Cerebellar dysfunction in progressive supranuclear palsy: a transcranial magnetic stimulation study.
Identifieur interne : 001A00 ( PubMed/Checkpoint ); précédent : 001999; suivant : 001A01Cerebellar dysfunction in progressive supranuclear palsy: a transcranial magnetic stimulation study.
Auteurs : Yuichiro Shirota [Japon] ; Masashi Hamada ; Ritsuko Hanajima ; Yasuo Terao ; Hideyuki Matsumoto ; Shinya Ohminami ; Shoji Tsuji ; Yoshikazu UgawaSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2010.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Analysis of Variance, Case-Control Studies, Cerebellar Diseases (etiology), Electroencephalography (methods), Electromyography (methods), Evoked Potentials, Motor (physiology), Female, Hand (innervation), Humans, Male, Middle Aged, Muscle, Skeletal (physiopathology), Reaction Time (physiology), Severity of Illness Index, Statistics as Topic, Statistics, Nonparametric, Supranuclear Palsy, Progressive (complications), Time Factors, Transcranial Magnetic Stimulation.
- MESH :
- complications : Supranuclear Palsy, Progressive.
- etiology : Cerebellar Diseases.
- innervation : Hand.
- methods : Electroencephalography, Electromyography.
- physiology : Evoked Potentials, Motor, Reaction Time.
- physiopathology : Muscle, Skeletal.
- Aged, Aged, 80 and over, Analysis of Variance, Case-Control Studies, Female, Humans, Male, Middle Aged, Severity of Illness Index, Statistics as Topic, Statistics, Nonparametric, Time Factors, Transcranial Magnetic Stimulation.
Abstract
Progressive supranuclear palsy (PSP) rarely shows cerebellar signs and symptoms even though the cerebellar dentate nuclei are involved pathologically. This study evaluates cerebellar function using transcranial magnetic stimulation (TMS) to determine whether subclinical cerebellar involvement is present in PSP patients. We studied 11 patients with PSP, 11 patients with Parkinson's disease (PD), and 10 age-matched controls. Patients were examined with their usual medications and in their relative on state. Motor evoked potentials (MEPs) were recorded from the hand muscle. Cerebellar function was evaluated using suppressive effects of TMS over the cerebellum on MEPs elicited by TMS over the contralateral motor cortex, which we call cerebellar inhibition (CBI). Interstimulus intervals (ISIs) of 4 to 8 ms were used, and the time course of CBI was analyzed. The CBI was reduced in PSP patients. By contrast, the CBI was normal in PD patients in their on state. Although the CBI in their off state should be examined in future studies, the results described herein suggest that Purkinje cells or the dentato-thalamo-cortical pathway assessed by CBI is involved in PSP. Our results are compatible with the pathological findings showing severe dentate nucleus degeneration in PSP patients.
DOI: 10.1002/mds.23298
PubMed: 20818672
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cerebellar dysfunction in progressive supranuclear palsy: a transcranial magnetic stimulation study.</title><author><name sortKey="Shirota, Yuichiro" sort="Shirota, Yuichiro" uniqKey="Shirota Y" first="Yuichiro" last="Shirota">Yuichiro Shirota</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Division of Neuroscience, Graduate School of Medicine, University of Tokyo, Tokyo, Japan. yshirota-tky@umin.ac.jp</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Division of Neuroscience, Graduate School of Medicine, University of Tokyo, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Hamada, Masashi" sort="Hamada, Masashi" uniqKey="Hamada M" first="Masashi" last="Hamada">Masashi Hamada</name></author><author><name sortKey="Hanajima, Ritsuko" sort="Hanajima, Ritsuko" uniqKey="Hanajima R" first="Ritsuko" last="Hanajima">Ritsuko Hanajima</name></author><author><name sortKey="Terao, Yasuo" sort="Terao, Yasuo" uniqKey="Terao Y" first="Yasuo" last="Terao">Yasuo Terao</name></author><author><name sortKey="Matsumoto, Hideyuki" sort="Matsumoto, Hideyuki" uniqKey="Matsumoto H" first="Hideyuki" last="Matsumoto">Hideyuki Matsumoto</name></author><author><name sortKey="Ohminami, Shinya" sort="Ohminami, Shinya" uniqKey="Ohminami S" first="Shinya" last="Ohminami">Shinya Ohminami</name></author><author><name sortKey="Tsuji, Shoji" sort="Tsuji, Shoji" uniqKey="Tsuji S" first="Shoji" last="Tsuji">Shoji Tsuji</name></author><author><name sortKey="Ugawa, Yoshikazu" sort="Ugawa, Yoshikazu" uniqKey="Ugawa Y" first="Yoshikazu" last="Ugawa">Yoshikazu Ugawa</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="doi">10.1002/mds.23298</idno><idno type="RBID">pubmed:20818672</idno><idno 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sortKey="Hamada, Masashi" sort="Hamada, Masashi" uniqKey="Hamada M" first="Masashi" last="Hamada">Masashi Hamada</name></author><author><name sortKey="Hanajima, Ritsuko" sort="Hanajima, Ritsuko" uniqKey="Hanajima R" first="Ritsuko" last="Hanajima">Ritsuko Hanajima</name></author><author><name sortKey="Terao, Yasuo" sort="Terao, Yasuo" uniqKey="Terao Y" first="Yasuo" last="Terao">Yasuo Terao</name></author><author><name sortKey="Matsumoto, Hideyuki" sort="Matsumoto, Hideyuki" uniqKey="Matsumoto H" first="Hideyuki" last="Matsumoto">Hideyuki Matsumoto</name></author><author><name sortKey="Ohminami, Shinya" sort="Ohminami, Shinya" uniqKey="Ohminami S" first="Shinya" last="Ohminami">Shinya Ohminami</name></author><author><name sortKey="Tsuji, Shoji" sort="Tsuji, Shoji" uniqKey="Tsuji S" first="Shoji" last="Tsuji">Shoji Tsuji</name></author><author><name sortKey="Ugawa, Yoshikazu" sort="Ugawa, Yoshikazu" uniqKey="Ugawa Y" first="Yoshikazu" last="Ugawa">Yoshikazu Ugawa</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Analysis of Variance</term><term>Case-Control Studies</term><term>Cerebellar Diseases (etiology)</term><term>Electroencephalography (methods)</term><term>Electromyography (methods)</term><term>Evoked Potentials, Motor (physiology)</term><term>Female</term><term>Hand (innervation)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Muscle, Skeletal (physiopathology)</term><term>Reaction Time (physiology)</term><term>Severity of Illness Index</term><term>Statistics as Topic</term><term>Statistics, Nonparametric</term><term>Supranuclear Palsy, Progressive (complications)</term><term>Time Factors</term><term>Transcranial Magnetic Stimulation</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cerebellar Diseases</term></keywords><keywords scheme="MESH" qualifier="innervation" xml:lang="en"><term>Hand</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Electroencephalography</term><term>Electromyography</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Evoked Potentials, Motor</term><term>Reaction Time</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Muscle, Skeletal</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Analysis of Variance</term><term>Case-Control Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Severity of Illness Index</term><term>Statistics as Topic</term><term>Statistics, Nonparametric</term><term>Time Factors</term><term>Transcranial Magnetic Stimulation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Progressive supranuclear palsy (PSP) rarely shows cerebellar signs and symptoms even though the cerebellar dentate nuclei are involved pathologically. This study evaluates cerebellar function using transcranial magnetic stimulation (TMS) to determine whether subclinical cerebellar involvement is present in PSP patients. We studied 11 patients with PSP, 11 patients with Parkinson's disease (PD), and 10 age-matched controls. Patients were examined with their usual medications and in their relative on state. Motor evoked potentials (MEPs) were recorded from the hand muscle. Cerebellar function was evaluated using suppressive effects of TMS over the cerebellum on MEPs elicited by TMS over the contralateral motor cortex, which we call cerebellar inhibition (CBI). Interstimulus intervals (ISIs) of 4 to 8 ms were used, and the time course of CBI was analyzed. The CBI was reduced in PSP patients. By contrast, the CBI was normal in PD patients in their on state. Although the CBI in their off state should be examined in future studies, the results described herein suggest that Purkinje cells or the dentato-thalamo-cortical pathway assessed by CBI is involved in PSP. Our results are compatible with the pathological findings showing severe dentate nucleus degeneration in PSP patients.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">20818672</PMID><DateCreated><Year>2010</Year><Month>10</Month><Day>26</Day></DateCreated><DateCompleted><Year>2011</Year><Month>02</Month><Day>22</Day></DateCompleted><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>25</Volume><Issue>14</Issue><PubDate><Year>2010</Year><Month>Oct</Month><Day>30</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Cerebellar dysfunction in progressive supranuclear palsy: a transcranial magnetic stimulation study.</ArticleTitle><Pagination><MedlinePgn>2413-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.23298</ELocationID><Abstract><AbstractText>Progressive supranuclear palsy (PSP) rarely shows cerebellar signs and symptoms even though the cerebellar dentate nuclei are involved pathologically. This study evaluates cerebellar function using transcranial magnetic stimulation (TMS) to determine whether subclinical cerebellar involvement is present in PSP patients. We studied 11 patients with PSP, 11 patients with Parkinson's disease (PD), and 10 age-matched controls. Patients were examined with their usual medications and in their relative on state. Motor evoked potentials (MEPs) were recorded from the hand muscle. Cerebellar function was evaluated using suppressive effects of TMS over the cerebellum on MEPs elicited by TMS over the contralateral motor cortex, which we call cerebellar inhibition (CBI). Interstimulus intervals (ISIs) of 4 to 8 ms were used, and the time course of CBI was analyzed. The CBI was reduced in PSP patients. By contrast, the CBI was normal in PD patients in their on state. Although the CBI in their off state should be examined in future studies, the results described herein suggest that Purkinje cells or the dentato-thalamo-cortical pathway assessed by CBI is involved in PSP. Our results are compatible with the pathological findings showing severe dentate nucleus degeneration in PSP patients.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Shirota</LastName><ForeName>Yuichiro</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Neurology, Division of Neuroscience, Graduate School of Medicine, University of Tokyo, Tokyo, Japan. yshirota-tky@umin.ac.jp</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hamada</LastName><ForeName>Masashi</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Hanajima</LastName><ForeName>Ritsuko</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Terao</LastName><ForeName>Yasuo</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Matsumoto</LastName><ForeName>Hideyuki</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Ohminami</LastName><ForeName>Shinya</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Tsuji</LastName><ForeName>Shoji</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Ugawa</LastName><ForeName>Yoshikazu</ForeName><Initials>Y</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000369">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName 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UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006225">Hand</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000294">innervation</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D018482">Muscle, Skeletal</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011930">Reaction Time</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012720">Severity of Illness Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013223">Statistics as Topic</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D018709">Statistics, Nonparametric</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013494">Supranuclear Palsy, Progressive</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000150">complications</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013997">Time Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D050781">Transcranial Magnetic Stimulation</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2010</Year><Month>9</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2010</Year><Month>9</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2011</Year><Month>2</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.23298</ArticleId><ArticleId IdType="pubmed">20818672</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Japon</li></country><settlement><li>Tokyo</li></settlement></list><tree><noCountry><name sortKey="Hamada, Masashi" sort="Hamada, Masashi" uniqKey="Hamada M" first="Masashi" last="Hamada">Masashi Hamada</name><name sortKey="Hanajima, Ritsuko" sort="Hanajima, Ritsuko" uniqKey="Hanajima R" first="Ritsuko" last="Hanajima">Ritsuko Hanajima</name><name sortKey="Matsumoto, Hideyuki" sort="Matsumoto, Hideyuki" uniqKey="Matsumoto H" first="Hideyuki" last="Matsumoto">Hideyuki Matsumoto</name><name sortKey="Ohminami, Shinya" sort="Ohminami, Shinya" uniqKey="Ohminami S" first="Shinya" last="Ohminami">Shinya Ohminami</name><name sortKey="Terao, Yasuo" sort="Terao, Yasuo" uniqKey="Terao Y" first="Yasuo" last="Terao">Yasuo Terao</name><name sortKey="Tsuji, Shoji" sort="Tsuji, Shoji" uniqKey="Tsuji S" first="Shoji" last="Tsuji">Shoji Tsuji</name><name sortKey="Ugawa, Yoshikazu" sort="Ugawa, Yoshikazu" uniqKey="Ugawa Y" first="Yoshikazu" last="Ugawa">Yoshikazu Ugawa</name></noCountry><country name="Japon"><noRegion><name sortKey="Shirota, Yuichiro" sort="Shirota, Yuichiro" uniqKey="Shirota Y" first="Yuichiro" last="Shirota">Yuichiro Shirota</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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