Increased medial orbitofrontal [18F]fluorodopa uptake in Parkinsonian impulse control disorders.
Identifieur interne : 000D81 ( PubMed/Checkpoint ); précédent : 000D80; suivant : 000D82Increased medial orbitofrontal [18F]fluorodopa uptake in Parkinsonian impulse control disorders.
Auteurs : Juho Joutsa [Finlande] ; Kirsti Martikainen ; Solja Niemel ; Jarkko Johansson ; Sarita Forsback ; Juha O. Rinne ; Valtteri KaasinenSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2012.
English descriptors
- KwdEn :
- Aged, Compulsive Behavior (complications), Compulsive Behavior (metabolism), Dihydroxyphenylalanine (analogs & derivatives), Frontal Lobe (metabolism), Humans, Impulse Control Disorders (complications), Impulse Control Disorders (metabolism), Male, Middle Aged, Parkinsonian Disorders (complications), Parkinsonian Disorders (metabolism).
- MESH :
- chemical , analogs & derivatives : Dihydroxyphenylalanine.
- complications : Compulsive Behavior, Impulse Control Disorders, Parkinsonian Disorders.
- metabolism : Compulsive Behavior, Frontal Lobe, Impulse Control Disorders, Parkinsonian Disorders.
- Aged, Humans, Male, Middle Aged.
Abstract
Impulse control disorders (ICDs) occur frequently in PD patients.
DOI: 10.1002/mds.24941
PubMed: 22649006
Affiliations:
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pubmed:22649006Le document en format XML
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<author><name sortKey="Joutsa, Juho" sort="Joutsa, Juho" uniqKey="Joutsa J" first="Juho" last="Joutsa">Juho Joutsa</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, University of Turku and Turku University Hospital, Turku, Finland. jtjout@utu.fi</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Neurology, University of Turku and Turku University Hospital, Turku</wicri:regionArea>
<placeName><settlement type="city">Turku</settlement>
<region type="région" nuts="2">Finlande occidentale</region>
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<author><name sortKey="Martikainen, Kirsti" sort="Martikainen, Kirsti" uniqKey="Martikainen K" first="Kirsti" last="Martikainen">Kirsti Martikainen</name>
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<author><name sortKey="Niemel, Solja" sort="Niemel, Solja" uniqKey="Niemel S" first="Solja" last="Niemel">Solja Niemel</name>
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<author><name sortKey="Johansson, Jarkko" sort="Johansson, Jarkko" uniqKey="Johansson J" first="Jarkko" last="Johansson">Jarkko Johansson</name>
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<author><name sortKey="Forsback, Sarita" sort="Forsback, Sarita" uniqKey="Forsback S" first="Sarita" last="Forsback">Sarita Forsback</name>
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<author><name sortKey="Rinne, Juha O" sort="Rinne, Juha O" uniqKey="Rinne J" first="Juha O" last="Rinne">Juha O. Rinne</name>
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<author><name sortKey="Kaasinen, Valtteri" sort="Kaasinen, Valtteri" uniqKey="Kaasinen V" first="Valtteri" last="Kaasinen">Valtteri Kaasinen</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Increased medial orbitofrontal [18F]fluorodopa uptake in Parkinsonian impulse control disorders.</title>
<author><name sortKey="Joutsa, Juho" sort="Joutsa, Juho" uniqKey="Joutsa J" first="Juho" last="Joutsa">Juho Joutsa</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, University of Turku and Turku University Hospital, Turku, Finland. jtjout@utu.fi</nlm:affiliation>
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<wicri:regionArea>Department of Neurology, University of Turku and Turku University Hospital, Turku</wicri:regionArea>
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<author><name sortKey="Martikainen, Kirsti" sort="Martikainen, Kirsti" uniqKey="Martikainen K" first="Kirsti" last="Martikainen">Kirsti Martikainen</name>
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<author><name sortKey="Niemel, Solja" sort="Niemel, Solja" uniqKey="Niemel S" first="Solja" last="Niemel">Solja Niemel</name>
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<author><name sortKey="Johansson, Jarkko" sort="Johansson, Jarkko" uniqKey="Johansson J" first="Jarkko" last="Johansson">Jarkko Johansson</name>
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<author><name sortKey="Forsback, Sarita" sort="Forsback, Sarita" uniqKey="Forsback S" first="Sarita" last="Forsback">Sarita Forsback</name>
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<author><name sortKey="Rinne, Juha O" sort="Rinne, Juha O" uniqKey="Rinne J" first="Juha O" last="Rinne">Juha O. Rinne</name>
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<author><name sortKey="Kaasinen, Valtteri" sort="Kaasinen, Valtteri" uniqKey="Kaasinen V" first="Valtteri" last="Kaasinen">Valtteri Kaasinen</name>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2012" type="published">2012</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Compulsive Behavior (complications)</term>
<term>Compulsive Behavior (metabolism)</term>
<term>Dihydroxyphenylalanine (analogs & derivatives)</term>
<term>Frontal Lobe (metabolism)</term>
<term>Humans</term>
<term>Impulse Control Disorders (complications)</term>
<term>Impulse Control Disorders (metabolism)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinsonian Disorders (complications)</term>
<term>Parkinsonian Disorders (metabolism)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Dihydroxyphenylalanine</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Compulsive Behavior</term>
<term>Impulse Control Disorders</term>
<term>Parkinsonian Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Compulsive Behavior</term>
<term>Frontal Lobe</term>
<term>Impulse Control Disorders</term>
<term>Parkinsonian Disorders</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
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<front><div type="abstract" xml:lang="en">Impulse control disorders (ICDs) occur frequently in PD patients.</div>
</front>
</TEI>
<pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">22649006</PMID>
<DateCreated><Year>2012</Year>
<Month>05</Month>
<Day>31</Day>
</DateCreated>
<DateCompleted><Year>2012</Year>
<Month>10</Month>
<Day>25</Day>
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<DateRevised><Year>2012</Year>
<Month>11</Month>
<Day>15</Day>
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<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>27</Volume>
<Issue>6</Issue>
<PubDate><Year>2012</Year>
<Month>May</Month>
</PubDate>
</JournalIssue>
<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
<ISOAbbreviation>Mov. Disord.</ISOAbbreviation>
</Journal>
<ArticleTitle>Increased medial orbitofrontal [18F]fluorodopa uptake in Parkinsonian impulse control disorders.</ArticleTitle>
<Pagination><MedlinePgn>778-82</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.24941</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Impulse control disorders (ICDs) occur frequently in PD patients.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">To investigate the possible involvement of the mesostriatal and mesolimbic monoaminergic function in ICDs associated with PD, we examined patients with (n = 10) and without (n = 10) ICDs using the brain [(18) F]fluorodopa PET.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Patients with ICDs (e.g., pathological gambling, hypersexuality, and compulsive eating) showed up to 35% higher [(18) F]fluorodopa uptake in the medial orbitofrontal cortex, compared to control patients, but no differences in the striatum. The results remained significant also after excluding subjects with comorbid psychiatric disorders.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Increased monoaminergic activity in the medial orbitofrontal cortex might be associated with increased sensitivity for ICDs under dopamine-replacement therapy in PD.</AbstractText>
<CopyrightInformation>Copyright © 2012 Movement Disorder Society.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Joutsa</LastName>
<ForeName>Juho</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, University of Turku and Turku University Hospital, Turku, Finland. jtjout@utu.fi</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Martikainen</LastName>
<ForeName>Kirsti</ForeName>
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<Author ValidYN="Y"><LastName>Niemelä</LastName>
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<Author ValidYN="Y"><LastName>Johansson</LastName>
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<Author ValidYN="Y"><LastName>Forsback</LastName>
<ForeName>Sarita</ForeName>
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<Author ValidYN="Y"><LastName>Rinne</LastName>
<ForeName>Juha O</ForeName>
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<Author ValidYN="Y"><LastName>Kaasinen</LastName>
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<ChemicalList><Chemical><RegistryNumber>2C598205QX</RegistryNumber>
<NameOfSubstance UI="C043437">fluorodopa F 18</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>63-84-3</RegistryNumber>
<NameOfSubstance UI="D004295">Dihydroxyphenylalanine</NameOfSubstance>
</Chemical>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D020734">Parkinsonian Disorders</DescriptorName>
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<tree><noCountry><name sortKey="Forsback, Sarita" sort="Forsback, Sarita" uniqKey="Forsback S" first="Sarita" last="Forsback">Sarita Forsback</name>
<name sortKey="Johansson, Jarkko" sort="Johansson, Jarkko" uniqKey="Johansson J" first="Jarkko" last="Johansson">Jarkko Johansson</name>
<name sortKey="Kaasinen, Valtteri" sort="Kaasinen, Valtteri" uniqKey="Kaasinen V" first="Valtteri" last="Kaasinen">Valtteri Kaasinen</name>
<name sortKey="Martikainen, Kirsti" sort="Martikainen, Kirsti" uniqKey="Martikainen K" first="Kirsti" last="Martikainen">Kirsti Martikainen</name>
<name sortKey="Niemel, Solja" sort="Niemel, Solja" uniqKey="Niemel S" first="Solja" last="Niemel">Solja Niemel</name>
<name sortKey="Rinne, Juha O" sort="Rinne, Juha O" uniqKey="Rinne J" first="Juha O" last="Rinne">Juha O. Rinne</name>
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<country name="Finlande"><region name="Finlande occidentale"><name sortKey="Joutsa, Juho" sort="Joutsa, Juho" uniqKey="Joutsa J" first="Juho" last="Joutsa">Juho Joutsa</name>
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