Parkinson's disease : A broken nosology
Identifieur interne :
000F40 ( PascalFrancis/Curation );
précédent :
000F39;
suivant :
000F41
Parkinson's disease : A broken nosology
Auteurs : John Hardy [
États-Unis,
Royaume-Uni] ;
Andrew J. Lees [
Royaume-Uni]
Source :
-
Movement disorders [ 0885-3185 ] ; 2005.
RBID : Pascal:05-0457450
Descripteurs français
English descriptors
Abstract
Parkinson's disease (PD) is a clinical diagnosis. We argue here that if we are to make progress in understanding its underlying pathogenesis, there is a need to have a pathological definition of disease that includes the presence of Lewy bodies and nigral loss in the ventrolateral tier of the pars compacta of the substantia nigra. Using such a definition, there is only one certain and known cause: mutations in the α-synuclein gene. However, the phenotype of this one known cause is broader than PD and encompasses Lewy body dementia.
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A11 | 01 | 1 | | @1 HARDY (John) |
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A11 | 02 | 1 | | @1 LEES (Andrew J.) |
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A12 | 02 | 1 | | @1 WENNING (Gregor K.) @9 ed. |
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A14 | 01 | | | @1 Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health @2 Bethesda, Maryland @3 USA @Z 1 aut. |
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C01 | 01 | | ENG | @0 Parkinson's disease (PD) is a clinical diagnosis. We argue here that if we are to make progress in understanding its underlying pathogenesis, there is a need to have a pathological definition of disease that includes the presence of Lewy bodies and nigral loss in the ventrolateral tier of the pars compacta of the substantia nigra. Using such a definition, there is only one certain and known cause: mutations in the α-synuclein gene. However, the phenotype of this one known cause is broader than PD and encompasses Lewy body dementia. |
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C03 | 01 | X | SPA | @0 Sistema nervioso patología @5 01 |
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C03 | 02 | X | FRE | @0 Parkinson maladie @5 02 |
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C03 | 02 | X | ENG | @0 Parkinson disease @5 02 |
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C03 | 02 | X | SPA | @0 Parkinson enfermedad @5 02 |
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C07 | 02 | X | FRE | @0 Extrapyramidal syndrome @5 38 |
---|
C07 | 02 | X | ENG | @0 Extrapyramidal syndrome @5 38 |
---|
C07 | 02 | X | SPA | @0 Extrapiramidal síndrome @5 38 |
---|
C07 | 03 | X | FRE | @0 Maladie dégénérative @5 39 |
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C07 | 03 | X | ENG | @0 Degenerative disease @5 39 |
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C07 | 03 | X | SPA | @0 Enfermedad degenerativa @5 39 |
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|
pR |
A30 | 01 | 1 | ENG | @1 Atypical Parkinsonian Disorders - From Protein Dysfunction to Therapeutic Intervention. International Meeting @3 Innsbruck AUT @4 2003-02-19 |
---|
|
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Le document en format XML
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