Parkinson's disease : A broken nosology
Identifieur interne :
000F40 ( PascalFrancis/Curation );
précédent :
000F39;
suivant :
000F41
Parkinson's disease : A broken nosology
Auteurs : John Hardy [
États-Unis,
Royaume-Uni] ;
Andrew J. Lees [
Royaume-Uni]
Source :
-
Movement disorders [ 0885-3185 ] ; 2005.
RBID : Pascal:05-0457450
Descripteurs français
English descriptors
Abstract
Parkinson's disease (PD) is a clinical diagnosis. We argue here that if we are to make progress in understanding its underlying pathogenesis, there is a need to have a pathological definition of disease that includes the presence of Lewy bodies and nigral loss in the ventrolateral tier of the pars compacta of the substantia nigra. Using such a definition, there is only one certain and known cause: mutations in the α-synuclein gene. However, the phenotype of this one known cause is broader than PD and encompasses Lewy body dementia.
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| A11 | 02 | 1 | | @1 LEES (Andrew J.) |
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| C01 | 01 | | ENG | @0 Parkinson's disease (PD) is a clinical diagnosis. We argue here that if we are to make progress in understanding its underlying pathogenesis, there is a need to have a pathological definition of disease that includes the presence of Lewy bodies and nigral loss in the ventrolateral tier of the pars compacta of the substantia nigra. Using such a definition, there is only one certain and known cause: mutations in the α-synuclein gene. However, the phenotype of this one known cause is broader than PD and encompasses Lewy body dementia. |
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| C03 | 04 | X | ENG | @0 Lewy body dementia @2 NM @5 10 |
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| C07 | 03 | X | FRE | @0 Maladie dégénérative @5 39 |
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| C07 | 03 | X | ENG | @0 Degenerative disease @5 39 |
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| N44 | 01 | | | @1 OTO |
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| N82 | | | | @1 OTO |
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|
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| pR |
| A30 | 01 | 1 | ENG | @1 Atypical Parkinsonian Disorders - From Protein Dysfunction to Therapeutic Intervention. International Meeting @3 Innsbruck AUT @4 2003-02-19 |
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Le document en format XML
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