History of smoking and olfaction in Parkinson’s disease
Identifieur interne : 000405 ( Pmc/Curation ); précédent : 000404; suivant : 000406History of smoking and olfaction in Parkinson’s disease
Auteurs : Elisabeth B. Lucassen [États-Unis] ; Nicholas W. Sterling [États-Unis] ; Eun-Young Lee [États-Unis] ; Honglei Chen [États-Unis] ; Mechelle M. Lewis [États-Unis] ; Lan Kong [États-Unis] ; Xuemei Huang [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2014.
Abstract
Olfactory dysfunction is the most common pre-motor symptom in Parkinson’s disease, and smoking is known to be associated with lower risk of PD. This study tested the hypothesis that smoking is associated with better olfaction in PD.
Smoking history was obtained from 76 PD subjects [22 with a history of smoking (smokers), 54 who never smoked (non-smokers)], and 70 Controls (17 smokers, 53 non-smokers). Olfaction was assessed using the 40-item University of Pennsylvania Smell Identification Test (UPSIT). The olfactory scores between groups and subgroups were compared using analysis of covariance with adjustment for age, gender, and MAO-B inhibitor usage.
Overall the olfactory score was lower in PD compared to Controls (olfactory scores: 21.54 vs. 33.45, p<0.0001). Among Controls, there was no significant difference in olfaction between smokers and non-smokers (olfactory scores: 33.2 vs. 34.2, p=0.95). Among PD subjects, however, smokers scored significantly better regarding olfaction compared to non-smokers (olfactory scores: 24.4 vs. 19.9, p=0.02).
These data suggest that history of smoking is associated with better olfaction among PD patients. The finding may be related to why smoking may be protective against PD. Further studies are needed to confirm this finding and investigate the underlying mechanism(s).
Url:
DOI: 10.1002/mds.25912
PubMed: 24833119
PubMed Central: 4107167
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title>
<p id="P1">Olfactory dysfunction is the most common pre-motor symptom in Parkinson’s disease, and smoking is known to be associated with lower risk of PD. This study tested the hypothesis that smoking is associated with better olfaction in PD.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">Smoking history was obtained from 76 PD subjects [22 with a history of smoking (smokers), 54 who never smoked (non-smokers)], and 70 Controls (17 smokers, 53 non-smokers). Olfaction was assessed using the 40-item University of Pennsylvania Smell Identification Test (UPSIT). The olfactory scores between groups and subgroups were compared using analysis of covariance with adjustment for age, gender, and MAO-B inhibitor usage.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Overall the olfactory score was lower in PD compared to Controls (olfactory scores: 21.54 vs. 33.45, p<0.0001). Among Controls, there was no significant difference in olfaction between smokers and non-smokers (olfactory scores: 33.2 vs. 34.2, p=0.95). Among PD subjects, however, smokers scored significantly better regarding olfaction compared to non-smokers (olfactory scores: 24.4 vs. 19.9, p=0.02).</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">These data suggest that history of smoking is associated with better olfaction among PD patients. The finding may be related to why smoking may be protective against PD. Further studies are needed to confirm this finding and investigate the underlying mechanism(s).</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8610688</journal-id>
<journal-id journal-id-type="pubmed-jr-id">5937</journal-id>
<journal-id journal-id-type="nlm-ta">Mov Disord</journal-id>
<journal-id journal-id-type="iso-abbrev">Mov. Disord.</journal-id>
<journal-title-group><journal-title>Movement disorders : official journal of the Movement Disorder Society</journal-title>
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<article-id pub-id-type="doi">10.1002/mds.25912</article-id>
<article-id pub-id-type="manuscript">NIHMS600472</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>History of smoking and olfaction in Parkinson’s disease</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Lucassen</surname>
<given-names>Elisabeth B.</given-names>
</name>
<degrees>M.D.</degrees>
<xref ref-type="aff" rid="A1">1</xref>
<xref rid="FN1" ref-type="author-notes">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sterling</surname>
<given-names>Nicholas W.</given-names>
</name>
<degrees>M.S.</degrees>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
<xref rid="FN1" ref-type="author-notes">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lee</surname>
<given-names>Eun-Young</given-names>
</name>
<degrees>Ph.D</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chen</surname>
<given-names>Honglei</given-names>
</name>
<degrees>Ph.D.</degrees>
<xref ref-type="aff" rid="A7">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lewis</surname>
<given-names>Mechelle M.</given-names>
</name>
<degrees>Ph.D.</degrees>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kong</surname>
<given-names>Lan</given-names>
</name>
<degrees>Ph.D.</degrees>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Huang</surname>
<given-names>Xuemei</given-names>
</name>
<degrees>M.D., Ph.D.</degrees>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A3">3</xref>
<xref ref-type="aff" rid="A4">4</xref>
<xref ref-type="aff" rid="A5">5</xref>
<xref ref-type="aff" rid="A6">6</xref>
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<aff id="A1"><label>1</label>
Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033, USA</aff>
<aff id="A2"><label>2</label>
Department of Public Health Sciences, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033, USA</aff>
<aff id="A3"><label>3</label>
Department of Pharmacology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033, USA</aff>
<aff id="A4"><label>4</label>
Department of Radiology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033, USA</aff>
<aff id="A5"><label>5</label>
Department of Neurosurgery, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033, USA</aff>
<aff id="A6"><label>6</label>
Department of Kinesiology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033, USA</aff>
<aff id="A7"><label>7</label>
National Institute of Environmental Health Sciences, Research Triangle Park, NC 27705</aff>
<author-notes><corresp id="FN1">Corresponding Author: Xuemei Huang, M.D., Ph.D., Professor and Vice Chair of Research, Department of Neurology, Penn State Hershey Medical Center, 500 University Dr., H-037, Hershey, PA 17033-0850, USA, Voice: 717-531-0005 X 287082 Fax: 717-531-0226, <email>xuemei@psu.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>9</day>
<month>6</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="epub"><day>16</day>
<month>5</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="ppub"><month>7</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>01</day>
<month>7</month>
<year>2015</year>
</pub-date>
<volume>29</volume>
<issue>8</issue>
<fpage>1069</fpage>
<lpage>1074</lpage>
<pmc-comment>elocation-id from pubmed: 10.1002/mds.25912</pmc-comment>
<abstract><sec id="S1"><title>Objective</title>
<p id="P1">Olfactory dysfunction is the most common pre-motor symptom in Parkinson’s disease, and smoking is known to be associated with lower risk of PD. This study tested the hypothesis that smoking is associated with better olfaction in PD.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">Smoking history was obtained from 76 PD subjects [22 with a history of smoking (smokers), 54 who never smoked (non-smokers)], and 70 Controls (17 smokers, 53 non-smokers). Olfaction was assessed using the 40-item University of Pennsylvania Smell Identification Test (UPSIT). The olfactory scores between groups and subgroups were compared using analysis of covariance with adjustment for age, gender, and MAO-B inhibitor usage.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Overall the olfactory score was lower in PD compared to Controls (olfactory scores: 21.54 vs. 33.45, p<0.0001). Among Controls, there was no significant difference in olfaction between smokers and non-smokers (olfactory scores: 33.2 vs. 34.2, p=0.95). Among PD subjects, however, smokers scored significantly better regarding olfaction compared to non-smokers (olfactory scores: 24.4 vs. 19.9, p=0.02).</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">These data suggest that history of smoking is associated with better olfaction among PD patients. The finding may be related to why smoking may be protective against PD. Further studies are needed to confirm this finding and investigate the underlying mechanism(s).</p>
</sec>
</abstract>
<kwd-group><kwd>Smoking</kwd>
<kwd>Parkinson’s disease</kwd>
<kwd>Olfactory</kwd>
<kwd>Cigarette</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
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