Checkpoint
Pmc
Racine
Checkpoint
Pmc
Exploration
Accueil
Racine
Racine

Movement Disorders (revue)

Attention, ce site est en cours de développement !
Attention, site généré par des moyens informatiques à partir de corpus bruts.
Les informations ne sont donc pas validées.

History of smoking and olfaction in Parkinson’s disease

Identifieur interne : 000031 ( Pmc/Checkpoint ); précédent : 000030; suivant : 000032

History of smoking and olfaction in Parkinson’s disease

Auteurs : Elisabeth B. Lucassen [États-Unis] ; Nicholas W. Sterling [États-Unis] ; Eun-Young Lee [États-Unis] ; Honglei Chen [États-Unis] ; Mechelle M. Lewis [États-Unis] ; Lan Kong [États-Unis] ; Xuemei Huang [États-Unis]

Source :

RBID : PMC:4107167

Abstract

Objective

Olfactory dysfunction is the most common pre-motor symptom in Parkinson’s disease, and smoking is known to be associated with lower risk of PD. This study tested the hypothesis that smoking is associated with better olfaction in PD.

Methods

Smoking history was obtained from 76 PD subjects [22 with a history of smoking (smokers), 54 who never smoked (non-smokers)], and 70 Controls (17 smokers, 53 non-smokers). Olfaction was assessed using the 40-item University of Pennsylvania Smell Identification Test (UPSIT). The olfactory scores between groups and subgroups were compared using analysis of covariance with adjustment for age, gender, and MAO-B inhibitor usage.

Results

Overall the olfactory score was lower in PD compared to Controls (olfactory scores: 21.54 vs. 33.45, p<0.0001). Among Controls, there was no significant difference in olfaction between smokers and non-smokers (olfactory scores: 33.2 vs. 34.2, p=0.95). Among PD subjects, however, smokers scored significantly better regarding olfaction compared to non-smokers (olfactory scores: 24.4 vs. 19.9, p=0.02).

Conclusions

These data suggest that history of smoking is associated with better olfaction among PD patients. The finding may be related to why smoking may be protective against PD. Further studies are needed to confirm this finding and investigate the underlying mechanism(s).


Url:
DOI: 10.1002/mds.25912
PubMed: 24833119
PubMed Central: 4107167


Affiliations:

Links toward previous steps (curation, corpus...)

Links to Exploration step

PMC:4107167

Le document en format XML

<record>
<TEI>
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en">History of smoking and olfaction in Parkinson’s disease</title>
<author>
<name sortKey="Lucassen, Elisabeth B" sort="Lucassen, Elisabeth B" uniqKey="Lucassen E" first="Elisabeth B." last="Lucassen">Elisabeth B. Lucassen</name>
<affiliation wicri:level="1">
<nlm:aff id="A1">Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033</wicri:regionArea>
<wicri:noRegion>Hershey PA 17033</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Sterling, Nicholas W" sort="Sterling, Nicholas W" uniqKey="Sterling N" first="Nicholas W." last="Sterling">Nicholas W. Sterling</name>
<affiliation wicri:level="1">
<nlm:aff id="A1">Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033</wicri:regionArea>
<wicri:noRegion>Hershey PA 17033</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A2">Department of Public Health Sciences, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Public Health Sciences, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033</wicri:regionArea>
<wicri:noRegion>Hershey PA 17033</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Lee, Eun Young" sort="Lee, Eun Young" uniqKey="Lee E" first="Eun-Young" last="Lee">Eun-Young Lee</name>
<affiliation wicri:level="1">
<nlm:aff id="A1">Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033</wicri:regionArea>
<wicri:noRegion>Hershey PA 17033</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Chen, Honglei" sort="Chen, Honglei" uniqKey="Chen H" first="Honglei" last="Chen">Honglei Chen</name>
<affiliation wicri:level="2">
<nlm:aff id="A7">National Institute of Environmental Health Sciences, Research Triangle Park, NC 27705</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>National Institute of Environmental Health Sciences, Research Triangle Park</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Lewis, Mechelle M" sort="Lewis, Mechelle M" uniqKey="Lewis M" first="Mechelle M." last="Lewis">Mechelle M. Lewis</name>
<affiliation wicri:level="1">
<nlm:aff id="A1">Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033</wicri:regionArea>
<wicri:noRegion>Hershey PA 17033</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A3">Department of Pharmacology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pharmacology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033</wicri:regionArea>
<wicri:noRegion>Hershey PA 17033</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Kong, Lan" sort="Kong, Lan" uniqKey="Kong L" first="Lan" last="Kong">Lan Kong</name>
<affiliation wicri:level="1">
<nlm:aff id="A2">Department of Public Health Sciences, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Public Health Sciences, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033</wicri:regionArea>
<wicri:noRegion>Hershey PA 17033</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Huang, Xuemei" sort="Huang, Xuemei" uniqKey="Huang X" first="Xuemei" last="Huang">Xuemei Huang</name>
<affiliation wicri:level="1">
<nlm:aff id="A1">Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033</wicri:regionArea>
<wicri:noRegion>Hershey PA 17033</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A3">Department of Pharmacology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pharmacology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033</wicri:regionArea>
<wicri:noRegion>Hershey PA 17033</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A4">Department of Radiology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Radiology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033</wicri:regionArea>
<wicri:noRegion>Hershey PA 17033</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A5">Department of Neurosurgery, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurosurgery, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033</wicri:regionArea>
<wicri:noRegion>Hershey PA 17033</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A6">Department of Kinesiology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Kinesiology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033</wicri:regionArea>
<wicri:noRegion>Hershey PA 17033</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">PMC</idno>
<idno type="pmid">24833119</idno>
<idno type="pmc">4107167</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107167</idno>
<idno type="RBID">PMC:4107167</idno>
<idno type="doi">10.1002/mds.25912</idno>
<date when="2014">2014</date>
<idno type="wicri:Area/Pmc/Corpus">000405</idno>
<idno type="wicri:Area/Pmc/Curation">000405</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000031</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title xml:lang="en" level="a" type="main">History of smoking and olfaction in Parkinson’s disease</title>
<author>
<name sortKey="Lucassen, Elisabeth B" sort="Lucassen, Elisabeth B" uniqKey="Lucassen E" first="Elisabeth B." last="Lucassen">Elisabeth B. Lucassen</name>
<affiliation wicri:level="1">
<nlm:aff id="A1">Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033</wicri:regionArea>
<wicri:noRegion>Hershey PA 17033</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Sterling, Nicholas W" sort="Sterling, Nicholas W" uniqKey="Sterling N" first="Nicholas W." last="Sterling">Nicholas W. Sterling</name>
<affiliation wicri:level="1">
<nlm:aff id="A1">Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033</wicri:regionArea>
<wicri:noRegion>Hershey PA 17033</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A2">Department of Public Health Sciences, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Public Health Sciences, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033</wicri:regionArea>
<wicri:noRegion>Hershey PA 17033</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Lee, Eun Young" sort="Lee, Eun Young" uniqKey="Lee E" first="Eun-Young" last="Lee">Eun-Young Lee</name>
<affiliation wicri:level="1">
<nlm:aff id="A1">Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033</wicri:regionArea>
<wicri:noRegion>Hershey PA 17033</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Chen, Honglei" sort="Chen, Honglei" uniqKey="Chen H" first="Honglei" last="Chen">Honglei Chen</name>
<affiliation wicri:level="2">
<nlm:aff id="A7">National Institute of Environmental Health Sciences, Research Triangle Park, NC 27705</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>National Institute of Environmental Health Sciences, Research Triangle Park</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Lewis, Mechelle M" sort="Lewis, Mechelle M" uniqKey="Lewis M" first="Mechelle M." last="Lewis">Mechelle M. Lewis</name>
<affiliation wicri:level="1">
<nlm:aff id="A1">Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033</wicri:regionArea>
<wicri:noRegion>Hershey PA 17033</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A3">Department of Pharmacology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pharmacology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033</wicri:regionArea>
<wicri:noRegion>Hershey PA 17033</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Kong, Lan" sort="Kong, Lan" uniqKey="Kong L" first="Lan" last="Kong">Lan Kong</name>
<affiliation wicri:level="1">
<nlm:aff id="A2">Department of Public Health Sciences, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Public Health Sciences, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033</wicri:regionArea>
<wicri:noRegion>Hershey PA 17033</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Huang, Xuemei" sort="Huang, Xuemei" uniqKey="Huang X" first="Xuemei" last="Huang">Xuemei Huang</name>
<affiliation wicri:level="1">
<nlm:aff id="A1">Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033</wicri:regionArea>
<wicri:noRegion>Hershey PA 17033</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A3">Department of Pharmacology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pharmacology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033</wicri:regionArea>
<wicri:noRegion>Hershey PA 17033</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A4">Department of Radiology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Radiology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033</wicri:regionArea>
<wicri:noRegion>Hershey PA 17033</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A5">Department of Neurosurgery, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurosurgery, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033</wicri:regionArea>
<wicri:noRegion>Hershey PA 17033</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A6">Department of Kinesiology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Kinesiology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033</wicri:regionArea>
<wicri:noRegion>Hershey PA 17033</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series>
<title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint>
<date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass></textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">
<sec id="S1">
<title>Objective</title>
<p id="P1">Olfactory dysfunction is the most common pre-motor symptom in Parkinson’s disease, and smoking is known to be associated with lower risk of PD. This study tested the hypothesis that smoking is associated with better olfaction in PD.</p>
</sec>
<sec id="S2">
<title>Methods</title>
<p id="P2">Smoking history was obtained from 76 PD subjects [22 with a history of smoking (smokers), 54 who never smoked (non-smokers)], and 70 Controls (17 smokers, 53 non-smokers). Olfaction was assessed using the 40-item University of Pennsylvania Smell Identification Test (UPSIT). The olfactory scores between groups and subgroups were compared using analysis of covariance with adjustment for age, gender, and MAO-B inhibitor usage.</p>
</sec>
<sec id="S3">
<title>Results</title>
<p id="P3">Overall the olfactory score was lower in PD compared to Controls (olfactory scores: 21.54 vs. 33.45, p<0.0001). Among Controls, there was no significant difference in olfaction between smokers and non-smokers (olfactory scores: 33.2 vs. 34.2, p=0.95). Among PD subjects, however, smokers scored significantly better regarding olfaction compared to non-smokers (olfactory scores: 24.4 vs. 19.9, p=0.02).</p>
</sec>
<sec id="S4">
<title>Conclusions</title>
<p id="P4">These data suggest that history of smoking is associated with better olfaction among PD patients. The finding may be related to why smoking may be protective against PD. Further studies are needed to confirm this finding and investigate the underlying mechanism(s).</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article">
<pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front>
<journal-meta>
<journal-id journal-id-type="nlm-journal-id">8610688</journal-id>
<journal-id journal-id-type="pubmed-jr-id">5937</journal-id>
<journal-id journal-id-type="nlm-ta">Mov Disord</journal-id>
<journal-id journal-id-type="iso-abbrev">Mov. Disord.</journal-id>
<journal-title-group>
<journal-title>Movement disorders : official journal of the Movement Disorder Society</journal-title>
</journal-title-group>
<issn pub-type="ppub">0885-3185</issn>
<issn pub-type="epub">1531-8257</issn>
</journal-meta>
<article-meta>
<article-id pub-id-type="pmid">24833119</article-id>
<article-id pub-id-type="pmc">4107167</article-id>
<article-id pub-id-type="doi">10.1002/mds.25912</article-id>
<article-id pub-id-type="manuscript">NIHMS600472</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Article</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>History of smoking and olfaction in Parkinson’s disease</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Lucassen</surname>
<given-names>Elisabeth B.</given-names>
</name>
<degrees>M.D.</degrees>
<xref ref-type="aff" rid="A1">1</xref>
<xref rid="FN1" ref-type="author-notes">*</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Sterling</surname>
<given-names>Nicholas W.</given-names>
</name>
<degrees>M.S.</degrees>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
<xref rid="FN1" ref-type="author-notes">*</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Lee</surname>
<given-names>Eun-Young</given-names>
</name>
<degrees>Ph.D</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Chen</surname>
<given-names>Honglei</given-names>
</name>
<degrees>Ph.D.</degrees>
<xref ref-type="aff" rid="A7">7</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Lewis</surname>
<given-names>Mechelle M.</given-names>
</name>
<degrees>Ph.D.</degrees>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Kong</surname>
<given-names>Lan</given-names>
</name>
<degrees>Ph.D.</degrees>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Huang</surname>
<given-names>Xuemei</given-names>
</name>
<degrees>M.D., Ph.D.</degrees>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A3">3</xref>
<xref ref-type="aff" rid="A4">4</xref>
<xref ref-type="aff" rid="A5">5</xref>
<xref ref-type="aff" rid="A6">6</xref>
</contrib>
</contrib-group>
<aff id="A1">
<label>1</label>
Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033, USA</aff>
<aff id="A2">
<label>2</label>
Department of Public Health Sciences, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033, USA</aff>
<aff id="A3">
<label>3</label>
Department of Pharmacology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033, USA</aff>
<aff id="A4">
<label>4</label>
Department of Radiology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033, USA</aff>
<aff id="A5">
<label>5</label>
Department of Neurosurgery, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033, USA</aff>
<aff id="A6">
<label>6</label>
Department of Kinesiology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033, USA</aff>
<aff id="A7">
<label>7</label>
National Institute of Environmental Health Sciences, Research Triangle Park, NC 27705</aff>
<author-notes>
<corresp id="FN1">Corresponding Author: Xuemei Huang, M.D., Ph.D., Professor and Vice Chair of Research, Department of Neurology, Penn State Hershey Medical Center, 500 University Dr., H-037, Hershey, PA 17033-0850, USA, Voice: 717-531-0005 X 287082 Fax: 717-531-0226,
<email>xuemei@psu.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted">
<day>9</day>
<month>6</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="epub">
<day>16</day>
<month>5</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="ppub">
<month>7</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="pmc-release">
<day>01</day>
<month>7</month>
<year>2015</year>
</pub-date>
<volume>29</volume>
<issue>8</issue>
<fpage>1069</fpage>
<lpage>1074</lpage>
<pmc-comment>elocation-id from pubmed: 10.1002/mds.25912</pmc-comment>
<abstract>
<sec id="S1">
<title>Objective</title>
<p id="P1">Olfactory dysfunction is the most common pre-motor symptom in Parkinson’s disease, and smoking is known to be associated with lower risk of PD. This study tested the hypothesis that smoking is associated with better olfaction in PD.</p>
</sec>
<sec id="S2">
<title>Methods</title>
<p id="P2">Smoking history was obtained from 76 PD subjects [22 with a history of smoking (smokers), 54 who never smoked (non-smokers)], and 70 Controls (17 smokers, 53 non-smokers). Olfaction was assessed using the 40-item University of Pennsylvania Smell Identification Test (UPSIT). The olfactory scores between groups and subgroups were compared using analysis of covariance with adjustment for age, gender, and MAO-B inhibitor usage.</p>
</sec>
<sec id="S3">
<title>Results</title>
<p id="P3">Overall the olfactory score was lower in PD compared to Controls (olfactory scores: 21.54 vs. 33.45, p<0.0001). Among Controls, there was no significant difference in olfaction between smokers and non-smokers (olfactory scores: 33.2 vs. 34.2, p=0.95). Among PD subjects, however, smokers scored significantly better regarding olfaction compared to non-smokers (olfactory scores: 24.4 vs. 19.9, p=0.02).</p>
</sec>
<sec id="S4">
<title>Conclusions</title>
<p id="P4">These data suggest that history of smoking is associated with better olfaction among PD patients. The finding may be related to why smoking may be protective against PD. Further studies are needed to confirm this finding and investigate the underlying mechanism(s).</p>
</sec>
</abstract>
<kwd-group>
<kwd>Smoking</kwd>
<kwd>Parkinson’s disease</kwd>
<kwd>Olfactory</kwd>
<kwd>Cigarette</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations>
<list>
<country>
<li>États-Unis</li>
</country>
<region>
<li>Caroline du Nord</li>
</region>
</list>
<tree>
<country name="États-Unis">
<noRegion>
<name sortKey="Lucassen, Elisabeth B" sort="Lucassen, Elisabeth B" uniqKey="Lucassen E" first="Elisabeth B." last="Lucassen">Elisabeth B. Lucassen</name>
</noRegion>
<name sortKey="Chen, Honglei" sort="Chen, Honglei" uniqKey="Chen H" first="Honglei" last="Chen">Honglei Chen</name>
<name sortKey="Huang, Xuemei" sort="Huang, Xuemei" uniqKey="Huang X" first="Xuemei" last="Huang">Xuemei Huang</name>
<name sortKey="Huang, Xuemei" sort="Huang, Xuemei" uniqKey="Huang X" first="Xuemei" last="Huang">Xuemei Huang</name>
<name sortKey="Huang, Xuemei" sort="Huang, Xuemei" uniqKey="Huang X" first="Xuemei" last="Huang">Xuemei Huang</name>
<name sortKey="Huang, Xuemei" sort="Huang, Xuemei" uniqKey="Huang X" first="Xuemei" last="Huang">Xuemei Huang</name>
<name sortKey="Huang, Xuemei" sort="Huang, Xuemei" uniqKey="Huang X" first="Xuemei" last="Huang">Xuemei Huang</name>
<name sortKey="Kong, Lan" sort="Kong, Lan" uniqKey="Kong L" first="Lan" last="Kong">Lan Kong</name>
<name sortKey="Lee, Eun Young" sort="Lee, Eun Young" uniqKey="Lee E" first="Eun-Young" last="Lee">Eun-Young Lee</name>
<name sortKey="Lewis, Mechelle M" sort="Lewis, Mechelle M" uniqKey="Lewis M" first="Mechelle M." last="Lewis">Mechelle M. Lewis</name>
<name sortKey="Lewis, Mechelle M" sort="Lewis, Mechelle M" uniqKey="Lewis M" first="Mechelle M." last="Lewis">Mechelle M. Lewis</name>
<name sortKey="Sterling, Nicholas W" sort="Sterling, Nicholas W" uniqKey="Sterling N" first="Nicholas W." last="Sterling">Nicholas W. Sterling</name>
<name sortKey="Sterling, Nicholas W" sort="Sterling, Nicholas W" uniqKey="Sterling N" first="Nicholas W." last="Sterling">Nicholas W. Sterling</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Pmc/Checkpoint

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000031 | SxmlIndent | more

Ou

HfdSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd -nk 000031 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    Pmc
   |étape=   Checkpoint
   |type=    RBID
   |clé=     PMC:4107167
   |texte=   History of smoking and olfaction in Parkinson’s disease
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/RBID.i   -Sk "pubmed:24833119" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd   \
       | NlmPubMed2Wicri -a MovDisordV3
Wicri

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024