Blood Oxygenation Level Dependent Activation in Basal Ganglia Nuclei Relates to Specific Symptoms in De Novo Parkinson's Disease
Identifieur interne : 000111 ( Pmc/Curation ); précédent : 000110; suivant : 000112Blood Oxygenation Level Dependent Activation in Basal Ganglia Nuclei Relates to Specific Symptoms in De Novo Parkinson's Disease
Auteurs : Janey Prodoehl [États-Unis] ; Mathew Spraker [États-Unis] ; Daniel Corcos [États-Unis] ; Cynthia Comella [États-Unis] ; David Vaillancourt [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2010.
Abstract
To aid the development of symptomatic and disease modifying therapies in Parkinson's disease (PD), there is a strong need to identify non-invasive measures of basal ganglia function that are sensitive to disease severity. This study examines the relation between blood oxygenation level dependent (BOLD) activation in every nucleus of the basal ganglia and symptom-specific disease severity in early stage, de novo PD. BOLD activation measured at 3 Tesla was compared between 20 early stage de novo PD patients and 20 controls during an established precision grip force task. In addition to the basal ganglia nuclei, activation in specific thalamic and cortical regions was examined. There were three novel findings. First, there were significant negative correlations between total motor Unified Parkinson's Disease Rating Scale (UPDRS) and BOLD activation in bilateral caudate, bilateral putamen, contralateral external segment of the globus pallidus, bilateral subthalamic nucleus, contralateral substantia nigra, and thalamus. Second, bradykinesia was the symptom that most consistently predicted BOLD activation in the basal ganglia and thalamus. Also, BOLD activation in the contralateral internal globus pallidus was related to tremor. Third, the reduced cortical activity in primary motor cortex and supplementary motor area in de novo PD did not relate to motor symptoms. These findings demonstrate that BOLD activity in nuclei of the basal ganglia relates most consistently to bradykinesia. The findings demonstrate that functional magnetic resonance imaging has strong potential to serve as a non-invasive marker for the state of basal ganglia function in de novo PD.
Url:
DOI: 10.1002/mds.23360
PubMed: 20725915
PubMed Central: 2952037
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<front><div type="abstract" xml:lang="en"><p id="P7">To aid the development of symptomatic and disease modifying therapies in Parkinson's disease (PD), there is a strong need to identify non-invasive measures of basal ganglia function that are sensitive to disease severity. This study examines the relation between blood oxygenation level dependent (BOLD) activation in every nucleus of the basal ganglia and symptom-specific disease severity in early stage, de novo PD. BOLD activation measured at 3 Tesla was compared between 20 early stage de novo PD patients and 20 controls during an established precision grip force task. In addition to the basal ganglia nuclei, activation in specific thalamic and cortical regions was examined. There were three novel findings. First, there were significant negative correlations between total motor Unified Parkinson's Disease Rating Scale (UPDRS) and BOLD activation in bilateral caudate, bilateral putamen, contralateral external segment of the globus pallidus, bilateral subthalamic nucleus, contralateral substantia nigra, and thalamus. Second, bradykinesia was the symptom that most consistently predicted BOLD activation in the basal ganglia and thalamus. Also, BOLD activation in the contralateral internal globus pallidus was related to tremor. Third, the reduced cortical activity in primary motor cortex and supplementary motor area in de novo PD did not relate to motor symptoms. These findings demonstrate that BOLD activity in nuclei of the basal ganglia relates most consistently to bradykinesia. The findings demonstrate that functional magnetic resonance imaging has strong potential to serve as a non-invasive marker for the state of basal ganglia function in de novo PD.</p>
</div>
</front>
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<journal-id journal-id-type="nlm-ta">Mov Disord</journal-id>
<journal-title>Movement disorders : official journal of the Movement Disorder Society</journal-title>
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<title-group><article-title>Blood Oxygenation Level Dependent Activation in Basal Ganglia Nuclei Relates to Specific Symptoms in De Novo Parkinson's Disease</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Prodoehl</surname>
<given-names>Janey</given-names>
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<degrees>PT, PhD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
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<contrib contrib-type="author"><name><surname>Spraker</surname>
<given-names>Mathew</given-names>
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<degrees>PhD</degrees>
<xref ref-type="aff" rid="A2">2</xref>
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<contrib contrib-type="author"><name><surname>Corcos</surname>
<given-names>Daniel</given-names>
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<degrees>PhD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="aff" rid="A4">4</xref>
<xref ref-type="aff" rid="A5">5</xref>
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<contrib contrib-type="author"><name><surname>Comella</surname>
<given-names>Cynthia</given-names>
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<degrees>MD</degrees>
<xref ref-type="aff" rid="A5">5</xref>
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<contrib contrib-type="author"><name><surname>Vaillancourt</surname>
<given-names>David</given-names>
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<degrees>PhD</degrees>
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<aff id="A1"><label>1</label>
Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL</aff>
<aff id="A2"><label>2</label>
Department of Bioengineering, University of Illinois at Chicago, Chicago, IL</aff>
<aff id="A3"><label>3</label>
Department of Neurology and Rehabilitation, University of Illinois at Chicago, Chicago, IL</aff>
<aff id="A4"><label>4</label>
Department of Physical Therapy University of Illinois at Chicago, Chicago, IL</aff>
<aff id="A5"><label>5</label>
Department of Neurological Sciences Rush University Medical Center, Chicago, IL</aff>
<author-notes><fn id="FN1"><p id="P1"><bold>Author Roles</bold>
</p>
<p id="P2">Janey Prodoehl, PT, PhD: Conception and design, recruitment of patients, acquisition of data, analysis and interpretation of data, drafting all of the submitted publication material, critical revision of the submitted publication material, and statistics.</p>
<p id="P3">Mathew B. Spraker, PhD: Acquisition of data, interpretation of data, critical revision of the submitted publication material, and statistics.</p>
<p id="P4">Daniel M. Corcos, PhD: Conception and design, interpretation of data, critical revision of the submitted publication material, and statistics.</p>
<p id="P5">Cynthia L. Comella, MD: Recruitment and assessment of patients, interpretation of data, critical revision of the submitted publication material.</p>
<p id="P6">David E. Vaillancourt, PhD: Conception and design, acquisition of data, analysis and interpretation of data, drafting all of the submitted publication material, critical revision of the submitted publication material and statistics.</p>
</fn>
<corresp id="CR1">Mailing Address: David E. Vaillancourt, Ph.D. University of Illinois at Chicago 1919 West Taylor Street 650 AHSB, M/C 994 Chicago, IL 60612 Tel: 00-1 312-355-2541 Fax: 00-1-312-355-2305 <email>court1@uic.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>13</day>
<month>7</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="ppub"><day>15</day>
<month>10</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>15</day>
<month>10</month>
<year>2011</year>
</pub-date>
<volume>25</volume>
<issue>13</issue>
<fpage>2035</fpage>
<lpage>2043</lpage>
<abstract><p id="P7">To aid the development of symptomatic and disease modifying therapies in Parkinson's disease (PD), there is a strong need to identify non-invasive measures of basal ganglia function that are sensitive to disease severity. This study examines the relation between blood oxygenation level dependent (BOLD) activation in every nucleus of the basal ganglia and symptom-specific disease severity in early stage, de novo PD. BOLD activation measured at 3 Tesla was compared between 20 early stage de novo PD patients and 20 controls during an established precision grip force task. In addition to the basal ganglia nuclei, activation in specific thalamic and cortical regions was examined. There were three novel findings. First, there were significant negative correlations between total motor Unified Parkinson's Disease Rating Scale (UPDRS) and BOLD activation in bilateral caudate, bilateral putamen, contralateral external segment of the globus pallidus, bilateral subthalamic nucleus, contralateral substantia nigra, and thalamus. Second, bradykinesia was the symptom that most consistently predicted BOLD activation in the basal ganglia and thalamus. Also, BOLD activation in the contralateral internal globus pallidus was related to tremor. Third, the reduced cortical activity in primary motor cortex and supplementary motor area in de novo PD did not relate to motor symptoms. These findings demonstrate that BOLD activity in nuclei of the basal ganglia relates most consistently to bradykinesia. The findings demonstrate that functional magnetic resonance imaging has strong potential to serve as a non-invasive marker for the state of basal ganglia function in de novo PD.</p>
</abstract>
<kwd-group><kwd>fMRI</kwd>
<kwd>Parkinson's disease</kwd>
<kwd>Basal Ganglia</kwd>
<kwd>BOLD</kwd>
<kwd>disease severity</kwd>
</kwd-group>
<contract-num rid="NS1">R01 NS058487-04
||NS</contract-num>
<contract-num rid="NS1">R01 NS052318-06
||NS</contract-num>
<contract-sponsor id="NS1">National Institute of Neurological Disorders and Stroke : NINDS</contract-sponsor>
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