MovDisordV3, PascalFrancis, Curation, bibRecord, 000C09

Imaging of activated microglia with PET and [11C]PK 11195 in corticobasal degeneration

Identifieur interne : 000C09 ( PascalFrancis/Curation ); précédent : 000C08; suivant : 000C10

Imaging of activated microglia with PET and [11C]PK 11195 in corticobasal degeneration

Auteurs : K. Henkel [Allemagne] ; J. Karitzky [Allemagne] ; M. Schmid [Allemagne] ; I. Mader [Allemagne] ; G. Glatting [Allemagne] ; J. W. Unger [Allemagne] ; B. Neumaier [Allemagne] ; A. C. Ludolph [Allemagne] ; S. N. Reske [Allemagne] ; G. B. Landwehrmeyer [Allemagne]

Source :

Movement disorders [ 0885-3185 ] ; 2004.

RBID : Pascal:04-0455135

Descripteurs français

Pascal (Inist)
- Dégénérescence, Microglie, Positon, Système nerveux pathologie, Tomoscintigraphie.

English descriptors

KwdEn :
- Degeneration, Emission tomography, Microglia, Nervous system diseases, Positron.

Abstract

Positron emission tomography (PET) using [¹¹C]PK 11195, a ligand for peripheral benzodiazepine receptor binding sites, offers the opportunity to image activated microglia in vivo. This tool may therefore be used to display the occurrence of microglial activation in the course of neurodegeneration. A patient with the clinical diagnosis of corticobasal degeneration (CBD) and left-sided symptoms was studied using fluorodeoxyglucose (FDG) and [¹¹C]PK 11195 PET. We found a marked right hemispheric hypometabolism and asymmetric microglial activation in corresponding areas of the basal ganglia and right temporal and parietal cortex. [¹¹C]PK 11195 PET suggests involvement of microglial activation in the pathogenesis of CBD.

A01	`01`	`1`		`@0 0885-3185`
A03		`1`		`@0 Mov. disord.`
A05				`@2 19`
A06				`@2 7`
A08	`01`	`1`	`ENG`	`@1 Imaging of activated microglia with PET and [¹¹C]PK 11195 in corticobasal degeneration`
A11	`01`	`1`		`@1 HENKEL (K.)`
A11	`02`	`1`		`@1 KARITZKY (J.)`
A11	`03`	`1`		`@1 SCHMID (M.)`
A11	`04`	`1`		`@1 MADER (I.)`
A11	`05`	`1`		`@1 GLATTING (G.)`
A11	`06`	`1`		`@1 UNGER (J. W.)`
A11	`07`	`1`		`@1 NEUMAIER (B.)`
A11	`08`	`1`		`@1 LUDOLPH (A. C.)`
A11	`09`	`1`		`@1 RESKE (S. N.)`
A11	`10`	`1`		`@1 LANDWEHRMEYER (G. B.)`
A14	`01`			`@1 Department of Neurology University of Ulm @2 Ulm @3 DEU @Z 1 aut. @Z 2 aut. @Z 6 aut. @Z 8 aut. @Z 10 aut.`
A14	`02`			`@1 Department of Nuclear Medicine, University of Ulm @2 Ulm @3 DEU @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 5 aut. @Z 7 aut. @Z 9 aut.`
A14	`03`			`@1 Department of Neuroradiology, University of Tübingen @2 Tübingen @3 DEU @Z 4 aut.`
A20				`@1 817-821`
A21				`@1 2004`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 20953 @5 354000113929420110`
A44				`@0 0000 @1 © 2004 INIST-CNRS. All rights reserved.`
A45				`@0 13 ref.`
A47	`01`	`1`		`@0 04-0455135`
A60				`@1 P @3 CC`
A61				`@0 A`
A64	`01`	`1`		`@0 Movement disorders`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 Positron emission tomography (PET) using [¹¹C]PK 11195, a ligand for peripheral benzodiazepine receptor binding sites, offers the opportunity to image activated microglia in vivo. This tool may therefore be used to display the occurrence of microglial activation in the course of neurodegeneration. A patient with the clinical diagnosis of corticobasal degeneration (CBD) and left-sided symptoms was studied using fluorodeoxyglucose (FDG) and [¹¹C]PK 11195 PET. We found a marked right hemispheric hypometabolism and asymmetric microglial activation in corresponding areas of the basal ganglia and right temporal and parietal cortex. [¹¹C]PK 11195 PET suggests involvement of microglial activation in the pathogenesis of CBD.
C02	`01`	`X`		`@0 002B17`
C03	`01`	`X`	`FRE`	`@0 Dégénérescence @5 01`
C03	`01`	`X`	`ENG`	`@0 Degeneration @5 01`
C03	`01`	`X`	`SPA`	`@0 Degeneración @5 01`
C03	`02`	`X`	`FRE`	`@0 Microglie @5 02`
C03	`02`	`X`	`ENG`	`@0 Microglia @5 02`
C03	`02`	`X`	`SPA`	`@0 Microglia @5 02`
C03	`03`	`X`	`FRE`	`@0 Positon @5 03`
C03	`03`	`X`	`ENG`	`@0 Positron @5 03`
C03	`03`	`X`	`SPA`	`@0 Positrón @5 03`
C03	`04`	`X`	`FRE`	`@0 Système nerveux pathologie @5 04`
C03	`04`	`X`	`ENG`	`@0 Nervous system diseases @5 04`
C03	`04`	`X`	`SPA`	`@0 Sistema nervioso patología @5 04`
C03	`05`	`X`	`FRE`	`@0 Tomoscintigraphie @5 05`
C03	`05`	`X`	`ENG`	`@0 Emission tomography @5 05`
C03	`05`	`X`	`SPA`	`@0 Tomocentelleografía @5 05`
C07	`01`	`X`	`FRE`	`@0 Névroglie @5 37`
C07	`01`	`X`	`ENG`	`@0 Neuroglia @5 37`
C07	`01`	`X`	`SPA`	`@0 Neuroglia @5 37`
C07	`02`	`X`	`FRE`	`@0 Exploration radioisotopique @5 38`
C07	`02`	`X`	`ENG`	`@0 Radionuclide study @5 38`
C07	`02`	`X`	`SPA`	`@0 Exploración radioisotópica @5 38`
N21				`@1 257`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Links toward previous steps (curation, corpus...)

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Pascal:04-0455135

Le document en format XML

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<author><name sortKey="Ludolph, A C" sort="Ludolph, A C" uniqKey="Ludolph A" first="A. C." last="Ludolph">A. C. Ludolph</name>
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<author><name sortKey="Reske, S N" sort="Reske, S N" uniqKey="Reske S" first="S. N." last="Reske">S. N. Reske</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Nuclear Medicine, University of Ulm</s1>
<s2>Ulm</s2>
<s3>DEU</s3>
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<author><name sortKey="Landwehrmeyer, G B" sort="Landwehrmeyer, G B" uniqKey="Landwehrmeyer G" first="G. B." last="Landwehrmeyer">G. B. Landwehrmeyer</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology University of Ulm</s1>
<s2>Ulm</s2>
<s3>DEU</s3>
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</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2004">2004</date>
</imprint>
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<seriesStmt><title level="j" type="main">Movement disorders</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Degeneration</term>
<term>Emission tomography</term>
<term>Microglia</term>
<term>Nervous system diseases</term>
<term>Positron</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Dégénérescence</term>
<term>Microglie</term>
<term>Positon</term>
<term>Système nerveux pathologie</term>
<term>Tomoscintigraphie</term>
</keywords>
</textClass>
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<front><div type="abstract" xml:lang="en">Positron emission tomography (PET) using [<sup>11</sup>
C]PK 11195, a ligand for peripheral benzodiazepine receptor binding sites, offers the opportunity to image activated microglia in vivo. This tool may therefore be used to display the occurrence of microglial activation in the course of neurodegeneration. A patient with the clinical diagnosis of corticobasal degeneration (CBD) and left-sided symptoms was studied using fluorodeoxyglucose (FDG) and [<sup>11</sup>
C]PK 11195 PET. We found a marked right hemispheric hypometabolism and asymmetric microglial activation in corresponding areas of the basal ganglia and right temporal and parietal cortex. [<sup>11</sup>
C]PK 11195 PET suggests involvement of microglial activation in the pathogenesis of CBD.</div>
</front>
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<fA11 i1="07" i2="1"><s1>NEUMAIER (B.)</s1>
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<fA11 i1="08" i2="1"><s1>LUDOLPH (A. C.)</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>RESKE (S. N.)</s1>
</fA11>
<fA11 i1="10" i2="1"><s1>LANDWEHRMEYER (G. B.)</s1>
</fA11>
<fA14 i1="01"><s1>Department of Neurology University of Ulm</s1>
<s2>Ulm</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Department of Nuclear Medicine, University of Ulm</s1>
<s2>Ulm</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Department of Neuroradiology, University of Tübingen</s1>
<s2>Tübingen</s2>
<s3>DEU</s3>
<sZ>4 aut.</sZ>
</fA14>
<fA20><s1>817-821</s1>
</fA20>
<fA21><s1>2004</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>20953</s2>
<s5>354000113929420110</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2004 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>13 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>04-0455135</s0>
</fA47>
<fA60><s1>P</s1>
<s3>CC</s3>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Movement disorders</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Positron emission tomography (PET) using [<sup>11</sup>
C]PK 11195, a ligand for peripheral benzodiazepine receptor binding sites, offers the opportunity to image activated microglia in vivo. This tool may therefore be used to display the occurrence of microglial activation in the course of neurodegeneration. A patient with the clinical diagnosis of corticobasal degeneration (CBD) and left-sided symptoms was studied using fluorodeoxyglucose (FDG) and [<sup>11</sup>
C]PK 11195 PET. We found a marked right hemispheric hypometabolism and asymmetric microglial activation in corresponding areas of the basal ganglia and right temporal and parietal cortex. [<sup>11</sup>
C]PK 11195 PET suggests involvement of microglial activation in the pathogenesis of CBD.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B17</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Dégénérescence</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Degeneration</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Degeneración</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Microglie</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Microglia</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Microglia</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Positon</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Positron</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Positrón</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Système nerveux pathologie</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Tomoscintigraphie</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Emission tomography</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Tomocentelleografía</s0>
<s5>05</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Névroglie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Neuroglia</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Neuroglia</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Exploration radioisotopique</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Radionuclide study</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Exploración radioisotópica</s0>
<s5>38</s5>
</fC07>
<fN21><s1>257</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

Imaging of activated microglia with PET and [11C]PK 11195 in corticobasal degeneration

Imaging of activated microglia with PET and [11C]PK 11195 in corticobasal degeneration

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