MovDisordV3, PascalFrancis, Corpus, bibRecord, 001D81

Parkinson's disease : A broken nosology

Identifieur interne : 001D81 ( PascalFrancis/Corpus ); précédent : 001D80; suivant : 001D82

Parkinson's disease : A broken nosology

Auteurs : John Hardy ; Andrew J. Lees

Source :

Movement disorders [ 0885-3185 ] ; 2005.

RBID : Pascal:05-0457450

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Parkinson maladie, Nosologie, Démence corps Lewy.

English descriptors

KwdEn :
- Lewy body dementia, Nervous system diseases, Nosology, Parkinson disease.

Abstract

Parkinson's disease (PD) is a clinical diagnosis. We argue here that if we are to make progress in understanding its underlying pathogenesis, there is a need to have a pathological definition of disease that includes the presence of Lewy bodies and nigral loss in the ventrolateral tier of the pars compacta of the substantia nigra. Using such a definition, there is only one certain and known cause: mutations in the α-synuclein gene. However, the phenotype of this one known cause is broader than PD and encompasses Lewy body dementia.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A03		`1`		`@0 Mov. disord.`
A05				`@2 20`
A06				`@3 SUP12`
A08	`01`	`1`	`ENG`	`@1 Parkinson's disease : A broken nosology`
A09	`01`	`1`	`ENG`	`@1 Atypical Parkinsonian Disorders`
A11	`01`	`1`		`@1 HARDY (John)`
A11	`02`	`1`		`@1 LEES (Andrew J.)`
A12	`01`	`1`		`@1 POEWE (Werner) @9 ed.`
A12	`02`	`1`		`@1 WENNING (Gregor K.) @9 ed.`
A14	`01`			`@1 Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health @2 Bethesda, Maryland @3 USA @Z 1 aut.`
A14	`02`			`@1 Reta Lila Weston Institute of Neurological Studies, University College London @2 London @3 GBR @Z 1 aut. @Z 2 aut.`
A15	`01`			`@1 Department of Neurology, Medical University Innsbruck @2 Innsbruck @3 AUT @Z 1 aut. @Z 2 aut.`
A20				`@2 S2-S4`
A21				`@1 2005`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 20953 @5 354000132714250010`
A44				`@0 0000 @1 © 2005 INIST-CNRS. All rights reserved.`
A45				`@0 34 ref.`
A47	`01`	`1`		`@0 05-0457450`
A60				`@1 P @2 C`
A61				`@0 A`
A64	`01`	`1`		`@0 Movement disorders`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 Parkinson's disease (PD) is a clinical diagnosis. We argue here that if we are to make progress in understanding its underlying pathogenesis, there is a need to have a pathological definition of disease that includes the presence of Lewy bodies and nigral loss in the ventrolateral tier of the pars compacta of the substantia nigra. Using such a definition, there is only one certain and known cause: mutations in the α-synuclein gene. However, the phenotype of this one known cause is broader than PD and encompasses Lewy body dementia.
C02	`01`	`X`		`@0 002B17`
C02	`02`	`X`		`@0 002B17G`
C02	`03`	`X`		`@0 002B17A03`
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C03	`01`	`X`	`ENG`	`@0 Nervous system diseases @5 01`
C03	`01`	`X`	`SPA`	`@0 Sistema nervioso patología @5 01`
C03	`02`	`X`	`FRE`	`@0 Parkinson maladie @5 02`
C03	`02`	`X`	`ENG`	`@0 Parkinson disease @5 02`
C03	`02`	`X`	`SPA`	`@0 Parkinson enfermedad @5 02`
C03	`03`	`X`	`FRE`	`@0 Nosologie @5 09`
C03	`03`	`X`	`ENG`	`@0 Nosology @5 09`
C03	`03`	`X`	`SPA`	`@0 Nosología @5 09`
C03	`04`	`X`	`FRE`	`@0 Démence corps Lewy @2 NM @5 10`
C03	`04`	`X`	`ENG`	`@0 Lewy body dementia @2 NM @5 10`
C03	`04`	`X`	`SPA`	`@0 Demencia cuerpos Lewy @2 NM @5 10`
C07	`01`	`X`	`FRE`	`@0 Encéphale pathologie @5 37`
C07	`01`	`X`	`ENG`	`@0 Cerebral disorder @5 37`
C07	`01`	`X`	`SPA`	`@0 Encéfalo patología @5 37`
C07	`02`	`X`	`FRE`	`@0 Extrapyramidal syndrome @5 38`
C07	`02`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 38`
C07	`02`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 38`
C07	`03`	`X`	`FRE`	`@0 Maladie dégénérative @5 39`
C07	`03`	`X`	`ENG`	`@0 Degenerative disease @5 39`
C07	`03`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 39`
C07	`04`	`X`	`FRE`	`@0 Système nerveux central pathologie @5 40`
C07	`04`	`X`	`ENG`	`@0 Central nervous system disease @5 40`
C07	`04`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 40`
N21				`@1 318`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

A30	`01`	`1`	`ENG`	`@1 Atypical Parkinsonian Disorders - From Protein Dysfunction to Therapeutic Intervention. International Meeting @3 Innsbruck AUT @4 2003-02-19`

Format Inist (serveur)

NO :	PASCAL 05-0457450 INIST
ET :	Parkinson's disease : A broken nosology
AU :	HARDY (John); LEES (Andrew J.); POEWE (Werner); WENNING (Gregor K.)
AF :	Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health/Bethesda, Maryland/Etats-Unis (1 aut.); Reta Lila Weston Institute of Neurological Studies, University College London/London/Royaume-Uni (1 aut., 2 aut.); Department of Neurology, Medical University Innsbruck/Innsbruck/Autriche (1 aut., 2 aut.)
DT :	Publication en série; Congrès; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2005; Vol. 20; No. SUP12; S2-S4; Bibl. 34 ref.
LA :	Anglais
EA :	Parkinson's disease (PD) is a clinical diagnosis. We argue here that if we are to make progress in understanding its underlying pathogenesis, there is a need to have a pathological definition of disease that includes the presence of Lewy bodies and nigral loss in the ventrolateral tier of the pars compacta of the substantia nigra. Using such a definition, there is only one certain and known cause: mutations in the α-synuclein gene. However, the phenotype of this one known cause is broader than PD and encompasses Lewy body dementia.
CC :	002B17; 002B17G; 002B17A03
FD :	Système nerveux pathologie; Parkinson maladie; Nosologie; Démence corps Lewy
FG :	Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie
ED :	Nervous system diseases; Parkinson disease; Nosology; Lewy body dementia
EG :	Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease
SD :	Sistema nervioso patología; Parkinson enfermedad; Nosología; Demencia cuerpos Lewy
LO :	INIST-20953.354000132714250010
ID :	05-0457450

Links to Exploration step

Pascal:05-0457450

Le document en format XML

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<ET>Parkinson's disease : A broken nosology</ET>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Parkinson's disease : A broken nosology

Parkinson's disease : A broken nosology

Source :

Descripteurs français

English descriptors

Abstract

Notice en format standard (ISO 2709)

Format Inist (serveur)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri