor symptoms of Parkinson's disease (PD). Some cognitive deficits are thought to be related to abnormal dopamine homeostasis. The latter is influenced by catechol-O-methyltransferase (COMT), an enzyme that degrades dopamine. Previous research suggests a relationship between the COMT val158met functional polymorphism (SNP) and measures of executive function. We evaluated this hypothesis in a cohort of PD patients with an extensive neuropsychological test battery. Cognitive assessment and COMT genotyping were performed in 153 early PD patients from outpatient clinics general hospitals in the Netherlands. Our results do not support a direct effect of COMT val158met genotype on performance on neuropsychological measures of attention and executive function, but they suggest that genotype may interact with dopaminergic medication use to influence cognitive ability.
DOI: 10.1002/mds.23319
PubMed: 20878993
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:20878993Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Catechol-O-methyltransferase val158met and cognitive function in Parkinson's disease.</title>
<author><name sortKey="Hoogland, Jeroen" sort="Hoogland, Jeroen" uniqKey="Hoogland J" first="Jeroen" last="Hoogland">Jeroen Hoogland</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="De Bie, Rob M A" sort="De Bie, Rob M A" uniqKey="De Bie R" first="Rob M A" last="De Bie">Rob M A. De Bie</name>
</author>
<author><name sortKey="Williams Gray, Caroline H" sort="Williams Gray, Caroline H" uniqKey="Williams Gray C" first="Caroline H" last="Williams-Gray">Caroline H. Williams-Gray</name>
</author>
<author><name sortKey="Muslimovi, Dino" sort="Muslimovi, Dino" uniqKey="Muslimovi D" first="Dino" last="Muslimovi">Dino Muslimovi</name>
</author>
<author><name sortKey="Schmand, Ben" sort="Schmand, Ben" uniqKey="Schmand B" first="Ben" last="Schmand">Ben Schmand</name>
</author>
<author><name sortKey="Post, Bart" sort="Post, Bart" uniqKey="Post B" first="Bart" last="Post">Bart Post</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2010">2010</date>
<idno type="doi">10.1002/mds.23319</idno>
<idno type="RBID">pubmed:20878993</idno>
<idno type="pmid">20878993</idno>
<idno type="wicri:Area/PubMed/Corpus">001543</idno>
<idno type="wicri:Area/PubMed/Curation">001543</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001A01</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Catechol-O-methyltransferase val158met and cognitive function in Parkinson's disease.</title>
<author><name sortKey="Hoogland, Jeroen" sort="Hoogland, Jeroen" uniqKey="Hoogland J" first="Jeroen" last="Hoogland">Jeroen Hoogland</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="De Bie, Rob M A" sort="De Bie, Rob M A" uniqKey="De Bie R" first="Rob M A" last="De Bie">Rob M A. De Bie</name>
</author>
<author><name sortKey="Williams Gray, Caroline H" sort="Williams Gray, Caroline H" uniqKey="Williams Gray C" first="Caroline H" last="Williams-Gray">Caroline H. Williams-Gray</name>
</author>
<author><name sortKey="Muslimovi, Dino" sort="Muslimovi, Dino" uniqKey="Muslimovi D" first="Dino" last="Muslimovi">Dino Muslimovi</name>
</author>
<author><name sortKey="Schmand, Ben" sort="Schmand, Ben" uniqKey="Schmand B" first="Ben" last="Schmand">Ben Schmand</name>
</author>
<author><name sortKey="Post, Bart" sort="Post, Bart" uniqKey="Post B" first="Bart" last="Post">Bart Post</name>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2010" type="published">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age Factors</term>
<term>Aged</term>
<term>Analysis of Variance</term>
<term>Attention (physiology)</term>
<term>Catechol O-Methyltransferase (genetics)</term>
<term>Cognition (physiology)</term>
<term>Cognition Disorders (genetics)</term>
<term>Cognition Disorders (physiopathology)</term>
<term>Cognition Disorders (psychology)</term>
<term>Executive Function (physiology)</term>
<term>Female</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neuropsychological Tests</term>
<term>Parkinson Disease (genetics)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson Disease (psychology)</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Sex Factors</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Catechol O-Methyltransferase</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Cognition Disorders</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Attention</term>
<term>Cognition</term>
<term>Executive Function</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Cognition Disorders</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Cognition Disorders</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Age Factors</term>
<term>Aged</term>
<term>Analysis of Variance</term>
<term>Female</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neuropsychological Tests</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Sex Factors</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Cognitive dysfunction is one of the most incapacitating non-motor symptoms of Parkinson's disease (PD). Some cognitive deficits are thought to be related to abnormal dopamine homeostasis. The latter is influenced by catechol-O-methyltransferase (COMT), an enzyme that degrades dopamine. Previous research suggests a relationship between the COMT val158met functional polymorphism (SNP) and measures of executive function. We evaluated this hypothesis in a cohort of PD patients with an extensive neuropsychological test battery. Cognitive assessment and COMT genotyping were performed in 153 early PD patients from outpatient clinics general hospitals in the Netherlands. Our results do not support a direct effect of COMT val158met genotype on performance on neuropsychological measures of attention and executive function, but they suggest that genotype may interact with dopaminergic medication use to influence cognitive ability.</div>
</front>
</TEI>
<pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">20878993</PMID>
<DateCreated><Year>2010</Year>
<Month>11</Month>
<Day>11</Day>
</DateCreated>
<DateCompleted><Year>2011</Year>
<Month>02</Month>
<Day>25</Day>
</DateCompleted>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>25</Volume>
<Issue>15</Issue>
<PubDate><Year>2010</Year>
<Month>Nov</Month>
<Day>15</Day>
</PubDate>
</JournalIssue>
<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
<ISOAbbreviation>Mov. Disord.</ISOAbbreviation>
</Journal>
<ArticleTitle>Catechol-O-methyltransferase val158met and cognitive function in Parkinson's disease.</ArticleTitle>
<Pagination><MedlinePgn>2550-4</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.23319</ELocationID>
<Abstract><AbstractText>Cognitive dysfunction is one of the most incapacitating non-motor symptoms of Parkinson's disease (PD). Some cognitive deficits are thought to be related to abnormal dopamine homeostasis. The latter is influenced by catechol-O-methyltransferase (COMT), an enzyme that degrades dopamine. Previous research suggests a relationship between the COMT val158met functional polymorphism (SNP) and measures of executive function. We evaluated this hypothesis in a cohort of PD patients with an extensive neuropsychological test battery. Cognitive assessment and COMT genotyping were performed in 153 early PD patients from outpatient clinics general hospitals in the Netherlands. Our results do not support a direct effect of COMT val158met genotype on performance on neuropsychological measures of attention and executive function, but they suggest that genotype may interact with dopaminergic medication use to influence cognitive ability.</AbstractText>
<CopyrightInformation>© 2010 Movement Disorder Society.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hoogland</LastName>
<ForeName>Jeroen</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>de Bie</LastName>
<ForeName>Rob M A</ForeName>
<Initials>RM</Initials>
</Author>
<Author ValidYN="Y"><LastName>Williams-Gray</LastName>
<ForeName>Caroline H</ForeName>
<Initials>CH</Initials>
</Author>
<Author ValidYN="Y"><LastName>Muslimović</LastName>
<ForeName>Dino</ForeName>
<Initials>D</Initials>
</Author>
<Author ValidYN="Y"><LastName>Schmand</LastName>
<ForeName>Ben</ForeName>
<Initials>B</Initials>
</Author>
<Author ValidYN="Y"><LastName>Post</LastName>
<ForeName>Bart</ForeName>
<Initials>B</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Mov Disord</MedlineTA>
<NlmUniqueID>8610688</NlmUniqueID>
<ISSNLinking>0885-3185</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>EC 2.1.1.6</RegistryNumber>
<NameOfSubstance UI="D002394">Catechol O-Methyltransferase</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000367">Age Factors</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D000704">Analysis of Variance</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D001288">Attention</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D002394">Catechol O-Methyltransferase</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D003071">Cognition</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D003072">Cognition Disorders</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName>
<QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName>
<QualifierName MajorTopicYN="N" UI="Q000523">psychology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D056344">Executive Function</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D005838">Genotype</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D009483">Neuropsychological Tests</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName>
<QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName>
<QualifierName MajorTopicYN="N" UI="Q000523">psychology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D020641">Polymorphism, Single Nucleotide</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D012737">Sex Factors</DescriptorName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2010</Year>
<Month>9</Month>
<Day>30</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2010</Year>
<Month>9</Month>
<Day>30</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2011</Year>
<Month>2</Month>
<Day>26</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="doi">10.1002/mds.23319</ArticleId>
<ArticleId IdType="pubmed">20878993</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Pays-Bas</li>
</country>
<region><li>Hollande-Septentrionale</li>
</region>
<settlement><li>Amsterdam</li>
</settlement>
</list>
<tree><noCountry><name sortKey="De Bie, Rob M A" sort="De Bie, Rob M A" uniqKey="De Bie R" first="Rob M A" last="De Bie">Rob M A. De Bie</name>
<name sortKey="Muslimovi, Dino" sort="Muslimovi, Dino" uniqKey="Muslimovi D" first="Dino" last="Muslimovi">Dino Muslimovi</name>
<name sortKey="Post, Bart" sort="Post, Bart" uniqKey="Post B" first="Bart" last="Post">Bart Post</name>
<name sortKey="Schmand, Ben" sort="Schmand, Ben" uniqKey="Schmand B" first="Ben" last="Schmand">Ben Schmand</name>
<name sortKey="Williams Gray, Caroline H" sort="Williams Gray, Caroline H" uniqKey="Williams Gray C" first="Caroline H" last="Williams-Gray">Caroline H. Williams-Gray</name>
</noCountry>
<country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Hoogland, Jeroen" sort="Hoogland, Jeroen" uniqKey="Hoogland J" first="Jeroen" last="Hoogland">Jeroen Hoogland</name>
</region>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/PubMed/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001A01 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 001A01 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= PubMed |étape= Checkpoint |type= RBID |clé= pubmed:20878993 |texte= Catechol-O-methyltransferase val158met and cognitive function in Parkinson's disease. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i -Sk "pubmed:20878993" \ | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd \ | NlmPubMed2Wicri -a MovDisordV3
This area was generated with Dilib version V0.6.23. |