Increased medial orbitofrontal [18F]fluorodopa uptake in Parkinsonian impulse control disorders.
Identifieur interne : 000D63 ( PubMed/Curation ); précédent : 000D62; suivant : 000D64Increased medial orbitofrontal [18F]fluorodopa uptake in Parkinsonian impulse control disorders.
Auteurs : Juho Joutsa [Finlande] ; Kirsti Martikainen ; Solja Niemel ; Jarkko Johansson ; Sarita Forsback ; Juha O. Rinne ; Valtteri KaasinenSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2012.
English descriptors
- KwdEn :
- Aged, Compulsive Behavior (complications), Compulsive Behavior (metabolism), Dihydroxyphenylalanine (analogs & derivatives), Frontal Lobe (metabolism), Humans, Impulse Control Disorders (complications), Impulse Control Disorders (metabolism), Male, Middle Aged, Parkinsonian Disorders (complications), Parkinsonian Disorders (metabolism).
- MESH :
- chemical , analogs & derivatives : Dihydroxyphenylalanine.
- complications : Compulsive Behavior, Impulse Control Disorders, Parkinsonian Disorders.
- metabolism : Compulsive Behavior, Frontal Lobe, Impulse Control Disorders, Parkinsonian Disorders.
- Aged, Humans, Male, Middle Aged.
Abstract
Impulse control disorders (ICDs) occur frequently in PD patients.
DOI: 10.1002/mds.24941
PubMed: 22649006
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Increased medial orbitofrontal [18F]fluorodopa uptake in Parkinsonian impulse control disorders.</title><author><name sortKey="Joutsa, Juho" sort="Joutsa, Juho" uniqKey="Joutsa J" first="Juho" last="Joutsa">Juho Joutsa</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University of Turku and Turku University Hospital, Turku, Finland. jtjout@utu.fi</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Neurology, University of Turku and Turku University Hospital, Turku</wicri:regionArea></affiliation></author><author><name sortKey="Martikainen, Kirsti" sort="Martikainen, Kirsti" uniqKey="Martikainen K" first="Kirsti" last="Martikainen">Kirsti Martikainen</name></author><author><name sortKey="Niemel, Solja" sort="Niemel, Solja" uniqKey="Niemel S" first="Solja" last="Niemel">Solja Niemel</name></author><author><name sortKey="Johansson, Jarkko" sort="Johansson, Jarkko" uniqKey="Johansson J" first="Jarkko" last="Johansson">Jarkko Johansson</name></author><author><name sortKey="Forsback, Sarita" sort="Forsback, Sarita" uniqKey="Forsback S" first="Sarita" last="Forsback">Sarita Forsback</name></author><author><name sortKey="Rinne, Juha O" sort="Rinne, Juha O" uniqKey="Rinne J" first="Juha O" last="Rinne">Juha O. Rinne</name></author><author><name sortKey="Kaasinen, Valtteri" sort="Kaasinen, Valtteri" uniqKey="Kaasinen V" first="Valtteri" last="Kaasinen">Valtteri Kaasinen</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="doi">10.1002/mds.24941</idno><idno type="RBID">pubmed:22649006</idno><idno type="pmid">22649006</idno><idno type="wicri:Area/PubMed/Corpus">000D63</idno><idno type="wicri:Area/PubMed/Curation">000D63</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Increased medial orbitofrontal [18F]fluorodopa uptake in Parkinsonian impulse control disorders.</title><author><name sortKey="Joutsa, Juho" sort="Joutsa, Juho" uniqKey="Joutsa J" first="Juho" last="Joutsa">Juho Joutsa</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University of Turku and Turku University Hospital, Turku, Finland. jtjout@utu.fi</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Neurology, University of Turku and Turku University Hospital, Turku</wicri:regionArea></affiliation></author><author><name sortKey="Martikainen, Kirsti" sort="Martikainen, Kirsti" uniqKey="Martikainen K" first="Kirsti" last="Martikainen">Kirsti Martikainen</name></author><author><name sortKey="Niemel, Solja" sort="Niemel, Solja" uniqKey="Niemel S" first="Solja" last="Niemel">Solja Niemel</name></author><author><name sortKey="Johansson, Jarkko" sort="Johansson, Jarkko" uniqKey="Johansson J" first="Jarkko" last="Johansson">Jarkko Johansson</name></author><author><name sortKey="Forsback, Sarita" sort="Forsback, Sarita" uniqKey="Forsback S" first="Sarita" last="Forsback">Sarita Forsback</name></author><author><name sortKey="Rinne, Juha O" sort="Rinne, Juha O" uniqKey="Rinne J" first="Juha O" last="Rinne">Juha O. Rinne</name></author><author><name sortKey="Kaasinen, Valtteri" sort="Kaasinen, Valtteri" uniqKey="Kaasinen V" first="Valtteri" last="Kaasinen">Valtteri Kaasinen</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Compulsive Behavior (complications)</term><term>Compulsive Behavior (metabolism)</term><term>Dihydroxyphenylalanine (analogs & derivatives)</term><term>Frontal Lobe (metabolism)</term><term>Humans</term><term>Impulse Control Disorders (complications)</term><term>Impulse Control Disorders (metabolism)</term><term>Male</term><term>Middle Aged</term><term>Parkinsonian Disorders (complications)</term><term>Parkinsonian Disorders (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Dihydroxyphenylalanine</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Compulsive Behavior</term><term>Impulse Control Disorders</term><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Compulsive Behavior</term><term>Frontal Lobe</term><term>Impulse Control Disorders</term><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Impulse control disorders (ICDs) occur frequently in PD patients.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">22649006</PMID><DateCreated><Year>2012</Year><Month>05</Month><Day>31</Day></DateCreated><DateCompleted><Year>2012</Year><Month>10</Month><Day>25</Day></DateCompleted><DateRevised><Year>2012</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>27</Volume><Issue>6</Issue><PubDate><Year>2012</Year><Month>May</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Increased medial orbitofrontal [18F]fluorodopa uptake in Parkinsonian impulse control disorders.</ArticleTitle><Pagination><MedlinePgn>778-82</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.24941</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Impulse control disorders (ICDs) occur frequently in PD patients.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">To investigate the possible involvement of the mesostriatal and mesolimbic monoaminergic function in ICDs associated with PD, we examined patients with (n = 10) and without (n = 10) ICDs using the brain [(18) F]fluorodopa PET.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Patients with ICDs (e.g., pathological gambling, hypersexuality, and compulsive eating) showed up to 35% higher [(18) F]fluorodopa uptake in the medial orbitofrontal cortex, compared to control patients, but no differences in the striatum. The results remained significant also after excluding subjects with comorbid psychiatric disorders.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Increased monoaminergic activity in the medial orbitofrontal cortex might be associated with increased sensitivity for ICDs under dopamine-replacement therapy in PD.</AbstractText><CopyrightInformation>Copyright © 2012 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Joutsa</LastName><ForeName>Juho</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Turku and Turku University Hospital, Turku, Finland. jtjout@utu.fi</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martikainen</LastName><ForeName>Kirsti</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Niemelä</LastName><ForeName>Solja</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Johansson</LastName><ForeName>Jarkko</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Forsback</LastName><ForeName>Sarita</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Rinne</LastName><ForeName>Juha O</ForeName><Initials>JO</Initials></Author><Author ValidYN="Y"><LastName>Kaasinen</LastName><ForeName>Valtteri</ForeName><Initials>V</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2012</Year><Month>02</Month><Day>05</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>2C598205QX</RegistryNumber><NameOfSubstance UI="C043437">fluorodopa F 18</NameOfSubstance></Chemical><Chemical><RegistryNumber>63-84-3</RegistryNumber><NameOfSubstance UI="D004295">Dihydroxyphenylalanine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D003192">Compulsive Behavior</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000150">complications</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004295">Dihydroxyphenylalanine</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000031">analogs & derivatives</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005625">Frontal Lobe</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007174">Impulse Control Disorders</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000150">complications</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D020734">Parkinsonian Disorders</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000150">complications</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2011</Year><Month>8</Month><Day>3</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2011</Year><Month>12</Month><Day>6</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2012</Year><Month>1</Month><Day>6</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2012</Year><Month>2</Month><Day>5</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>6</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>6</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>10</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.24941</ArticleId><ArticleId IdType="pubmed">22649006</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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