Risk for Parkinson disease among patients with osteoarthritis: a Danish cohort study
Identifieur interne : 000110 ( Pmc/Curation ); précédent : 000109; suivant : 000111Risk for Parkinson disease among patients with osteoarthritis: a Danish cohort study
Auteurs : Kathrine Rugbjerg [Danemark] ; S Ren Friis [Danemark] ; Thomas L. J Rgensen [Danemark] ; Beate Ritz [États-Unis] ; Lise Korbo [Danemark] ; J Rgen H. Olsen [Danemark]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2010.
Abstract
It has been suggested that use of non-steroidal anti-inflammatory drugs (NSAID) protects against Parkinson disease, although the results are not consistent. We investigated the risk for Parkinson disease in patients with osteoarthritis, who are typically intensive users of NSAID.
Using the files of the National Danish Hospital Register for the period 1977–2006, we identified a cohort of 134 176 patients with osteoarthritis severe enough to have required subsequent hip or knee implant surgery. The number of first hospital contacts for Parkinson disease among cohort members in 1986–2007 was compared with that expected from the age-, gender- and period-specific hospital contact rates of the general Danish population, and standardized incidence ratios (SIRs) and associated 95% confidence intervals (CIs) were derived. Cohort members were also linked to the Danish Cancer Register to estimate the SIRs for colorectal and lung cancer. We observed a slightly increased risk for Parkinson disease among patients with osteoarthritis and subsequent implant surgery (SIR, 1.07; 95% CI, 0.99–1.16). Decreased SIRs were found for both colorectal cancer (0.92; 95% CI, 0.88–0.97), consistent with a high prevalence of NSAID use among cohort members, and for lung cancer (0.77; 95% CI, 0.73–0.80), indicating a lower prevalence of smoking than usual. Our results do not support the hypothesis that patients with prolonged use of NSAID and other analgesics are at reduced risk for Parkinson disease. A possible lower smoking prevalence among patients with osteoarthritis might explain the slightly increased risk for Parkinson disease.
Url:
DOI: 10.1002/mds.23274
PubMed: 20721917
PubMed Central: 2992436
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<front><div type="abstract" xml:lang="en"><p id="P1">It has been suggested that use of non-steroidal anti-inflammatory drugs (NSAID) protects against Parkinson disease, although the results are not consistent. We investigated the risk for Parkinson disease in patients with osteoarthritis, who are typically intensive users of NSAID.</p>
<p id="P2">Using the files of the National Danish Hospital Register for the period 1977–2006, we identified a cohort of 134 176 patients with osteoarthritis severe enough to have required subsequent hip or knee implant surgery. The number of first hospital contacts for Parkinson disease among cohort members in 1986–2007 was compared with that expected from the age-, gender- and period-specific hospital contact rates of the general Danish population, and standardized incidence ratios (SIRs) and associated 95% confidence intervals (CIs) were derived. Cohort members were also linked to the Danish Cancer Register to estimate the SIRs for colorectal and lung cancer. We observed a slightly increased risk for Parkinson disease among patients with osteoarthritis and subsequent implant surgery (SIR, 1.07; 95% CI, 0.99–1.16). Decreased SIRs were found for both colorectal cancer (0.92; 95% CI, 0.88–0.97), consistent with a high prevalence of NSAID use among cohort members, and for lung cancer (0.77; 95% CI, 0.73–0.80), indicating a lower prevalence of smoking than usual. Our results do not support the hypothesis that patients with prolonged use of NSAID and other analgesics are at reduced risk for Parkinson disease. A possible lower smoking prevalence among patients with osteoarthritis might explain the slightly increased risk for Parkinson disease.</p>
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<aff id="A1"><label>1</label>
Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark</aff>
<aff id="A2"><label>2</label>
Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark</aff>
<aff id="A3"><label>3</label>
Department of Epidemiology and Environmental Sciences, School of Public Health, University of California at Los Angeles, California, USA</aff>
<aff id="A4"><label>4</label>
Department of Neurology, Bispebjerg Hospital, Copenhagen, Denmark</aff>
<author-notes><corresp id="FN1">Corresponding author: Kathrine Rugbjerg, Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, DK-2100 Copenhagen, Denmark; Phone: +45 35 25 76 37; fax: +45 35 25 77 34; <email>rugbjerg@cancer.dk</email>
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<abstract><p id="P1">It has been suggested that use of non-steroidal anti-inflammatory drugs (NSAID) protects against Parkinson disease, although the results are not consistent. We investigated the risk for Parkinson disease in patients with osteoarthritis, who are typically intensive users of NSAID.</p>
<p id="P2">Using the files of the National Danish Hospital Register for the period 1977–2006, we identified a cohort of 134 176 patients with osteoarthritis severe enough to have required subsequent hip or knee implant surgery. The number of first hospital contacts for Parkinson disease among cohort members in 1986–2007 was compared with that expected from the age-, gender- and period-specific hospital contact rates of the general Danish population, and standardized incidence ratios (SIRs) and associated 95% confidence intervals (CIs) were derived. Cohort members were also linked to the Danish Cancer Register to estimate the SIRs for colorectal and lung cancer. We observed a slightly increased risk for Parkinson disease among patients with osteoarthritis and subsequent implant surgery (SIR, 1.07; 95% CI, 0.99–1.16). Decreased SIRs were found for both colorectal cancer (0.92; 95% CI, 0.88–0.97), consistent with a high prevalence of NSAID use among cohort members, and for lung cancer (0.77; 95% CI, 0.73–0.80), indicating a lower prevalence of smoking than usual. Our results do not support the hypothesis that patients with prolonged use of NSAID and other analgesics are at reduced risk for Parkinson disease. A possible lower smoking prevalence among patients with osteoarthritis might explain the slightly increased risk for Parkinson disease.</p>
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<contract-num rid="ES1">R01 ES013717-01A1
||ES</contract-num>
<contract-sponsor id="ES1">National Institute of Environmental Health Sciences : NIEHS</contract-sponsor>
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