Movement Disorders (revue)

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Pathological laughter and crying in patients with multiple system atrophy-cerebellar type

Identifieur interne : 001619 ( PascalFrancis/Curation ); précédent : 001618; suivant : 001620

Pathological laughter and crying in patients with multiple system atrophy-cerebellar type

Auteurs : Josef Parvizi [États-Unis] ; Jeffrey Joseph [États-Unis] ; Daniel Z. Press [États-Unis] ; Jeremy D. Schmahmann [États-Unis]

Source :

RBID : Pascal:07-0263055

Descripteurs français

English descriptors

Abstract

In the cerebellar type of multiple system atrophy (MSA-C), the burden of pathological changes involves the cerebellum and its associated brainstem structures in the basis pontis and the inferior olivary nucleus, and as a result, the clinical phenotype is dominated early on by the cerebellar dysfunction. We report our clinical and post mortem findings in a patient with MSA-C who exhibited pathological laughter in the absence of any congruent changes of mood. A review of the clinical notes of 27 other patients with MSA-C revealed a problem with pathological laughter, or crying, or both in 9 more patients. Our finding of about 36% occurrence suggests that the problem of dysregulation of emotional expression is more prevalent in MSA-C than the paucity of reports in the literature suggests. Our findings are consistent with the view that the cerebellum and its interconnected structures may be involved in the regulation of emotional expression.
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A08 01  1  ENG  @1 Pathological laughter and crying in patients with multiple system atrophy-cerebellar type
A11 01  1    @1 PARVIZI (Josef)
A11 02  1    @1 JOSEPH (Jeffrey)
A11 03  1    @1 PRESS (Daniel Z.)
A11 04  1    @1 SCHMAHMANN (Jeremy D.)
A14 01      @1 Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School @2 Boston, Massachusetts @3 USA @Z 1 aut. @Z 2 aut. @Z 3 aut.
A14 02      @1 Department of Neurology, Massachusetts General Hospital, Harvard Medical School @2 Boston, Massachusetts @3 USA @Z 4 aut.
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A44       @0 0000 @1 © 2007 INIST-CNRS. All rights reserved.
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A60       @1 P
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C01 01    ENG  @0 In the cerebellar type of multiple system atrophy (MSA-C), the burden of pathological changes involves the cerebellum and its associated brainstem structures in the basis pontis and the inferior olivary nucleus, and as a result, the clinical phenotype is dominated early on by the cerebellar dysfunction. We report our clinical and post mortem findings in a patient with MSA-C who exhibited pathological laughter in the absence of any congruent changes of mood. A review of the clinical notes of 27 other patients with MSA-C revealed a problem with pathological laughter, or crying, or both in 9 more patients. Our finding of about 36% occurrence suggests that the problem of dysregulation of emotional expression is more prevalent in MSA-C than the paucity of reports in the literature suggests. Our findings are consistent with the view that the cerebellum and its interconnected structures may be involved in the regulation of emotional expression.
C02 01  X    @0 002B17
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C03 01  X  FRE  @0 Système nerveux pathologie @5 01
C03 01  X  ENG  @0 Nervous system diseases @5 01
C03 01  X  SPA  @0 Sistema nervioso patología @5 01
C03 02  X  FRE  @0 Atrophie multisystématisée @2 NM @5 02
C03 02  X  ENG  @0 Multiple system atrophy @2 NM @5 02
C03 02  X  SPA  @0 Atrofia multisistematizada @2 NM @5 02
C03 03  X  FRE  @0 Rire @5 09
C03 03  X  ENG  @0 Laughter @5 09
C03 03  X  SPA  @0 Risa @5 09
C03 04  X  FRE  @0 Pleur @5 10
C03 04  X  ENG  @0 Crying @5 10
C03 04  X  SPA  @0 Lloro @5 10
C03 05  X  FRE  @0 Homme @5 11
C03 05  X  ENG  @0 Human @5 11
C03 05  X  SPA  @0 Hombre @5 11
C03 06  X  FRE  @0 Cervelet @5 12
C03 06  X  ENG  @0 Cerebellum @5 12
C03 06  X  SPA  @0 Cerebelo @5 12
C03 07  X  FRE  @0 Olivopontocérébelleux @5 13
C03 07  X  ENG  @0 Olivopontocerebellar @5 13
C03 07  X  SPA  @0 Olivopontocerebeloso @5 13
C03 08  X  FRE  @0 Emotion émotivité @5 14
C03 08  X  ENG  @0 Emotion emotionality @5 14
C03 08  X  SPA  @0 Emoción emotividad @5 14
C03 09  X  FRE  @0 Comportement @5 15
C03 09  X  ENG  @0 Behavior @5 15
C03 09  X  SPA  @0 Conducta @5 15
C07 01  X  FRE  @0 Encéphale @5 37
C07 01  X  ENG  @0 Encephalon @5 37
C07 01  X  SPA  @0 Encéfalo @5 37
C07 02  X  FRE  @0 Système nerveux central @5 38
C07 02  X  ENG  @0 Central nervous system @5 38
C07 02  X  SPA  @0 Sistema nervioso central @5 38
C07 03  X  FRE  @0 Affect affectivité @5 39
C07 03  X  ENG  @0 Affect affectivity @5 39
C07 03  X  SPA  @0 Afecto afectividad @5 39
N21       @1 176
N44 01      @1 OTO
N82       @1 OTO

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Pascal:07-0263055

Le document en format XML

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