Levodopa in the treatment of Parkinson's disease: Current controversies
Identifieur interne : 000C47 ( PascalFrancis/Curation ); précédent : 000C46; suivant : 000C48Levodopa in the treatment of Parkinson's disease: Current controversies
Auteurs : C. Warren Olanow [États-Unis] ; Yves Agid [France] ; Yoshi Mizuno [Japon] ; Alberto Albanese [Italie] ; U. Bonucelli [Italie] ; Philip Damier [France] ; Justo De Yebenes [Espagne] ; Oscar Gershanik [Argentine] ; Mark Guttman [Canada] ; F. Grandas [Espagne] ; Mark Hallett [États-Unis] ; Ole Hornykiewicz [Autriche] ; Peter Jenner [Royaume-Uni] ; R. Katzenschlager [Royaume-Uni] ; William J. Langston [États-Unis] ; Peter Lewitt [États-Unis] ; Eldad Melamed [Israël] ; M. A. Mena [Espagne] ; P. P. Michel [France] ; Catherine Mytilineou [États-Unis] ; Jose A. Obeso [Espagne] ; Werner Poewe [Autriche] ; Niall Quinn [Royaume-Uni] ; R. Raisman-Vozari [France] ; Ali H. Rajput [Canada] ; Olivier Rascol [France] ; Christina Sampaio ; Fabrizio StocchiSource :
- Movement disorders [ 0885-3185 ] ; 2004.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
Levodopa is the most effective symptomatic agent in the treatment of Parkinson's disease (PD) and the "gold standard" against which new agents must be compared. However, there remain two areas of controversy: (1) whether levodopa is toxic, and (2) whether levodopa directly causes motor complications. Levodopa is toxic to cultured dopamine neurons, and this may be a problem in PD where there is evidence of oxidative stress in the nigra. However, there is little firm evidence to suggest that levodopa is toxic in vivo or in PD. Clinical trials have not clarified this situation. Levodopa is also associated with motor complications. Increasing evidence suggests that they are related, at least in part, to the short half-life of the drug (and its potential to induce pulsatile stimulation of dopamine receptors) rather than to specific properties of the molecule. Treatment strategies that provide more continuous stimulation of dopamine receptors provide reduced motor complications in MPTP monkeys and PD patients. These studies raise the possibility that more continuous and physiological delivery of levodopa might reduce the risk of motor complications. Clinical trials to test this hypothesis are underway. We review current evidence relating to these areas of controversy.
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<author><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name>
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<author><name sortKey="Sampaio, Christina" sort="Sampaio, Christina" uniqKey="Sampaio C" first="Christina" last="Sampaio">Christina Sampaio</name>
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<author><name sortKey="Stocchi, Fabrizio" sort="Stocchi, Fabrizio" uniqKey="Stocchi F" first="Fabrizio" last="Stocchi">Fabrizio Stocchi</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Levodopa in the treatment of Parkinson's disease: Current controversies</title>
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<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Mount Sinai School of Medicine, Nest York</s1>
<s2>New York</s2>
<s3>USA</s3>
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</inist:fA14>
<country>États-Unis</country>
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<author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Hopital de la Salpetriere</s1>
<s2>Paris</s2>
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<author><name sortKey="Mizuno, Yoshi" sort="Mizuno, Yoshi" uniqKey="Mizuno Y" first="Yoshi" last="Mizuno">Yoshi Mizuno</name>
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<author><name sortKey="Grandas, F" sort="Grandas, F" uniqKey="Grandas F" first="F." last="Grandas">F. Grandas</name>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Hopital General G Maranon, Libertad, Velilla De San Antonio</s1>
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<author><name sortKey="Hallett, Mark" sort="Hallett, Mark" uniqKey="Hallett M" first="Mark" last="Hallett">Mark Hallett</name>
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<author><name sortKey="Hornykiewicz, Ole" sort="Hornykiewicz, Ole" uniqKey="Hornykiewicz O" first="Ole" last="Hornykiewicz">Ole Hornykiewicz</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Brain Research Institute, Vienna University Medical School</s1>
<s2>Vienna</s2>
<s3>AUT</s3>
<sZ>12 aut.</sZ>
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<author><name sortKey="Jenner, Peter" sort="Jenner, Peter" uniqKey="Jenner P" first="Peter" last="Jenner">Peter Jenner</name>
<affiliation wicri:level="1"><inist:fA14 i1="13"><s1>King's College London, Hodgkin Building, Guy's Campus</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
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<author><name sortKey="Katzenschlager, R" sort="Katzenschlager, R" uniqKey="Katzenschlager R" first="R." last="Katzenschlager">R. Katzenschlager</name>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>National Hospital for Neurology and Neurosurgery</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
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<author><name sortKey="Langston, William J" sort="Langston, William J" uniqKey="Langston W" first="William J." last="Langston">William J. Langston</name>
<affiliation wicri:level="1"><inist:fA14 i1="15"><s1>The Parkinson's Institute</s1>
<s2>Sunnyvale, California</s2>
<s3>USA</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
</affiliation>
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<author><name sortKey="Lewitt, Peter" sort="Lewitt, Peter" uniqKey="Lewitt P" first="Peter" last="Lewitt">Peter Lewitt</name>
<affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Departments of Neurology, Psychiatry and Behavioral Neuroscience, Wayne State University School of Medicine</s1>
<s2>Detroit, Michigan</s2>
<s3>USA</s3>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
</affiliation>
</author>
<author><name sortKey="Melamed, Eldad" sort="Melamed, Eldad" uniqKey="Melamed E" first="Eldad" last="Melamed">Eldad Melamed</name>
<affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Department of Neurology, Robin Medical Center, Beilinson Campus, Petah Tiqva</s1>
<s3>ISR</s3>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Israël</country>
</affiliation>
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<affiliation wicri:level="1"><inist:fA14 i1="21"><s1>Universitarie of Navarra</s1>
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<s3>ESP</s3>
<sZ>21 aut.</sZ>
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<s2>Innsbruck, Tyrol</s2>
<s3>AUT</s3>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
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<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Hopital de la Salpetriere</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>24 aut.</sZ>
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<affiliation wicri:level="1"><inist:fA14 i1="24"><s1>Royal University Hospital</s1>
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<affiliation wicri:level="1"><inist:fA14 i1="25"><s1>Clinic University Center, Faculty of Medicine, Allees Jules-Guesde</s1>
<s2>Toulouse</s2>
<s3>FRA</s3>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Sampaio, Christina" sort="Sampaio, Christina" uniqKey="Sampaio C" first="Christina" last="Sampaio">Christina Sampaio</name>
</author>
<author><name sortKey="Stocchi, Fabrizio" sort="Stocchi, Fabrizio" uniqKey="Stocchi F" first="Fabrizio" last="Stocchi">Fabrizio Stocchi</name>
</author>
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<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2004">2004</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
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</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Levodopa</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
<term>Treatment</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term>
<term>Lévodopa</term>
<term>Traitement</term>
<term>Parkinson maladie</term>
</keywords>
</textClass>
</profileDesc>
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<front><div type="abstract" xml:lang="en">Levodopa is the most effective symptomatic agent in the treatment of Parkinson's disease (PD) and the "gold standard" against which new agents must be compared. However, there remain two areas of controversy: (1) whether levodopa is toxic, and (2) whether levodopa directly causes motor complications. Levodopa is toxic to cultured dopamine neurons, and this may be a problem in PD where there is evidence of oxidative stress in the nigra. However, there is little firm evidence to suggest that levodopa is toxic in vivo or in PD. Clinical trials have not clarified this situation. Levodopa is also associated with motor complications. Increasing evidence suggests that they are related, at least in part, to the short half-life of the drug (and its potential to induce pulsatile stimulation of dopamine receptors) rather than to specific properties of the molecule. Treatment strategies that provide more continuous stimulation of dopamine receptors provide reduced motor complications in MPTP monkeys and PD patients. These studies raise the possibility that more continuous and physiological delivery of levodopa might reduce the risk of motor complications. Clinical trials to test this hypothesis are underway. We review current evidence relating to these areas of controversy.</div>
</front>
</TEI>
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<fA08 i1="01" i2="1" l="ENG"><s1>Levodopa in the treatment of Parkinson's disease: Current controversies</s1>
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<fA11 i1="01" i2="1"><s1>OLANOW (C. Warren)</s1>
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<sZ>1 aut.</sZ>
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<sZ>24 aut.</sZ>
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<sZ>4 aut.</sZ>
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<fA14 i1="06"><s1>Hopital Laennec, Clinique Neurologique</s1>
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<fA14 i1="07"><s1>Fundación Jiménez Díaz, Universidad Autónoma de Madrid</s1>
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<s3>ARG</s3>
<sZ>8 aut.</sZ>
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<s2>Markham, Ontario</s2>
<s3>CAN</s3>
<sZ>9 aut.</sZ>
</fA14>
<fA14 i1="10"><s1>Hopital General G Maranon, Libertad, Velilla De San Antonio</s1>
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<s3>ESP</s3>
<sZ>10 aut.</sZ>
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<fA14 i1="11"><s1>Human Motor Control Section, National Institute of Neurological Disease Center, National Institutes of Health</s1>
<s2>Bethesda, Maryland</s2>
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<sZ>11 aut.</sZ>
</fA14>
<fA14 i1="12"><s1>Brain Research Institute, Vienna University Medical School</s1>
<s2>Vienna</s2>
<s3>AUT</s3>
<sZ>12 aut.</sZ>
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<fA14 i1="13"><s1>King's College London, Hodgkin Building, Guy's Campus</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>13 aut.</sZ>
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<fA14 i1="14"><s1>National Hospital for Neurology and Neurosurgery</s1>
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<sZ>14 aut.</sZ>
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<fA14 i1="15"><s1>The Parkinson's Institute</s1>
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<sZ>15 aut.</sZ>
</fA14>
<fA14 i1="16"><s1>Departments of Neurology, Psychiatry and Behavioral Neuroscience, Wayne State University School of Medicine</s1>
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<s3>USA</s3>
<sZ>16 aut.</sZ>
</fA14>
<fA14 i1="17"><s1>Department of Neurology, Robin Medical Center, Beilinson Campus, Petah Tiqva</s1>
<s3>ISR</s3>
<sZ>17 aut.</sZ>
</fA14>
<fA14 i1="18"><s1>Departmento Neurobiologia-Investigacion, Hospital Romon y Cajal, Ctra de Colmenar</s1>
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<fA14 i1="19"><s1>Institute National de la Sante et de la Recherche Medical, Hopital de la Salpetriere</s1>
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<sZ>19 aut.</sZ>
</fA14>
<fA14 i1="20"><s1>Department of Neurology, Mount Sinai School of Medicine</s1>
<s2>New York, New York</s2>
<s3>USA</s3>
<sZ>20 aut.</sZ>
</fA14>
<fA14 i1="21"><s1>Universitarie of Navarra</s1>
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<sZ>21 aut.</sZ>
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<fA14 i1="22"><s1>University Hospital Innsbruck, Department of Neurology</s1>
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<fA14 i1="24"><s1>Royal University Hospital</s1>
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<fC01 i1="01" l="ENG"><s0>Levodopa is the most effective symptomatic agent in the treatment of Parkinson's disease (PD) and the "gold standard" against which new agents must be compared. However, there remain two areas of controversy: (1) whether levodopa is toxic, and (2) whether levodopa directly causes motor complications. Levodopa is toxic to cultured dopamine neurons, and this may be a problem in PD where there is evidence of oxidative stress in the nigra. However, there is little firm evidence to suggest that levodopa is toxic in vivo or in PD. Clinical trials have not clarified this situation. Levodopa is also associated with motor complications. Increasing evidence suggests that they are related, at least in part, to the short half-life of the drug (and its potential to induce pulsatile stimulation of dopamine receptors) rather than to specific properties of the molecule. Treatment strategies that provide more continuous stimulation of dopamine receptors provide reduced motor complications in MPTP monkeys and PD patients. These studies raise the possibility that more continuous and physiological delivery of levodopa might reduce the risk of motor complications. Clinical trials to test this hypothesis are underway. We review current evidence relating to these areas of controversy.</s0>
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<fC02 i1="01" i2="X"><s0>002B17</s0>
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<fC02 i1="03" i2="X"><s0>002B02U01</s0>
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