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Alpha-synuclein REP1 variants and survival in Parkinson’s disease

Identifieur interne : 000391 ( Pmc/Corpus ); précédent : 000390; suivant : 000392

Alpha-synuclein REP1 variants and survival in Parkinson’s disease

Auteurs : Sun Ju Chung ; Joanna M. Biernacka ; Sebastian M. Armasu ; Kari Anderson ; Roberta Frigerio ; Jan O. Aasly ; Grazia Annesi ; Anna Rita Bentivoglio ; Laura Brighina ; Marie-Christine Chartier-Harlin ; Stefano Goldwurm ; Georgios Hadjigeorgiou ; Barbara Jasinska-Myga ; Beom Seok Jeon ; Yun Joong Kim ; Rejko Krüger ; Suzanne Lesage ; Katerina Markopoulou ; George Mellick ; Karen E. Morrison ; Andreas Puschmann ; Eng-King Tan ; Jessie Theuns ; Karin Wirdefeldt ; Zbigniew K. Wszolek ; Alexis Elbaz ; Demetrius M. Maraganore

Source :

RBID : PMC:4172351

Abstract

Objectives

To determine if alpha-synuclein REP1 genotypes are associated with survival in Parkinson’s disease.

Methods

Investigators from the Genetic Epidemiology of Parkinson’s Disease Consortium provided REP1 genotypes and baseline and follow-up clinical data for cases. The primary outcome was time to death. Cox proportional hazards regression models were used to assess the association of REP1 genotypes with survival.

Results

Twenty-one sites contributed data for 6,154 cases. There was no significant association between alpha-synuclein REP1 genotypes and survival in Parkinson’s disease. However, there was a significant association between REP1 genotypes and age at onset of PD (Hazard Ratio = 1.06, 95% Confidence Interval = 1.01–1.10, p value = 0.01).

Conclusions

In our large consortium study, alpha-synuclein REP1 genotypes were not associated with survival in Parkinson’s disease. Further studies of α–synuclein’s role in disease progression and long-term outcomes are needed.


Url:
DOI: 10.1002/mds.25841
PubMed: 24578302
PubMed Central: 4172351

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