Alpha-synuclein REP1 variants and survival in Parkinson’s disease
Identifieur interne : 000049 ( Pmc/Checkpoint ); précédent : 000048; suivant : 000050Alpha-synuclein REP1 variants and survival in Parkinson’s disease
Auteurs : Sun Ju Chung [Corée du Sud] ; Joanna M. Biernacka [États-Unis] ; Sebastian M. Armasu [États-Unis] ; Kari Anderson [États-Unis] ; Roberta Frigerio [États-Unis] ; Jan O. Aasly [Norvège] ; Grazia Annesi [Italie] ; Anna Rita Bentivoglio [Italie] ; Laura Brighina [Italie] ; Marie-Christine Chartier-Harlin [France] ; Stefano Goldwurm [Italie] ; Georgios Hadjigeorgiou [Grèce] ; Barbara Jasinska-Myga [Pologne, États-Unis] ; Beom Seok Jeon [Corée du Sud] ; Yun Joong Kim [Corée du Sud] ; Rejko Krüger [Allemagne] ; Suzanne Lesage [France] ; Katerina Markopoulou [États-Unis] ; George Mellick [Australie] ; Karen E. Morrison ; Andreas Puschmann [Suède] ; Eng-King Tan [Singapour] ; Jessie Theuns [Belgique] ; Karin Wirdefeldt [Suède] ; Zbigniew K. Wszolek [États-Unis] ; Alexis Elbaz [France] ; Demetrius M. Maraganore [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2014.
Abstract
To determine if alpha-synuclein REP1 genotypes are associated with survival in Parkinson’s disease.
Investigators from the Genetic Epidemiology of Parkinson’s Disease Consortium provided REP1 genotypes and baseline and follow-up clinical data for cases. The primary outcome was time to death. Cox proportional hazards regression models were used to assess the association of REP1 genotypes with survival.
Twenty-one sites contributed data for 6,154 cases. There was no significant association between alpha-synuclein REP1 genotypes and survival in Parkinson’s disease. However, there was a significant association between REP1 genotypes and age at onset of PD (Hazard Ratio = 1.06, 95% Confidence Interval = 1.01–1.10,
In our large consortium study, alpha-synuclein REP1 genotypes were not associated with survival in Parkinson’s disease. Further studies of α–synuclein’s role in disease progression and long-term outcomes are needed.
Url:
DOI: 10.1002/mds.25841
PubMed: 24578302
PubMed Central: 4172351
Affiliations:
- Allemagne, Australie, Belgique, Corée du Sud, France, Grèce, Italie, Norvège, Pologne, Singapour, Suède, États-Unis
- Bade-Wurtemberg, District de Tübingen, Floride, Illinois, Latium, Lombardie, Minnesota, Province d'Anvers, Svealand, Trøndelag, Île-de-France
- Anvers, Lille, Milan, Paris, Rome, Stockholm, Séoul, Trondheim, Tübingen, Villejuif
- Université d'Anvers
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last="Bentivoglio">Anna Rita Bentivoglio</name><affiliation wicri:level="3"><nlm:aff id="A6">Department of Neurology, Catholic University, Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology, Catholic University, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Brighina, Laura" sort="Brighina, Laura" uniqKey="Brighina L" first="Laura" last="Brighina">Laura Brighina</name><affiliation wicri:level="1"><nlm:aff id="A7">Department of Neurology, San Gerardo Hospital, Monza, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology, San Gerardo Hospital, Monza</wicri:regionArea><wicri:noRegion>Monza</wicri:noRegion></affiliation></author><author><name sortKey="Chartier Harlin, Marie Christine" sort="Chartier Harlin, Marie Christine" uniqKey="Chartier Harlin M" first="Marie-Christine" last="Chartier-Harlin">Marie-Christine Chartier-Harlin</name><affiliation wicri:level="1"><nlm:aff id="A8">Inserm UMR837, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm UMR837, Lille</wicri:regionArea><placeName><settlement type="city">Lille</settlement></placeName></affiliation><affiliation><nlm:aff id="A9">Univ Lille Nord de France</nlm:aff></affiliation></author><author><name sortKey="Goldwurm, Stefano" sort="Goldwurm, Stefano" uniqKey="Goldwurm S" first="Stefano" last="Goldwurm">Stefano Goldwurm</name><affiliation wicri:level="3"><nlm:aff id="A10">Parkinson Institute, IstitutiClinici di Perfezionamento, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Parkinson Institute, IstitutiClinici di Perfezionamento, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Hadjigeorgiou, Georgios" sort="Hadjigeorgiou, Georgios" uniqKey="Hadjigeorgiou G" first="Georgios" last="Hadjigeorgiou">Georgios Hadjigeorgiou</name><affiliation wicri:level="1"><nlm:aff id="A11">Faculty of Medicine, University of Thessalia, Larissa, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Faculty of Medicine, University of Thessalia, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation></author><author><name sortKey="Jasinska Myga, Barbara" sort="Jasinska Myga, Barbara" uniqKey="Jasinska Myga B" first="Barbara" last="Jasinska-Myga">Barbara Jasinska-Myga</name><affiliation wicri:level="1"><nlm:aff id="A12">Department of Neurology, Medical University of Silesia, Katowice, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Neurology, Medical University of Silesia, Katowice</wicri:regionArea><wicri:noRegion>Katowice</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="A13">Department of Neurology, Mayo Clinic, Jacksonville, FL USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Department of Neurology, Mayo Clinic, Jacksonville</wicri:cityArea></affiliation></author><author><name sortKey="Jeon, Beom Seok" sort="Jeon, Beom Seok" uniqKey="Jeon B" first="Beom Seok" last="Jeon">Beom Seok Jeon</name><affiliation wicri:level="3"><nlm:aff id="A14">Seoul National University Hospital, Seoul, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Seoul National University Hospital, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Kim, Yun Joong" sort="Kim, Yun Joong" uniqKey="Kim Y" first="Yun Joong" last="Kim">Yun Joong Kim</name><affiliation wicri:level="3"><nlm:aff id="A15">Department of Neurology, Hallym University, Seoul, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Neurology, Hallym University, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Kruger, Rejko" sort="Kruger, Rejko" uniqKey="Kruger R" first="Rejko" last="Krüger">Rejko Krüger</name><affiliation wicri:level="3"><nlm:aff id="A16">Center of Neurology and Hertie-Institute for Clinical Brain Research, Tübingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center of Neurology and Hertie-Institute for Clinical Brain Research, Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Lesage, Suzanne" sort="Lesage, Suzanne" uniqKey="Lesage S" first="Suzanne" last="Lesage">Suzanne Lesage</name><affiliation wicri:level="1"><nlm:aff id="A17">Université Pierre et Marie Curie-Paris6, Centre de Recherche de l’Institut du Cerveau et de la Moelleépinière, UMR-S975; Inserm, U975, Cnrs, UMR 7225, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Pierre et Marie Curie-Paris6, Centre de Recherche de l’Institut du Cerveau et de la Moelleépinière, UMR-S975; Inserm, U975, Cnrs, UMR 7225, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Markopoulou, Katerina" sort="Markopoulou, Katerina" uniqKey="Markopoulou K" first="Katerina" last="Markopoulou">Katerina Markopoulou</name><affiliation wicri:level="2"><nlm:aff id="A18">Department of Neurology, NorthShore University HealthSystem, Evanston, IL USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Neurology, NorthShore University HealthSystem, Evanston</wicri:cityArea></affiliation></author><author><name sortKey="Mellick, George" sort="Mellick, George" uniqKey="Mellick G" first="George" last="Mellick">George Mellick</name><affiliation wicri:level="1"><nlm:aff id="A19">Eskitis Institute for Cell and Molecular Therapies, Griffith University, Nathan, QLD, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Eskitis Institute for Cell and Molecular Therapies, Griffith University, Nathan, QLD</wicri:regionArea><wicri:noRegion>QLD</wicri:noRegion></affiliation></author><author><name sortKey="Morrison, Karen E" sort="Morrison, Karen E" uniqKey="Morrison K" first="Karen E." last="Morrison">Karen E. Morrison</name><affiliation><nlm:aff id="A20">School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham UK</nlm:aff><wicri:noCountry code="subfield">Birmingham UK</wicri:noCountry></affiliation></author><author><name sortKey="Puschmann, Andreas" sort="Puschmann, Andreas" uniqKey="Puschmann A" first="Andreas" last="Puschmann">Andreas Puschmann</name><affiliation wicri:level="1"><nlm:aff id="A21">Section of Neurology, Department of Clinical Sciences, Lund University, Lund, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Section of Neurology, Department of Clinical Sciences, Lund University, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Tan, Eng King" sort="Tan, Eng King" uniqKey="Tan E" first="Eng-King" last="Tan">Eng-King Tan</name><affiliation wicri:level="1"><nlm:aff id="A22">Singapore General Hospital, National Neuroscience Institute, Singapore, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore General Hospital, National Neuroscience Institute, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author><author><name sortKey="Theuns, Jessie" sort="Theuns, Jessie" uniqKey="Theuns J" first="Jessie" last="Theuns">Jessie Theuns</name><affiliation wicri:level="1"><nlm:aff id="A23">Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp</wicri:regionArea><wicri:noRegion>Antwerp</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A24">Institute Born-Bunge, University of Antwerp, Antwerp, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Institute Born-Bunge, University of Antwerp, Antwerp</wicri:regionArea><orgName type="university">Université d'Anvers</orgName><placeName><settlement type="city">Anvers</settlement><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation></author><author><name sortKey="Wirdefeldt, Karin" sort="Wirdefeldt, Karin" uniqKey="Wirdefeldt K" first="Karin" last="Wirdefeldt">Karin Wirdefeldt</name><affiliation wicri:level="3"><nlm:aff id="A25">Department of Medical Epidemiology and Biostatistics and Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics and Department of Clinical Neuroscience, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name><affiliation wicri:level="2"><nlm:aff id="A26">Department of Neurology, Mayo Clinic, Jacksonville, FL USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Department of Neurology, Mayo Clinic, Jacksonville</wicri:cityArea></affiliation></author><author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name><affiliation wicri:level="3"><nlm:aff id="A27">Inserm, Centre for Research in Epidemiology and Population Health, U1018, Social and occupational determinants of health, F-94807, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, Centre for Research in Epidemiology and Population Health, U1018, Social and occupational determinants of health, F-94807, Villejuif</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Villejuif</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A28">Univ Versailles St-Quentin, UMRS 1018, F-94807, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ Versailles St-Quentin, UMRS 1018, F-94807, Villejuif</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Villejuif</settlement></placeName></affiliation></author><author><name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M." last="Maraganore">Demetrius M. Maraganore</name><affiliation wicri:level="2"><nlm:aff id="A18">Department of Neurology, NorthShore University HealthSystem, Evanston, IL USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Neurology, NorthShore University HealthSystem, Evanston</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24578302</idno><idno type="pmc">4172351</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172351</idno><idno type="RBID">PMC:4172351</idno><idno type="doi">10.1002/mds.25841</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000391</idno><idno type="wicri:Area/Pmc/Curation">000391</idno><idno type="wicri:Area/Pmc/Checkpoint">000049</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Alpha-synuclein REP1 variants and survival in Parkinson’s disease</title><author><name sortKey="Chung, Sun Ju" sort="Chung, Sun Ju" uniqKey="Chung S" first="Sun Ju" last="Chung">Sun Ju Chung</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Biernacka, Joanna M" sort="Biernacka, Joanna M" uniqKey="Biernacka J" first="Joanna M." last="Biernacka">Joanna M. Biernacka</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Health Sciences Research, Mayo Clinic, Rochester, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Department of Health Sciences Research, Mayo Clinic, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Armasu, Sebastian M" sort="Armasu, Sebastian M" uniqKey="Armasu S" first="Sebastian M." last="Armasu">Sebastian M. Armasu</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Health Sciences Research, Mayo Clinic, Rochester, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Department of Health Sciences Research, Mayo Clinic, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Anderson, Kari" sort="Anderson, Kari" uniqKey="Anderson K" first="Kari" last="Anderson">Kari Anderson</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Health Sciences Research, Mayo Clinic, Rochester, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Department of Health Sciences Research, Mayo Clinic, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Frigerio, Roberta" sort="Frigerio, Roberta" uniqKey="Frigerio R" first="Roberta" last="Frigerio">Roberta Frigerio</name><affiliation wicri:level="2"><nlm:aff id="A3">Research Institute, NorthShore University HealthSystem, Evanston, IL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Research Institute, NorthShore University HealthSystem, Evanston</wicri:cityArea></affiliation></author><author><name sortKey="Aasly, Jan O" sort="Aasly, Jan O" uniqKey="Aasly J" first="Jan O." last="Aasly">Jan O. Aasly</name><affiliation wicri:level="3"><nlm:aff id="A4">St. Olav’s Hospital, Department of Neurology, Trondheim, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>St. Olav’s Hospital, Department of Neurology, Trondheim</wicri:regionArea><placeName><settlement type="city">Trondheim</settlement><region type="région" nuts="2">Trøndelag</region></placeName></affiliation></author><author><name sortKey="Annesi, Grazia" sort="Annesi, Grazia" uniqKey="Annesi G" first="Grazia" last="Annesi">Grazia Annesi</name><affiliation wicri:level="1"><nlm:aff id="A5">Institute of Neurological Sciences, National Research Council, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Neurological Sciences, National Research Council</wicri:regionArea><wicri:noRegion>National Research Council</wicri:noRegion></affiliation></author><author><name sortKey="Bentivoglio, Anna Rita" sort="Bentivoglio, Anna Rita" uniqKey="Bentivoglio A" first="Anna Rita" last="Bentivoglio">Anna Rita Bentivoglio</name><affiliation wicri:level="3"><nlm:aff id="A6">Department of Neurology, Catholic University, Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology, Catholic University, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Brighina, Laura" sort="Brighina, Laura" uniqKey="Brighina L" first="Laura" last="Brighina">Laura Brighina</name><affiliation wicri:level="1"><nlm:aff id="A7">Department of Neurology, San Gerardo Hospital, Monza, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology, San Gerardo Hospital, Monza</wicri:regionArea><wicri:noRegion>Monza</wicri:noRegion></affiliation></author><author><name sortKey="Chartier Harlin, Marie Christine" sort="Chartier Harlin, Marie Christine" uniqKey="Chartier Harlin M" first="Marie-Christine" last="Chartier-Harlin">Marie-Christine Chartier-Harlin</name><affiliation wicri:level="1"><nlm:aff id="A8">Inserm UMR837, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm UMR837, Lille</wicri:regionArea><placeName><settlement type="city">Lille</settlement></placeName></affiliation><affiliation><nlm:aff id="A9">Univ Lille Nord de France</nlm:aff></affiliation></author><author><name sortKey="Goldwurm, Stefano" sort="Goldwurm, Stefano" uniqKey="Goldwurm S" first="Stefano" last="Goldwurm">Stefano Goldwurm</name><affiliation wicri:level="3"><nlm:aff id="A10">Parkinson Institute, IstitutiClinici di Perfezionamento, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Parkinson Institute, IstitutiClinici di Perfezionamento, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Hadjigeorgiou, Georgios" sort="Hadjigeorgiou, Georgios" uniqKey="Hadjigeorgiou G" first="Georgios" last="Hadjigeorgiou">Georgios Hadjigeorgiou</name><affiliation wicri:level="1"><nlm:aff id="A11">Faculty of Medicine, University of Thessalia, Larissa, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Faculty of Medicine, University of Thessalia, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation></author><author><name sortKey="Jasinska Myga, Barbara" sort="Jasinska Myga, Barbara" uniqKey="Jasinska Myga B" first="Barbara" last="Jasinska-Myga">Barbara Jasinska-Myga</name><affiliation wicri:level="1"><nlm:aff id="A12">Department of Neurology, Medical University of Silesia, Katowice, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Neurology, Medical University of Silesia, Katowice</wicri:regionArea><wicri:noRegion>Katowice</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="A13">Department of Neurology, Mayo Clinic, Jacksonville, FL USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Department of Neurology, Mayo Clinic, Jacksonville</wicri:cityArea></affiliation></author><author><name sortKey="Jeon, Beom Seok" sort="Jeon, Beom Seok" uniqKey="Jeon B" first="Beom Seok" last="Jeon">Beom Seok Jeon</name><affiliation wicri:level="3"><nlm:aff id="A14">Seoul National University Hospital, Seoul, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Seoul National University Hospital, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Kim, Yun Joong" sort="Kim, Yun Joong" uniqKey="Kim Y" first="Yun Joong" last="Kim">Yun Joong Kim</name><affiliation wicri:level="3"><nlm:aff id="A15">Department of Neurology, Hallym University, Seoul, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Neurology, Hallym University, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Kruger, Rejko" sort="Kruger, Rejko" uniqKey="Kruger R" first="Rejko" last="Krüger">Rejko Krüger</name><affiliation wicri:level="3"><nlm:aff id="A16">Center of Neurology and Hertie-Institute for Clinical Brain Research, Tübingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center of Neurology and Hertie-Institute for Clinical Brain Research, Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Lesage, Suzanne" sort="Lesage, Suzanne" uniqKey="Lesage S" first="Suzanne" last="Lesage">Suzanne Lesage</name><affiliation wicri:level="1"><nlm:aff id="A17">Université Pierre et Marie Curie-Paris6, Centre de Recherche de l’Institut du Cerveau et de la Moelleépinière, UMR-S975; Inserm, U975, Cnrs, UMR 7225, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Pierre et Marie Curie-Paris6, Centre de Recherche de l’Institut du Cerveau et de la Moelleépinière, UMR-S975; Inserm, U975, Cnrs, UMR 7225, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Markopoulou, Katerina" sort="Markopoulou, Katerina" uniqKey="Markopoulou K" first="Katerina" last="Markopoulou">Katerina Markopoulou</name><affiliation wicri:level="2"><nlm:aff id="A18">Department of Neurology, NorthShore University HealthSystem, Evanston, IL USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Neurology, NorthShore University HealthSystem, Evanston</wicri:cityArea></affiliation></author><author><name sortKey="Mellick, George" sort="Mellick, George" uniqKey="Mellick G" first="George" last="Mellick">George Mellick</name><affiliation wicri:level="1"><nlm:aff id="A19">Eskitis Institute for Cell and Molecular Therapies, Griffith University, Nathan, QLD, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Eskitis Institute for Cell and Molecular Therapies, Griffith University, Nathan, QLD</wicri:regionArea><wicri:noRegion>QLD</wicri:noRegion></affiliation></author><author><name sortKey="Morrison, Karen E" sort="Morrison, Karen E" uniqKey="Morrison K" first="Karen E." last="Morrison">Karen E. Morrison</name><affiliation><nlm:aff id="A20">School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham UK</nlm:aff><wicri:noCountry code="subfield">Birmingham UK</wicri:noCountry></affiliation></author><author><name sortKey="Puschmann, Andreas" sort="Puschmann, Andreas" uniqKey="Puschmann A" first="Andreas" last="Puschmann">Andreas Puschmann</name><affiliation wicri:level="1"><nlm:aff id="A21">Section of Neurology, Department of Clinical Sciences, Lund University, Lund, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Section of Neurology, Department of Clinical Sciences, Lund University, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Tan, Eng King" sort="Tan, Eng King" uniqKey="Tan E" first="Eng-King" last="Tan">Eng-King Tan</name><affiliation wicri:level="1"><nlm:aff id="A22">Singapore General Hospital, National Neuroscience Institute, Singapore, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore General Hospital, National Neuroscience Institute, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author><author><name sortKey="Theuns, Jessie" sort="Theuns, Jessie" uniqKey="Theuns J" first="Jessie" last="Theuns">Jessie Theuns</name><affiliation wicri:level="1"><nlm:aff id="A23">Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp</wicri:regionArea><wicri:noRegion>Antwerp</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A24">Institute Born-Bunge, University of Antwerp, Antwerp, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Institute Born-Bunge, University of Antwerp, Antwerp</wicri:regionArea><orgName type="university">Université d'Anvers</orgName><placeName><settlement type="city">Anvers</settlement><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation></author><author><name sortKey="Wirdefeldt, Karin" sort="Wirdefeldt, Karin" uniqKey="Wirdefeldt K" first="Karin" last="Wirdefeldt">Karin Wirdefeldt</name><affiliation wicri:level="3"><nlm:aff id="A25">Department of Medical Epidemiology and Biostatistics and Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics and Department of Clinical Neuroscience, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name><affiliation wicri:level="2"><nlm:aff id="A26">Department of Neurology, Mayo Clinic, Jacksonville, FL USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Department of Neurology, Mayo Clinic, Jacksonville</wicri:cityArea></affiliation></author><author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name><affiliation wicri:level="3"><nlm:aff id="A27">Inserm, Centre for Research in Epidemiology and Population Health, U1018, Social and occupational determinants of health, F-94807, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, Centre for Research in Epidemiology and Population Health, U1018, Social and occupational determinants of health, F-94807, Villejuif</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Villejuif</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A28">Univ Versailles St-Quentin, UMRS 1018, F-94807, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ Versailles St-Quentin, UMRS 1018, F-94807, Villejuif</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Villejuif</settlement></placeName></affiliation></author><author><name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M." last="Maraganore">Demetrius M. Maraganore</name><affiliation wicri:level="2"><nlm:aff id="A18">Department of Neurology, NorthShore University HealthSystem, Evanston, IL USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Neurology, NorthShore University HealthSystem, Evanston</wicri:cityArea></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objectives</title><p id="P1">To determine if alpha-synuclein REP1 genotypes are associated with survival in Parkinson’s disease.</p></sec><sec id="S2"><title>Methods</title><p id="P2">Investigators from the Genetic Epidemiology of Parkinson’s Disease Consortium provided REP1 genotypes and baseline and follow-up clinical data for cases. The primary outcome was time to death. Cox proportional hazards regression models were used to assess the association of REP1 genotypes with survival.</p></sec><sec id="S3"><title>Results</title><p id="P3">Twenty-one sites contributed data for 6,154 cases. There was no significant association between alpha-synuclein REP1 genotypes and survival in Parkinson’s disease. However, there was a significant association between REP1 genotypes and age at onset of PD (Hazard Ratio = 1.06, 95% Confidence Interval = 1.01–1.10, <italic>p</italic> value = 0.01).</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">In our large consortium study, alpha-synuclein REP1 genotypes were not associated with survival in Parkinson’s disease. Further studies of α–synuclein’s role in disease progression and long-term outcomes are needed.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8610688</journal-id><journal-id journal-id-type="pubmed-jr-id">5937</journal-id><journal-id journal-id-type="nlm-ta">Mov Disord</journal-id><journal-id journal-id-type="iso-abbrev">Mov. Disord.</journal-id><journal-title-group><journal-title>Movement disorders : official journal of the Movement Disorder Society</journal-title></journal-title-group><issn pub-type="ppub">0885-3185</issn><issn pub-type="epub">1531-8257</issn></journal-meta><article-meta><article-id pub-id-type="pmid">24578302</article-id><article-id pub-id-type="pmc">4172351</article-id><article-id pub-id-type="doi">10.1002/mds.25841</article-id><article-id pub-id-type="manuscript">NIHMS628194</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Alpha-synuclein REP1 variants and survival in Parkinson’s disease</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Chung</surname><given-names>Sun Ju</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Biernacka</surname><given-names>Joanna M.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Armasu</surname><given-names>Sebastian M.</given-names></name><degrees>MS</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Anderson</surname><given-names>Kari</given-names></name><degrees>MS</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Frigerio</surname><given-names>Roberta</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Aasly</surname><given-names>Jan O.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Annesi</surname><given-names>Grazia</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Bentivoglio</surname><given-names>Anna Rita</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Brighina</surname><given-names>Laura</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Chartier-Harlin</surname><given-names>Marie-Christine</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A8">8</xref><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Goldwurm</surname><given-names>Stefano</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Hadjigeorgiou</surname><given-names>Georgios</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Jasinska-Myga</surname><given-names>Barbara</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A12">12</xref><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Jeon</surname><given-names>Beom Seok</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Kim</surname><given-names>Yun Joong</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A15">15</xref></contrib><contrib contrib-type="author"><name><surname>Krüger</surname><given-names>Rejko</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A16">16</xref></contrib><contrib contrib-type="author"><name><surname>Lesage</surname><given-names>Suzanne</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A17">17</xref></contrib><contrib contrib-type="author"><name><surname>Markopoulou</surname><given-names>Katerina</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A18">18</xref></contrib><contrib contrib-type="author"><name><surname>Mellick</surname><given-names>George</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A19">19</xref></contrib><contrib contrib-type="author"><name><surname>Morrison</surname><given-names>Karen E.</given-names></name><degrees>DPhil</degrees><xref ref-type="aff" rid="A20">20</xref></contrib><contrib contrib-type="author"><name><surname>Puschmann</surname><given-names>Andreas</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A21">21</xref></contrib><contrib contrib-type="author"><name><surname>Tan</surname><given-names>Eng-King</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A22">22</xref></contrib><contrib contrib-type="author"><name><surname>Theuns</surname><given-names>Jessie</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A23">23</xref><xref ref-type="aff" rid="A24">24</xref></contrib><contrib contrib-type="author"><name><surname>Wirdefeldt</surname><given-names>Karin</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A25">25</xref></contrib><contrib contrib-type="author"><name><surname>Wszolek</surname><given-names>Zbigniew K.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A26">26</xref></contrib><contrib contrib-type="author"><name><surname>Elbaz</surname><given-names>Alexis</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A27">27</xref><xref ref-type="aff" rid="A28">28</xref></contrib><contrib contrib-type="author"><name><surname>Maraganore</surname><given-names>Demetrius M.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A18">18</xref><xref rid="FN1" ref-type="author-notes">*</xref></contrib><on-behalf-of>on behalf of the Genetic Epidemiology of Parkinson’s Disease Consortium</on-behalf-of></contrib-group><aff id="A1"><label>1</label>Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea</aff><aff id="A2"><label>2</label>Department of Health Sciences Research, Mayo Clinic, Rochester, MN</aff><aff id="A3"><label>3</label>Research Institute, NorthShore University HealthSystem, Evanston, IL</aff><aff id="A4"><label>4</label>St. Olav’s Hospital, Department of Neurology, Trondheim, Norway</aff><aff id="A5"><label>5</label>Institute of Neurological Sciences, National Research Council, Italy</aff><aff id="A6"><label>6</label>Department of Neurology, Catholic University, Rome, Italy</aff><aff id="A7"><label>7</label>Department of Neurology, San Gerardo Hospital, Monza, Italy</aff><aff id="A8"><label>8</label>Inserm UMR837, Lille, France</aff><aff id="A9"><label>9</label>Univ Lille Nord de France</aff><aff id="A10"><label>10</label>Parkinson Institute, IstitutiClinici di Perfezionamento, Milan, Italy</aff><aff id="A11"><label>11</label>Faculty of Medicine, University of Thessalia, Larissa, Greece</aff><aff id="A12"><label>12</label>Department of Neurology, Medical University of Silesia, Katowice, Poland</aff><aff id="A13"><label>13</label>Department of Neurology, Mayo Clinic, Jacksonville, FL USA</aff><aff id="A14"><label>14</label>Seoul National University Hospital, Seoul, Republic of Korea</aff><aff id="A15"><label>15</label>Department of Neurology, Hallym University, Seoul, Korea</aff><aff id="A16"><label>16</label>Center of Neurology and Hertie-Institute for Clinical Brain Research, Tübingen, Germany</aff><aff id="A17"><label>17</label>Université Pierre et Marie Curie-Paris6, Centre de Recherche de l’Institut du Cerveau et de la Moelleépinière, UMR-S975; Inserm, U975, Cnrs, UMR 7225, Paris, France</aff><aff id="A18"><label>18</label>Department of Neurology, NorthShore University HealthSystem, Evanston, IL USA</aff><aff id="A19"><label>19</label>Eskitis Institute for Cell and Molecular Therapies, Griffith University, Nathan, QLD, Australia</aff><aff id="A20"><label>20</label>School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham UK</aff><aff id="A21"><label>21</label>Section of Neurology, Department of Clinical Sciences, Lund University, Lund, Sweden</aff><aff id="A22"><label>22</label>Singapore General Hospital, National Neuroscience Institute, Singapore, Singapore</aff><aff id="A23"><label>23</label>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium</aff><aff id="A24"><label>24</label>Institute Born-Bunge, University of Antwerp, Antwerp, Belgium</aff><aff id="A25"><label>25</label>Department of Medical Epidemiology and Biostatistics and Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden</aff><aff id="A26"><label>26</label>Department of Neurology, Mayo Clinic, Jacksonville, FL USA</aff><aff id="A27"><label>27</label>Inserm, Centre for Research in Epidemiology and Population Health, U1018, Social and occupational determinants of health, F-94807, Villejuif, France</aff><aff id="A28"><label>28</label>Univ Versailles St-Quentin, UMRS 1018, F-94807, Villejuif, France</aff><author-notes><corresp id="FN1"><label>*</label>Corresponding Author: Dr. Demetrius M. Maraganore, Ruth Cain Ruggles Chairman, Department of Neurology, NorthShore University HealthSystem, 2650 Ridge Avenue, Evanston, IL 60201. <email>dmaraganore@northshore.org</email>, Telephone: +1 847 570 1678, Fax: +1 847 733 5565</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>15</day><month>9</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>27</day><month>2</month><year>2014</year></pub-date><pub-date pub-type="ppub"><month>7</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>7</month><year>2015</year></pub-date><volume>29</volume><issue>8</issue><fpage>1053</fpage><lpage>1057</lpage><pmc-comment>elocation-id from pubmed: 10.1002/mds.25841</pmc-comment>
<abstract><sec id="S1"><title>Objectives</title><p id="P1">To determine if alpha-synuclein REP1 genotypes are associated with survival in Parkinson’s disease.</p></sec><sec id="S2"><title>Methods</title><p id="P2">Investigators from the Genetic Epidemiology of Parkinson’s Disease Consortium provided REP1 genotypes and baseline and follow-up clinical data for cases. The primary outcome was time to death. Cox proportional hazards regression models were used to assess the association of REP1 genotypes with survival.</p></sec><sec id="S3"><title>Results</title><p id="P3">Twenty-one sites contributed data for 6,154 cases. There was no significant association between alpha-synuclein REP1 genotypes and survival in Parkinson’s disease. However, there was a significant association between REP1 genotypes and age at onset of PD (Hazard Ratio = 1.06, 95% Confidence Interval = 1.01–1.10, <italic>p</italic> value = 0.01).</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">In our large consortium study, alpha-synuclein REP1 genotypes were not associated with survival in Parkinson’s disease. Further studies of α–synuclein’s role in disease progression and long-term outcomes are needed.</p></sec></abstract><kwd-group><kwd>Parkinson’s disease</kwd><kwd>α-synuclein</kwd><kwd>gene</kwd><kwd>survival</kwd><kwd>association</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Belgique</li><li>Corée du Sud</li><li>France</li><li>Grèce</li><li>Italie</li><li>Norvège</li><li>Pologne</li><li>Singapour</li><li>Suède</li><li>États-Unis</li></country><region><li>Bade-Wurtemberg</li><li>District de Tübingen</li><li>Floride</li><li>Illinois</li><li>Latium</li><li>Lombardie</li><li>Minnesota</li><li>Province d'Anvers</li><li>Svealand</li><li>Trøndelag</li><li>Île-de-France</li></region><settlement><li>Anvers</li><li>Lille</li><li>Milan</li><li>Paris</li><li>Rome</li><li>Stockholm</li><li>Séoul</li><li>Trondheim</li><li>Tübingen</li><li>Villejuif</li></settlement><orgName><li>Université d'Anvers</li></orgName></list><tree><noCountry><name sortKey="Morrison, Karen E" sort="Morrison, Karen E" uniqKey="Morrison K" first="Karen E." last="Morrison">Karen E. Morrison</name></noCountry><country name="Corée du Sud"><noRegion><name sortKey="Chung, Sun Ju" sort="Chung, Sun Ju" uniqKey="Chung S" first="Sun Ju" last="Chung">Sun Ju Chung</name></noRegion><name sortKey="Jeon, Beom Seok" sort="Jeon, Beom Seok" uniqKey="Jeon B" first="Beom Seok" last="Jeon">Beom Seok Jeon</name><name sortKey="Kim, Yun Joong" sort="Kim, Yun Joong" uniqKey="Kim Y" first="Yun Joong" last="Kim">Yun Joong Kim</name></country><country name="États-Unis"><region name="Minnesota"><name sortKey="Biernacka, Joanna M" sort="Biernacka, Joanna M" uniqKey="Biernacka J" first="Joanna M." last="Biernacka">Joanna M. Biernacka</name></region><name sortKey="Anderson, Kari" sort="Anderson, Kari" uniqKey="Anderson K" first="Kari" last="Anderson">Kari Anderson</name><name sortKey="Armasu, Sebastian M" sort="Armasu, Sebastian M" uniqKey="Armasu S" first="Sebastian M." last="Armasu">Sebastian M. Armasu</name><name sortKey="Frigerio, Roberta" sort="Frigerio, Roberta" uniqKey="Frigerio R" first="Roberta" last="Frigerio">Roberta Frigerio</name><name sortKey="Jasinska Myga, Barbara" sort="Jasinska Myga, Barbara" uniqKey="Jasinska Myga B" first="Barbara" last="Jasinska-Myga">Barbara Jasinska-Myga</name><name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M." last="Maraganore">Demetrius M. Maraganore</name><name sortKey="Markopoulou, Katerina" sort="Markopoulou, Katerina" uniqKey="Markopoulou K" first="Katerina" last="Markopoulou">Katerina Markopoulou</name><name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name></country><country name="Norvège"><region name="Trøndelag"><name sortKey="Aasly, Jan O" sort="Aasly, Jan O" uniqKey="Aasly J" first="Jan O." last="Aasly">Jan O. Aasly</name></region></country><country name="Italie"><noRegion><name sortKey="Annesi, Grazia" sort="Annesi, Grazia" uniqKey="Annesi G" first="Grazia" last="Annesi">Grazia Annesi</name></noRegion><name sortKey="Bentivoglio, Anna Rita" sort="Bentivoglio, Anna Rita" uniqKey="Bentivoglio A" first="Anna Rita" last="Bentivoglio">Anna Rita Bentivoglio</name><name sortKey="Brighina, Laura" sort="Brighina, Laura" uniqKey="Brighina L" first="Laura" last="Brighina">Laura Brighina</name><name sortKey="Goldwurm, Stefano" sort="Goldwurm, Stefano" uniqKey="Goldwurm S" first="Stefano" last="Goldwurm">Stefano Goldwurm</name></country><country name="France"><noRegion><name sortKey="Chartier Harlin, Marie Christine" sort="Chartier Harlin, Marie Christine" uniqKey="Chartier Harlin M" first="Marie-Christine" last="Chartier-Harlin">Marie-Christine Chartier-Harlin</name></noRegion><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name><name sortKey="Lesage, Suzanne" sort="Lesage, Suzanne" uniqKey="Lesage S" first="Suzanne" last="Lesage">Suzanne Lesage</name></country><country name="Grèce"><noRegion><name sortKey="Hadjigeorgiou, Georgios" sort="Hadjigeorgiou, Georgios" uniqKey="Hadjigeorgiou G" first="Georgios" last="Hadjigeorgiou">Georgios Hadjigeorgiou</name></noRegion></country><country name="Pologne"><noRegion><name sortKey="Jasinska Myga, Barbara" sort="Jasinska Myga, Barbara" uniqKey="Jasinska Myga B" first="Barbara" last="Jasinska-Myga">Barbara Jasinska-Myga</name></noRegion></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Kruger, Rejko" sort="Kruger, Rejko" uniqKey="Kruger R" first="Rejko" last="Krüger">Rejko Krüger</name></region></country><country name="Australie"><noRegion><name sortKey="Mellick, George" sort="Mellick, George" uniqKey="Mellick G" first="George" last="Mellick">George Mellick</name></noRegion></country><country name="Suède"><noRegion><name sortKey="Puschmann, Andreas" sort="Puschmann, Andreas" uniqKey="Puschmann A" first="Andreas" last="Puschmann">Andreas Puschmann</name></noRegion><name sortKey="Wirdefeldt, Karin" sort="Wirdefeldt, Karin" uniqKey="Wirdefeldt K" first="Karin" last="Wirdefeldt">Karin Wirdefeldt</name></country><country name="Singapour"><noRegion><name sortKey="Tan, Eng King" sort="Tan, Eng King" uniqKey="Tan E" first="Eng-King" last="Tan">Eng-King Tan</name></noRegion></country><country name="Belgique"><noRegion><name sortKey="Theuns, Jessie" sort="Theuns, Jessie" uniqKey="Theuns J" first="Jessie" last="Theuns">Jessie Theuns</name></noRegion><name sortKey="Theuns, Jessie" sort="Theuns, Jessie" uniqKey="Theuns J" first="Jessie" last="Theuns">Jessie Theuns</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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