Transcranial Direct Current Stimulation for the Treatment of Focal Hand Dystonia
Identifieur interne : 000236 ( Pmc/Curation ); précédent : 000235; suivant : 000237Transcranial Direct Current Stimulation for the Treatment of Focal Hand Dystonia
Auteurs : David H. Benninger [États-Unis, Suisse] ; Mikhail Lomarev [États-Unis, Russie] ; Grisel Lopez [États-Unis] ; Natassja Pal [États-Unis] ; David A. Luckenbaugh [États-Unis] ; Mark Hallett [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2011.
Abstract
The treatment of Writer’s Cramp, a task-specific focal hand dystonia, needs new approaches. A deficiency of inhibition in the motor cortex might cause Writer’s Cramp. Transcranial direct current stimulation modulates cortical excitability and may provide a therapeutic alternative.
In this randomized, double-blind, sham-controlled study, we investigated efficacy of cathodal stimulation of contralateral motor cortex in 3-sessions within one week. Assessment over a 2-week period included clinical scales, subjective ratings, kinematic handwriting analysis and neurophysiological evaluation.
Twelve patients with unilateral dystonic Writer’s Cramp were investigated, 6 received transcranial direct current and 6 sham-stimulation. Cathodal transcranial direct current stimulation had no favorable effects on clinical scales, and failed to restore normal handwriting kinematics and cortical inhibition. Subjective worsening remained unexplained leading to premature study termination.
Repeated sessions of cathodal transcranial direct current stimulation of the motor cortex yielded no favorable results supporting a therapeutic potential in Writer’s Cramp.
Url:
DOI: 10.1002/mds.23691
PubMed: 21495074
PubMed Central: 4180819
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Benninger</name><affiliation wicri:level="2"><nlm:aff id="A1">Medical Neurology Branch, National Institutes of Health, Bethesda, MD USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Medical Neurology Branch, National Institutes of Health, Bethesda</wicri:cityArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">Department of Neurology, University Hospital of Basel, Basel, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Neurology, University Hospital of Basel, Basel</wicri:regionArea></affiliation></author><author><name sortKey="Lomarev, Mikhail" sort="Lomarev, Mikhail" uniqKey="Lomarev M" first="Mikhail" last="Lomarev">Mikhail Lomarev</name><affiliation wicri:level="2"><nlm:aff id="A1">Medical Neurology Branch, National Institutes of Health, Bethesda, MD USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Medical Neurology Branch, National Institutes of Health, Bethesda</wicri:cityArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">St. Petersburg V.M. 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Benninger</name><affiliation wicri:level="2"><nlm:aff id="A1">Medical Neurology Branch, National Institutes of Health, Bethesda, MD USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Medical Neurology Branch, National Institutes of Health, Bethesda</wicri:cityArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">Department of Neurology, University Hospital of Basel, Basel, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Neurology, University Hospital of Basel, Basel</wicri:regionArea></affiliation></author><author><name sortKey="Lomarev, Mikhail" sort="Lomarev, Mikhail" uniqKey="Lomarev M" first="Mikhail" last="Lomarev">Mikhail Lomarev</name><affiliation wicri:level="2"><nlm:aff id="A1">Medical Neurology Branch, National Institutes of Health, Bethesda, MD USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Medical Neurology Branch, National Institutes of Health, Bethesda</wicri:cityArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">St. Petersburg V.M. Bekhterev Psychoneurological Research Institute, Saint-Petersburg, Russia</nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea>St. Petersburg V.M. Bekhterev Psychoneurological Research Institute, Saint-Petersburg</wicri:regionArea></affiliation></author><author><name sortKey="Lopez, Grisel" sort="Lopez, Grisel" uniqKey="Lopez G" first="Grisel" last="Lopez">Grisel Lopez</name><affiliation wicri:level="2"><nlm:aff id="A1">Medical Neurology Branch, National Institutes of Health, Bethesda, MD USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Medical Neurology Branch, National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Pal, Natassja" sort="Pal, Natassja" uniqKey="Pal N" first="Natassja" last="Pal">Natassja Pal</name><affiliation wicri:level="2"><nlm:aff id="A1">Medical Neurology Branch, National Institutes of Health, Bethesda, MD USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Medical Neurology Branch, National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Luckenbaugh, David A" sort="Luckenbaugh, David A" uniqKey="Luckenbaugh D" first="David A." last="Luckenbaugh">David A. Luckenbaugh</name><affiliation wicri:level="2"><nlm:aff id="A2">National Institute of Neurological Disorders and Stroke, and National Institute of Mental Health (NIMH), National Institutes of Health, Bethesda, MD USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>National Institute of Neurological Disorders and Stroke, and National Institute of Mental Health (NIMH), National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Hallett, Mark" sort="Hallett, Mark" uniqKey="Hallett M" first="Mark" last="Hallett">Mark Hallett</name><affiliation wicri:level="2"><nlm:aff id="A1">Medical Neurology Branch, National Institutes of Health, Bethesda, MD USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Medical Neurology Branch, National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">The treatment of Writer’s Cramp, a task-specific focal hand dystonia, needs new approaches. A deficiency of inhibition in the motor cortex might cause Writer’s Cramp. Transcranial direct current stimulation modulates cortical excitability and may provide a therapeutic alternative.</p></sec><sec id="S2"><title>Methods</title><p id="P2">In this randomized, double-blind, sham-controlled study, we investigated efficacy of cathodal stimulation of contralateral motor cortex in 3-sessions within one week. Assessment over a 2-week period included clinical scales, subjective ratings, kinematic handwriting analysis and neurophysiological evaluation.</p></sec><sec id="S3"><title>Results</title><p id="P3">Twelve patients with unilateral dystonic Writer’s Cramp were investigated, 6 received transcranial direct current and 6 sham-stimulation. Cathodal transcranial direct current stimulation had no favorable effects on clinical scales, and failed to restore normal handwriting kinematics and cortical inhibition. Subjective worsening remained unexplained leading to premature study termination.</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">Repeated sessions of cathodal transcranial direct current stimulation of the motor cortex yielded no favorable results supporting a therapeutic potential in Writer’s Cramp.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8610688</journal-id><journal-id journal-id-type="pubmed-jr-id">5937</journal-id><journal-id journal-id-type="nlm-ta">Mov Disord</journal-id><journal-id journal-id-type="iso-abbrev">Mov. Disord.</journal-id><journal-title-group><journal-title>Movement disorders : official journal of the Movement Disorder Society</journal-title></journal-title-group><issn pub-type="ppub">0885-3185</issn><issn pub-type="epub">1531-8257</issn></journal-meta><article-meta><article-id pub-id-type="pmid">21495074</article-id><article-id pub-id-type="pmc">4180819</article-id><article-id pub-id-type="doi">10.1002/mds.23691</article-id><article-id pub-id-type="manuscript">NIHMS628353</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Transcranial Direct Current Stimulation for the Treatment of Focal Hand Dystonia</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Benninger</surname><given-names>David H.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Lomarev</surname><given-names>Mikhail</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A4">4</xref><email>Mlom2005@hotmail.com</email></contrib><contrib contrib-type="author"><name><surname>Lopez</surname><given-names>Grisel</given-names></name><xref ref-type="aff" rid="A1">1</xref><email>glopez@mail.nih.gov</email></contrib><contrib contrib-type="author"><name><surname>Pal</surname><given-names>Natassja</given-names></name><xref ref-type="aff" rid="A1">1</xref><email>natassja.pal@gmail.com</email></contrib><contrib contrib-type="author"><name><surname>Luckenbaugh</surname><given-names>David A.</given-names></name><xref ref-type="aff" rid="A2">2</xref><email>luckenbd@mail.nih.gov</email></contrib><contrib contrib-type="author"><name><surname>Hallett</surname><given-names>Mark</given-names></name><xref ref-type="aff" rid="A1">1</xref><email>hallettm@ninds.nih.gov</email></contrib></contrib-group><aff id="A1"><label>1</label>Medical Neurology Branch, National Institutes of Health, Bethesda, MD USA</aff><aff id="A2"><label>2</label>National Institute of Neurological Disorders and Stroke, and National Institute of Mental Health (NIMH), National Institutes of Health, Bethesda, MD USA</aff><aff id="A3"><label>3</label>Department of Neurology, University Hospital of Basel, Basel, Switzerland</aff><aff id="A4"><label>4</label>St. Petersburg V.M. Bekhterev Psychoneurological Research Institute, Saint-Petersburg, Russia</aff><author-notes><corresp id="FN1">Correspondence: David H. Benninger, MD, Department of Neurology, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland, Tel. 00 41 61 265 56 85, Fax. 0041 61 265 44 91, <email>DBenninger@uhbs.ch</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>16</day><month>9</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>14</day><month>4</month><year>2011</year></pub-date><pub-date pub-type="ppub"><day>1</day><month>8</month><year>2011</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>10</month><year>2014</year></pub-date><volume>26</volume><issue>9</issue><fpage>1698</fpage><lpage>1702</lpage><pmc-comment>elocation-id from pubmed: 10.1002/mds.23691</pmc-comment>
<abstract><sec id="S1"><title>Background</title><p id="P1">The treatment of Writer’s Cramp, a task-specific focal hand dystonia, needs new approaches. A deficiency of inhibition in the motor cortex might cause Writer’s Cramp. Transcranial direct current stimulation modulates cortical excitability and may provide a therapeutic alternative.</p></sec><sec id="S2"><title>Methods</title><p id="P2">In this randomized, double-blind, sham-controlled study, we investigated efficacy of cathodal stimulation of contralateral motor cortex in 3-sessions within one week. Assessment over a 2-week period included clinical scales, subjective ratings, kinematic handwriting analysis and neurophysiological evaluation.</p></sec><sec id="S3"><title>Results</title><p id="P3">Twelve patients with unilateral dystonic Writer’s Cramp were investigated, 6 received transcranial direct current and 6 sham-stimulation. Cathodal transcranial direct current stimulation had no favorable effects on clinical scales, and failed to restore normal handwriting kinematics and cortical inhibition. Subjective worsening remained unexplained leading to premature study termination.</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">Repeated sessions of cathodal transcranial direct current stimulation of the motor cortex yielded no favorable results supporting a therapeutic potential in Writer’s Cramp.</p></sec></abstract><kwd-group><kwd>transcranial direct current stimulation (tDCS)</kwd><kwd>non-invasive brain stimulation</kwd><kwd>therapeutic study</kwd><kwd>Focal Hand Dystonia</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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