MovDisordV3, PascalFrancis, Curation, bibRecord, 001385

Case-control study of UCHL1 S18Y variant in Parkinson's disease

Identifieur interne : 001385 ( PascalFrancis/Curation ); précédent : 001384; suivant : 001386

Case-control study of UCHL1 S18Y variant in Parkinson's disease

Auteurs : Eng-King Tan [Singapour] ; Kim-Yoong Puong [Singapour] ; Stephanie Fook-Chong [Singapour] ; Eva Chua [Singapour] ; HUI SHEN [Singapour] ; YIH YUEN [Singapour] ; Ratnagopal Pavanni [Singapour] ; Meng-Cheong Wong [Singapour] ; Kathiravelu Puvan [Singapour] ; YI ZHAO [Singapour]

Source :

Movement disorders [ 0885-3185 ] ; 2006.

RBID : Pascal:06-0538606

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Parkinson maladie, Etude cas témoin, Polymorphisme, Survie.

English descriptors

KwdEn :
- Case control study, Nervous system diseases, Parkinson disease, Polymorphism, Survival.

Abstract

A recent meta-analysis observed a greater significant inverse association of the ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y variant with Parkinson's disease (PD) for Asian (predominantly Japanese) populations compared with Caucasian populations. We performed an independent case-control study in 335 PD and 341 control subjects with data from a Chinese population to investigate the age-of-onset effect of the UCHL1 variant in PD. The Y/Y and Y/S genotypes were less frequent in the PD young-onset group than in controls and the frequency of the Y alleles was higher in young controls compared to young-onset PD (age at examination ≤ 65 years; P = 0.003). Multivariate analysis revealed the Y/Y genotype was significantly lower (P = 0.008) in the young-onset PD (Y/Y vs. S/S: odds ratio [OR]: 0.42; 95% confidence interval [CI]: 0.24, 0.74; S/Y vs. S/S: OR: 0.66, 95% CI: 0.41,1.08) compared with controls, but this difference was not seen for the late-onset PD. Kaplan-Meier analysis carried out on PD subjects demonstrated that the Y/Y genotype was associated with a later onset of PD than Y/S plus S/S genotypes (P = 0.05). We provided an independent confirmation of the protective effect of the UCHL1 S18Y variant (Y/Y genotype) against PD in young Chinese subjects. Further functional studies of the S18Y variant in both cell and animal models will be of interest.

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C01	`01`		`ENG`	@0 A recent meta-analysis observed a greater significant inverse association of the ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y variant with Parkinson's disease (PD) for Asian (predominantly Japanese) populations compared with Caucasian populations. We performed an independent case-control study in 335 PD and 341 control subjects with data from a Chinese population to investigate the age-of-onset effect of the UCHL1 variant in PD. The Y/Y and Y/S genotypes were less frequent in the PD young-onset group than in controls and the frequency of the Y alleles was higher in young controls compared to young-onset PD (age at examination ≤ 65 years; P = 0.003). Multivariate analysis revealed the Y/Y genotype was significantly lower (P = 0.008) in the young-onset PD (Y/Y vs. S/S: odds ratio [OR]: 0.42; 95% confidence interval [CI]: 0.24, 0.74; S/Y vs. S/S: OR: 0.66, 95% CI: 0.41,1.08) compared with controls, but this difference was not seen for the late-onset PD. Kaplan-Meier analysis carried out on PD subjects demonstrated that the Y/Y genotype was associated with a later onset of PD than Y/S plus S/S genotypes (P = 0.05). We provided an independent confirmation of the protective effect of the UCHL1 S18Y variant (Y/Y genotype) against PD in young Chinese subjects. Further functional studies of the S18Y variant in both cell and animal models will be of interest.
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Pascal:06-0538606

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Case-control study of UCHL1 S18Y variant in Parkinson's disease</title>
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<author><name sortKey="Wong, Meng Cheong" sort="Wong, Meng Cheong" uniqKey="Wong M" first="Meng-Cheong" last="Wong">Meng-Cheong Wong</name>
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<author><name sortKey="Puvan, Kathiravelu" sort="Puvan, Kathiravelu" uniqKey="Puvan K" first="Kathiravelu" last="Puvan">Kathiravelu Puvan</name>
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<author><name sortKey="Yi Zhao" sort="Yi Zhao" uniqKey="Yi Zhao" last="Yi Zhao">YI ZHAO</name>
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<front><div type="abstract" xml:lang="en">A recent meta-analysis observed a greater significant inverse association of the ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y variant with Parkinson's disease (PD) for Asian (predominantly Japanese) populations compared with Caucasian populations. We performed an independent case-control study in 335 PD and 341 control subjects with data from a Chinese population to investigate the age-of-onset effect of the UCHL1 variant in PD. The Y/Y and Y/S genotypes were less frequent in the PD young-onset group than in controls and the frequency of the Y alleles was higher in young controls compared to young-onset PD (age at examination ≤ 65 years; P = 0.003). Multivariate analysis revealed the Y/Y genotype was significantly lower (P = 0.008) in the young-onset PD (Y/Y vs. S/S: odds ratio [OR]: 0.42; 95% confidence interval [CI]: 0.24, 0.74; S/Y vs. S/S: OR: 0.66, 95% CI: 0.41,1.08) compared with controls, but this difference was not seen for the late-onset PD. Kaplan-Meier analysis carried out on PD subjects demonstrated that the Y/Y genotype was associated with a later onset of PD than Y/S plus S/S genotypes (P = 0.05). We provided an independent confirmation of the protective effect of the UCHL1 S18Y variant (Y/Y genotype) against PD in young Chinese subjects. Further functional studies of the S18Y variant in both cell and animal models will be of interest.</div>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Case-control study of UCHL1 S18Y variant in Parkinson's disease

Case-control study of UCHL1 S18Y variant in Parkinson's disease

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