Impaired Sense of Smell and Color Discrimination in Monogenic and Idiopathic Parkinson's Disease
Identifieur interne : 002529 ( PascalFrancis/Curation ); précédent : 002528; suivant : 002530Impaired Sense of Smell and Color Discrimination in Monogenic and Idiopathic Parkinson's Disease
Auteurs : Lena Kertelge [Allemagne] ; Norbert Brüggemann [Allemagne] ; Alexander Schmidt [Allemagne] ; Vera Tadic [Allemagne] ; Claudia Wisse [Allemagne] ; Sylwia Dankert [Allemagne] ; Laura Drude [Allemagne] ; Joyce Van Der Vegt [Pays-Bas, Allemagne] ; Hartwig Siebner [Allemagne] ; Heike Pawlack [Allemagne] ; Peter P. Pramstaller [Italie] ; Maria Isabel Behrens [Chili] ; Alfredo Ramirez [Allemagne] ; Dirk Reichel [Allemagne] ; Carsten Buhmann [Allemagne] ; Johann Hagenah [Allemagne] ; Christine Klein [Allemagne] ; Katja Lohmann [Allemagne] ; Meike Kasten [Allemagne]Source :
- Movement disorders [ 0885-3185 ] ; 2010.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
Olfaction is typically impaired in idiopathic Parkinson's disease (IPD), but its role is uncertain in monogenic PD. Diminished color discrimination has been suggested as another early sign of dopaminergic dysfunction but not been systematically studied. Furthermore, it is unknown whether both deficits are linked. We examined 100 patients with IPD, 27 manifesting mutation carriers (MC), 20 nonmanifesting mutation carriers (NMC), and 110 controls. Participants underwent a standardized neurological examination, the University of Pennsylvania Smell Identification Test (UPSIT), the Farnsworth-Munsell (FM) color discrimination test, and mutation testing in known PD genes. The monogenic group consisted of 15 Parkin (6MC/9NMC), 17 PINK1 (10MC/7NMC), 8 LRRK2 (4MC/4NMC), 3 SNCA (MC), and 4 ATP13A2 (MC) carriers. Olfaction was most impaired in IPD (UPSIT percentiles 10.1 ± 13.5) compared with all other groups (MC 13.8 ± 11.9, NMC 19.6 ± 13.0, controls 33.8 ± 22.4). Within MC, carriers of two mutations in Parkin and PINK1 showed higher UPSIT percentiles than LRRK2 and SNCA carriers. Color discrimination was reduced in IPD (FM total error score 134.8 ± 92.7). In MC (122.4 ± 142.4), the reduction was most pronounced in LRRK2, NMC (80.0 ± 38.8) were comparable with controls (97.2 ± 61.1). UPSIT and FM scores were correlated in the control (r = -0.305; P = 0.002) and the IPD group (r = -0.303; P = 0.006) but not among mutation carriers. First, we confirmed olfaction and color discrimination to be impaired in IPD and suggest olfaction to be a premotor sign. Second, olfaction differed between carriers with one and two mutations in Parkin/PINK1-associated PD. Third, olfaction and color discrimination impairment do not necessarily evolve in parallel.
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Impaired Sense of Smell and Color Discrimination in Monogenic and Idiopathic Parkinson's Disease</title>
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<s3>NLD</s3>
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<sZ>8 aut.</sZ>
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<author><name sortKey="Pawlack, Heike" sort="Pawlack, Heike" uniqKey="Pawlack H" first="Heike" last="Pawlack">Heike Pawlack</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Section of Clincal and Molecular Neurogenetics at the Department of Neurology, University of Luebeck</s1>
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<author><name sortKey="Isabel Behrens, Maria" sort="Isabel Behrens, Maria" uniqKey="Isabel Behrens M" first="Maria" last="Isabel Behrens">Maria Isabel Behrens</name>
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<sZ>12 aut.</sZ>
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<sZ>1 aut.</sZ>
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<author><name sortKey="Reichel, Dirk" sort="Reichel, Dirk" uniqKey="Reichel D" first="Dirk" last="Reichel">Dirk Reichel</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Section of Clincal and Molecular Neurogenetics at the Department of Neurology, University of Luebeck</s1>
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<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Section of Clincal and Molecular Neurogenetics at the Department of Neurology, University of Luebeck</s1>
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<author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Section of Clincal and Molecular Neurogenetics at the Department of Neurology, University of Luebeck</s1>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
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<author><name sortKey="Lohmann, Katja" sort="Lohmann, Katja" uniqKey="Lohmann K" first="Katja" last="Lohmann">Katja Lohmann</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Section of Clincal and Molecular Neurogenetics at the Department of Neurology, University of Luebeck</s1>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
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<author><name sortKey="Kasten, Meike" sort="Kasten, Meike" uniqKey="Kasten M" first="Meike" last="Kasten">Meike Kasten</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Psychiatry and Psychotherapy, University of Luebeck</s1>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>19 aut.</sZ>
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<country>Allemagne</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Section of Clincal and Molecular Neurogenetics at the Department of Neurology, University of Luebeck</s1>
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<sZ>1 aut.</sZ>
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</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
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<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Color</term>
<term>Discrimination</term>
<term>Idiopathic</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
<term>Parkinsonism</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term>
<term>Parkinsonisme</term>
<term>Pathologie du système nerveux</term>
<term>Couleur</term>
<term>Discrimination</term>
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<front><div type="abstract" xml:lang="en">Olfaction is typically impaired in idiopathic Parkinson's disease (IPD), but its role is uncertain in monogenic PD. Diminished color discrimination has been suggested as another early sign of dopaminergic dysfunction but not been systematically studied. Furthermore, it is unknown whether both deficits are linked. We examined 100 patients with IPD, 27 manifesting mutation carriers (MC), 20 nonmanifesting mutation carriers (NMC), and 110 controls. Participants underwent a standardized neurological examination, the University of Pennsylvania Smell Identification Test (UPSIT), the Farnsworth-Munsell (FM) color discrimination test, and mutation testing in known PD genes. The monogenic group consisted of 15 Parkin (6MC/9NMC), 17 PINK1 (10MC/7NMC), 8 LRRK2 (4MC/4NMC), 3 SNCA (MC), and 4 ATP13A2 (MC) carriers. Olfaction was most impaired in IPD (UPSIT percentiles 10.1 ± 13.5) compared with all other groups (MC 13.8 ± 11.9, NMC 19.6 ± 13.0, controls 33.8 ± 22.4). Within MC, carriers of two mutations in Parkin and PINK1 showed higher UPSIT percentiles than LRRK2 and SNCA carriers. Color discrimination was reduced in IPD (FM total error score 134.8 ± 92.7). In MC (122.4 ± 142.4), the reduction was most pronounced in LRRK2, NMC (80.0 ± 38.8) were comparable with controls (97.2 ± 61.1). UPSIT and FM scores were correlated in the control (r = -0.305; P = 0.002) and the IPD group (r = -0.303; P = 0.006) but not among mutation carriers. First, we confirmed olfaction and color discrimination to be impaired in IPD and suggest olfaction to be a premotor sign. Second, olfaction differed between carriers with one and two mutations in Parkin/PINK1-associated PD. Third, olfaction and color discrimination impairment do not necessarily evolve in parallel.</div>
</front>
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<fA08 i1="01" i2="1" l="ENG"><s1>Impaired Sense of Smell and Color Discrimination in Monogenic and Idiopathic Parkinson's Disease</s1>
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<fA14 i1="01"><s1>Department of Psychiatry and Psychotherapy, University of Luebeck</s1>
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<sZ>17 aut.</sZ>
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</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Idiopathique</s0>
<s5>11</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Idiopathic</s0>
<s5>11</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Idiopático</s0>
<s5>11</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Pathologie du système nerveux central</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>40</s5>
</fC07>
<fN21><s1>347</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
</record>
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